Investigating Host-Microbial Interactions after Bariatric Surgery

Informacje na temat projektu

EnteroBariatric

Identyfikator umowy o grant: 715662

DOI

10.3030/715662

Projekt został zamknięty

Data podpisania przez KE 3 Listopada 2016

Data rozpoczęcia 1 Sierpnia 2017

Data zakończenia 31 Stycznia 2025

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 1 499 091,00

Wkład UE

€ 1 499 091,00

Koordynowany przez

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (30)

Lipid profiling of mouse intestinal organoids for studying <i>APC</i> mutations

Autorzy: Zoë Jukes, Anne Freier, Maria Glymenaki, Richard Brown, Lee Parry, Elizabeth Want, Panagiotis A. Vorkas, Jia V. Li
Opublikowane w: Bioscience Reports, Numer 41, 2021, ISSN 0144-8463
Wydawca: Kluwer Academic Publishers
DOI: 10.1042/bsr20202915

Chronic treatment with glucagon-like peptide-1 and glucagon receptor co-agonist causes weight loss-independent improvements in hepatic steatosis in mice with diet-induced obesity

Autorzy: Emma Rose McGlone, David C.D. Hope, Iona Davies, Marian Dore, Rob Goldin, Ben Jones, Zhigang Liu, Jia V. Li, Panagiotis A. Vorkas, Bernard Khoo, David Carling, James Minnion, Stephen R. Bloom, Tricia M-M. Tan
Opublikowane w: Biomedicine &amp; Pharmacotherapy, Numer 176, 2024, Strona(/y) 116888, ISSN 0753-3322
Wydawca: Elsevier Masson
DOI: 10.1016/j.biopha.2024.116888

Tumour Necrosis Factor-Alpha (TNF-α)-Induced Metastatic Phenotype in Colorectal Cancer Epithelial Cells: Mechanistic Support for the Role of MicroRNA-21

Autorzy: Aminah G. Alotaibi, Jia V. Li, Nigel J. Gooderham
Opublikowane w: Cancers, Numer 15, 2025, Strona(/y) 627, ISSN 2072-6694
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15030627

Roux-en-Y gastric bypass-associated fecal tyramine promotes colon cancer risk via increased DNA damage, cell proliferation, and inflammation

Autorzy: Maria Glymenaki, Sophie Curio, Smeeta Shrestha, Qi Zhong, Laura Rushton, Rachael Barry, Mona El-Bahrawy, Julian R. Marchesi, Yulan Wang, Nigel J. Gooderham, Nadia Guerra, Jia V. Li
Opublikowane w: Microbiome, Numer 13, 2025, ISSN 2049-2618
Wydawca: Springer Science and Business Media LLC
DOI: 10.1186/s40168-025-02049-2

Rectal swabs as a viable alternative to faecal sampling for the analysis of gut microbiota functionality and composition

Autorzy: Shiva T. Radhakrishnan, Kate I. Gallagher, Benjamin H. Mullish, Jose I. Serrano-Contreras, James L. Alexander, Jesus Miguens Blanco, Nathan P. Danckert, Maria Valdivia-Garcia, Billy J. Hopkins, Anik Ghai, Azad Ayub, Jia V. Li, Julian R. Marchesi, Horace R. T. Williams
Opublikowane w: Scientific Reports, Numer 13, 2023, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-022-27131-9

Improved Quantitation of Short-Chain Carboxylic Acids in Human Biofluids Using 3-Nitrophenylhydrazine Derivatization and Liquid Chromatography with Tandem Mass Spectrometry (LC-MS/MS)

Autorzy: Maria Valdivia-Garcia, Katie Chappell, Stephane Camuzeaux, Lucía Olmo-García, Verena Horneffer-van der Sluis, Shiva T. Radhakrishnan, Hannah Stephens, Sonia Bouri, Lucia M. de Campos Braz, Horace R.T. Williams, Mathew R. Lewis, Gary Frost, Jia V. Li
Opublikowane w: SSRN Electronic Journal, 2023, ISSN 1556-5068
Wydawca: Elsevier BV
DOI: 10.2139/ssrn.4163686

Differential effects of L‐ and D‐phenylalanine on pancreatic and gastrointestinal hormone release in humans: A randomized crossover study

Autorzy: Anjali Amin, James Frampton, Zhigang Liu, Georgia Franco‐Becker, Mariana Norton, Aos Alaa, Jia V. Li, Kevin G. Murphy
Opublikowane w: Diabetes, Obesity and Metabolism, Numer 23, 2024, Strona(/y) 147-157, ISSN 1462-8902
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/dom.14204

Roux-en-Y gastric bypass surgery in Zucker rats induces bacterial and systemic metabolic changes independent of caloric restriction-induced weight loss

Autorzy: Florian Seyfried, Jutarop Phetcharaburanin, Maria Glymenaki, Arno Nordbeck, Mohammed Hankir, Jeremy K Nicholson, Elaine Holmes, Julian R. Marchesi, Jia V. Li
Opublikowane w: Gut Microbes, Numer 13, 2025, ISSN 1949-0976
Wydawca: Landes Bioscience
DOI: 10.1080/19490976.2021.1875108

Multiomic features associated with mucosal healing and inflammation in paediatric Crohn’s disease

Autorzy: Henry Taylor, Jose Ivan Serrano‐Contreras, Julie A. K. McDonald, Jenny Epstein, JM Fell, Rocio C. Seoane, Jia V. Li, Julian R. Marchesi, Ailsa L. Hart
Opublikowane w: Alimentary Pharmacology &amp; Therapeutics, Numer 52, 2023, Strona(/y) 1491-1502, ISSN 0269-2813
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/apt.16086

Indole-3-Aldehyde Reduces Inflammatory Responses and Restores Intestinal Epithelial Barrier Function Partially via Aryl Hydrocarbon Receptor (AhR) in Experimental Colitis Models

Autorzy: Mu Wang, Jian Guo, Ailsa L Hart, Jia V Li
Opublikowane w: Journal of Inflammation Research, Numer Volume 16, 2023, Strona(/y) 5845-5864, ISSN 1178-7031
Wydawca: Dove Medical Press Ltd
DOI: 10.2147/jir.s432747

The Metabolomic Effects of Tripeptide Gut Hormone Infusion Compared to Roux-en-Y Gastric Bypass and Caloric Restriction

Autorzy: Ben Jones, Caroline Sands, Kleopatra Alexiadou, James Minnion, George Tharakan, Preeshila Behary, Ahmed R Ahmed, Sanjay Purkayastha, Matthew R Lewis, Stephen Bloom, Jia V Li, Tricia M Tan
Opublikowane w: The Journal of Clinical Endocrinology &amp; Metabolism, Numer 107, 2024, Strona(/y) e767-e782, ISSN 0021-972X
Wydawca: The Endocrine Society
DOI: 10.1210/clinem/dgab608

Derivatization to reduce background interferences for simultaneous quantitation of trimethylamine (TMA) and trimethylamine-N-oxide (TMAO) using liquid chromatography with tandem mass spectrometry

Autorzy: Maria A. Valdivia-Garcia, Yang Bi, Kaoutar Abaakil, Jia V Li
Opublikowane w: Journal of Pharmaceutical and Biomedical Analysis, Numer 252, 2024, Strona(/y) 116480, ISSN 0731-7085
Wydawca: Elsevier BV
DOI: 10.1016/j.jpba.2024.116480

Stability in fecal metabolites amid a diverse gut microbiome composition: a one-month longitudinal study of variability in healthy individuals

Autorzy: Matteo Sangermani, Indri Desiati, Solveig M. Jørgensen, Jia V. Li, Trygve Andreassen, Tone F. Bathen, Guro F. Giskeødegård
Opublikowane w: Gut Microbes, Numer 16, 2024, ISSN 1949-0976
Wydawca: Landes Bioscience
DOI: 10.1080/19490976.2024.2427878

The double burden of malnutrition in individuals: Identifying key challenges and re‐thinking research focus

Autorzy: Agklinta Kiosia, Aygul Dagbasi, James A. Berkley, John P. H. Wilding, Andrew J. Prendergast, Jia V. Li, Jon Swann, John C. Mathers, Marko Kerac, Douglas Morrison, Lesley Drake, Andre Briend, Kathryn Maitland, Gary Frost
Opublikowane w: Nutrition Bulletin, Numer 49, 2024, Strona(/y) 132-145, ISSN 1471-9827
Wydawca: Wiley
DOI: 10.1111/nbu.12670

Effects of Vancomycin and Ciprofloxacin on the NMRI Mouse Metabolism

Autorzy: Zhigang Liu, Bing Xia, Jasmina Saric, Jürg Utzinger, Elaine Holmes, Jennifer Keiser, Jia V. Li
Opublikowane w: Journal of Proteome Research, Numer 17/10, 2018, Strona(/y) 3565-3573, ISSN 1535-3893
Wydawca: American Chemical Society
DOI: 10.1021/acs.jproteome.8b00583

Inhibiting Growth of Clostridioides difficile by Restoring Valerate, Produced by the Intestinal Microbiota

Autorzy: Julie A.K. McDonald, Benjamin H. Mullish, Alexandros Pechlivanis, Zhigang Liu, Jerusa Brignardello, Dina Kao, Elaine Holmes, Jia V. Li, Thomas B. Clarke, Mark R. Thursz, Julian R. Marchesi
Opublikowane w: Gastroenterology, Numer 155/5, 2018, Strona(/y) 1495-1507.e15, ISSN 0016-5085
Wydawca: W. B. Saunders Co., Ltd.
DOI: 10.1053/j.gastro.2018.07.014

Differences in Fecal Gut Microbiota, Short-Chain Fatty Acids and Bile Acids Link Colorectal Cancer Risk to Dietary Changes Associated with Urbanization Among Zimbabweans

Autorzy: L. Katsidzira, S. Ocvirk, A. Wilson, J. Li, C. B. Mahachi, D. Soni, J. DeLany, J. K. Nicholson, E. G. Zoetendal, S. J. D. O’Keefe
Opublikowane w: Nutrition and Cancer, Numer 71/8, 2019, Strona(/y) 1313-1324, ISSN 0163-5581
Wydawca: Lawrence Erlbaum Associates Inc.
DOI: 10.1080/01635581.2019.1602659

Longitudinal metabolic and gut bacterial profiling of pregnant women with previous bariatric surgery

Autorzy: Kiana Ashley West, Chidimma Kanu, Tanya Maric, Julie Anne Kathryn McDonald, Jeremy K Nicholson, Jia V Li, Mark R Johnson, Elaine Holmes, Makrina D Savvidou
Opublikowane w: Gut, 2020, Strona(/y) gutjnl-2019-319620, ISSN 0017-5749
Wydawca: BMJ Publishing Group
DOI: 10.1136/gutjnl-2019-319620

Post-operative delirium associated with metabolic alterations following hemi-arthroplasty in older patients

Autorzy: Yong Guo, Yingchuan Li, Yinan Zhang, Shudong Fang, Xiaotao Xu, Aihua Zhao, Junfeng Zhang, Jia V Li, Daqing Ma, Wei Jia, Wei Jiang
Opublikowane w: Age and Ageing, Numer 49/1, 2019, Strona(/y) 88-95, ISSN 0002-0729
Wydawca: Oxford University Press
DOI: 10.1093/ageing/afz132

A biochemical comparison of the lung, colonic, brain, renal, and ovarian cancer cell lines using 1H-NMR spectroscopy

Autorzy: Cong Hu, Zhigang Liu, Hailin Zhao, Lingzhi Wu, Qingquan Lian, Daqing Ma, Jia V. Li
Opublikowane w: Bioscience Reports, Numer 40/4, 2020, ISSN 0144-8463
Wydawca: Kluwer Academic Publishers
DOI: 10.1042/bsr20194027

Microbiota- and Radiotherapy-Induced Gastrointestinal Side-Effects (MARS) Study: A Large Pilot Study of the Microbiome in Acute and Late-Radiation Enteropathy

Autorzy: Miguel Reis Ferreira, H. Jervoise N. Andreyev, Kabir Mohammed, Lesley Truelove, Sharon M. Gowan, Jia Li, Sarah L. Gulliford, Julian R. Marchesi, David P. Dearnaley
Opublikowane w: Clinical Cancer Research, Numer 25/21, 2019, Strona(/y) 6487-6500, ISSN 1078-0432
Wydawca: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-19-0960

In vitro metabolomic footprint of the Echinococcus multilocularis metacestode

Autorzy: Dominic Ritler, Reto Rufener, Jia V. Li, Urs Kämpfer, Joachim Müller, Claudia Bühr, Stefan Schürch, Britta Lundström-Stadelmann
Opublikowane w: Scientific Reports, Numer 9/1, 2019, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-019-56073-y

Evaluation of Direct from Sample Metabolomics of Human Feces Using Rapid Evaporative Ionization Mass Spectrometry

Autorzy: Simon J. S. Cameron, James L. Alexander, Frances Bolt, Adam Burke, Hutan Ashrafian, Julian Teare, Julian R. Marchesi, James Kinross, Jia V. Li, Zoltán Takáts
Opublikowane w: Analytical Chemistry, Numer 91/21, 2019, Strona(/y) 13448-13457, ISSN 0003-2700
Wydawca: American Chemical Society
DOI: 10.1021/acs.analchem.9b02358

A prospective cohort analysis of gut microbial co-metabolism in Alaska Native and rural African people at high and low risk of colorectal cancer

Autorzy: Soeren Ocvirk, Annette S Wilson, Joram M Posma, Jia V Li, Kathryn R Koller, Gretchen M Day, Christie A Flanagan, Jill Evon Otto, Pam E Sacco, Frank D Sacco, Flora R Sapp, Amy S Wilson, Keith Newton, Faye Brouard, James P DeLany, Marissa Behnning, Corynn N Appolonia, Devavrata Soni, Faheem Bhatti, Barbara Methé, Adam Fitch, Alison Morris, H Rex Gaskins, James Kinross, Jeremy K Nicholson, Timothy K
Opublikowane w: The American Journal of Clinical Nutrition, Numer 111/2, 2019, Strona(/y) 406-419, ISSN 0002-9165
Wydawca: American Society for Clinical Nutrition, Inc.
DOI: 10.1093/ajcn/nqz301

Monosodium Glutamate (MSG) Renders Alkalinizing Properties and Its Urinary Metabolic Markers of MSG Consumption in Rats

Autorzy: Nahok, Li, Phetcharaburanin, Abdul, Wongkham, Thanan, Silsirivanit, Anutrakulchai, Selmi, Cha’on
Opublikowane w: Biomolecules, Numer 9/10, 2019, Strona(/y) 542, ISSN 2218-273X
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biom9100542

Bile salt metabolism is not the only factor contributing to Clostridioides ( Clostridium ) difficile disease severity in the murine model of disease

Autorzy: Caitlin A. Jukes, Umer Zeeshan Ijaz, Anthony Buckley, Janice Spencer, June Irvine, Denise Candlish, Jia V. Li, Julian R. Marchesi, Gillian Douce
Opublikowane w: Gut Microbes, Numer 11/3, 2020, Strona(/y) 481-496, ISSN 1949-0976
Wydawca: Landes Bioscience
DOI: 10.1080/19490976.2019.1678996

Sevoflurane but not propofol enhances ovarian cancer cell biology through regulating cellular metabolic and signaling mechanisms

Autorzy: Cong Hu, Bincheng Wang, Zhigang Liu, Qiling Chen, Masashi Ishikawa, Han Lin, Qingquan Lian, Jun Li, Jia V. Li, Daqing Ma, null null
Opublikowane w: Cell Biology and Toxicology, Numer 39, 2023, Strona(/y) 1395-1411, ISSN 0742-2091
Wydawca: Kluwer Academic Publishers
DOI: 10.1007/s10565-022-09766-6

Improved Spatial Resolution of Metabolites in Tissue Biopsies Using High-Resolution Magic-Angle-Spinning Slice Localization NMR Spectroscopy

Autorzy: Elisabeth V. Vonhof, Martial Piotto, Elaine Holmes, John C. Lindon, Jeremy K. Nicholson, Jia V. Li
Opublikowane w: Analytical Chemistry, Numer 92, 2023, Strona(/y) 11516-11519, ISSN 0003-2700
Wydawca: American Chemical Society
DOI: 10.1021/acs.analchem.0c02377

Tumour necrosis factor-α (TNF-α) enhances dietary carcinogen-induced DNA damage in colorectal cancer epithelial cells through activation of JNK signaling pathway

Autorzy: Aminah G. Alotaibi, Jia V. Li, Nigel J. Gooderham
Opublikowane w: Toxicology, Numer 457, 2022, Strona(/y) 152806, ISSN 0300-483X
Wydawca: Elsevier BV
DOI: 10.1016/j.tox.2021.152806

Roux-en-Y gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype

Autorzy: Jia V. Li, Hutan Ashrafian, Magali Sarafian, Daniel Homola, Laura Rushton, Grace Barker, Paula Momo Cabrera, Matthew R. Lewis, Ara Darzi, Edward Lin, Nana Adwoa Gletsu-Miller, Stephen L. Atkin, Thozhukat Sathyapalan, Nigel J. Gooderham, Jeremy K. Nicholson, Julian R. Marchesi, Thanos Athanasiou, Elaine Holmes
Opublikowane w: Microbiome, Numer 9, 2021, ISSN 2049-2618
Wydawca: Springer Science and Business Media LLC
DOI: 10.1186/s40168-021-01086-x

Book chapters (1)

Metabolic Profiling in IBD

Autorzy: Maria Glymenaki, Jia V. Li, Julian R. Marchesi
Opublikowane w: Biomarkers in Inflammatory Bowel Diseases, 2019, Strona(/y) 303-312, ISBN 978-3-030-11445-9
Wydawca: Springer International Publishing
DOI: 10.1007/978-3-030-11446-6_25

Non-peer reviewed articles (1)

Diet changes due to urbanization in South Africa are linked to microbiome and metabolome signatures of Westernization and colorectal cancer

Autorzy: M. C. Ramaboli, S. Ocvirk, M. Khan Mirzaei, B. L. Eberhart, M. Valdivia-Garcia, A. Metwaly, K. Neuhaus, G. Barker, J. Ru, L. T. Nesengani, D. Mahdi-Joest, A. S. Wilson, S. K. Joni, D. C. Layman, J. Zheng, R. Mandal, Q. Chen, M. R. Perez, S. Fortuin, B. Gaunt, D. Wishart, B. Methé, D. Haller, J. V. Li, L. Deng, R. Swart, S. J. D. O’Keefe
Opublikowane w: Nature Communications, Numer 15, 2024, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-024-46265-0

Thesis and dissertations (1)

Investigating the metabolic function of the gut microbiota in colorectal carcinogenesis via choline metabolism

Autorzy: Yang Bi
Opublikowane w: 2024
Wydawca: Imperial College London