Objective Magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) and are two well-established powerful and versatile tools that are extensively used in many fields of research, in clinics and in industry.Despite considerable efforts involving highly sophisticated instrumentation, these techniques suffer from low sensitivity, which keeps many of today’s most interesting problems in modern analytical sciences below the limits of MR detection. Hyperpolarization (HP) in principle provides a solution to this limitation. We have recently pioneered breakthrough approaches using dissolution dynamic nuclear polarization (d-DNP) for preparing nuclear spins in highly aligned states, and therefore boosting sensitivity in several proof-of-concept reports on model systems. The proposed project aims to leverage these new advances through a series of new concepts i) to generate the highest possible hyperpolarization that can be transported in a persistent state, and ii) to demonstrate their use in magnetic resonance experiments with > 10’000 fold sensitivity enhancements, with the potential of revolutionizing the fields of MRI and NMR.By physically separating the source of polarization from the substrate at a microscopic level, we will achieve polarized samples with lifetimes of days that can be stored and transported over long distances to MRI centers, hospitals and NMR laboratories. Notable applications in the fields of drug discovery, metabolomics and real-time metabolic imaging in living animals will be demonstrated.These goals require a leap forward with respect to today’s protocols, and we propose to achieve this through a combination of innovative sample formulations, new NMR methodology and advanced instrumentation.This project will yield to a broadly applicable method revolutionizing analytical chemistry, drug discovery and medical diagnostics, and thereby will provide a powerful tool to solve challenges at the forefront of molecular and chemical sciences today. Fields of science natural scienceschemical sciencesanalytical chemistrymedical and health sciencesclinical medicineradiologynuclear medicineengineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imaging Keywords Nuclear magnetic resonance (NMR) magnetic resonance imaging (MRI) hyperpolarization dissolution dynamic nuclear polarization Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Topic(s) ERC-2016-STG - ERC Starting Grant Call for proposal ERC-2016-STG See other projects for this call Funding Scheme ERC-STG - Starting Grant Coordinator UNIVERSITE LYON 1 CLAUDE BERNARD Net EU contribution € 1 816 250,00 Address Boulevard du 11 novembre 1918 num43 69622 Villeurbanne cedex France See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Beneficiaries (2) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITE LYON 1 CLAUDE BERNARD France Net EU contribution € 1 816 250,00 Address Boulevard du 11 novembre 1918 num43 69622 Villeurbanne cedex See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France Net EU contribution € 178 750,00 Address Rue michel ange 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
