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Novel therapeutic approaches to improve gastrointestinal wound healing

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Conformational selection of vasopressin upon V1a receptor binding.

Author(s): Kateryna Che; Markus Muttenthaler; Dennis Kurzbach
Published in: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 5826-5833 (2021), 4, 2021, ISSN 2001-0370
Publisher: Elsevier B.V.
DOI: 10.1016/j.csbj.2021.10.024

Chemical Synthesis of TFF3 Reveals Novel Mechanistic Insights and a Gut-Stable Metabolite.

Author(s): Nayara Braga Emidio; Rajeshwari Meli; Hue N. T. Tran; Hayeon Baik; Séverine Morisset-Lopez; Alysha G. Elliott; Mark A. T. Blaskovich; Sabrina Spiller; Annette G. Beck-Sickinger; Christina I. Schroeder; Christina I. Schroeder; Markus Muttenthaler; Markus Muttenthaler
Published in: Journal of Medicinal Chemistry, 5, 2021, Page(s) 9484-9495, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00767

Neuropeptide signalling systems – An underexplored target for venom drug discovery

Author(s): Helen C. Mendel, Quentin Kaas, Markus Muttenthaler
Published in: Biochemical Pharmacology, 2020, Page(s) 114129, ISSN 0006-2952
Publisher: Elsevier BV
DOI: 10.1016/j.bcp.2020.114129

Heterodimeric Insecticidal Peptide Provides New Insights into the Molecular and Functional Diversity of Ant Venoms.

Author(s): Axel Touchard; Helen C. Mendel; Isabelle Boulogne; Volker Herzig; Volker Herzig; Nayara Braga Emidio; Glenn F. King; Mathilde Triquigneaux; Lucie Jaquillard; Rémy Béroud; Michel De Waard; Olivier Delalande; Alain Dejean; Alain Dejean; Markus Muttenthaler; Markus Muttenthaler; Christophe Duplais
Published in: ACS Pharmacology & Translational Science, 2, 2020, ISSN 2575-9108
Publisher: ACS
DOI: 10.1021/acsptsci.0c00119

Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action

Author(s): Nayara Braga Emidio, Hayeon Baik, David Lee, René Stürmer, Jörn Heuer, Alysha G. Elliott, Mark A. T. Blaskovich, Katharina Haupenthal, Nicole Tegtmeyer, Werner Hoffmann, Christina I. Schroeder, Markus Muttenthaler
Published in: Chemical Communications, 56/47, 2020, Page(s) 6420-6423, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cc02321c

Structure, Function, and Therapeutic Potential of the Trefoil Factor Family in the Gastrointestinal Tract

Author(s): Nayara Braga Emidio, Stuart M. Brierley, Christina I. Schroeder, Markus Muttenthaler
Published in: ACS Pharmacology & Translational Science, 3/4, 2020, Page(s) 583-597, ISSN 2575-9108
Publisher: American Chemical Society
DOI: 10.1021/acsptsci.0c00023

The oxytocin receptor signalling system and breast cancer: a critical review

Author(s): Huiping Liu, Christian W. Gruber, Paul F. Alewood, Andreas Möller, Markus Muttenthaler
Published in: Oncogene, 39/37, 2020, Page(s) 5917-5932, ISSN 0950-9232
Publisher: Nature Publishing Group
DOI: 10.1038/s41388-020-01415-8

Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency.

Author(s): Alicia Peschel; Fernanda C. Cardoso; Andrew A. Walker; Thomas Durek; M. Rhia L. Stone; Nayara Braga Emidio; Philip E. Dawson; Markus Muttenthaler; Markus Muttenthaler; Glenn F. King
Published in: Journal of Medicinal Chemistry, 2, 2020, Page(s) 12773-12785, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c01107

Improving the Gastrointestinal Stability of Linaclotide

Author(s): Nayara Braga Emidio; Hue N. T. Tran; Åsa Andersson; Philip E. Dawson; Fernando Albericio; Irina Vetter; Markus Muttenthaler; Markus Muttenthaler
Published in: Journal of Medicinal Chemistry, 1, 2021, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00380

On the Utility of Chemical Strategies to Improve Peptide Gut Stability

Author(s): Thomas Kremsmayr; Aws Aljnabi; Juan B. Blanco-Canosa; Hue N. T. Tran; Nayara Braga Emidio; Markus Muttenthaler
Published in: Journal of Medicinal Chemistry, 1, 2022, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.2c00094

Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides

Author(s): Volker Herzig, Aline de Araujo, Kathryn Greenwood, Yanni Chin, Monique Windley, Youmie Chong, Markus Muttenthaler, Mehdi Mobli, Neil Audsley, Graham Nicholson, Paul Alewood, Glenn King
Published in: Biomedicines, 6/3, 2018, Page(s) 90, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines6030090

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development

Author(s): Sarah Arrowsmith, Peter Keov, Markus Muttenthaler, Christian W. Gruber
Published in: Journal of Visualized Experiments, 131, 2018, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/56639

Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species

Author(s): Markus Muttenthaler, Åsa Andersson, Irina Vetter, Rohit Menon, Marta Busnelli, Lotten Ragnarsson, Christian Bergmayr, Sarah Arrowsmith, Jennifer R. Deuis, Han Sheng Chiu, Nathan J. Palpant, Margaret O’Brien, Terry J. Smith, Susan Wray, Inga D. Neumann, Christian W. Gruber, Richard J. Lewis, Paul F. Alewood
Published in: Science Signaling, 10/508, 2017, Page(s) eaan3398, ISSN 1937-9145
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scisignal.aan3398

Trefoil Factor Family: Unresolved Questions and Clinical Perspectives

Author(s): Nayara Braga Emidio, Werner Hoffmann, Stuart M. Brierley, Markus Muttenthaler
Published in: Trends in Biochemical Sciences, 44/5, 2019, Page(s) 387-390, ISSN 0968-0004
Publisher: Elsevier BV
DOI: 10.1016/j.tibs.2019.01.004

Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity

Author(s): Zita Liutkevičiūtė, Esther Gil-Mansilla, Thomas Eder, Barbara Casillas-Pérez, Maria Giulia Di Giglio, Edin Muratspahić, Florian Grebien, Thomas Rattei, Markus Muttenthaler, Sylvia Cremer, Christian W. Gruber
Published in: The FASEB Journal, 32/12, 2018, Page(s) 6808-6821, ISSN 0892-6638
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201800443

Advancing the Frontiers of Chemical Protein Synthesis—The 7th CPS Meeting, Haifa, Israel

Author(s): Anne C. Conibear, Markus Muttenthaler
Published in: Cell Chemical Biology, 25/3, 2018, Page(s) 247-254, ISSN 2451-9456
Publisher: CellPress
DOI: 10.1016/j.chembiol.2018.03.001

The Tumor Suppressor TFF1 Occurs in Different Forms and Interacts with Multiple Partners in the Human Gastric Mucus Barrier: Indications for Diverse Protective Functions

Author(s): Jörn Heuer, Franziska Heuer, René Stürmer, Sönke Harder, Hartmut Schlüter, Nayara Braga Emidio, Markus Muttenthaler, Dörthe Jechorek, Frank Meyer, Werner Hoffmann
Published in: International Journal of Molecular Sciences, 21/7, 2020, Page(s) 2508, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072508

I8-arachnotocin–an arthropod-derived G protein-biased ligand of the human vasopressin V2 receptor

Author(s): Leopold Duerrauer, Edin Muratspahić, Jasmin Gattringer, Peter Keov, Helen C. Mendel, Kevin D. G. Pfleger, Markus Muttenthaler, Christian W. Gruber
Published in: Scientific Reports, 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-55675-w

On-Resin Strategy to Label α-Conotoxins: Cy5-RgIA, a Potent α9α10 Nicotinic Acetylcholine Receptor Imaging Probe

Author(s): Markus Muttenthaler, Simon T. Nevin, Marco Inserra, Richard J. Lewis, David J. Adams, Paul F. Alewood
Published in: Australian Journal of Chemistry, 73/4, 2020, Page(s) 327, ISSN 0004-9425
Publisher: Commonwealth Scientific and Industrial Research Organization Publishing
DOI: 10.1071/ch19456

Conotoxins: Chemistry and Biology

Author(s): Ai-Hua Jin, Markus Muttenthaler, Sebastien Dutertre, S.W.A. Himaya, Quentin Kaas, David J. Craik, Richard J. Lewis, Paul F. Alewood
Published in: Chemical Reviews, 119/21, 2019, Page(s) 11510-11549, ISSN 0009-2665
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrev.9b00207

Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin

Author(s): Zoltan Dekan; Thomas Kremsmayr; Peter Keov; Mathilde Godin; Ngari Teakle; Leopold Dürrauer; Huang Xiang; Dalia Gharib; Christian Bergmayr; Roland Hellinger; Marta Vilaseca; Dennis Kurzbach; Fernando Albericio; Paul F. Alewood; Christian W. Gruber; Christian W. Gruber; Markus Muttenthaler; Markus Muttenthaler
Published in: Chemical Science, 5, 2021, Page(s) 4057-4062, ISSN 2041-6539
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sc05501h

Trends in peptide drug discovery

Author(s): Markus Muttenthaler, Glenn F. King, David J. Adams, Paul F. Alewood
Published in: Nature Reviews Drug Discovery, 2021, Page(s) 309-325, ISSN 1474-1784
Publisher: Nature
DOI: 10.1038/s41573-020-00135-8

Anhydrous Hydrogen Fluoride Cleavage in Boc Solid Phase Peptide Synthesis

Author(s): Kirtikumar B. Jadhav, Katrina J. Woolcock, Markus Muttenthaler
Published in: Peptide Synthesis - Methods and Protocols, 2103, 2020, Page(s) 41-57, ISBN 978-1-0716-0226-3
Publisher: Springer US
DOI: 10.1007/978-1-0716-0227-0_4