Understanding the mechanisms of human acute myeloid leukaemia (AML) evolution

Información del proyecto

MAMLE

Identificador del acuerdo de subvención: 714731

DOI 10.3030/714731

Proyecto cerrado

Fecha de la firma de la CE 31 Enero 2017

Fecha de inicio 1 Febrero 2017

Fecha de finalización 31 Enero 2022

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total € 1 750 000,00

Aportación de la UE € 1 750 000,00

Coordinado por

WEIZMANN INSTITUTE OF SCIENCE
Israel

Publicaciones

Peer reviewed articles (5)

Pseudo-mutant P53 is a unique phenotype ofDNMT3A-mutated pre-leukemia

Autores: Amos Tuval, Yardena Brilon, Hadas Azogy, Yoni Moskovitz, Dena Leshkowitz, Tomer M. Salame, Mark D. Minden, Perry Tal, Varda Rotter, Moshe Oren, Nathali Kaushansky, and Liran I. Shlush
Publicado en: Haematologica, 2022, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2021.280329.

Male predominance in AML is associated with specific preleukemic mutations

Autores: Aviv De-Morgan, Manja Meggendorfer, Claudia Haferlach & Liran Shlush
Publicado en: Leukemia, Edición 08876924, 2021, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/s41375-020-0935-5

Prediction of acute myeloid leukaemia risk in healthy individuals

Autores: Sagi Abelson, Grace Collord, Stanley W. K. Ng, Omer Weissbrod, Netta Mendelson Cohen, Elisabeth Niemeyer, Noam Barda, Philip C. Zuzarte, Lawrence Heisler, Yogi Sundaravadanam, Robert Luben, Shabina Hayat, Ting Ting Wang, Zhen Zhao, Iulia Cirlan, Trevor J. Pugh, David Soave, Karen Ng, Calli Latimer, Claire Hardy, Keiran Raine, David Jones, Diana Hoult, Abigail Britten, John D. McPherson, Mattias Jo
Publicado en: Nature, Edición 559/7714, 2018, Página(s) 400-404, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-018-0317-6

Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining

Autores: Tzah Feldman, Akhiad Bercovich, Yoni Moskovitz, Noa Chapal-Ilani, Amanda Mitchell, Jessie J. F. Medeiros, Tamir Biezuner, Nathali Kaushansky, Mark D. Minden, Vikas Gupta, Michael Milyavsky, Zvi Livneh, Amos Tanay & Liran I. Shlush
Publicado en: Nature Communications, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-22803-y

Dasatinib response in acute myeloid leukemia is correlated with FLT3/ITD, PTPN11 mutations and a unique gene expression signature

Autores: Sigal Tavor, Tali Shalit,Noa Chapal Ilani, Yoni Moskovitz, Nir Livnat, Yoram Groner, Haim Barr Mark D. Minden, Alexander Plotnikov, Michael W. Deininger, Nathali Kaushansky Liran I. Shlush
Publicado en: Haematologica, 2020, ISSN 0390-6078
Editor: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.240705