Molecular Mechanical Adhesives

Project Information

MMA

Grant agreement ID: 715207

DOI

10.3030/715207

Project closed

EC signature date 16 November 2016

Start date 1 April 2017

End date 31 March 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 466 916,00

EU contribution

€ 1 466 916,00

Coordinated by

UNIVERSITAT BASEL
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (15)

High force catch bond mechanism of bacterial adhesion in the human gut

Author(s): Zhaowei Liu, Haipei Liu, Andrés M. Vera, Rafael C. Bernardi, Philip Tinnefeld, Michael A. Nash
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18063-x

Next Generation Methods for Single-Molecule Force Spectroscopy on Polyproteins and Receptor-Ligand Complexes

Author(s): Byeongseon Yang, Zhaowei Liu, Haipei Liu, Michael A. Nash
Published in: Frontiers in Molecular Biosciences, Issue 7, 2020, ISSN 2296-889X
Publisher: Frontiers
DOI: 10.3389/fmolb.2020.00085

Adhesive Virulence Factors of Staphylococcus aureus Resist Digestion by Coagulation Proteases Thrombin and Plasmin

Author(s): Fanny Risser, Joanan López-Morales, and Michael A. Nash
Published in: ACS Bio Med Chem Au, 2022, ISSN 2694-2437
Publisher: american chemical society
DOI: 10.1021/acsbiomedchemau.2c00042

Titrating Avidity of Yeast-Displayed Proteins Using a Transcriptional Regulator

Author(s): Joanan Lopez-Morales; Rosario Vanella; Gordana Kovacevic; Mariana Sá Santos; Michael A. Nash
Published in: ACS Synthetic Biology, Issue 12 (2), 2022, ISSN 2161-5063
Publisher: American Chemical Society
DOI: 10.3929/ethz-b-000601183

Influence of Fluorination on Single-Molecule Unfolding and Rupture Pathways of a Mechanostable Protein Adhesion Complex

Author(s): Byeongseon Yang, Haipei Liu, Zhaowei Liu, Regina Doenen, Michael A. Nash
Published in: Nano Letters, Issue 20/12, 2020, Page(s) 8940-8950, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.0c04178

Optimal Sacrificial Domains in Mechanical Polyproteins: S. epidermidis Adhesins Are Tuned for Work Dissipation

Author(s): Haipei Liu; Zhaowei Liu; Byeongseon Yang; Joanan Lopez Morales; Michael A. Nash
Published in: JACS Au, Issue 2(6), 2022, ISSN 2691-3704
Publisher: american chemical society
DOI: 10.1021/jacsau.2c00121

Bioorthogonal Elastin-like Polypeptide Scaffolds for Immunoassay Enhancement

Author(s): Duy Tien Ta, Rosario Vanella, Michael A. Nash
Published in: ACS Applied Materials & Interfaces, Issue 10/36, 2018, Page(s) 30147-30154, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.8b10092

Combining in Vitro and in Silico Single-Molecule Force Spectroscopy to Characterize and Tune Cellulosomal Scaffoldin Mechanics

Author(s): Tobias Verdorfer, Rafael C. Bernardi, Aylin Meinhold, Wolfgang Ott, Zaida Luthey-Schulten, Michael A. Nash, Hermann E. Gaub
Published in: Journal of the American Chemical Society, Issue 139/49, 2017, Page(s) 17841-17852, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.7b07574

Mechanical Polyprotein Assembly Using Sfp and Sortase-Mediated Domain Oligomerization for Single-Molecule Studies

Author(s): Haipei Liu, Duy Tien Ta, Michael A. Nash
Published in: Small Methods, Issue 2/6, 2018, Page(s) 1800039, ISSN 2366-9608
Publisher: Wiley
DOI: 10.1002/smtd.201800039

Elastin-like Polypeptide Linkers for Single-Molecule Force Spectroscopy

Author(s): Wolfgang Ott, Markus A. Jobst, Magnus S. Bauer, Ellis Durner, Lukas F. Milles, Michael A. Nash, Hermann E. Gaub
Published in: ACS Nano, Issue 11/6, 2017, Page(s) 6346-6354, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.7b02694

Removal of a Conserved Disulfide Bond Does Not Compromise Mechanical Stability of a VHH Antibody Complex

Author(s): Haipei Liu, Valentin Schittny, Michael A. Nash
Published in: Nano Letters, Issue 19/8, 2019, Page(s) 5524-5529, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.9b02062

Mechanisms of Nanonewton Mechanostability in a Protein Complex Revealed by Molecular Dynamics Simulations and Single-Molecule Force Spectroscopy

Author(s): Rafael C. Bernardi, Ellis Durner, Constantin Schoeler, Klara H. Malinowska, Bruna G. Carvalho, Edward A. Bayer, Zaida Luthey-Schulten, Hermann E. Gaub, Michael A. Nash
Published in: Journal of the American Chemical Society, Issue 141/37, 2019, Page(s) 14752-14763, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.9b06776

Phase Separation of Intrinsically Disordered Protein Polymers Mechanically Stiffens Fibrin Clots

Author(s): Ivan Urosev, Joanan Lopez Morales, Michael A. Nash
Published in: Advanced Functional Materials, Issue 30/51, 2020, Page(s) 2005245, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202005245

Engineered Molecular Therapeutics Targeting Fibrin and the Coagulation System: a Biophysical Perspective

Author(s): Fanny Risser; Ivan Urosev; Joanan López-Morales; Yang Sun; Michael A. Nash
Published in: Biophysical Reviews, Issue 14 (2), 2022, ISSN 1867-2469
Publisher: Springer
DOI: 10.3929/ethz-b-000544951

Mapping Mechanostable Pulling Geometries of a Therapeutic Anticalin/CTLA-4 Protein Complex

Author(s): Zhaowei Liu; Rodrigo A. Moreira; Ana Dujmović; Haipei Liu; Byeongseon Yang; Adolfo B. Poma; Michael A. Nash
Published in: Nano Letters, Issue 22 (1), 2022, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.3929/ethz-b-000523717