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CORDIS - EU research results
CORDIS

Sweet Theranostics in Bitter Infections - Seek and Destroy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Neutralizing the impact of the virulence factor LecA from Pseudomonas aeruginosa on human cells with new glycomimetic inhibitors (opens in new window)

Author(s): Eva Zahorska, Francesca Rosato4,5+, Kai Stober4,5+, Sakonwan Kuhaudomlarp6-8, Joscha Meiers, Dirk Hauck, Dorina Reith4,5, Emilie Gillon6, Katharina Rox2,9, Anne Imberty6, Winfried Römer4,5,10*, Alexander Titz1-3*
Published in: Angew. Chem. Int. Ed. Engl, 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202215535

Directing Drugs to Bugs: Antibiotic-Carbohydrate Conjugates Targeting Biofilm-Associated Lectins of Pseudomonas aeruginosa. (opens in new window)

Author(s): Joscha Meiers; Eva Zahorska; Teresa Röhrig; Dirk Hauck; Stefanie Wagner; Alexander Titz
Published in: United States, Issue 2, 2020, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c00856

Nano-in-Microparticles for Aerosol Delivery ofAntibiotic-Loaded, Fucose-Derivatized, andMacrophage-Targeted Liposomes to Combat MycobacterialInfections: In Vitro Deposition, Pulmonary BarrierInteractions, and Targeted Delivery (opens in new window)

Author(s): Benedikt C. Huck, Durairaj Thiyagarajan, Aghiad Bali, Annette Boese,Karen F. W. Besecke, Constantin Hozsa, Robert K. Gieseler, Marcus Furch,Cristiane Carvalho-Wodarz, Franziska Waldow, Dominik Schwudke, Olga Metelkina,Alexander Titz, Hanno Huwer, Konrad Schwarzkopf, Jessica Hoppstädter,Alexandra K. Kiemer, Marcus Koch, Brigitta Loretz,* and Claus-Michael Lehr
Published in: Advanced Healthcare Materials, 2022, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202102117

Targeting extracellular lectins of <i>Pseudomonas aeruginosa</i> with glycomimetic liposomes (opens in new window)

Author(s): Olga Metelkina; Benedikt Huck; Jonathan S. O'Connor; Marcus Koch; Andreas Manz; Claus-Michael Lehr; Alexander Titz
Published in: Crossref, Issue 1, 2022, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1tb02086b

Discovery of <i>N</i>-β-<scp>l</scp>-Fucosyl Amides as High-Affinity Ligands for the <i>Pseudomonas aeruginosa</i> Lectin LecB (opens in new window)

Author(s): Patrycja Mała; Eike Siebs; Joscha Meiers; Katharina Rox; Annabelle Varrot; Anne Imberty; Alexander Titz
Published in: Crossref, Issue 4, 2022, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.2c01373

A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from D-galactose pentaacetate (opens in new window)

Author(s): Eva Zahorska, Sakonwan Kuhaudomlarp, Saverio Minervini, Sultaan Yousaf, Martin Lepsik, Thorsten Kinsinger, Anna K. H. Hirsch, Anne Imberty and Alexander Titz
Published in: ChemComm, 2020, ISSN 1364-548X
Publisher: Royal Chemical Society
DOI: 10.1039/d0cc03490h

Covalent Lectin Inhibition and Application in Bacterial Biofilm Imaging (opens in new window)

Author(s): Stefanie Wagner, Dirk Hauck, Michael Hoffmann, Roman Sommer, Ines Joachim, Rolf Müller, Anne Imberty, Annabelle Varrot, Alexander Titz
Published in: Angewandte Chemie International Edition, Issue 56/52, 2017, Page(s) 16559-16564, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201709368

Anti-biofilm Agents against Pseudomonas aeruginosa : A Structure–Activity Relationship Study of C -Glycosidic LecB Inhibitors (opens in new window)

Author(s): Roman Sommer, Katharina Rox, Stefanie Wagner, Dirk Hauck, Sarah S. Henrikus, Shelby Newsad, Tatjana Arnold, Thomas Ryckmans, Mark Brönstrup, Anne Imberty, Annabelle Varrot, Rolf W. Hartmann, Alexander Titz
Published in: Journal of Medicinal Chemistry, Issue 62/20, 2019, Page(s) 9201-9216, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.9b01120

Lectin-Targeted Prodrugs Activated by <i>Pseudomonas aeruginosa</i> for Self-Destructive Antibiotic Release (opens in new window)

Author(s): Joscha Meiers; Katharina Rox; Alexander Titz
Published in: Crossref, Issue 2, 2022, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.1021/acs.jmedchem.2c01214

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