Understanding the physical biology of adult blood stem cells

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Single-cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal

Auteurs: Mairi S. Shepherd, Juan Li, Nicola K. Wilson, Caroline A. Oedekoven, Jiangbing Li, Miriam Belmonte, Juergen Fink, Janine C. M. Prick, Dean C. Pask, Tina L. Hamilton, Dirk Loeffler, Anjana Rao, Timm Schröder, Berthold Göttgens, Anthony R. Green, David G. Kent
Publié dans: BLOOD, 2018, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2017-12-821066

Identification and characterization of in vitro expanded hematopoietic stem cells

Auteurs: James Che; Daniel Bode; Iwo Kucinski; Alyssa H Cull; Fiona Bain; Hans J Becker; Maria Jassinskaja; Melania Barile; Grace Boyd; Miriam Belmonte; Andy G X Zeng; Kyomi J Igarashi; Juan Rubio-Lara; Mairi S Shepherd; Anna Clay; John E Dick; Adam C Wilkinson; Hiromitsu Nakauchi; Satoshi Yamazaki; Berthold Göttgens; David G Kent
Publié dans: EMBO Reports, 2022, ISSN 1469-221X
Éditeur: Nature Publishing Group
DOI: 10.15252/embr.202255502

A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice

Auteurs: Joakim S. Dahlin, Fiona K. Hamey, Blanca Pijuan-Sala, Mairi Shepherd, Winnie W. Y. Lau, Sonia Nestorowa, Caleb Weinreb, Samuel Wolock, Rebecca Hannah, Evangelia Diamanti, David G. Kent, Berthold Göttgens, Nicola K. Wilson
Publié dans: BLOOD, 2018, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2017-12-821413

Somatic mutation landscapes at single-molecule resolution

Auteurs: Federico Abascal, Luke M. R. Harvey, Emily Mitchell, Andrew R. J. Lawson, Stefanie V. Lensing, Peter Ellis, Andrew J. C. Russell, Raul E. Alcantara, Adrian Baez-Ortega, Yichen Wang, Eugene Jing Kwa, Henry Lee-Six, Alex Cagan, Tim H. H. Coorens, Michael Spencer Chapman, Sigurgeir Olafsson, Steven Leonard, David Jones, Heather E. Machado, Megan Davies, Nina F. Øbro, Krishnaa T. Mahubani, Kieren All
Publié dans: Nature, 2021, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-021-03477-4

Clonal dynamics of haematopoiesis across the human lifespan

Auteurs: Emily Mitchell, Michael Spencer Chapman, Nicholas Williams, Kevin J. Dawson, Nicole Mende, Emily F. Calderbank, Hyunchul Jung, Thomas Mitchell, Tim H. H. Coorens, David H. Spencer, Heather Machado, Henry Lee-Six, Megan Davies, Daniel Hayler, Margarete A. Fabre, Krishnaa Mahbubani, Federico Abascal, Alex Cagan, George S. Vassiliou, Joanna Baxter, Inigo Martincorena, Michael R. Stratton, David G. Ke
Publié dans: Nature, 2022, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-022-04786-y

Population dynamics of normal human blood inferred from somatic mutations

Auteurs: Henry Lee-Six, Nina Friesgaard Øbro, Mairi S. Shepherd, Sebastian Grossmann, Kevin Dawson, Miriam Belmonte, Robert J. Osborne, Brian J. P. Huntly, Inigo Martincorena, Elizabeth Anderson, Laura O’Neill, Michael R. Stratton, Elisa Laurenti, Anthony R. Green, David G. Kent, Peter J. Campbell
Publié dans: Nature, Numéro 561/7724, 2018, Page(s) 473-478, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-018-0497-0

A track of the clones: new developments in cellular barcoding

Auteurs: Anne-Marie Lyne, David G. Kent, Elisa Laurenti, Kerstin Cornils, Ingmar Glauche, Leïla Perié
Publié dans: Experimental Hematology, Numéro 68, 2018, Page(s) 15-20, ISSN 0301-472X
Éditeur: Elsevier BV
DOI: 10.1016/j.exphem.2018.11.005

Hematopoietic stem cells retain functional potential and molecular identity in hibernation cultures

Auteurs: Caroline A. Oedekoven; Miriam Belmonte; Daniel Bode; Fiona K. Hamey; Mairi S. Shepherd; James Lok Chi Che; Grace Boyd; Craig McDonald; Serena Belluschi; Evangelia Diamanti; Hugo P. Bastos; Katherine S. Bridge; Berthold Göttgens; Elisa Laurenti; David G. Kent
Publié dans: Stem Cell Reports, 2021, ISSN 2213-6711
Éditeur: Cell Press
DOI: 10.1016/j.stemcr.2021.04.002

HOXA9 has the hallmarks of a biological switch with implications in blood cancers

Auteurs: Laure Talarmain, Matthew A. Clarke, David Shorthouse, Lilia Cabrera-Cosme, David G. Kent, Jasmin Fisher & Benjamin A. Hall
Publié dans: Nature Communications, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-33189-w

Exploiting Single-Cell Tools in Gene and Cell Therapy

Auteurs: Daniel Bode; Alyssa H. Cull; Juan A. Rubio-Lara; and David G. Kent
Publié dans: Frontiers in Immunology, 2021, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2021.702636

Protocol to maintain single functional mouse hematopoietic stem cells in vitro without cell division

Auteurs: Miriam Belmonte; David G Kent
Publié dans: STAR Protocols, 2021, ISSN 2666-1667
Éditeur: Cell Press
DOI: 10.1016/j.xpro.2021.100927

Diverse mutational landscapes in human lymphocytes

Auteurs: Heather E. Machado, Emily Mitchell, Nina F. Øbro, Kirsten Kübler, Megan Davies, Daniel Leongamornlert, Alyssa Cull, Francesco Maura, Mathijs A. Sanders, Alex T. J. Cagan, Craig McDonald, Miriam Belmonte, Mairi S. Shepherd, Felipe A. Vieira Braga, Robert J. Osborne, Krishnaa Mahbubani, Iñigo Martincorena, Elisa Laurenti, Anthony R. Green, Gad Getz, Paz Polak, Kourosh Saeb-Parsy, Daniel J. Hodson
Publié dans: Nature, 2022, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-022-05072-7

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