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Computational Design of Novel Functional Proteins for Immunoengineering

Publicaciones

A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy

Autores: Greta Giordano-Attianese, Pablo Gainza, Elise Gray-Gaillard, Elisabetta Cribioli, Sailan Shui, Seonghoon Kim, Mi-Jeong Kwak, Sabrina Vollers, Angel De Jesus Corria Osorio, Patrick Reichenbach, Jaume Bonet, Byung-Ha Oh, Melita Irving, George Coukos, Bruno E. Correia
Publicado en: Nature Biotechnology, Edición 38/4, 2020, Página(s) 426-432, ISSN 1087-0156
Editor: Nature Publishing Group
DOI: 10.1038/s41587-019-0403-9

RosettaSurf-A surface-centric computational design approach.

Autores: Andreas Scheck; Stéphane Rosset; Michaël Defferrard; Andreas Loukas; Jaume Bonet; Pierre Vandergheynst; Bruno E. Correia
Publicado en: Plos Computational Biology, Edición 9, 2022, ISSN 1544-9173
Editor: Public Library of Science
DOI: 10.1371/journal.pcbi.1009178

Bottom-up de novo design of functional proteins with complex structural features

Autores: Che Yang, Fabian Sesterhenn, Jaume Bonet, Eva A. van Aalen, Leo Scheller, Luciano A. Abriata, Johannes T. Cramer, Xiaolin Wen, Stéphane Rosset, Sandrine Georgeon, Theodore Jardetzky, Thomas Krey, Martin Fussenegger, Maarten Merkx, Bruno E. Correia
Publicado en: Nature Chemical Biology, Edición 17/4, 2021, Página(s) 492-500, ISSN 1552-4450
Editor: Nature Publishing Group
DOI: 10.1038/s41589-020-00699-x

A rational blueprint for the design of chemically-controlled protein switches

Autores: Sailan Shui, Pablo Gainza, Leo Scheller, Che Yang, Yoichi Kurumida, Stéphane Rosset, Sandrine Georgeon, Raphaël B. Di Roberto, Rocío Castellanos-Rueda, Sai T. Reddy, Bruno E. Correia
Publicado en: Nature Communications, Edición 12/1, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-25735-9

De novo protein design enables the precise induction of RSV-neutralizing antibodies

Autores: Fabian Sesterhenn, Che Yang, Jaume Bonet, Johannes T. Cramer, Xiaolin Wen, Yimeng Wang, Chi-I Chiang, Luciano A. Abriata, Iga Kucharska, Giacomo Castoro, Sabrina S. Vollers, Marie Galloux, Elie Dheilly, Stéphane Rosset, Patricia Corthésy, Sandrine Georgeon, Mélanie Villard, Charles-Adrien Richard, Delphyne Descamps, Teresa Delgado, Elisa Oricchio, Marie-Anne Rameix-Welti, Vicente Más, Sean Erv
Publicado en: Science, Edición 368/6492, 2020, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.aay5051

Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen

Autores: Fabian Sesterhenn, Marie Galloux, Sabrina S. Vollers, Lucia Csepregi, Che Yang, Delphyne Descamps, Jaume Bonet, Simon Friedensohn, Pablo Gainza, Patricia Corthésy, Man Chen, Stéphane Rosset, Marie-Anne Rameix-Welti, Jean-François Éléouët, Sai T. Reddy, Barney S. Graham, Sabine Riffault, Bruno E. Correia
Publicado en: PLOS Biology, Edición 17/2, 2019, Página(s) e3000164, ISSN 1545-7885
Editor: PLOS
DOI: 10.1371/journal.pbio.3000164

Rosetta FunFolDes – A general framework for the computational design of functional proteins

Autores: Jaume Bonet, Sarah Wehrle, Karen Schriever, Che Yang, Anne Billet, Fabian Sesterhenn, Andreas Scheck, Freyr Sverrisson, Barbora Veselkova, Sabrina Vollers, Roxanne Lourman, Mélanie Villard, Stéphane Rosset, Thomas Krey, Bruno E. Correia
Publicado en: PLOS Computational Biology, Edición 14/11, 2018, Página(s) e1006623, ISSN 1553-7358
Editor: PLOS
DOI: 10.1371/journal.pcbi.1006623

rstoolbox - a Python library for large-scale analysis of computational protein design data and structural bioinformatics

Autores: Jaume Bonet, Zander Harteveld, Fabian Sesterhenn, Andreas Scheck, Bruno E. Correia
Publicado en: BMC Bioinformatics, Edición 20/1, 2019, ISSN 1471-2105
Editor: BioMed Central
DOI: 10.1186/s12859-019-2796-3

Deciphering interaction fingerprints from protein molecular surfaces using geometric deep learning

Autores: P. Gainza, F. Sverrisson, F. Monti, E. Rodolà, D. Boscaini, M. M. Bronstein, B. E. Correia
Publicado en: Nature Methods, Edición 2019, 2019, ISSN 1548-7091
Editor: Nature Publishing Group
DOI: 10.1038/s41592-019-0666-6

Structure-based immunogen design-leading the way to the new age of precision vaccines.

Autores: Fabian Sesterhenn; Jaume Bonet; Bruno E. Correia; Bruno E. Correia
Publicado en: Current Opinion in Structural Biology, Edición 8, 2018, ISSN 0346-251X
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.sbi.2018.06.002

Derechos de propiedad intelectual

IMMUNOGEN

Número de solicitud/publicación: 18 197259
Fecha: 2018-09-27

IMMUNOGEN

Número de solicitud/publicación: 18 197259
Fecha: 2018-09-27
Solicitante(s): ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

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