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Novel therapeutic approaches to improve gastrointestinal wound healing

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Neuropeptide signalling systems – An underexplored target for venom drug discovery

Author(s): Helen C. Mendel, Quentin Kaas, Markus Muttenthaler
Published in: Biochemical Pharmacology, 2020, Page(s) 114129, ISSN 0006-2952
DOI: 10.1016/j.bcp.2020.114129

Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action

Author(s): Nayara Braga Emidio, Hayeon Baik, David Lee, René Stürmer, Jörn Heuer, Alysha G. Elliott, Mark A. T. Blaskovich, Katharina Haupenthal, Nicole Tegtmeyer, Werner Hoffmann, Christina I. Schroeder, Markus Muttenthaler
Published in: Chemical Communications, Issue 56/47, 2020, Page(s) 6420-6423, ISSN 1359-7345
DOI: 10.1039/d0cc02321c

Structure, Function, and Therapeutic Potential of the Trefoil Factor Family in the Gastrointestinal Tract

Author(s): Nayara Braga Emidio, Stuart M. Brierley, Christina I. Schroeder, Markus Muttenthaler
Published in: ACS Pharmacology & Translational Science, Issue 3/4, 2020, Page(s) 583-597, ISSN 2575-9108
DOI: 10.1021/acsptsci.0c00023

The oxytocin receptor signalling system and breast cancer: a critical review

Author(s): Huiping Liu, Christian W. Gruber, Paul F. Alewood, Andreas Möller, Markus Muttenthaler
Published in: Oncogene, Issue 39/37, 2020, Page(s) 5917-5932, ISSN 0950-9232
DOI: 10.1038/s41388-020-01415-8

Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides

Author(s): Volker Herzig, Aline de Araujo, Kathryn Greenwood, Yanni Chin, Monique Windley, Youmie Chong, Markus Muttenthaler, Mehdi Mobli, Neil Audsley, Graham Nicholson, Paul Alewood, Glenn King
Published in: Biomedicines, Issue 6/3, 2018, Page(s) 90, ISSN 2227-9059
DOI: 10.3390/biomedicines6030090

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development

Author(s): Sarah Arrowsmith, Peter Keov, Markus Muttenthaler, Christian W. Gruber
Published in: Journal of Visualized Experiments, Issue 131, 2018, ISSN 1940-087X
DOI: 10.3791/56639

Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species

Author(s): Markus Muttenthaler, Åsa Andersson, Irina Vetter, Rohit Menon, Marta Busnelli, Lotten Ragnarsson, Christian Bergmayr, Sarah Arrowsmith, Jennifer R. Deuis, Han Sheng Chiu, Nathan J. Palpant, Margaret O’Brien, Terry J. Smith, Susan Wray, Inga D. Neumann, Christian W. Gruber, Richard J. Lewis, Paul F. Alewood
Published in: Science Signaling, Issue 10/508, 2017, Page(s) eaan3398, ISSN 1937-9145
DOI: 10.1126/scisignal.aan3398

Trefoil Factor Family: Unresolved Questions and Clinical Perspectives

Author(s): Nayara Braga Emidio, Werner Hoffmann, Stuart M. Brierley, Markus Muttenthaler
Published in: Trends in Biochemical Sciences, Issue 44/5, 2019, Page(s) 387-390, ISSN 0968-0004
DOI: 10.1016/j.tibs.2019.01.004

Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity

Author(s): Zita Liutkevičiūtė, Esther Gil-Mansilla, Thomas Eder, Barbara Casillas-Pérez, Maria Giulia Di Giglio, Edin Muratspahić, Florian Grebien, Thomas Rattei, Markus Muttenthaler, Sylvia Cremer, Christian W. Gruber
Published in: The FASEB Journal, Issue 32/12, 2018, Page(s) 6808-6821, ISSN 0892-6638
DOI: 10.1096/fj.201800443

Advancing the Frontiers of Chemical Protein Synthesis—The 7th CPS Meeting, Haifa, Israel

Author(s): Anne C. Conibear, Markus Muttenthaler
Published in: Cell Chemical Biology, Issue 25/3, 2018, Page(s) 247-254, ISSN 2451-9456
DOI: 10.1016/j.chembiol.2018.03.001

The Tumor Suppressor TFF1 Occurs in Different Forms and Interacts with Multiple Partners in the Human Gastric Mucus Barrier: Indications for Diverse Protective Functions

Author(s): Jörn Heuer, Franziska Heuer, René Stürmer, Sönke Harder, Hartmut Schlüter, Nayara Braga Emidio, Markus Muttenthaler, Dörthe Jechorek, Frank Meyer, Werner Hoffmann
Published in: International Journal of Molecular Sciences, Issue 21/7, 2020, Page(s) 2508, ISSN 1422-0067
DOI: 10.3390/ijms21072508

I8-arachnotocin–an arthropod-derived G protein-biased ligand of the human vasopressin V2 receptor

Author(s): Leopold Duerrauer, Edin Muratspahić, Jasmin Gattringer, Peter Keov, Helen C. Mendel, Kevin D. G. Pfleger, Markus Muttenthaler, Christian W. Gruber
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-019-55675-w

On-Resin Strategy to Label α-Conotoxins: Cy5-RgIA, a Potent α9α10 Nicotinic Acetylcholine Receptor Imaging Probe

Author(s): Markus Muttenthaler, Simon T. Nevin, Marco Inserra, Richard J. Lewis, David J. Adams, Paul F. Alewood
Published in: Australian Journal of Chemistry, Issue 73/4, 2020, Page(s) 327, ISSN 0004-9425
DOI: 10.1071/ch19456

Conotoxins: Chemistry and Biology

Author(s): Ai-Hua Jin, Markus Muttenthaler, Sebastien Dutertre, S.W.A. Himaya, Quentin Kaas, David J. Craik, Richard J. Lewis, Paul F. Alewood
Published in: Chemical Reviews, Issue 119/21, 2019, Page(s) 11510-11549, ISSN 0009-2665
DOI: 10.1021/acs.chemrev.9b00207

Anhydrous Hydrogen Fluoride Cleavage in Boc Solid Phase Peptide Synthesis

Author(s): Kirtikumar B. Jadhav, Katrina J. Woolcock, Markus Muttenthaler
Published in: Peptide Synthesis - Methods and Protocols, Issue 2103, 2020, Page(s) 41-57
DOI: 10.1007/978-1-0716-0227-0_4