Novel therapeutic approaches to improve gastrointestinal wound healing

Publikacje

Conformational selection of vasopressin upon V1a receptor binding.

Autorzy: Kateryna Che; Markus Muttenthaler; Dennis Kurzbach
Opublikowane w: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 5826-5833 (2021), Numer 4, 2021, ISSN 2001-0370
Wydawca: Elsevier B.V.
DOI: 10.1016/j.csbj.2021.10.024

Chemical Synthesis of TFF3 Reveals Novel Mechanistic Insights and a Gut-Stable Metabolite.

Autorzy: Nayara Braga Emidio; Rajeshwari Meli; Hue N. T. Tran; Hayeon Baik; Séverine Morisset-Lopez; Alysha G. Elliott; Mark A. T. Blaskovich; Sabrina Spiller; Annette G. Beck-Sickinger; Christina I. Schroeder; Christina I. Schroeder; Markus Muttenthaler; Markus Muttenthaler
Opublikowane w: Journal of Medicinal Chemistry, Numer 5, 2021, Strona(/y) 9484-9495, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00767

Neuropeptide signalling systems – An underexplored target for venom drug discovery

Autorzy: Helen C. Mendel, Quentin Kaas, Markus Muttenthaler
Opublikowane w: Biochemical Pharmacology, 2020, Strona(/y) 114129, ISSN 0006-2952
Wydawca: Elsevier BV
DOI: 10.1016/j.bcp.2020.114129

Heterodimeric Insecticidal Peptide Provides New Insights into the Molecular and Functional Diversity of Ant Venoms.

Autorzy: Axel Touchard; Helen C. Mendel; Isabelle Boulogne; Volker Herzig; Volker Herzig; Nayara Braga Emidio; Glenn F. King; Mathilde Triquigneaux; Lucie Jaquillard; Rémy Béroud; Michel De Waard; Olivier Delalande; Alain Dejean; Alain Dejean; Markus Muttenthaler; Markus Muttenthaler; Christophe Duplais
Opublikowane w: ACS Pharmacology & Translational Science, Numer 2, 2020, ISSN 2575-9108
Wydawca: ACS
DOI: 10.1021/acsptsci.0c00119

High oxytocin receptor expression linked to increased cell migration and reduced survival in patients with triple-negative breast cancer

Autorzy: Liu, H. Muttenthaler, M.
Opublikowane w: Biomedicines, 2022, Strona(/y) 1595, ISSN 2227-9059
Wydawca: MDPI
DOI: 10.3390/biomedicines10071595

Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid receptor

Autorzy: Muratspahic, Edin; Deibler, Kristine; Han, Jianming; Tomasevic, Natasa; Jadhav, Kirtikumar B.; Olive-Marti, Aina-Leonor; Hochrainer, Nadine; Hellinger, Roland; Koehbach, Johannes; Fay, Jonathan F.; Rahman, Mohammad Homaidur; Hegazy, Lamees; Craven, Timothy W.; Varga, Balazs R.; Bhardwaj, Gaurav; Appourchaux, Kevin; Majumdar, Susruta; Muttenthaler, Markus; Hosseinzadeh, Parisa; Craik, David J.; Spe
Opublikowane w: Nature Communications, Numer 14(1), 2023, Strona(/y) 8064, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-43718-w

Expanding the versatility and scope of the oxime ligation: rapid bioconjugation to disulfide-rich peptides

Autorzy: Anke Hering; Nayara Braga Emidio; Markus Muttenthaler
Opublikowane w: Chemical Communications, Numer 58(65), 2022, Strona(/y) 9100-9103, ISSN 1359-7345
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d2cc03752a

Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action

Autorzy: Nayara Braga Emidio, Hayeon Baik, David Lee, René Stürmer, Jörn Heuer, Alysha G. Elliott, Mark A. T. Blaskovich, Katharina Haupenthal, Nicole Tegtmeyer, Werner Hoffmann, Christina I. Schroeder, Markus Muttenthaler
Opublikowane w: Chemical Communications, Numer 56/47, 2020, Strona(/y) 6420-6423, ISSN 1359-7345
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d0cc02321c

Structure, Function, and Therapeutic Potential of the Trefoil Factor Family in the Gastrointestinal Tract

Autorzy: Nayara Braga Emidio, Stuart M. Brierley, Christina I. Schroeder, Markus Muttenthaler
Opublikowane w: ACS Pharmacology & Translational Science, Numer 3/4, 2020, Strona(/y) 583-597, ISSN 2575-9108
Wydawca: American Chemical Society
DOI: 10.1021/acsptsci.0c00023

The oxytocin receptor signalling system and breast cancer: a critical review

Autorzy: Huiping Liu, Christian W. Gruber, Paul F. Alewood, Andreas Möller, Markus Muttenthaler
Opublikowane w: Oncogene, Numer 39/37, 2020, Strona(/y) 5917-5932, ISSN 0950-9232
Wydawca: Nature Publishing Group
DOI: 10.1038/s41388-020-01415-8

Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency.

Autorzy: Alicia Peschel; Fernanda C. Cardoso; Andrew A. Walker; Thomas Durek; M. Rhia L. Stone; Nayara Braga Emidio; Philip E. Dawson; Markus Muttenthaler; Markus Muttenthaler; Glenn F. King
Opublikowane w: Journal of Medicinal Chemistry, Numer 2, 2020, Strona(/y) 12773-12785, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c01107

Improving the Gastrointestinal Stability of Linaclotide

Autorzy: Nayara Braga Emidio; Hue N. T. Tran; Åsa Andersson; Philip E. Dawson; Fernando Albericio; Irina Vetter; Markus Muttenthaler; Markus Muttenthaler
Opublikowane w: Journal of Medicinal Chemistry, Numer 1, 2021, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00380

Mucosal biofilms are an endoscopic feature of irritable bowel syndrome and ulcerative colitis

Autorzy: Baumgartner, Maximilian Lang, Michaela Holley, Hunter Crepaz, Daniel Hausmann, Bela Pjevac, Petra Moser, Doris Haller, Felix Hof, Fabian Beer, Andrea Orgler, Elisabeth Frick, Adrian Khare, Vineeta Evstatiev, Rayko Strohmaier, Susanne Primas, Christian Dolak, Werner Koecher, Thomas Klavins, Kristaps Rath, Timo Neurath, Markus F. Berry, David Makristathis, Athanasios Muttenthaler, Markus Gasche, Chr
Opublikowane w: Gastroenterology, Numer 161(4), 2021, Strona(/y) 1245-1256.e20, ISSN 0016-5085
Wydawca: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2021.06.024

Approaches to Improve the Quantitation of Oxytocin in Human Serum by Mass Spectrometry

Autorzy: Hering, Anke; Jieu, Beverly; Jones, Alun; Muttenthaler, Markus
Opublikowane w: Frontiers in Chemistry, Numer 10, 2022, Strona(/y) 889154, ISSN 2296-2646
Wydawca: Frontiers
DOI: 10.3389/fchem.2022.889154

On the Utility of Chemical Strategies to Improve Peptide Gut Stability

Autorzy: Thomas Kremsmayr; Aws Aljnabi; Juan B. Blanco-Canosa; Hue N. T. Tran; Nayara Braga Emidio; Markus Muttenthaler
Opublikowane w: Journal of Medicinal Chemistry, Numer 1, 2022, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.1021/acs.jmedchem.2c00094

Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides

Autorzy: Volker Herzig, Aline de Araujo, Kathryn Greenwood, Yanni Chin, Monique Windley, Youmie Chong, Markus Muttenthaler, Mehdi Mobli, Neil Audsley, Graham Nicholson, Paul Alewood, Glenn King
Opublikowane w: Biomedicines, Numer 6/3, 2018, Strona(/y) 90, ISSN 2227-9059
Wydawca: MDPI
DOI: 10.3390/biomedicines6030090

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development

Autorzy: Sarah Arrowsmith, Peter Keov, Markus Muttenthaler, Christian W. Gruber
Opublikowane w: Journal of Visualized Experiments, Numer 131, 2018, ISSN 1940-087X
Wydawca: MYJoVE Corporation
DOI: 10.3791/56639

Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species

Autorzy: Markus Muttenthaler, Åsa Andersson, Irina Vetter, Rohit Menon, Marta Busnelli, Lotten Ragnarsson, Christian Bergmayr, Sarah Arrowsmith, Jennifer R. Deuis, Han Sheng Chiu, Nathan J. Palpant, Margaret O’Brien, Terry J. Smith, Susan Wray, Inga D. Neumann, Christian W. Gruber, Richard J. Lewis, Paul F. Alewood
Opublikowane w: Science Signaling, Numer 10/508, 2017, Strona(/y) eaan3398, ISSN 1937-9145
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/scisignal.aan3398

Trefoil Factor Family: Unresolved Questions and Clinical Perspectives

Autorzy: Nayara Braga Emidio, Werner Hoffmann, Stuart M. Brierley, Markus Muttenthaler
Opublikowane w: Trends in Biochemical Sciences, Numer 44/5, 2019, Strona(/y) 387-390, ISSN 0968-0004
Wydawca: Elsevier BV
DOI: 10.1016/j.tibs.2019.01.004

Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity

Autorzy: Zita Liutkevičiūtė, Esther Gil-Mansilla, Thomas Eder, Barbara Casillas-Pérez, Maria Giulia Di Giglio, Edin Muratspahić, Florian Grebien, Thomas Rattei, Markus Muttenthaler, Sylvia Cremer, Christian W. Gruber
Opublikowane w: The FASEB Journal, Numer 32/12, 2018, Strona(/y) 6808-6821, ISSN 0892-6638
Wydawca: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201800443

Advancing the Frontiers of Chemical Protein Synthesis—The 7th CPS Meeting, Haifa, Israel

Autorzy: Anne C. Conibear, Markus Muttenthaler
Opublikowane w: Cell Chemical Biology, Numer 25/3, 2018, Strona(/y) 247-254, ISSN 2451-9456
Wydawca: CellPress
DOI: 10.1016/j.chembiol.2018.03.001

The Tumor Suppressor TFF1 Occurs in Different Forms and Interacts with Multiple Partners in the Human Gastric Mucus Barrier: Indications for Diverse Protective Functions

Autorzy: Jörn Heuer, Franziska Heuer, René Stürmer, Sönke Harder, Hartmut Schlüter, Nayara Braga Emidio, Markus Muttenthaler, Dörthe Jechorek, Frank Meyer, Werner Hoffmann
Opublikowane w: International Journal of Molecular Sciences, Numer 21/7, 2020, Strona(/y) 2508, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072508

I8-arachnotocin–an arthropod-derived G protein-biased ligand of the human vasopressin V2 receptor

Autorzy: Leopold Duerrauer, Edin Muratspahić, Jasmin Gattringer, Peter Keov, Helen C. Mendel, Kevin D. G. Pfleger, Markus Muttenthaler, Christian W. Gruber
Opublikowane w: Scientific Reports, Numer 9/1, 2019, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-019-55675-w

On-Resin Strategy to Label α-Conotoxins: Cy5-RgIA, a Potent α9α10 Nicotinic Acetylcholine Receptor Imaging Probe

Autorzy: Markus Muttenthaler, Simon T. Nevin, Marco Inserra, Richard J. Lewis, David J. Adams, Paul F. Alewood
Opublikowane w: Australian Journal of Chemistry, Numer 73/4, 2020, Strona(/y) 327, ISSN 0004-9425
Wydawca: Commonwealth Scientific and Industrial Research Organization Publishing
DOI: 10.1071/ch19456

Conotoxins: Chemistry and Biology

Autorzy: Ai-Hua Jin, Markus Muttenthaler, Sebastien Dutertre, S.W.A. Himaya, Quentin Kaas, David J. Craik, Richard J. Lewis, Paul F. Alewood
Opublikowane w: Chemical Reviews, Numer 119/21, 2019, Strona(/y) 11510-11549, ISSN 0009-2665
Wydawca: American Chemical Society
DOI: 10.1021/acs.chemrev.9b00207

Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin

Autorzy: Zoltan Dekan; Thomas Kremsmayr; Peter Keov; Mathilde Godin; Ngari Teakle; Leopold Dürrauer; Huang Xiang; Dalia Gharib; Christian Bergmayr; Roland Hellinger; Marta Vilaseca; Dennis Kurzbach; Fernando Albericio; Paul F. Alewood; Christian W. Gruber; Christian W. Gruber; Markus Muttenthaler; Markus Muttenthaler
Opublikowane w: Chemical Science, Numer 5, 2021, Strona(/y) 4057-4062, ISSN 2041-6539
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d0sc05501h

Photoswitchable probes of oxytocin and vasopressin

Autorzy: Wirth, Ulrike; Raabe, Konstantin; Kalaba, Predrag; Keimpema, Erik; Muttenthaler, Markus; Koenig, Burkhard;
Opublikowane w: Journal of Medicinal Chemistry, Numer 66(21), 2023, Strona(/y) 14853-14865, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.1021/acs.jmedchem.3c01415

Trends in peptide drug discovery

Autorzy: Markus Muttenthaler, Glenn F. King, David J. Adams, Paul F. Alewood
Opublikowane w: Nature Reviews Drug Discovery, 2021, Strona(/y) 309-325, ISSN 1474-1784
Wydawca: Nature
DOI: 10.1038/s41573-020-00135-8

Fmoc solid phase peptide synthesis of oxytocin and analogues

Autorzy: Thomas Kremsmayr; Markus Muttenthaler
Opublikowane w: Methods in Molecular Biology, Numer 2384, 2022, Strona(/y) 175-199, ISSN 1940-6029
Wydawca: Springer
DOI: 10.1007/978-1-0716-1759-5_11

Anhydrous Hydrogen Fluoride Cleavage in Boc Solid Phase Peptide Synthesis

Autorzy: Kirtikumar B. Jadhav, Katrina J. Woolcock, Markus Muttenthaler
Opublikowane w: Peptide Synthesis - Methods and Protocols, Numer 2103, 2020, Strona(/y) 41-57, ISBN 978-1-0716-0226-3
Wydawca: Springer US
DOI: 10.1007/978-1-0716-0227-0_4

Wyszukiwanie danych OpenAIRE...

Publikacje

Udostępnij tę stronę

Pobierz