Understanding the physical biology of adult blood stem cells

Deliverables

Participation in the Open Research Data Pilot

Publications

Single-cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal

Author(s): Mairi S. Shepherd, Juan Li, Nicola K. Wilson, Caroline A. Oedekoven, Jiangbing Li, Miriam Belmonte, Juergen Fink, Janine C. M. Prick, Dean C. Pask, Tina L. Hamilton, Dirk Loeffler, Anjana Rao, Timm Schröder, Berthold Göttgens, Anthony R. Green, David G. Kent
Published in: BLOOD, 2018, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood-2017-12-821066

Identification and characterization of in vitro expanded hematopoietic stem cells

Author(s): James Che; Daniel Bode; Iwo Kucinski; Alyssa H Cull; Fiona Bain; Hans J Becker; Maria Jassinskaja; Melania Barile; Grace Boyd; Miriam Belmonte; Andy G X Zeng; Kyomi J Igarashi; Juan Rubio-Lara; Mairi S Shepherd; Anna Clay; John E Dick; Adam C Wilkinson; Hiromitsu Nakauchi; Satoshi Yamazaki; Berthold Göttgens; David G Kent
Published in: EMBO Reports, 2022, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.202255502

A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice

Author(s): Joakim S. Dahlin, Fiona K. Hamey, Blanca Pijuan-Sala, Mairi Shepherd, Winnie W. Y. Lau, Sonia Nestorowa, Caleb Weinreb, Samuel Wolock, Rebecca Hannah, Evangelia Diamanti, David G. Kent, Berthold Göttgens, Nicola K. Wilson
Published in: BLOOD, 2018, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood-2017-12-821413

Somatic mutation landscapes at single-molecule resolution

Author(s): Federico Abascal, Luke M. R. Harvey, Emily Mitchell, Andrew R. J. Lawson, Stefanie V. Lensing, Peter Ellis, Andrew J. C. Russell, Raul E. Alcantara, Adrian Baez-Ortega, Yichen Wang, Eugene Jing Kwa, Henry Lee-Six, Alex Cagan, Tim H. H. Coorens, Michael Spencer Chapman, Sigurgeir Olafsson, Steven Leonard, David Jones, Heather E. Machado, Megan Davies, Nina F. Øbro, Krishnaa T. Mahubani, Kieren All
Published in: Nature, 2021, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03477-4

Clonal dynamics of haematopoiesis across the human lifespan

Author(s): Emily Mitchell, Michael Spencer Chapman, Nicholas Williams, Kevin J. Dawson, Nicole Mende, Emily F. Calderbank, Hyunchul Jung, Thomas Mitchell, Tim H. H. Coorens, David H. Spencer, Heather Machado, Henry Lee-Six, Megan Davies, Daniel Hayler, Margarete A. Fabre, Krishnaa Mahbubani, Federico Abascal, Alex Cagan, George S. Vassiliou, Joanna Baxter, Inigo Martincorena, Michael R. Stratton, David G. Ke
Published in: Nature, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04786-y

Population dynamics of normal human blood inferred from somatic mutations

Author(s): Henry Lee-Six, Nina Friesgaard Øbro, Mairi S. Shepherd, Sebastian Grossmann, Kevin Dawson, Miriam Belmonte, Robert J. Osborne, Brian J. P. Huntly, Inigo Martincorena, Elizabeth Anderson, Laura O’Neill, Michael R. Stratton, Elisa Laurenti, Anthony R. Green, David G. Kent, Peter J. Campbell
Published in: Nature, Issue 561/7724, 2018, Page(s) 473-478, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0497-0

A track of the clones: new developments in cellular barcoding

Author(s): Anne-Marie Lyne, David G. Kent, Elisa Laurenti, Kerstin Cornils, Ingmar Glauche, Leïla Perié
Published in: Experimental Hematology, Issue 68, 2018, Page(s) 15-20, ISSN 0301-472X
Publisher: Elsevier BV
DOI: 10.1016/j.exphem.2018.11.005

Hematopoietic stem cells retain functional potential and molecular identity in hibernation cultures

Author(s): Caroline A. Oedekoven; Miriam Belmonte; Daniel Bode; Fiona K. Hamey; Mairi S. Shepherd; James Lok Chi Che; Grace Boyd; Craig McDonald; Serena Belluschi; Evangelia Diamanti; Hugo P. Bastos; Katherine S. Bridge; Berthold Göttgens; Elisa Laurenti; David G. Kent
Published in: Stem Cell Reports, 2021, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2021.04.002

HOXA9 has the hallmarks of a biological switch with implications in blood cancers

Author(s): Laure Talarmain, Matthew A. Clarke, David Shorthouse, Lilia Cabrera-Cosme, David G. Kent, Jasmin Fisher & Benjamin A. Hall
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-33189-w

Exploiting Single-Cell Tools in Gene and Cell Therapy

Author(s): Daniel Bode; Alyssa H. Cull; Juan A. Rubio-Lara; and David G. Kent
Published in: Frontiers in Immunology, 2021, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2021.702636

Protocol to maintain single functional mouse hematopoietic stem cells in vitro without cell division

Author(s): Miriam Belmonte; David G Kent
Published in: STAR Protocols, 2021, ISSN 2666-1667
Publisher: Cell Press
DOI: 10.1016/j.xpro.2021.100927

Diverse mutational landscapes in human lymphocytes

Author(s): Heather E. Machado, Emily Mitchell, Nina F. Øbro, Kirsten Kübler, Megan Davies, Daniel Leongamornlert, Alyssa Cull, Francesco Maura, Mathijs A. Sanders, Alex T. J. Cagan, Craig McDonald, Miriam Belmonte, Mairi S. Shepherd, Felipe A. Vieira Braga, Robert J. Osborne, Krishnaa Mahbubani, Iñigo Martincorena, Elisa Laurenti, Anthony R. Green, Gad Getz, Paz Polak, Kourosh Saeb-Parsy, Daniel J. Hodson
Published in: Nature, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-05072-7

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