Computational Design of Novel Functional Proteins for Immunoengineering

Project Information

DeNovoImmunoDesign

Grant agreement ID: 716058

DOI 10.3030/716058

Project closed

EC signature date 18 October 2016

Start date 1 March 2017

End date 31 December 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 695 489,00

EU contribution € 1 695 489,00

Coordinated by

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

Publications

Peer reviewed articles (10)

A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy

Author(s): Greta Giordano-Attianese, Pablo Gainza, Elise Gray-Gaillard, Elisabetta Cribioli, Sailan Shui, Seonghoon Kim, Mi-Jeong Kwak, Sabrina Vollers, Angel De Jesus Corria Osorio, Patrick Reichenbach, Jaume Bonet, Byung-Ha Oh, Melita Irving, George Coukos, Bruno E. Correia
Published in: Nature Biotechnology, Issue 38/4, 2020, Page(s) 426-432, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/s41587-019-0403-9

RosettaSurf-A surface-centric computational design approach.

Author(s): Andreas Scheck; Stéphane Rosset; Michaël Defferrard; Andreas Loukas; Jaume Bonet; Pierre Vandergheynst; Bruno E. Correia
Published in: Plos Computational Biology, Issue 9, 2022, ISSN 1544-9173
Publisher: Public Library of Science
DOI: 10.1371/journal.pcbi.1009178

Bottom-up de novo design of functional proteins with complex structural features

Author(s): Che Yang, Fabian Sesterhenn, Jaume Bonet, Eva A. van Aalen, Leo Scheller, Luciano A. Abriata, Johannes T. Cramer, Xiaolin Wen, Stéphane Rosset, Sandrine Georgeon, Theodore Jardetzky, Thomas Krey, Martin Fussenegger, Maarten Merkx, Bruno E. Correia
Published in: Nature Chemical Biology, Issue 17/4, 2021, Page(s) 492-500, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-020-00699-x

A rational blueprint for the design of chemically-controlled protein switches

Author(s): Sailan Shui, Pablo Gainza, Leo Scheller, Che Yang, Yoichi Kurumida, Stéphane Rosset, Sandrine Georgeon, Raphaël B. Di Roberto, Rocío Castellanos-Rueda, Sai T. Reddy, Bruno E. Correia
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25735-9

De novo protein design enables the precise induction of RSV-neutralizing antibodies

Author(s): Fabian Sesterhenn, Che Yang, Jaume Bonet, Johannes T. Cramer, Xiaolin Wen, Yimeng Wang, Chi-I Chiang, Luciano A. Abriata, Iga Kucharska, Giacomo Castoro, Sabrina S. Vollers, Marie Galloux, Elie Dheilly, Stéphane Rosset, Patricia Corthésy, Sandrine Georgeon, Mélanie Villard, Charles-Adrien Richard, Delphyne Descamps, Teresa Delgado, Elisa Oricchio, Marie-Anne Rameix-Welti, Vicente Más, Sean Erv
Published in: Science, Issue 368/6492, 2020, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aay5051

Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen

Author(s): Fabian Sesterhenn, Marie Galloux, Sabrina S. Vollers, Lucia Csepregi, Che Yang, Delphyne Descamps, Jaume Bonet, Simon Friedensohn, Pablo Gainza, Patricia Corthésy, Man Chen, Stéphane Rosset, Marie-Anne Rameix-Welti, Jean-François Éléouët, Sai T. Reddy, Barney S. Graham, Sabine Riffault, Bruno E. Correia
Published in: PLOS Biology, Issue 17/2, 2019, Page(s) e3000164, ISSN 1545-7885
Publisher: PLOS
DOI: 10.1371/journal.pbio.3000164

Rosetta FunFolDes – A general framework for the computational design of functional proteins

Author(s): Jaume Bonet, Sarah Wehrle, Karen Schriever, Che Yang, Anne Billet, Fabian Sesterhenn, Andreas Scheck, Freyr Sverrisson, Barbora Veselkova, Sabrina Vollers, Roxanne Lourman, Mélanie Villard, Stéphane Rosset, Thomas Krey, Bruno E. Correia
Published in: PLOS Computational Biology, Issue 14/11, 2018, Page(s) e1006623, ISSN 1553-7358
Publisher: PLOS
DOI: 10.1371/journal.pcbi.1006623

rstoolbox - a Python library for large-scale analysis of computational protein design data and structural bioinformatics

Author(s): Jaume Bonet, Zander Harteveld, Fabian Sesterhenn, Andreas Scheck, Bruno E. Correia
Published in: BMC Bioinformatics, Issue 20/1, 2019, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/s12859-019-2796-3

Deciphering interaction fingerprints from protein molecular surfaces using geometric deep learning

Author(s): P. Gainza, F. Sverrisson, F. Monti, E. Rodolà, D. Boscaini, M. M. Bronstein, B. E. Correia
Published in: Nature Methods, Issue 2019, 2019, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-019-0666-6

Structure-based immunogen design-leading the way to the new age of precision vaccines.

Author(s): Fabian Sesterhenn; Jaume Bonet; Bruno E. Correia; Bruno E. Correia
Published in: Current Opinion in Structural Biology, Issue 8, 2018, ISSN 0346-251X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.sbi.2018.06.002

Intellectual Property Rights

Patent (2)

IMMUNOGEN

Application/Publication number: 18 197259
Date: 2018-09-27

IMMUNOGEN

Application/Publication number: 18 197259
Date: 2018-09-27
Applicant(s): ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE