Novel therapeutic approaches to improve gastrointestinal wound healing

Project Information

GUTPEPTIDES

Grant agreement ID: 714366

DOI

10.3030/714366

Project closed

EC signature date 5 December 2016

Start date 1 September 2017

End date 31 August 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 487 396,00

EU contribution

€ 1 487 396,00

Coordinated by

UNIVERSITAT WIEN
Austria

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (28)

Conformational selection of vasopressin upon V1a receptor binding.

Author(s): Kateryna Che; Markus Muttenthaler; Dennis Kurzbach
Published in: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 5826-5833 (2021), Issue 4, 2021, ISSN 2001-0370
Publisher: Elsevier B.V.
DOI: 10.1016/j.csbj.2021.10.024

Chemical Synthesis of TFF3 Reveals Novel Mechanistic Insights and a Gut-Stable Metabolite.

Author(s): Nayara Braga Emidio; Rajeshwari Meli; Hue N. T. Tran; Hayeon Baik; Séverine Morisset-Lopez; Alysha G. Elliott; Mark A. T. Blaskovich; Sabrina Spiller; Annette G. Beck-Sickinger; Christina I. Schroeder; Christina I. Schroeder; Markus Muttenthaler; Markus Muttenthaler
Published in: Journal of Medicinal Chemistry, Issue 64(13), 2021, Page(s) 9484-9495, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00767

Neuropeptide signalling systems – An underexplored target for venom drug discovery

Author(s): Helen C. Mendel, Quentin Kaas, Markus Muttenthaler
Published in: Biochemical Pharmacology, Issue 181, 2020, Page(s) 114129, ISSN 0006-2952
Publisher: Elsevier BV
DOI: 10.1016/j.bcp.2020.114129

Heterodimeric Insecticidal Peptide Provides New Insights into the Molecular and Functional Diversity of Ant Venoms.

Author(s): Axel Touchard; Helen C. Mendel; Isabelle Boulogne; Volker Herzig; Volker Herzig; Nayara Braga Emidio; Glenn F. King; Mathilde Triquigneaux; Lucie Jaquillard; Rémy Béroud; Michel De Waard; Olivier Delalande; Alain Dejean; Alain Dejean; Markus Muttenthaler; Markus Muttenthaler; Christophe Duplais
Published in: ACS Pharmacology & Translational Science, Issue 3(6), 2020, Page(s) 1211-1224, ISSN 2575-9108
Publisher: ACS
DOI: 10.1021/acsptsci.0c00119

High oxytocin receptor expression linked to increased cell migration and reduced survival in patients with triple-negative breast cancer

Author(s): Liu, H. Muttenthaler, M.
Published in: Biomedicines, 2022, Page(s) 1595, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines10071595

Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid receptor

Author(s): Muratspahic, Edin; Deibler, Kristine; Han, Jianming; Tomasevic, Natasa; Jadhav, Kirtikumar B.; Olive-Marti, Aina-Leonor; Hochrainer, Nadine; Hellinger, Roland; Koehbach, Johannes; Fay, Jonathan F.; Rahman, Mohammad Homaidur; Hegazy, Lamees; Craven, Timothy W.; Varga, Balazs R.; Bhardwaj, Gaurav; Appourchaux, Kevin; Majumdar, Susruta; Muttenthaler, Markus; Hosseinzadeh, Parisa; Craik, David J.; Spe
Published in: Nature Communications, Issue 14(1), 2023, Page(s) 8064, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-43718-w

Expanding the versatility and scope of the oxime ligation: rapid bioconjugation to disulfide-rich peptides

Author(s): Anke Hering; Nayara Braga Emidio; Markus Muttenthaler
Published in: Chemical Communications, Issue 58(65), 2022, Page(s) 9100-9103, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2cc03752a

Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action

Author(s): Nayara Braga Emidio, Hayeon Baik, David Lee, René Stürmer, Jörn Heuer, Alysha G. Elliott, Mark A. T. Blaskovich, Katharina Haupenthal, Nicole Tegtmeyer, Werner Hoffmann, Christina I. Schroeder, Markus Muttenthaler
Published in: Chemical Communications, Issue 56/47, 2020, Page(s) 6420-6423, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cc02321c

Structure, Function, and Therapeutic Potential of the Trefoil Factor Family in the Gastrointestinal Tract

Author(s): Nayara Braga Emidio, Stuart M. Brierley, Christina I. Schroeder, Markus Muttenthaler
Published in: ACS Pharmacology & Translational Science, Issue 3/4, 2020, Page(s) 583-597, ISSN 2575-9108
Publisher: American Chemical Society
DOI: 10.1021/acsptsci.0c00023

The oxytocin receptor signalling system and breast cancer: a critical review

Author(s): Huiping Liu, Christian W. Gruber, Paul F. Alewood, Andreas Möller, Markus Muttenthaler
Published in: Oncogene, Issue 39/37, 2020, Page(s) 5917-5932, ISSN 0950-9232
Publisher: Nature Publishing Group
DOI: 10.1038/s41388-020-01415-8

Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency.

Author(s): Alicia Peschel; Fernanda C. Cardoso; Andrew A. Walker; Thomas Durek; M. Rhia L. Stone; Nayara Braga Emidio; Philip E. Dawson; Markus Muttenthaler; Markus Muttenthaler; Glenn F. King
Published in: Journal of Medicinal Chemistry, Issue 2, 2020, Page(s) 12773-12785, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c01107

Improving the Gastrointestinal Stability of Linaclotide

Author(s): Nayara Braga Emidio; Hue N. T. Tran; Åsa Andersson; Philip E. Dawson; Fernando Albericio; Irina Vetter; Markus Muttenthaler; Markus Muttenthaler
Published in: Journal of Medicinal Chemistry, Issue 64(12), 2021, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00380

Mucosal biofilms are an endoscopic feature of irritable bowel syndrome and ulcerative colitis

Author(s): Baumgartner, Maximilian Lang, Michaela Holley, Hunter Crepaz, Daniel Hausmann, Bela Pjevac, Petra Moser, Doris Haller, Felix Hof, Fabian Beer, Andrea Orgler, Elisabeth Frick, Adrian Khare, Vineeta Evstatiev, Rayko Strohmaier, Susanne Primas, Christian Dolak, Werner Koecher, Thomas Klavins, Kristaps Rath, Timo Neurath, Markus F. Berry, David Makristathis, Athanasios Muttenthaler, Markus Gasche, Chr
Published in: Gastroenterology, Issue 161(4), 2021, Page(s) 1245-1256.e20, ISSN 0016-5085
Publisher: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2021.06.024

Approaches to Improve the Quantitation of Oxytocin in Human Serum by Mass Spectrometry

Author(s): Hering, Anke; Jieu, Beverly; Jones, Alun; Muttenthaler, Markus
Published in: Frontiers in Chemistry, Issue 10, 2022, Page(s) 889154, ISSN 2296-2646
Publisher: Frontiers
DOI: 10.3389/fchem.2022.889154

On the Utility of Chemical Strategies to Improve Peptide Gut Stability

Author(s): Thomas Kremsmayr; Aws Aljnabi; Juan B. Blanco-Canosa; Hue N. T. Tran; Nayara Braga Emidio; Markus Muttenthaler
Published in: Journal of Medicinal Chemistry, Issue 1, 2022, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.2c00094

Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides

Author(s): Volker Herzig, Aline de Araujo, Kathryn Greenwood, Yanni Chin, Monique Windley, Youmie Chong, Markus Muttenthaler, Mehdi Mobli, Neil Audsley, Graham Nicholson, Paul Alewood, Glenn King
Published in: Biomedicines, Issue 6/3, 2018, Page(s) 90, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines6030090

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development

Author(s): Sarah Arrowsmith, Peter Keov, Markus Muttenthaler, Christian W. Gruber
Published in: Journal of Visualized Experiments, Issue 131, 2018, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/56639

Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species

Author(s): Markus Muttenthaler, Åsa Andersson, Irina Vetter, Rohit Menon, Marta Busnelli, Lotten Ragnarsson, Christian Bergmayr, Sarah Arrowsmith, Jennifer R. Deuis, Han Sheng Chiu, Nathan J. Palpant, Margaret O’Brien, Terry J. Smith, Susan Wray, Inga D. Neumann, Christian W. Gruber, Richard J. Lewis, Paul F. Alewood
Published in: Science Signaling, Issue 10/508, 2017, Page(s) eaan3398, ISSN 1937-9145
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scisignal.aan3398

Trefoil Factor Family: Unresolved Questions and Clinical Perspectives

Author(s): Nayara Braga Emidio, Werner Hoffmann, Stuart M. Brierley, Markus Muttenthaler
Published in: Trends in Biochemical Sciences, Issue 44/5, 2019, Page(s) 387-390, ISSN 0968-0004
Publisher: Elsevier BV
DOI: 10.1016/j.tibs.2019.01.004

Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity

Author(s): Zita Liutkevičiūtė, Esther Gil-Mansilla, Thomas Eder, Barbara Casillas-Pérez, Maria Giulia Di Giglio, Edin Muratspahić, Florian Grebien, Thomas Rattei, Markus Muttenthaler, Sylvia Cremer, Christian W. Gruber
Published in: The FASEB Journal, Issue 32/12, 2018, Page(s) 6808-6821, ISSN 0892-6638
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201800443

Advancing the Frontiers of Chemical Protein Synthesis—The 7th CPS Meeting, Haifa, Israel

Author(s): Anne C. Conibear, Markus Muttenthaler
Published in: Cell Chemical Biology, Issue 25/3, 2018, Page(s) 247-254, ISSN 2451-9456
Publisher: CellPress
DOI: 10.1016/j.chembiol.2018.03.001

The Tumor Suppressor TFF1 Occurs in Different Forms and Interacts with Multiple Partners in the Human Gastric Mucus Barrier: Indications for Diverse Protective Functions

Author(s): Jörn Heuer, Franziska Heuer, René Stürmer, Sönke Harder, Hartmut Schlüter, Nayara Braga Emidio, Markus Muttenthaler, Dörthe Jechorek, Frank Meyer, Werner Hoffmann
Published in: International Journal of Molecular Sciences, Issue 21/7, 2020, Page(s) 2508, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072508

I8-arachnotocin–an arthropod-derived G protein-biased ligand of the human vasopressin V2 receptor

Author(s): Leopold Duerrauer, Edin Muratspahić, Jasmin Gattringer, Peter Keov, Helen C. Mendel, Kevin D. G. Pfleger, Markus Muttenthaler, Christian W. Gruber
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-55675-w

On-Resin Strategy to Label α-Conotoxins: Cy5-RgIA, a Potent α9α10 Nicotinic Acetylcholine Receptor Imaging Probe

Author(s): Markus Muttenthaler, Simon T. Nevin, Marco Inserra, Richard J. Lewis, David J. Adams, Paul F. Alewood
Published in: Australian Journal of Chemistry, Issue 73/4, 2020, Page(s) 327, ISSN 0004-9425
Publisher: Commonwealth Scientific and Industrial Research Organization Publishing
DOI: 10.1071/ch19456

Conotoxins: Chemistry and Biology

Author(s): Ai-Hua Jin, Markus Muttenthaler, Sebastien Dutertre, S.W.A. Himaya, Quentin Kaas, David J. Craik, Richard J. Lewis, Paul F. Alewood
Published in: Chemical Reviews, Issue 119/21, 2019, Page(s) 11510-11549, ISSN 0009-2665
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrev.9b00207

Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin

Author(s): Zoltan Dekan; Thomas Kremsmayr; Peter Keov; Mathilde Godin; Ngari Teakle; Leopold Dürrauer; Huang Xiang; Dalia Gharib; Christian Bergmayr; Roland Hellinger; Marta Vilaseca; Dennis Kurzbach; Fernando Albericio; Paul F. Alewood; Christian W. Gruber; Christian W. Gruber; Markus Muttenthaler; Markus Muttenthaler
Published in: Chemical Science, Issue 12, 2021, Page(s) 4057-4062, ISSN 2041-6539
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sc05501h

Photoswitchable probes of oxytocin and vasopressin

Author(s): Wirth, Ulrike; Raabe, Konstantin; Kalaba, Predrag; Keimpema, Erik; Muttenthaler, Markus; Koenig, Burkhard;
Published in: Journal of Medicinal Chemistry, Issue 66(21), 2023, Page(s) 14853-14865, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.3c01415

Trends in peptide drug discovery

Author(s): Markus Muttenthaler, Glenn F. King, David J. Adams, Paul F. Alewood
Published in: Nature Reviews Drug Discovery, 2021, Page(s) 309-325, ISSN 1474-1784
Publisher: Nature
DOI: 10.1038/s41573-020-00135-8

Book chapters (2)

Fmoc solid phase peptide synthesis of oxytocin and analogues

Author(s): Thomas Kremsmayr; Markus Muttenthaler
Published in: Methods in Molecular Biology, Issue 2384, 2022, Page(s) 175-199, ISSN 1940-6029
Publisher: Springer
DOI: 10.1007/978-1-0716-1759-5_11

Anhydrous Hydrogen Fluoride Cleavage in Boc Solid Phase Peptide Synthesis

Author(s): Kirtikumar B. Jadhav, Katrina J. Woolcock, Markus Muttenthaler
Published in: Peptide Synthesis - Methods and Protocols, Issue 2103, 2020, Page(s) 41-57, ISBN 978-1-0716-0226-3
Publisher: Springer US
DOI: 10.1007/978-1-0716-0227-0_4