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Cardio Ultraefficient nanoParticles for Inhalation of Drug prOducts

Objective

The incidence of Cardiovascular Disease (CD) claims worldwide 17.1 million lives a year, with an estimated 31% of all deaths globally and a EU cost of 139 billion euros. Up to 40% of all deaths occur among the elderly. In spite of all medical efforts, the 5-year mortality was reduced significantly less than that of malignant diseases. This highlights the urgent need to overcome the difficulties associated with present pharmacological therapies (i.e. drug instability, and unspecific targeting) by developing new ground-breaking therapeutic strategies that go far beyond any current regimens. New approaches for safe, efficient, and heart-specific delivery of therapeutics are strongly required. CUPIDO is envisioned to meet these critical needs by providing an unconventional and effective strategy based on nanoparticle-assisted delivery of clinically available and novel therapeutics to the diseased heart. In particular, CUPIDO will develop innovative bioinspired hybrid nanoparticles formulated as biologicals delivery, which are i) biocompatible and biodegradable, ii) designed for crossing biological barriers, and iii) guidable to the heart. A combination of multidisciplinary manufacturing and validation approaches will be employed, bringing the envisioned product beyond the currently available clinical and day-to-day management of CD individuals. Scale-up production, and respect of medical regulatory requirements will allow CUPIDO to deliver a final product for future late pre-clinical and clinical studies. Altogether, CUPIDO will foster the translation of nanomedical applications toward the cardiac field, which although still in its start, offers great potential to overcome the limitations associated to the currently pharmacological treatments.

Call for proposal

H2020-NMBP-2016-2017

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Sub call

H2020-NMBP-2016-two-stage

Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE
Net EU contribution
€ 1 800 141,25
Address
Piazzale Aldo Moro 7
00185 Roma
Italy

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Region
Centro (IT) Lazio Roma
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (12)

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
Net EU contribution
€ 484 585,00
Address
Chariteplatz 1
10117 Berlin

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Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
SIMULA RESEARCH LABORATORY AS
Norway
Net EU contribution
€ 442 338,75
Address
Kristian August Gate 23
0164 Oslo

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Region
Norge Oslo og Viken Oslo
Activity type
Research Organisations
Non-EU contribution
€ 0,00
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Net EU contribution
€ 689 983,75
Address
South Kensington Campus Exhibition Road
SW7 2AZ London

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
BIOEMISSION TECHNOLOGY SOLUTIONS IKE
Greece
Net EU contribution
€ 351 750,00
Address
L. Mesogeion 387
153 43 Agia Paraskevi (Athina)

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Βόρειος Τομέας Αθηνών Aττική Αττική
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
IN SRL IMPRESA SOCIALE
Italy
Net EU contribution
€ 300 285,00
Address
Via Carducci 9a
33100 Udine

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nord-Est Friuli-Venezia Giulia Udine
Activity type
Other
Non-EU contribution
€ 0,00
CAMBRIDGE INNOVATION TECHNOLOGIES CONSULTING LIMITED
United Kingdom
Net EU contribution
€ 314 913,75
Address
St John's Innovation Centre Cowley Road
CB4 0WS Cambridge

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
East of England East Anglia Cambridgeshire CC
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
France
Net EU contribution
€ 219 908,75
Address
Pierre Brossolette 1
91380 Chilly Mazarin

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Region
Ile-de-France Ile-de-France Essonne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
NEMERA LA VERPILLIERE
France
Net EU contribution
€ 400 000,00
Address
20 Avenue De La Gare
38292 La Verpilliere

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Region
Auvergne-Rhône-Alpes Rhône-Alpes Isère
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
FIN-CERAMICA FAENZA SPA
Italy
Net EU contribution
€ 490 000,00
Address
Via Granarolo 177/3
48018 Faenza

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Region
Nord-Est Emilia-Romagna Ravenna
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
LIFE CORPORATION SA

Participation ended

Luxembourg
Net EU contribution
€ 0,00
Address
20 Rue Jean-pierre Beicht
1226 Luxembourg

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Luxembourg Luxembourg Luxembourg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
PLUMESTARS SRL
Italy
Net EU contribution
€ 300 000,00
Address
Strada Inzani 1
43124 Parma Pr

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nord-Est Emilia-Romagna Parma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
L.I.F.E. ITALIA SRL
Italy
Net EU contribution
€ 300 875,00
Address
Via Dei Gracchi 35
20146 Milano

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nord-Ovest Lombardia Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00