Novel therapeutic approaches to improve gastrointestinal wound healing

Informazioni relative al progetto

GUTPEPTIDES

ID dell’accordo di sovvenzione: 714366

DOI

10.3030/714366

Progetto chiuso

Data della firma CE 5 Dicembre 2016

Data di avvio 1 Settembre 2017

Data di completamento 31 Agosto 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 487 396,00

Contributo UE

€ 1 487 396,00

Coordinato da

UNIVERSITAT WIEN
Austria

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (28)

Conformational selection of vasopressin upon V1a receptor binding.

Autori: Kateryna Che; Markus Muttenthaler; Dennis Kurzbach
Pubblicato in: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 5826-5833 (2021), Numero 4, 2021, ISSN 2001-0370
Editore: Elsevier B.V.
DOI: 10.1016/j.csbj.2021.10.024

Chemical Synthesis of TFF3 Reveals Novel Mechanistic Insights and a Gut-Stable Metabolite.

Autori: Nayara Braga Emidio; Rajeshwari Meli; Hue N. T. Tran; Hayeon Baik; Séverine Morisset-Lopez; Alysha G. Elliott; Mark A. T. Blaskovich; Sabrina Spiller; Annette G. Beck-Sickinger; Christina I. Schroeder; Christina I. Schroeder; Markus Muttenthaler; Markus Muttenthaler
Pubblicato in: Journal of Medicinal Chemistry, Numero 64(13), 2021, Pagina/e 9484-9495, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00767

Neuropeptide signalling systems – An underexplored target for venom drug discovery

Autori: Helen C. Mendel, Quentin Kaas, Markus Muttenthaler
Pubblicato in: Biochemical Pharmacology, Numero 181, 2020, Pagina/e 114129, ISSN 0006-2952
Editore: Elsevier BV
DOI: 10.1016/j.bcp.2020.114129

Heterodimeric Insecticidal Peptide Provides New Insights into the Molecular and Functional Diversity of Ant Venoms.

Autori: Axel Touchard; Helen C. Mendel; Isabelle Boulogne; Volker Herzig; Volker Herzig; Nayara Braga Emidio; Glenn F. King; Mathilde Triquigneaux; Lucie Jaquillard; Rémy Béroud; Michel De Waard; Olivier Delalande; Alain Dejean; Alain Dejean; Markus Muttenthaler; Markus Muttenthaler; Christophe Duplais
Pubblicato in: ACS Pharmacology & Translational Science, Numero 3(6), 2020, Pagina/e 1211-1224, ISSN 2575-9108
Editore: ACS
DOI: 10.1021/acsptsci.0c00119

High oxytocin receptor expression linked to increased cell migration and reduced survival in patients with triple-negative breast cancer

Autori: Liu, H. Muttenthaler, M.
Pubblicato in: Biomedicines, 2022, Pagina/e 1595, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/biomedicines10071595

Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid receptor

Autori: Muratspahic, Edin; Deibler, Kristine; Han, Jianming; Tomasevic, Natasa; Jadhav, Kirtikumar B.; Olive-Marti, Aina-Leonor; Hochrainer, Nadine; Hellinger, Roland; Koehbach, Johannes; Fay, Jonathan F.; Rahman, Mohammad Homaidur; Hegazy, Lamees; Craven, Timothy W.; Varga, Balazs R.; Bhardwaj, Gaurav; Appourchaux, Kevin; Majumdar, Susruta; Muttenthaler, Markus; Hosseinzadeh, Parisa; Craik, David J.; Spe
Pubblicato in: Nature Communications, Numero 14(1), 2023, Pagina/e 8064, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-43718-w

Expanding the versatility and scope of the oxime ligation: rapid bioconjugation to disulfide-rich peptides

Autori: Anke Hering; Nayara Braga Emidio; Markus Muttenthaler
Pubblicato in: Chemical Communications, Numero 58(65), 2022, Pagina/e 9100-9103, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d2cc03752a

Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action

Autori: Nayara Braga Emidio, Hayeon Baik, David Lee, René Stürmer, Jörn Heuer, Alysha G. Elliott, Mark A. T. Blaskovich, Katharina Haupenthal, Nicole Tegtmeyer, Werner Hoffmann, Christina I. Schroeder, Markus Muttenthaler
Pubblicato in: Chemical Communications, Numero 56/47, 2020, Pagina/e 6420-6423, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d0cc02321c

Structure, Function, and Therapeutic Potential of the Trefoil Factor Family in the Gastrointestinal Tract

Autori: Nayara Braga Emidio, Stuart M. Brierley, Christina I. Schroeder, Markus Muttenthaler
Pubblicato in: ACS Pharmacology & Translational Science, Numero 3/4, 2020, Pagina/e 583-597, ISSN 2575-9108
Editore: American Chemical Society
DOI: 10.1021/acsptsci.0c00023

The oxytocin receptor signalling system and breast cancer: a critical review

Autori: Huiping Liu, Christian W. Gruber, Paul F. Alewood, Andreas Möller, Markus Muttenthaler
Pubblicato in: Oncogene, Numero 39/37, 2020, Pagina/e 5917-5932, ISSN 0950-9232
Editore: Nature Publishing Group
DOI: 10.1038/s41388-020-01415-8

Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency.

Autori: Alicia Peschel; Fernanda C. Cardoso; Andrew A. Walker; Thomas Durek; M. Rhia L. Stone; Nayara Braga Emidio; Philip E. Dawson; Markus Muttenthaler; Markus Muttenthaler; Glenn F. King
Pubblicato in: Journal of Medicinal Chemistry, Numero 2, 2020, Pagina/e 12773-12785, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c01107

Improving the Gastrointestinal Stability of Linaclotide

Autori: Nayara Braga Emidio; Hue N. T. Tran; Åsa Andersson; Philip E. Dawson; Fernando Albericio; Irina Vetter; Markus Muttenthaler; Markus Muttenthaler
Pubblicato in: Journal of Medicinal Chemistry, Numero 64(12), 2021, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00380

Mucosal biofilms are an endoscopic feature of irritable bowel syndrome and ulcerative colitis

Autori: Baumgartner, Maximilian Lang, Michaela Holley, Hunter Crepaz, Daniel Hausmann, Bela Pjevac, Petra Moser, Doris Haller, Felix Hof, Fabian Beer, Andrea Orgler, Elisabeth Frick, Adrian Khare, Vineeta Evstatiev, Rayko Strohmaier, Susanne Primas, Christian Dolak, Werner Koecher, Thomas Klavins, Kristaps Rath, Timo Neurath, Markus F. Berry, David Makristathis, Athanasios Muttenthaler, Markus Gasche, Chr
Pubblicato in: Gastroenterology, Numero 161(4), 2021, Pagina/e 1245-1256.e20, ISSN 0016-5085
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2021.06.024

Approaches to Improve the Quantitation of Oxytocin in Human Serum by Mass Spectrometry

Autori: Hering, Anke; Jieu, Beverly; Jones, Alun; Muttenthaler, Markus
Pubblicato in: Frontiers in Chemistry, Numero 10, 2022, Pagina/e 889154, ISSN 2296-2646
Editore: Frontiers
DOI: 10.3389/fchem.2022.889154

On the Utility of Chemical Strategies to Improve Peptide Gut Stability

Autori: Thomas Kremsmayr; Aws Aljnabi; Juan B. Blanco-Canosa; Hue N. T. Tran; Nayara Braga Emidio; Markus Muttenthaler
Pubblicato in: Journal of Medicinal Chemistry, Numero 1, 2022, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.2c00094

Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides

Autori: Volker Herzig, Aline de Araujo, Kathryn Greenwood, Yanni Chin, Monique Windley, Youmie Chong, Markus Muttenthaler, Mehdi Mobli, Neil Audsley, Graham Nicholson, Paul Alewood, Glenn King
Pubblicato in: Biomedicines, Numero 6/3, 2018, Pagina/e 90, ISSN 2227-9059
Editore: MDPI
DOI: 10.3390/biomedicines6030090

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development

Autori: Sarah Arrowsmith, Peter Keov, Markus Muttenthaler, Christian W. Gruber
Pubblicato in: Journal of Visualized Experiments, Numero 131, 2018, ISSN 1940-087X
Editore: MYJoVE Corporation
DOI: 10.3791/56639

Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species

Autori: Markus Muttenthaler, Åsa Andersson, Irina Vetter, Rohit Menon, Marta Busnelli, Lotten Ragnarsson, Christian Bergmayr, Sarah Arrowsmith, Jennifer R. Deuis, Han Sheng Chiu, Nathan J. Palpant, Margaret O’Brien, Terry J. Smith, Susan Wray, Inga D. Neumann, Christian W. Gruber, Richard J. Lewis, Paul F. Alewood
Pubblicato in: Science Signaling, Numero 10/508, 2017, Pagina/e eaan3398, ISSN 1937-9145
Editore: American Association for the Advancement of Science
DOI: 10.1126/scisignal.aan3398

Trefoil Factor Family: Unresolved Questions and Clinical Perspectives

Autori: Nayara Braga Emidio, Werner Hoffmann, Stuart M. Brierley, Markus Muttenthaler
Pubblicato in: Trends in Biochemical Sciences, Numero 44/5, 2019, Pagina/e 387-390, ISSN 0968-0004
Editore: Elsevier BV
DOI: 10.1016/j.tibs.2019.01.004

Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity

Autori: Zita Liutkevičiūtė, Esther Gil-Mansilla, Thomas Eder, Barbara Casillas-Pérez, Maria Giulia Di Giglio, Edin Muratspahić, Florian Grebien, Thomas Rattei, Markus Muttenthaler, Sylvia Cremer, Christian W. Gruber
Pubblicato in: The FASEB Journal, Numero 32/12, 2018, Pagina/e 6808-6821, ISSN 0892-6638
Editore: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201800443

Advancing the Frontiers of Chemical Protein Synthesis—The 7th CPS Meeting, Haifa, Israel

Autori: Anne C. Conibear, Markus Muttenthaler
Pubblicato in: Cell Chemical Biology, Numero 25/3, 2018, Pagina/e 247-254, ISSN 2451-9456
Editore: CellPress
DOI: 10.1016/j.chembiol.2018.03.001

The Tumor Suppressor TFF1 Occurs in Different Forms and Interacts with Multiple Partners in the Human Gastric Mucus Barrier: Indications for Diverse Protective Functions

Autori: Jörn Heuer, Franziska Heuer, René Stürmer, Sönke Harder, Hartmut Schlüter, Nayara Braga Emidio, Markus Muttenthaler, Dörthe Jechorek, Frank Meyer, Werner Hoffmann
Pubblicato in: International Journal of Molecular Sciences, Numero 21/7, 2020, Pagina/e 2508, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072508

I8-arachnotocin–an arthropod-derived G protein-biased ligand of the human vasopressin V2 receptor

Autori: Leopold Duerrauer, Edin Muratspahić, Jasmin Gattringer, Peter Keov, Helen C. Mendel, Kevin D. G. Pfleger, Markus Muttenthaler, Christian W. Gruber
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-55675-w

On-Resin Strategy to Label α-Conotoxins: Cy5-RgIA, a Potent α9α10 Nicotinic Acetylcholine Receptor Imaging Probe

Autori: Markus Muttenthaler, Simon T. Nevin, Marco Inserra, Richard J. Lewis, David J. Adams, Paul F. Alewood
Pubblicato in: Australian Journal of Chemistry, Numero 73/4, 2020, Pagina/e 327, ISSN 0004-9425
Editore: Commonwealth Scientific and Industrial Research Organization Publishing
DOI: 10.1071/ch19456

Conotoxins: Chemistry and Biology

Autori: Ai-Hua Jin, Markus Muttenthaler, Sebastien Dutertre, S.W.A. Himaya, Quentin Kaas, David J. Craik, Richard J. Lewis, Paul F. Alewood
Pubblicato in: Chemical Reviews, Numero 119/21, 2019, Pagina/e 11510-11549, ISSN 0009-2665
Editore: American Chemical Society
DOI: 10.1021/acs.chemrev.9b00207

Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin

Autori: Zoltan Dekan; Thomas Kremsmayr; Peter Keov; Mathilde Godin; Ngari Teakle; Leopold Dürrauer; Huang Xiang; Dalia Gharib; Christian Bergmayr; Roland Hellinger; Marta Vilaseca; Dennis Kurzbach; Fernando Albericio; Paul F. Alewood; Christian W. Gruber; Christian W. Gruber; Markus Muttenthaler; Markus Muttenthaler
Pubblicato in: Chemical Science, Numero 12, 2021, Pagina/e 4057-4062, ISSN 2041-6539
Editore: Royal Society of Chemistry
DOI: 10.1039/d0sc05501h

Photoswitchable probes of oxytocin and vasopressin

Autori: Wirth, Ulrike; Raabe, Konstantin; Kalaba, Predrag; Keimpema, Erik; Muttenthaler, Markus; Koenig, Burkhard;
Pubblicato in: Journal of Medicinal Chemistry, Numero 66(21), 2023, Pagina/e 14853-14865, ISSN 0022-2623
Editore: American Chemical Society
DOI: 10.1021/acs.jmedchem.3c01415

Trends in peptide drug discovery

Autori: Markus Muttenthaler, Glenn F. King, David J. Adams, Paul F. Alewood
Pubblicato in: Nature Reviews Drug Discovery, 2021, Pagina/e 309-325, ISSN 1474-1784
Editore: Nature
DOI: 10.1038/s41573-020-00135-8

Book chapters (2)

Fmoc solid phase peptide synthesis of oxytocin and analogues

Autori: Thomas Kremsmayr; Markus Muttenthaler
Pubblicato in: Methods in Molecular Biology, Numero 2384, 2022, Pagina/e 175-199, ISSN 1940-6029
Editore: Springer
DOI: 10.1007/978-1-0716-1759-5_11

Anhydrous Hydrogen Fluoride Cleavage in Boc Solid Phase Peptide Synthesis

Autori: Kirtikumar B. Jadhav, Katrina J. Woolcock, Markus Muttenthaler
Pubblicato in: Peptide Synthesis - Methods and Protocols, Numero 2103, 2020, Pagina/e 41-57, ISBN 978-1-0716-0226-3
Editore: Springer US
DOI: 10.1007/978-1-0716-0227-0_4