A Flexible Platform for the Application of SAM-dependent enzymes

Project Information

AppSAM

Grant agreement ID: 716966

DOI

10.3030/716966

Project closed

EC signature date 15 March 2017

Start date 1 October 2017

End date 30 September 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 219,00

EU contribution

€ 1 499 219,00

Coordinated by

ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

Enzymatic <i>S</i>‐Methylation of Thiols Catalyzed by Different <i>O</i>‐Methyltransferases

Author(s): Eman Abdelraheem; Emely Jockmann; Jianyu Li; Stefan Günther; Jennifer N. Andexer; Peter‐Leon Hagedoorn; Ulf Hanefeld
Published in: ChemCatChem, 2024, ISSN 1867-3899
Publisher: Wiley
DOI: 10.1002/cctc.202301217

Methyltransferases: Functions and Applications

Author(s): Eman Abdelraheem; Benjamin Thair; Romina Fernández Varela; Emely Jockmann; Désirée Popadić; Helen C. Hailes; John M. Ward; Adolfo M. Iribarren; Elizabeth S. Lewkowicz; Jennifer N. Andexer; Peter‐Leon Hagedoorn; Ulf Hanefeld
Published in: ChemBioChem, 2022, Page(s) e202200212, ISSN 1439-7633
Publisher: Wiley
DOI: 10.1002/cbic.202200212

A Cobalamin-Dependent Radical SAM Enzyme Catalyzes the Unique Cα-Methylation of Glutamine in Methyl-Coenzyme M Reductase

Author(s): Jana Gagsteiger,Sören Jahn,Lorenz Heidinger,Lukas Gericke,Jennifer N. Andexer,Thorsten Friedrich,Christoph Loenarz,Gunhild Layer
Published in: Angew. Chem. Int. Ed., 2022, ISSN 1521-3773
Publisher: Wiley
DOI: 10.1002/anie.202204198

Expanding the Substrate Scope of <i>N</i>‐ and <i>O</i>‐Methyltransferases from Plants for Chemoselective Alkylation**

Author(s): Emely Jockmann; Fabiana Subrizi; Michael K. F. Mohr; Eve M. Carter; Pia M. Hebecker; Désirée Popadić; Helen C. Hailes; Jennifer N. Andexer
Published in: ChemCatChem, 2023, ISSN 1867-3899
Publisher: Wiley
DOI: 10.1002/cctc.202300930

A bicyclic S -adenosylmethionine regeneration system applicable with different nucleosides or nucleotides as cofactor building blocks

Author(s): Désirée Popadić; Dipali Mhaindarkar; Mike H N Dang Thai; Helen C. Hailes; Silja Mordhorst; Jennifer N. Andexer
Published in: RSC Chemical Biology, 2 (3), 2021, ISSN 2633-0679
Publisher: Royal Society of Chemistry
DOI: 10.3929/ethz-b-000490473

Structure, function and substrate preferences of archaeal S-adenosyl-L-homocysteine hydrolases

Author(s): Lars-Hendrik Koeppl, Désirée Popadić, Raspudin Saleem-Batcha, Philipp Germer, Jennifer N. Andexer
Published in: Communications Biology, 2024, ISSN 2399-3642
Publisher: Nature Publishing Group
DOI: 10.1038/s42003-024-06078-9

Enzymatic Synthesis of <scp>l</scp>‐Methionine Analogues and Application in a Methyltransferase Catalysed Alkylation Cascade**

Author(s): Michael K. F. Mohr; Raspudin Saleem‐Batcha; Nicolas V. Cornelissen; Jennifer N. Andexer
Published in: Chem. Eur. J., 2023, Page(s) e202301503, ISSN 1521-3765
Publisher: Wiley
DOI: 10.1002/chem.202301503

Biomimetic <i>S</i>‐Adenosylmethionine Regeneration Starting from Multiple Byproducts Enables Biocatalytic Alkylation with Radical SAM Enzymes**

Author(s): Lukas Gericke; Dipali Mhaindarkar; Lukas C. Karst; Sören Jahn; Marco Kuge; Michael K. F. Mohr; Jana Gagsteiger; Nicolas V. Cornelissen; Xiaojin Wen; Silja Mordhorst; Henning J. Jessen; Andrea Rentmeister; Florian P. Seebeck; Gunhild Layer; Christoph Loenarz; Jennifer N. Andexer
Published in: ChemBioChem, 2023, Page(s) e202300133, ISSN 1439-7633
Publisher: Wiley
DOI: 10.1002/cbic.202300133

Other (2)

Archaeal S-adenosyl-L-homocysteine hydrolases: structure, function and substrate preferences

Author(s): Désirée Popadić, Raspudin Saleem-Batcha, Lars-Hendrik Köppl, Philipp Germer, Jennifer N. Andexer
Published in: bioRxiv, 2023
Publisher: bioRxiv
DOI: 10.1101/2023.05.12.540488

Enzymatische Methylierung in vitro: im Kreis herum oder „nur“ geradeaus?

Author(s): Jennifer N. Andexer
Published in: BIOspektrum, Issue 24, 2018, Page(s) 556-557
Publisher: Springer

Thesis and dissertations (1)

Biosynthesis and Utilisation of PRPP and Application to a Cofactor Regeneration System

Author(s): Lukas Karst
Published in: 2021
Publisher: PhD thesis, University of Freiburg