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Cardio Ultraefficient nanoParticles for Inhalation of Drug prOducts

Objective

The incidence of Cardiovascular Disease (CD) claims worldwide 17.1 million lives a year, with an estimated 31% of all deaths globally and a EU cost of 139 billion euros. Up to 40% of all deaths occur among the elderly. In spite of all medical efforts, the 5-year mortality was reduced significantly less than that of malignant diseases. This highlights the urgent need to overcome the difficulties associated with present pharmacological therapies (i.e. drug instability, and unspecific targeting) by developing new ground-breaking therapeutic strategies that go far beyond any current regimens. New approaches for safe, efficient, and heart-specific delivery of therapeutics are strongly required. CUPIDO is envisioned to meet these critical needs by providing an unconventional and effective strategy based on nanoparticle-assisted delivery of clinically available and novel therapeutics to the diseased heart. In particular, CUPIDO will develop innovative bioinspired hybrid nanoparticles formulated as biologicals delivery, which are i) biocompatible and biodegradable, ii) designed for crossing biological barriers, and iii) guidable to the heart. A combination of multidisciplinary manufacturing and validation approaches will be employed, bringing the envisioned product beyond the currently available clinical and day-to-day management of CD individuals. Scale-up production, and respect of medical regulatory requirements will allow CUPIDO to deliver a final product for future late pre-clinical and clinical studies. Altogether, CUPIDO will foster the translation of nanomedical applications toward the cardiac field, which although still in its start, offers great potential to overcome the limitations associated to the currently pharmacological treatments.

Field of science

  • /social sciences/sociology/demography/mortality

Call for proposal

H2020-NMBP-2016-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE
Address
Piazzale Aldo Moro 7
00185 Roma
Italy
Activity type
Research Organisations
EU contribution
€ 1 800 141,25

Participants (12)

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 484 585
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
SIMULA RESEARCH LABORATORY AS
Norway
EU contribution
€ 442 338,75
Address
Martin Linges Vei 17
1364 Fornebu
Activity type
Research Organisations
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 689 983,75
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
BIOEMISSION TECHNOLOGY SOLUTIONS IKE
Greece
EU contribution
€ 351 750
Address
Alexandras Avenue 116
114 72 Athina
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
IN SRL
Italy
EU contribution
€ 300 285
Address
Via Carducci 9A
33100 Udine
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CAMBRIDGE INNOVATION TECHNOLOGIES CONSULTING LIMITED
United Kingdom
EU contribution
€ 314 913,75
Address
St John's Innovation Centre Cowley Road
CB4 0WS Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
France
EU contribution
€ 219 908,75
Address
Pierre Brossolette 1
91380 Chilly Mazarin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NEMERA LA VERPILLIERE
France
EU contribution
€ 400 000
Address
20 Avenue De La Gare
38292 La Verpilliere
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FIN-CERAMICA FAENZA SPA
Italy
EU contribution
€ 490 000
Address
Via Granarolo 177/3
48018 Faenza
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LIFE CORPORATION SA

Participation ended

Luxembourg
EU contribution
€ 0
Address
20 Rue Jean-pierre Beicht
1226 Luxembourg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PLUMESTARS SRL
Italy
EU contribution
€ 300 000
Address
Strada Inzani 1
43124 Parma Pr
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
L.I.F.E. ITALIA SRL
Italy
EU contribution
€ 300 875
Address
Via Privata Della Torre 11
20127 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)