A Flexible Platform for the Application of SAM-dependent enzymes

Informazioni relative al progetto

AppSAM

ID dell’accordo di sovvenzione: 716966

DOI 10.3030/716966

Progetto chiuso

Data della firma CE 15 Marzo 2017

Data di avvio 1 Ottobre 2017

Data di completamento 30 Settembre 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 499 219,00

Contributo UE € 1 499 219,00

Coordinato da

ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany

Pubblicazioni

Peer reviewed articles (6)

Methyltransferases: Functions and Applications

Autori: Eman Abdelraheem; Benjamin Thair; Romina Fernández Varela; Emely Jockmann; Désirée Popadić; Helen C. Hailes; John M. Ward; Adolfo M. Iribarren; Elizabeth S. Lewkowicz; Jennifer N. Andexer; Peter‐Leon Hagedoorn; Ulf Hanefeld
Pubblicato in: ChemBioChem, 2022, Pagina/e e202200212, ISSN 1439-7633
Editore: Wiley
DOI: 10.1002/cbic.202200212

A Cobalamin-Dependent Radical SAM Enzyme Catalyzes the Unique Cα-Methylation of Glutamine in Methyl-Coenzyme M Reductase

Autori: Jana Gagsteiger,Sören Jahn,Lorenz Heidinger,Lukas Gericke,Jennifer N. Andexer,Thorsten Friedrich,Christoph Loenarz,Gunhild Layer
Pubblicato in: Angew. Chem. Int. Ed., 2022, ISSN 1521-3773
Editore: Wiley
DOI: 10.1002/anie.202204198

Expanding the Substrate Scope of <i>N</i>‐ and <i>O</i>‐Methyltransferases from Plants for Chemoselective Alkylation**

Autori: Emely Jockmann; Fabiana Subrizi; Michael K. F. Mohr; Eve M. Carter; Pia M. Hebecker; Désirée Popadić; Helen C. Hailes; Jennifer N. Andexer
Pubblicato in: ChemCatChem, 2023, ISSN 1867-3899
Editore: Wiley
DOI: 10.1002/cctc.202300930

A bicyclic S -adenosylmethionine regeneration system applicable with different nucleosides or nucleotides as cofactor building blocks

Autori: Désirée Popadić; Dipali Mhaindarkar; Mike H N Dang Thai; Helen C. Hailes; Silja Mordhorst; Jennifer N. Andexer
Pubblicato in: RSC Chemical Biology, 2 (3), 2021, ISSN 2633-0679
Editore: Royal Society of Chemistry
DOI: 10.3929/ethz-b-000490473

Enzymatic Synthesis of <scp>l</scp>‐Methionine Analogues and Application in a Methyltransferase Catalysed Alkylation Cascade**

Autori: Michael K. F. Mohr; Raspudin Saleem‐Batcha; Nicolas V. Cornelissen; Jennifer N. Andexer
Pubblicato in: Chem. Eur. J., 2023, Pagina/e e202301503, ISSN 1521-3765
Editore: Wiley
DOI: 10.1002/chem.202301503

Biomimetic <i>S</i>‐Adenosylmethionine Regeneration Starting from Multiple Byproducts Enables Biocatalytic Alkylation with Radical SAM Enzymes**

Autori: Lukas Gericke; Dipali Mhaindarkar; Lukas C. Karst; Sören Jahn; Marco Kuge; Michael K. F. Mohr; Jana Gagsteiger; Nicolas V. Cornelissen; Xiaojin Wen; Silja Mordhorst; Henning J. Jessen; Andrea Rentmeister; Florian P. Seebeck; Gunhild Layer; Christoph Loenarz; Jennifer N. Andexer
Pubblicato in: ChemBioChem, 2023, Pagina/e e202300133, ISSN 1439-7633
Editore: Wiley
DOI: 10.1002/cbic.202300133

Other (2)

Archaeal S-adenosyl-L-homocysteine hydrolases: structure, function and substrate preferences

Autori: Désirée Popadić, Raspudin Saleem-Batcha, Lars-Hendrik Köppl, Philipp Germer, Jennifer N. Andexer
Pubblicato in: bioRxiv, 2023
Editore: bioRxiv
DOI: 10.1101/2023.05.12.540488

Enzymatische Methylierung in vitro: im Kreis herum oder „nur“ geradeaus?

Autori: Jennifer N. Andexer
Pubblicato in: BIOspektrum, Numero 24, 2018, Pagina/e 556-557
Editore: Springer

Thesis and dissertations (1)

Biosynthesis and Utilisation of PRPP and Application to a Cofactor Regeneration System

Autori: Lukas Karst
Pubblicato in: 2021
Editore: PhD thesis, University of Freiburg