How to build a brain? Engineering molecular systems for mechanosensation and -protection in neurons

Project Information

MechanoSystems

Grant agreement ID: 715243

DOI

10.3030/715243

Project closed

EC signature date 27 March 2017

Start date 1 May 2017

End date 31 October 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 829 288,00

EU contribution

€ 1 829 288,00

Coordinated by

FUNDACIO INSTITUT DE CIENCIES FOTONIQUES
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (15)

Sexually dimorphic architecture and function of a mechanosensory circuit in C. elegans

Author(s): Setty H.; Salzberg Y.; Karimi S.; Berent-Barzel E.; Krieg M.; Oren-Suissa M.
Published in: Nature Communications, Issue 13, 2022, Page(s) 6825, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34661-3

FLInt: single shot safe harbor transgene integration via Fluorescent Landmark Interference

Author(s): Malaiwong N.; Porta-De-la-Riva M.; Krieg M.
Published in: G3: Genes, Genomes, Genetics, Issue 13, 2023, Page(s) jkad041, ISSN 2160-1836
Publisher: Genetics Society of America
DOI: 10.1093/g3journal/jkad041

Direct Force Measurements of Subcellular Mechanics in Confinement using Optical Tweezers

Author(s): Catala-Castro, Frederic; Venturini, Valeria; Ortiz-Vasquez, Santiago; Ruprecht, Verena; Krieg, Michael
Published in: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2021, Page(s) 174, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/62865

Volumetric imaging of fast cellular dynamics with deep learning enhanced bioluminescence microscopy

Author(s): Morales-Curiel L.F.; Gonzalez A.C.; Castro-Olvera G.; Lin L.-C.L.; El-Quessny M.; Porta-de-la-Riva M.; Severino J.; Morera L.B.; Venturini V.; Ruprecht V.; Ramallo D.; Loza-Alvarez P.; Krieg M.
Published in: Communications Biology, Issue 5, 2022, Page(s) 1330, ISSN 2399-3642
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42003-022-04292-x

The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior

Author(s): Venturini, Valeria; Pezzano, Fabio; Catala Castro, Frederic; Hakkinen, Hanna-Maria; Jimenez-Delgado, Senda; Colomer-Rosell, Mariona; Marro, Monica; Tolosa-Ramon, Queralt; Paz-Lopez, Sonia; Valverde, Miguel A.; Weghuber, Julian; Loza-Alvarez, Pablo; Krieg, Michael; Wieser, Stefan; Ruprecht, Verena
Published in: SCIENCE, Issue 370, 2020, Page(s) 3514, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aba2644

A MEC-2/stomatin condensate liquid-to-solid phase transition controls neuronal mechanotransduction during touch sensing

Author(s): Sanfeliu-Cerdán N.; Català-Castro F.; Mateos B.; Garcia-Cabau C.; Ribera M.; Ruider I.; Porta-de-la-Riva M.; Canals-Calderón A.; Wieser S.; Salvatella X.; Krieg M.
Published in: Nature Cell Biology, Issue 25, 2023, Page(s) 1590-1599, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-023-01247-0

Exploring cell and tissue mechanics with optical tweezers

Author(s): Catala-Castro, Frederic ; Schäffer, Erik; Krieg, Micheal
Published in: Journal of cell science, Issue 135,15, 2022, Page(s) 259355, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.259355

Integration of spatially opposing cues by a single interneuron guides decision-making in C. elegans

Author(s): Gat A.; Pechuk V.; Peedikayil-Kurien S.; Karimi S.; Goldman G.; Sela S.; Lubliner J.; Krieg M.; Oren-Suissa M.
Published in: Cell Reports, Issue 42, 2023, Page(s) 113075, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.113075

An asymmetric mechanical code ciphers curvature-dependent proprioceptor activity

Author(s): RAVI DAS, FREDERIC CATALÀ-CASTRO, NAWAPHAT MALAIWONG, NEUS SANFELIU-CERDÁN, MONTSERRAT PORTA-DE-LA-RIVA, ALEKSANDRA PIDDE, MICHAEL KRIEG
Published in: science advances, Issue 7, 2021, Page(s) 38, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abg4617

Axonal plasticity in response to active forces generated through magnetic nano-pulling

Author(s): Falconieri A.; De Vincentiis S.; Cappello V.; Convertino D.; Das R.; Ghignoli S.; Figoli S.; Luin S.; Català-Castro F.; Marchetti L.; Borello U.; Krieg M.; Raffa V.
Published in: Cell Reports, Issue 42, 2023, Page(s) 111912, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.111912

Rationally designed azobenzene photoswitches for efficient two-photon neuronal excitation

Author(s): Gisela Cabré, Aida Garrido-Charles, Miquel Moreno, Miquel Bosch, Montserrat Porta-de-la-Riva, Michael Krieg, Marta Gascón-Moya, Núria Camarero, Ricard Gelabert, José M. Lluch, Félix Busqué, Jordi Hernando, Pau Gorostiza, Ramon Alibés
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-08796-9

Direction Selectivity in Drosophila Proprioceptors Requires the Mechanosensory Channel Tmc

Author(s): Liping He, Sarun Gulyanon, Mirna Mihovilovic Skanata, Doycho Karagyozov, Ellie S. Heckscher, Michael Krieg, Gavriil Tsechpenakis, Marc Gershow, W. Daniel Tracey
Published in: Current Biology, Issue 29/6, 2019, Page(s) 945-956.e3, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2019.02.025

Atomic force microscopy-based mechanobiology

Author(s): Michael Krieg, Gotthold Fläschner, David Alsteens, Benjamin M. Gaub, Wouter H. Roos, Gijs J. L. Wuite, Hermann E. Gaub, Christoph Gerber, Yves F. Dufrêne, Daniel J. Müller
Published in: Nature Reviews Physics, Issue 1/1, 2019, Page(s) 41-57, ISSN 2522-5820
Publisher: Nature
DOI: 10.1038/s42254-018-0001-7

Cortical anchoring of the microtubule cytoskeleton is essential for neuron polarity

Author(s): Liu He, Robbelien Kooistra, Ravi Das, Ellen Oudejans, Eric van Leen, Johannes Ziegler, Sybren Portegies, Bart de Haan, Anna van Regteren Altena, Riccardo Stucchi, AF Maarten Altelaar, Stefan Wieser, Michael Krieg, Casper C Hoogenraad Is a corresponding author, Martin Harterink
Published in: elife, Issue 9, 2020, Page(s) e5511, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.1101/783837

Neuronal stretch reception – Making sense of the mechanosense

Author(s): Ravi Das, Stefan Wieser, Michael Krieg
Published in: Experimental Cell Research, Issue 378/1, 2019, Page(s) 104-112, ISSN 0014-4827
Publisher: Academic Press
DOI: 10.1016/j.yexcr.2019.01.028

Other (1)

Using a Microfluidics Device for Mechanical Stimulation and High Resolution Imaging of <em>C. elegans</em>

Author(s): Holger Fehlauer, Adam L. Nekimken, Anna A. Kim, Beth L. Pruitt, Miriam B. Goodman, Michael Krieg
Published in: Journal of Visualized Experiments, Issue 132, 2018, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/56530