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Targeting the transcriptional landscape in infant AML

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Publications

Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia

Author(s): Raj Bhayadia, Kathrin Krowiorz, Nadine Haetscher, Razan Jammal, Stephan Emmrich, Askar Obulkasim, Jan Fiedler, Adrian Schwarzer, Arefeh Rouhi, Michael Heuser, Susanne Wingert, Sabrina Bothur, Konstanze Döhner, Tobias Mätzig, Michelle Ng, Dirk Reinhardt, Hartmut Döhner, C. Michel Zwaan, Marry van den Heuvel Eibrink, Dirk Heckl, Maarten Fornerod, Thomas Thum, R. Keith Humphries, Michael A. Rieger
Published in: Journal of Clinical Oncology, Issue 36/10, 2018, Page(s) 1007-1016, ISSN 0732-183X
DOI: 10.1200/jco.2017.75.2204

Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications

Author(s): Maurice Labuhn, Felix F Adams, Michelle Ng, Sabine Knoess, Axel Schambach, Emmanuelle M Charpentier, Adrian Schwarzer, Juan L Mateo, Jan-Henning Klusmann, Dirk Heckl
Published in: Nucleic Acids Research, Issue 46/3, 2017, Page(s) 1375-1385, ISSN 0305-1048
DOI: 10.1093/nar/gkx1268

Low-dose cytarabine to prevent myeloid leukemia in children with Down syndrome: TMD Prevention 2007 study

Author(s): Marius Flasinski, Kira Scheibke, Martin Zimmermann, Ursula Creutzig, Katarina Reinhardt, Femke Verwer, Valerie de Haas, Vincent H. J. van der Velden, Christine von Neuhoff, C. Michel Zwaan, Dirk Reinhardt, Jan-Henning Klusmann
Published in: Blood Advances, Issue 2/13, 2018, Page(s) 1532-1540, ISSN 2473-9529
DOI: 10.1182/bloodadvances.2018018945

Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome

Author(s): Maurice Labuhn, Kelly Perkins, Sören Matzk, Leila Varghese, Catherine Garnett, Elli Papaemmanuil, Marlen Metzner, Alison Kennedy, Vyacheslav Amstislavskiy, Thomas Risch, Raj Bhayadia, David Samulowski, David Cruz Hernandez, Bilyana Stoilova, Valentina Iotchkova, Udo Oppermann, Carina Scheer, Kenichi Yoshida, Adrian Schwarzer, Jeffrey W. Taub, John D. Crispino, Mitchell J. Weiss, Yasuhide Hayashi,
Published in: Cancer Cell, Issue 36/2, 2019, Page(s) 123-138.e10, ISSN 1535-6108
DOI: 10.1016/j.ccell.2019.06.007

The Regulatory Roles of Long Noncoding RNAs in Acute Myeloid Leukemia

Author(s): Michelle Ng, Dirk Heckl, Jan-Henning Klusmann
Published in: Frontiers in Oncology, Issue 9, 2019, ISSN 2234-943X
DOI: 10.3389/fonc.2019.00570

The stem cell–specific long noncoding RNA HOXA10-AS in the pathogenesis of KMT2A-rearranged leukemia

Author(s): Sina Al-Kershi, Raj Bhayadia, Michelle Ng, Lonneke Verboon, Stephan Emmrich, Lucie Gack, Adrian Schwarzer, Till Strowig, Dirk Heckl, Jan-Henning Klusmann
Published in: Blood Advances, Issue 3/24, 2019, Page(s) 4252-4263, ISSN 2473-9529
DOI: 10.1182/bloodadvances.2019032029

The long non-coding RNA Cancer Susceptibility 15 is induced by Isocitrate Dehydrogenase mutations and maintains an immature phenotype in adult acute myeloid leukemia

Author(s): Sarah Grasedieck, Christoph Ruess, Kathrin Krowiorz, Susanne Lux, Nicole Pochert, Adrian Schwarzer, Jan-Henning Klusmann, Mojca Jongen-Lavrencic, Tobias Herold, Lars Bullinger, Jonathan R. Pollack, Arefeh Rouhi, Florian Kuchenbauer
Published in: Haematologica, 2020, Page(s) haematol.2019.235291, ISSN 0390-6078
DOI: 10.3324/haematol.2019.235291

Molecular Approaches to Treating Pediatric Leukemias

Author(s): Michaela Kuhlen, Jan-Henning Klusmann, Jessica I. Hoell
Published in: Frontiers in Pediatrics, Issue 7, 2019, ISSN 2296-2360
DOI: 10.3389/fped.2019.00368

Successes and challenges in the treatment of pediatric acute myeloid leukemia: a retrospective analysis of the AML-BFM trials from 1987 to 2012

Author(s): Mareike Rasche, Martin Zimmermann, Lisa Borschel, Jean-Pierre Bourquin, Michael Dworzak, Thomas Klingebiel, Thomas Lehrnbecher, Ursula Creutzig, Jan-Henning Klusmann, Dirk Reinhardt
Published in: Leukemia, Issue 32/10, 2018, Page(s) 2167-2177, ISSN 0887-6924
DOI: 10.1038/s41375-018-0071-7