Sweet Theranostics in Bitter Infections - Seek and Destroy | SWEETBULLETS | Project | Results | H2020 | CORDIS

Publications

Neutralizing the impact of the virulence factor LecA from Pseudomonas aeruginosa on human cells with new glycomimetic inhibitors

Auteurs: Eva Zahorska, Francesca Rosato4,5+, Kai Stober4,5+, Sakonwan Kuhaudomlarp6-8, Joscha Meiers, Dirk Hauck, Dorina Reith4,5, Emilie Gillon6, Katharina Rox2,9, Anne Imberty6, Winfried Römer4,5,10*, Alexander Titz1-3*
Publié dans: Angew. Chem. Int. Ed. Engl, 2022, ISSN 1433-7851
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202215535

Directing Drugs to Bugs: Antibiotic-Carbohydrate Conjugates Targeting Biofilm-Associated Lectins of Pseudomonas aeruginosa.

Auteurs: Joscha Meiers; Eva Zahorska; Teresa Röhrig; Dirk Hauck; Stefanie Wagner; Alexander Titz
Publié dans: United States, Numéro 2, 2020, ISSN 0022-2623
Éditeur: American Chemical Society
DOI: 10.1021/acs.jmedchem.0c00856

Nano-in-Microparticles for Aerosol Delivery ofAntibiotic-Loaded, Fucose-Derivatized, andMacrophage-Targeted Liposomes to Combat MycobacterialInfections: In Vitro Deposition, Pulmonary BarrierInteractions, and Targeted Delivery

Auteurs: Benedikt C. Huck, Durairaj Thiyagarajan, Aghiad Bali, Annette Boese,Karen F. W. Besecke, Constantin Hozsa, Robert K. Gieseler, Marcus Furch,Cristiane Carvalho-Wodarz, Franziska Waldow, Dominik Schwudke, Olga Metelkina,Alexander Titz, Hanno Huwer, Konrad Schwarzkopf, Jessica Hoppstädter,Alexandra K. Kiemer, Marcus Koch, Brigitta Loretz,* and Claus-Michael Lehr
Publié dans: Advanced Healthcare Materials, 2022, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202102117

Targeting extracellular lectins of Pseudomonas aeruginosa with glycomimetic liposomes

Auteurs: Olga Metelkina; Benedikt Huck; Jonathan S. O'Connor; Marcus Koch; Andreas Manz; Claus-Michael Lehr; Alexander Titz
Publié dans: Crossref, Numéro 1, 2022, ISSN 2050-7518
Éditeur: Royal Society of Chemistry
DOI: 10.1039/d1tb02086b

Discovery of N-β-<scp>l</scp>-Fucosyl Amides as High-Affinity Ligands for the Pseudomonas aeruginosa Lectin LecB

Auteurs: Patrycja Mała; Eike Siebs; Joscha Meiers; Katharina Rox; Annabelle Varrot; Anne Imberty; Alexander Titz
Publié dans: Crossref, Numéro 4, 2022, ISSN 0022-2623
Éditeur: American Chemical Society
DOI: 10.1021/acs.jmedchem.2c01373

A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from D-galactose pentaacetate

Auteurs: Eva Zahorska, Sakonwan Kuhaudomlarp, Saverio Minervini, Sultaan Yousaf, Martin Lepsik, Thorsten Kinsinger, Anna K. H. Hirsch, Anne Imberty and Alexander Titz
Publié dans: ChemComm, 2020, ISSN 1364-548X
Éditeur: Royal Chemical Society
DOI: 10.1039/d0cc03490h

Covalent Lectin Inhibition and Application in Bacterial Biofilm Imaging

Auteurs: Stefanie Wagner, Dirk Hauck, Michael Hoffmann, Roman Sommer, Ines Joachim, Rolf Müller, Anne Imberty, Annabelle Varrot, Alexander Titz
Publié dans: Angewandte Chemie International Edition, Numéro 56/52, 2017, Page(s) 16559-16564, ISSN 1433-7851
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201709368

Anti-biofilm Agents against Pseudomonas aeruginosa : A Structure–Activity Relationship Study of C -Glycosidic LecB Inhibitors

Auteurs: Roman Sommer, Katharina Rox, Stefanie Wagner, Dirk Hauck, Sarah S. Henrikus, Shelby Newsad, Tatjana Arnold, Thomas Ryckmans, Mark Brönstrup, Anne Imberty, Annabelle Varrot, Rolf W. Hartmann, Alexander Titz
Publié dans: Journal of Medicinal Chemistry, Numéro 62/20, 2019, Page(s) 9201-9216, ISSN 0022-2623
Éditeur: American Chemical Society
DOI: 10.1021/acs.jmedchem.9b01120

Lectin-Targeted Prodrugs Activated by Pseudomonas aeruginosa for Self-Destructive Antibiotic Release

Auteurs: Joscha Meiers; Katharina Rox; Alexander Titz
Publié dans: Crossref, Numéro 2, 2022, ISSN 0022-2623
Éditeur: American Chemical Society
DOI: 10.1021/acs.jmedchem.2c01214

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