Investigating Host-Microbial Interactions after Bariatric Surgery

Información del proyecto

EnteroBariatric

Identificador del acuerdo de subvención: 715662

DOI

10.3030/715662

Proyecto cerrado

Fecha de la firma de la CE 3 Noviembre 2016

Fecha de inicio 1 Agosto 2017

Fecha de finalización 31 Enero 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 499 091,00

Aportación de la UE

€ 1 499 091,00

Coordinado por

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (30)

Lipid profiling of mouse intestinal organoids for studying <i>APC</i> mutations

Autores: Zoë Jukes, Anne Freier, Maria Glymenaki, Richard Brown, Lee Parry, Elizabeth Want, Panagiotis A. Vorkas, Jia V. Li
Publicado en: Bioscience Reports, Edición 41, 2021, ISSN 0144-8463
Editor: Kluwer Academic Publishers
DOI: 10.1042/bsr20202915

Chronic treatment with glucagon-like peptide-1 and glucagon receptor co-agonist causes weight loss-independent improvements in hepatic steatosis in mice with diet-induced obesity

Autores: Emma Rose McGlone, David C.D. Hope, Iona Davies, Marian Dore, Rob Goldin, Ben Jones, Zhigang Liu, Jia V. Li, Panagiotis A. Vorkas, Bernard Khoo, David Carling, James Minnion, Stephen R. Bloom, Tricia M-M. Tan
Publicado en: Biomedicine &amp; Pharmacotherapy, Edición 176, 2024, Página(s) 116888, ISSN 0753-3322
Editor: Elsevier Masson
DOI: 10.1016/j.biopha.2024.116888

Tumour Necrosis Factor-Alpha (TNF-α)-Induced Metastatic Phenotype in Colorectal Cancer Epithelial Cells: Mechanistic Support for the Role of MicroRNA-21

Autores: Aminah G. Alotaibi, Jia V. Li, Nigel J. Gooderham
Publicado en: Cancers, Edición 15, 2025, Página(s) 627, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15030627

Roux-en-Y gastric bypass-associated fecal tyramine promotes colon cancer risk via increased DNA damage, cell proliferation, and inflammation

Autores: Maria Glymenaki, Sophie Curio, Smeeta Shrestha, Qi Zhong, Laura Rushton, Rachael Barry, Mona El-Bahrawy, Julian R. Marchesi, Yulan Wang, Nigel J. Gooderham, Nadia Guerra, Jia V. Li
Publicado en: Microbiome, Edición 13, 2025, ISSN 2049-2618
Editor: Springer Science and Business Media LLC
DOI: 10.1186/s40168-025-02049-2

Rectal swabs as a viable alternative to faecal sampling for the analysis of gut microbiota functionality and composition

Autores: Shiva T. Radhakrishnan, Kate I. Gallagher, Benjamin H. Mullish, Jose I. Serrano-Contreras, James L. Alexander, Jesus Miguens Blanco, Nathan P. Danckert, Maria Valdivia-Garcia, Billy J. Hopkins, Anik Ghai, Azad Ayub, Jia V. Li, Julian R. Marchesi, Horace R. T. Williams
Publicado en: Scientific Reports, Edición 13, 2023, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-022-27131-9

Improved Quantitation of Short-Chain Carboxylic Acids in Human Biofluids Using 3-Nitrophenylhydrazine Derivatization and Liquid Chromatography with Tandem Mass Spectrometry (LC-MS/MS)

Autores: Maria Valdivia-Garcia, Katie Chappell, Stephane Camuzeaux, Lucía Olmo-García, Verena Horneffer-van der Sluis, Shiva T. Radhakrishnan, Hannah Stephens, Sonia Bouri, Lucia M. de Campos Braz, Horace R.T. Williams, Mathew R. Lewis, Gary Frost, Jia V. Li
Publicado en: SSRN Electronic Journal, 2023, ISSN 1556-5068
Editor: Elsevier BV
DOI: 10.2139/ssrn.4163686

Differential effects of L‐ and D‐phenylalanine on pancreatic and gastrointestinal hormone release in humans: A randomized crossover study

Autores: Anjali Amin, James Frampton, Zhigang Liu, Georgia Franco‐Becker, Mariana Norton, Aos Alaa, Jia V. Li, Kevin G. Murphy
Publicado en: Diabetes, Obesity and Metabolism, Edición 23, 2024, Página(s) 147-157, ISSN 1462-8902
Editor: Blackwell Publishing Inc.
DOI: 10.1111/dom.14204

Roux-en-Y gastric bypass surgery in Zucker rats induces bacterial and systemic metabolic changes independent of caloric restriction-induced weight loss

Autores: Florian Seyfried, Jutarop Phetcharaburanin, Maria Glymenaki, Arno Nordbeck, Mohammed Hankir, Jeremy K Nicholson, Elaine Holmes, Julian R. Marchesi, Jia V. Li
Publicado en: Gut Microbes, Edición 13, 2025, ISSN 1949-0976
Editor: Landes Bioscience
DOI: 10.1080/19490976.2021.1875108

Multiomic features associated with mucosal healing and inflammation in paediatric Crohn’s disease

Autores: Henry Taylor, Jose Ivan Serrano‐Contreras, Julie A. K. McDonald, Jenny Epstein, JM Fell, Rocio C. Seoane, Jia V. Li, Julian R. Marchesi, Ailsa L. Hart
Publicado en: Alimentary Pharmacology &amp; Therapeutics, Edición 52, 2023, Página(s) 1491-1502, ISSN 0269-2813
Editor: Blackwell Publishing Inc.
DOI: 10.1111/apt.16086

Indole-3-Aldehyde Reduces Inflammatory Responses and Restores Intestinal Epithelial Barrier Function Partially via Aryl Hydrocarbon Receptor (AhR) in Experimental Colitis Models

Autores: Mu Wang, Jian Guo, Ailsa L Hart, Jia V Li
Publicado en: Journal of Inflammation Research, Edición Volume 16, 2023, Página(s) 5845-5864, ISSN 1178-7031
Editor: Dove Medical Press Ltd
DOI: 10.2147/jir.s432747

The Metabolomic Effects of Tripeptide Gut Hormone Infusion Compared to Roux-en-Y Gastric Bypass and Caloric Restriction

Autores: Ben Jones, Caroline Sands, Kleopatra Alexiadou, James Minnion, George Tharakan, Preeshila Behary, Ahmed R Ahmed, Sanjay Purkayastha, Matthew R Lewis, Stephen Bloom, Jia V Li, Tricia M Tan
Publicado en: The Journal of Clinical Endocrinology &amp; Metabolism, Edición 107, 2024, Página(s) e767-e782, ISSN 0021-972X
Editor: The Endocrine Society
DOI: 10.1210/clinem/dgab608

Derivatization to reduce background interferences for simultaneous quantitation of trimethylamine (TMA) and trimethylamine-N-oxide (TMAO) using liquid chromatography with tandem mass spectrometry

Autores: Maria A. Valdivia-Garcia, Yang Bi, Kaoutar Abaakil, Jia V Li
Publicado en: Journal of Pharmaceutical and Biomedical Analysis, Edición 252, 2024, Página(s) 116480, ISSN 0731-7085
Editor: Elsevier BV
DOI: 10.1016/j.jpba.2024.116480

Stability in fecal metabolites amid a diverse gut microbiome composition: a one-month longitudinal study of variability in healthy individuals

Autores: Matteo Sangermani, Indri Desiati, Solveig M. Jørgensen, Jia V. Li, Trygve Andreassen, Tone F. Bathen, Guro F. Giskeødegård
Publicado en: Gut Microbes, Edición 16, 2024, ISSN 1949-0976
Editor: Landes Bioscience
DOI: 10.1080/19490976.2024.2427878

The double burden of malnutrition in individuals: Identifying key challenges and re‐thinking research focus

Autores: Agklinta Kiosia, Aygul Dagbasi, James A. Berkley, John P. H. Wilding, Andrew J. Prendergast, Jia V. Li, Jon Swann, John C. Mathers, Marko Kerac, Douglas Morrison, Lesley Drake, Andre Briend, Kathryn Maitland, Gary Frost
Publicado en: Nutrition Bulletin, Edición 49, 2024, Página(s) 132-145, ISSN 1471-9827
Editor: Wiley
DOI: 10.1111/nbu.12670

Effects of Vancomycin and Ciprofloxacin on the NMRI Mouse Metabolism

Autores: Zhigang Liu, Bing Xia, Jasmina Saric, Jürg Utzinger, Elaine Holmes, Jennifer Keiser, Jia V. Li
Publicado en: Journal of Proteome Research, Edición 17/10, 2018, Página(s) 3565-3573, ISSN 1535-3893
Editor: American Chemical Society
DOI: 10.1021/acs.jproteome.8b00583

Inhibiting Growth of Clostridioides difficile by Restoring Valerate, Produced by the Intestinal Microbiota

Autores: Julie A.K. McDonald, Benjamin H. Mullish, Alexandros Pechlivanis, Zhigang Liu, Jerusa Brignardello, Dina Kao, Elaine Holmes, Jia V. Li, Thomas B. Clarke, Mark R. Thursz, Julian R. Marchesi
Publicado en: Gastroenterology, Edición 155/5, 2018, Página(s) 1495-1507.e15, ISSN 0016-5085
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.07.014

Differences in Fecal Gut Microbiota, Short-Chain Fatty Acids and Bile Acids Link Colorectal Cancer Risk to Dietary Changes Associated with Urbanization Among Zimbabweans

Autores: L. Katsidzira, S. Ocvirk, A. Wilson, J. Li, C. B. Mahachi, D. Soni, J. DeLany, J. K. Nicholson, E. G. Zoetendal, S. J. D. O’Keefe
Publicado en: Nutrition and Cancer, Edición 71/8, 2019, Página(s) 1313-1324, ISSN 0163-5581
Editor: Lawrence Erlbaum Associates Inc.
DOI: 10.1080/01635581.2019.1602659

Longitudinal metabolic and gut bacterial profiling of pregnant women with previous bariatric surgery

Autores: Kiana Ashley West, Chidimma Kanu, Tanya Maric, Julie Anne Kathryn McDonald, Jeremy K Nicholson, Jia V Li, Mark R Johnson, Elaine Holmes, Makrina D Savvidou
Publicado en: Gut, 2020, Página(s) gutjnl-2019-319620, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-319620

Post-operative delirium associated with metabolic alterations following hemi-arthroplasty in older patients

Autores: Yong Guo, Yingchuan Li, Yinan Zhang, Shudong Fang, Xiaotao Xu, Aihua Zhao, Junfeng Zhang, Jia V Li, Daqing Ma, Wei Jia, Wei Jiang
Publicado en: Age and Ageing, Edición 49/1, 2019, Página(s) 88-95, ISSN 0002-0729
Editor: Oxford University Press
DOI: 10.1093/ageing/afz132

A biochemical comparison of the lung, colonic, brain, renal, and ovarian cancer cell lines using 1H-NMR spectroscopy

Autores: Cong Hu, Zhigang Liu, Hailin Zhao, Lingzhi Wu, Qingquan Lian, Daqing Ma, Jia V. Li
Publicado en: Bioscience Reports, Edición 40/4, 2020, ISSN 0144-8463
Editor: Kluwer Academic Publishers
DOI: 10.1042/bsr20194027

Microbiota- and Radiotherapy-Induced Gastrointestinal Side-Effects (MARS) Study: A Large Pilot Study of the Microbiome in Acute and Late-Radiation Enteropathy

Autores: Miguel Reis Ferreira, H. Jervoise N. Andreyev, Kabir Mohammed, Lesley Truelove, Sharon M. Gowan, Jia Li, Sarah L. Gulliford, Julian R. Marchesi, David P. Dearnaley
Publicado en: Clinical Cancer Research, Edición 25/21, 2019, Página(s) 6487-6500, ISSN 1078-0432
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-19-0960

In vitro metabolomic footprint of the Echinococcus multilocularis metacestode

Autores: Dominic Ritler, Reto Rufener, Jia V. Li, Urs Kämpfer, Joachim Müller, Claudia Bühr, Stefan Schürch, Britta Lundström-Stadelmann
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-56073-y

Evaluation of Direct from Sample Metabolomics of Human Feces Using Rapid Evaporative Ionization Mass Spectrometry

Autores: Simon J. S. Cameron, James L. Alexander, Frances Bolt, Adam Burke, Hutan Ashrafian, Julian Teare, Julian R. Marchesi, James Kinross, Jia V. Li, Zoltán Takáts
Publicado en: Analytical Chemistry, Edición 91/21, 2019, Página(s) 13448-13457, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.9b02358

A prospective cohort analysis of gut microbial co-metabolism in Alaska Native and rural African people at high and low risk of colorectal cancer

Autores: Soeren Ocvirk, Annette S Wilson, Joram M Posma, Jia V Li, Kathryn R Koller, Gretchen M Day, Christie A Flanagan, Jill Evon Otto, Pam E Sacco, Frank D Sacco, Flora R Sapp, Amy S Wilson, Keith Newton, Faye Brouard, James P DeLany, Marissa Behnning, Corynn N Appolonia, Devavrata Soni, Faheem Bhatti, Barbara Methé, Adam Fitch, Alison Morris, H Rex Gaskins, James Kinross, Jeremy K Nicholson, Timothy K
Publicado en: The American Journal of Clinical Nutrition, Edición 111/2, 2019, Página(s) 406-419, ISSN 0002-9165
Editor: American Society for Clinical Nutrition, Inc.
DOI: 10.1093/ajcn/nqz301

Monosodium Glutamate (MSG) Renders Alkalinizing Properties and Its Urinary Metabolic Markers of MSG Consumption in Rats

Autores: Nahok, Li, Phetcharaburanin, Abdul, Wongkham, Thanan, Silsirivanit, Anutrakulchai, Selmi, Cha’on
Publicado en: Biomolecules, Edición 9/10, 2019, Página(s) 542, ISSN 2218-273X
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biom9100542

Bile salt metabolism is not the only factor contributing to Clostridioides ( Clostridium ) difficile disease severity in the murine model of disease

Autores: Caitlin A. Jukes, Umer Zeeshan Ijaz, Anthony Buckley, Janice Spencer, June Irvine, Denise Candlish, Jia V. Li, Julian R. Marchesi, Gillian Douce
Publicado en: Gut Microbes, Edición 11/3, 2020, Página(s) 481-496, ISSN 1949-0976
Editor: Landes Bioscience
DOI: 10.1080/19490976.2019.1678996

Sevoflurane but not propofol enhances ovarian cancer cell biology through regulating cellular metabolic and signaling mechanisms

Autores: Cong Hu, Bincheng Wang, Zhigang Liu, Qiling Chen, Masashi Ishikawa, Han Lin, Qingquan Lian, Jun Li, Jia V. Li, Daqing Ma, null null
Publicado en: Cell Biology and Toxicology, Edición 39, 2023, Página(s) 1395-1411, ISSN 0742-2091
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10565-022-09766-6

Improved Spatial Resolution of Metabolites in Tissue Biopsies Using High-Resolution Magic-Angle-Spinning Slice Localization NMR Spectroscopy

Autores: Elisabeth V. Vonhof, Martial Piotto, Elaine Holmes, John C. Lindon, Jeremy K. Nicholson, Jia V. Li
Publicado en: Analytical Chemistry, Edición 92, 2023, Página(s) 11516-11519, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.0c02377

Tumour necrosis factor-α (TNF-α) enhances dietary carcinogen-induced DNA damage in colorectal cancer epithelial cells through activation of JNK signaling pathway

Autores: Aminah G. Alotaibi, Jia V. Li, Nigel J. Gooderham
Publicado en: Toxicology, Edición 457, 2022, Página(s) 152806, ISSN 0300-483X
Editor: Elsevier BV
DOI: 10.1016/j.tox.2021.152806

Roux-en-Y gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype

Autores: Jia V. Li, Hutan Ashrafian, Magali Sarafian, Daniel Homola, Laura Rushton, Grace Barker, Paula Momo Cabrera, Matthew R. Lewis, Ara Darzi, Edward Lin, Nana Adwoa Gletsu-Miller, Stephen L. Atkin, Thozhukat Sathyapalan, Nigel J. Gooderham, Jeremy K. Nicholson, Julian R. Marchesi, Thanos Athanasiou, Elaine Holmes
Publicado en: Microbiome, Edición 9, 2021, ISSN 2049-2618
Editor: Springer Science and Business Media LLC
DOI: 10.1186/s40168-021-01086-x

Book chapters (1)

Metabolic Profiling in IBD

Autores: Maria Glymenaki, Jia V. Li, Julian R. Marchesi
Publicado en: Biomarkers in Inflammatory Bowel Diseases, 2019, Página(s) 303-312, ISBN 978-3-030-11445-9
Editor: Springer International Publishing
DOI: 10.1007/978-3-030-11446-6_25

Non-peer reviewed articles (1)

Diet changes due to urbanization in South Africa are linked to microbiome and metabolome signatures of Westernization and colorectal cancer

Autores: M. C. Ramaboli, S. Ocvirk, M. Khan Mirzaei, B. L. Eberhart, M. Valdivia-Garcia, A. Metwaly, K. Neuhaus, G. Barker, J. Ru, L. T. Nesengani, D. Mahdi-Joest, A. S. Wilson, S. K. Joni, D. C. Layman, J. Zheng, R. Mandal, Q. Chen, M. R. Perez, S. Fortuin, B. Gaunt, D. Wishart, B. Methé, D. Haller, J. V. Li, L. Deng, R. Swart, S. J. D. O’Keefe
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-46265-0

Thesis and dissertations (1)

Investigating the metabolic function of the gut microbiota in colorectal carcinogenesis via choline metabolism

Autores: Yang Bi
Publicado en: 2024
Editor: Imperial College London