Deliverables
Draft of manuscript(s) for peer-review on baseline and follow-up MRI data (for participants with both datasets). In addition to evaluation of: - Patient-reported outcome measures on post COVID-19 recovery management (using Dyspnea-12, St Georges Respiratory Questionnaire and the EQ-5D-5L) - Difference in the change in these MR derived biomarkers in those with known genetic variants associated with multi-organ disease (such as PNPLA3) and those without after SARS-CoV-2 infection. - Contextualisation of results using our existing data from the UK Biobank, which includes quantitative MRI with LiverMultiScan®.
Standard Operating Procedure for the protection of medical data, in accordance with current EU (Directive 2001/20/EC of the European Parliament and of the Council of 4 April 2001, Commision Directive 2005/28/EC, 8 April 2005) and national legislation.
Report on the first 100 baseline MRI scans of participants, covering: organ volume, fat infiltration and fibro-inflammation in kidney, liver, heart, pancreas and spleen; together with biochemical, haematological and immunological measures.
Report on all 507 baseline MRI scans of participants, covering: organ volume, fat infiltration and fibro-inflammation in kidney, liver, heart, pancreas and spleen; together with biochemical, haematological and immunological measures.
Report on changes in the organ-specific MRI biomarkers from cohort of participants with 6-month follow-up data.
Communication plan to be updated to include new sites, principal investigators and other updated information as necessary
Data management plan.
Communication plan and updates devliered at: -M12 -M24 -M36
Publications
Author(s): Shumbayawonda, E., Mouchti, S., Castelo-Branco, M., Caseiro Alves, F., Coenraad, M., Lamb, H., Beer, M., Schaapman, J., Costa, T., Thomaides-Brears, H., Kelly, M., Rymell, S., French, M., Jenkins, L., Waddell, T., Herdman, L., Tonev, D., Neubauer, S., Banerjee, R., Dollinger, M.
Published in: Gastroenterology, 158(6), S1, 2020, Page(s) S-1292
Publisher: Elsevier
Author(s): Roca-Fernández, A., Dennis, A., Nicholls, R., McGonigle, J., Kelly, M., Banerjee, R., Sanyal, A. J.
Published in: Hepatology, 72/S1, 2020, Page(s) 1A-130A
Publisher: John Wiley & Sons Inc.
Author(s): Thomaides-Brears, H.B., Shumbayawonda, E., Mouchti, S., Castelo-Branco, M., Caseiro Alves, F., Coenraad, M., Lamb, H., Beer, M., Schaapman, J., Costa, T., Kelly, M., Rymen, S., Herdman, L., Waddell, T., Neubauer, S., Banerjee, R., Dollinger, M.
Published in: Hepatology, 70/S1, 2019, Page(s) 188-1382, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
Author(s): Dimitar Tonev, Elizabeth Shumbayawonda, Louise Ann Tetlow, Laura Herdman, Marika French, Soubera Rymell, Helena Thomaides-Brears, Filipe Caseiro-Alves, Miguel Castelo-Branco, Carlos Ferreira, Minneke Coenraad, Hildo Lamb, Meinrad Beer, Matt Kelly, Rajarshi Banerjee, Matthias Dollinger
Published in: JMIR Research Protocols, 9/10, 2020, Page(s) e19189, ISSN 1929-0748
Publisher: JMIR Publications
DOI: 10.2196/19189
Author(s): Roca-Fernández,A., Dennis, A., Nicholls,R., McGonigle,J., Kelly,M., Banerjee, R.
Published in: medRxiv, 05/06/2020, 2020
Publisher: medRvix
DOI: 10.1101/2020.06.04.20122457
Author(s): Dennis, A., Wamil, M., Kapur, S., Alberts, J., Badley, A., Decker, G., Rizza, S., Banerjee, R., Banerjee, A.
Published in: medRxiv, 16/10/2020, 2020
Publisher: medRxiv
DOI: 10.1101/2020.10.14.20212555