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Cardio Ultraefficient nanoParticles for Inhalation of Drug prOducts

Deliverables

E-newsletter (M48)

Yearly update of the main project contacts and to external subscribers

Press releases (M24)

Outline what CUPIDO is, what it will do, who it is intended to, the innovation it will bring and its benefits.

Visual identity kit (M36)

Creation of a visual identity for the project, including the project logo and document templates, with the development of promotional and informational materials contributing to the overall perception of the project and its uniform impression.

Extended model, describing relationship between FeCaPs and deposition site when exposed to an external magnetic field (M30)

Definition of FeCaP deposition and flow at multiple scales taking into account various physico-chemical parameters such as particle size distribution, shape, magnetic susceptibility, etc

Validation of therapeutic efficiency of drug-loaded dpCaP/FedpCaPs in HFrEF mouse model

Definition of Proof of Concept that administration of dpCaP (and FedpCaP) therapeutic formulations exert beneficial cardiac effects in small animal model of cardiac disease.

E-newsletter (M24)

Yearly update of the main project contacts and to external subscribers

Summary of annual workshops and networking events building communities (M36)

Generation of period report regarding CUPIDO major results and activites

Aptamer-mediated guidance of CaP (M12)

CaP functionalized with aptamers for improved myocardial-specific targeting

In vivo assessment of the studied nanopartilces using different imaging modalities (M30)

In vivo assessment of loaded and unloaded dpCaPs and FedpCaPs for a full spectrum of biocompatibility, toxicity, blood-interaction, air/blood flow-interaction at pulmonary barrier, inflammatory responses, and pharmacokinetics.

Summary of annual workshops and networking events building communities (M12)

Generation of period report regarding CUPIDO major results and activites

Demonstration of the therapeutic effect of formulation for the treatment of cardiovascular function in mini-pigs

Definition of Proof of Concept that administration of dpCaP (and FedpCaP) therapeutic formulations exert beneficial cardiac effects in large animal model of cardiac disease.

Project videos (M48)

Interviews on key project figures produced and posted on YouTube and other networks to provide a basis for communication to a large audience

Data on the efficiency of wearable device for continuous remote monitoring of cardiopulmonary activity of mini-pigs

Validation of the efficacy of wearable device on continuous remote monitoring of cardiopulmonary activity of diseased mini-pigs upon inhalation treatment

Extended model, describing relationship between FeCaPs and deposition site when exposed to an external magnetic field (M12)

Definition of FeCaP deposition and flow at multiple scales taking into account various physico-chemical parameters such as particle size distribution, shape, magnetic susceptibility, etc

Extension of open-source flow simulation framework to also include porous media flow. Establish relationship between different nanoparticles and deposition sites in both small and large animal models (M36)

Definition of CaP deposition and flow at multiple scales taking into account various physico-chemical parameters such as particle size distribution, shape, magnetic susceptibility, etc

Validation of nanoparticle biodistribution in large animals

Demonstration of efficacy of nanoparticle biodistribution in large animals (mini-pigs).

Extension of open-source flow simulation framework to also include porous media flow. Establish relationship between different nanoparticles and deposition sites in both small and large animal models (M18)

Definition of CaP deposition and flow at multiple scales taking into account various physico-chemical parameters such as particle size distribution, shape, magnetic susceptibility, etc

EMD-mediated guidance of FeCaP (M24)

Optimized FeCaPs for electromagnetic-mediated guidance to the heart via an electromagnetic device.

Distribution of electromagnetic fields in the target area due to the drug targeting systems

Comparison of different system solutions able to generate the magnetic field gradient (or the magnetic field) needed to guide the FeCaPs at the level of the heart tissues

Press releases (M12)

Outline what CUPIDO is, what it will do, who it is intended to, the innovation it will bring and its benefits.

In vitro assessment of nanoparticle behavior at/across the pulmonary barrier (M24)

In vitro assessment of loaded and unloaded dpCaPs for a full spectrum of biocompatibility, toxicity, and air/blood flow-interaction at pulmonary barrier.

Training satisfaction questionnaires

Generation of training satisfaction questionnaires in regard of training topics and contents organized during the project

EMD-mediated guidance of FeCaP (M12)

Optimized FeCaPs for electromagnetic-mediated guidance to the heart via an electromagnetic device.

E-newsletter (M12)

Yearly update of the main project contacts and to external subscribers

Aptamer-mediated guidance of CaP (M20)

CaP functionalized with aptamers for improved myocardial-specific targeting

Press releases (M48)

Outline what CUPIDO is, what it will do, who it is intended to, the innovation it will bring and its benefits.

Visual identity kit (M12)

Creation of a visual identity for the project, including the project logo and document templates, with the development of promotional and informational materials contributing to the overall perception of the project and its uniform impression.

In vitro assessment of nanoparticle behavior at/across the pulmonary barrier (M12)

In vitro assessment of loaded and unloaded dpCaPs for a full spectrum of biocompatibility, toxicity, and air/blood flow-interaction at pulmonary barrier.

Web portal, social media

Facilitate the communication of information to the media and through the media to become the key multiplier to reach the wider public.

Wearable devices for usage on mini-pigs (M24)

Delivery of wearable garments designed and validated or a continuous and non-invasive monitoring of pig heart and respiratory activity

In vivo assessment of the studied nanopartilces using different imaging modalities (M12)

In vivo assessment of loaded and unloaded dpCaPs and FedpCaPs for a full spectrum of biocompatibility, toxicity, blood-interaction, air/blood flow-interaction at pulmonary barrier, inflammatory responses, and pharmacokinetics.

Summary of annual workshops and networking events building communities (M18)

Generation of period report regarding CUPIDO major results and activites

Summary of annual workshops and networking events building communities (M48)

Generation of period report regarding CUPIDO major results and activites

Project videos (M24)

Interviews on key project figures produced and posted on YouTube and other networks to provide a basis for communication to a large audience

Press releases (M3)

Outline what CUPIDO is, what it will do, who it is intended to, the innovation it will bring and its benefits.

Functional assessment (compatibility, physic-chemical and biological stability) of CaP restoration and drug release

The biological activity of the powders and the reconstitution of CaP population will be thoroughly evaluated in vitro in cardiomyocyte lines (HL-1), adult primary mouse cardiomyocytes and human induced pluripotent stem cells (hiPS)-derived cardiomyocytes.

Functional assessment (compatibility, physic-chemical and biological stability) of FeCaP restoration and drug release

The biological activity of the powders and the reconstitution of FeCaP population will be thoroughly evaluated in vitro in cardiomyocyte lines (HL-1), adult primary mouse cardiomyocytes and human induced pluripotent stem cells (hiPS)-derived cardiomyocytes.

Visual identity kit (M48)

Creation of a visual identity for the project, including the project logo and document templates, with the development of promotional and informational materials contributing to the overall perception of the project and its uniform impression.

Wearable devices for usage on mini-pigs (M36)

Delivery of wearable garments designed and validated or a continuous and non-invasive monitoring of pig heart and respiratory activity

Searching for OpenAIRE data...

Publications

Calcium Phosphate Nanoparticle Precipitation by a Continuous Flow Process: A Design of Experiment Approach

Author(s): Lorenzo Degli Esposti, Alessandro Dotti, Alessio Adamiano, Claudia Fabbi, Eride Quarta, Paolo Colombo, Daniele Catalucci, Claudio De Luca, Michele Iafisco
Published in: Crystals, 10/10, 2020, Page(s) 953, ISSN 2073-4352
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cryst10100953

Cardiac power output accurately reflects external cardiac work over a wide range of inotropic states in pigs

Author(s): Dawud Abawi, Alessandro Faragli, Michael Schwarzl, Martin Manninger, David Zweiker, Karl-Patrik Kresoja, Jochen Verderber, Birgit Zirngast, Heinrich Maechler, Paul Steendijk, Burkert Pieske, Heiner Post, Alessio Alogna
Published in: BMC Cardiovascular Disorders, 19/1, 2019, ISSN 1471-2261
Publisher: BioMed Central
DOI: 10.1186/s12872-019-1212-2

Inhalation of peptide-loaded nanoparticles improves heart failure

Author(s): Michele Miragoli, Paola Ceriotti, Michele Iafisco, Marco Vacchiano, Nicolò Salvarani, Alessio Alogna, Pierluigi Carullo, Gloria Belén Ramirez-Rodríguez, Tatiana Patrício, Lorenzo Degli Esposti, Francesca Rossi, Francesca Ravanetti, Silvana Pinelli, Rossella Alinovi, Marco Erreni, Stefano Rossi, Gianluigi Condorelli, Heiner Post, Anna Tampieri, Daniele Catalucci
Published in: Science Translational Medicine, 10/424, 2018, Page(s) eaan6205, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aan6205

The noncoding-RNA landscape in cardiovascular health and disease

Author(s): Vittoria Di Mauro, Maria Barandalla-Sobrados, Daniele Catalucci
Published in: Non-coding RNA Research, 2018, ISSN 2468-0540
Publisher: Elsevier
DOI: 10.1016/j.ncrna.2018.02.001

Cardiac kinematic parameters computed from video of in situ beating heart

Author(s): Lorenzo Fassina, Giacomo Rozzi, Stefano Rossi, Simone Scacchi, Maricla Galetti, Francesco Paolo Lo Muzio, Fabrizio Del Bianco, Piero Colli Franzone, Giuseppe Petrilli, Giuseppe Faggian, Michele Miragoli
Published in: Scientific Reports, 7, 2017, Page(s) 46143, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/srep46143

A combined low-frequency electromagnetic and fluidic stimulation for a controlled drug release from superparamagnetic calcium phosphate nanoparticles: potential application for cardiovascular diseases

Author(s): Alessandra Marrella, Michele Iafisco, Alessio Adamiano, Stefano Rossi, Maurizio Aiello, Maria Barandalla-Sobrados, Pierluigi Carullo, Michele Miragoli, Anna Tampieri, Silvia Scaglione, Daniele Catalucci
Published in: Journal of The Royal Society Interface, 15/144, 2018, Page(s) 20180236, ISSN 1742-5689
Publisher: The Royal Society
DOI: 10.1098/rsif.2018.0236

Calcium phosphate-based nanosystems for advanced targeted nanomedicine

Author(s): Lorenzo Degli Esposti, Francesca Carella, Alessio Adamiano, Anna Tampieri, Michele Iafisco
Published in: Drug Development and Industrial Pharmacy, 44/8, 2018, Page(s) 1223-1238, ISSN 0363-9045
Publisher: Marcel Dekker Inc.
DOI: 10.1080/03639045.2018.1451879

Time-Lapsing Perfusion: Proof of Concept of a Novel Method to Study Drug Delivery in Whole Organs

Author(s): Alexandra K. Diem, Kristian Valen-Sendstad
Published in: Biophysical Journal, 117/12, 2019, Page(s) 2316-2323, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2019.09.029

Artery.FE: An implementation of the 1D blood flow equations in FEniCS

Author(s): Syver Agdestein, Kristian Valen-Sendstad, Alexandra Diem
Published in: Journal of Open Source Software, 3/32, 2018, Page(s) 1107, ISSN 2475-9066
Publisher: Journal of Open Source Software
DOI: 10.21105/joss.01107

On the use of superparamagnetic hydroxyapatite nanoparticles as an agent for magnetic and nuclear in vivo imaging

Author(s): Alessio Adamiano, Michele Iafisco, Monica Sandri, Martina Basini, Paolo Arosio, Tamara Canu, Giovanni Sitia, Antonio Esposito, Vincenzo Iannotti, Giovanni Ausanio, Eirini Fragogeorgi, Maritina Rouchota, George Loudos, Alessandro Lascialfari, Anna Tampieri
Published in: Acta Biomaterialia, 73, 2018, Page(s) 458-469, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2018.04.040

Cardiovascular nanomedicine: the route ahead

Author(s): Michele Iafisco, Alessio Alogna, Michele Miragoli, Daniele Catalucci
Published in: Nanomedicine, 14/18, 2019, Page(s) 2391-2394, ISSN 1743-5889
Publisher: Future Medicine Ltd.
DOI: 10.2217/nnm-2019-0228

Magnetic calcium phosphates nanocomposites for the intracellular hyperthermia of cancers of bone and brain

Author(s): Alessio Adamiano, Victoria M Wu, Francesca Carella, Gianrico Lamura, Fabio Canepa, Anna Tampieri, Michele Iafisco, Vuk Uskoković
Published in: Nanomedicine, 14/10, 2019, Page(s) 1267-1289, ISSN 1743-5889
Publisher: Future Medicine Ltd.
DOI: 10.2217/nnm-2018-0372

Thermodilution vs estimated Fick cardiac output measurement in an elderly cohort of patients: A single-centre experience

Author(s): Karl-Patrik Kresoja, Alessandro Faragli, Dawud Abawi, Oliver Paul, Burkert Pieske, Heiner Post, Alessio Alogna
Published in: PLOS ONE, 14/12, 2019, Page(s) e0226561, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0226561

Novel Basic Science Insights to Improve the Management of Heart Failure: Review of the Working Group on Cellular and Molecular Biology of the Heart of the Italian Society of Cardiology

Author(s): Pietro Ameri, Gabriele Giacomo Schiattarella, Lia Crotti, Margherita Torchio, Edoardo Bertero, Daniele Rodolico, Maurizio Forte, Vittoria Di Mauro, Roberta Paolillo, Cristina Chimenti, Daniele Torella, Daniele Catalucci, Sebastiano Sciarretta, Cristina Basso, Ciro Indolfi, Cinzia Perrino
Published in: International Journal of Molecular Sciences, 21/4, 2020, Page(s) 1192, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21041192

Porous Modelling of Cardiac Perfusion under Contraction to Demonstrate the Distribution of Therapeutic Nanoparticles

Author(s): Alexandra Diem, Kristian Valen-Sendstad
Published in: 2019 Computing in Cardiology Conference (CinC), 2019, ISBN 978-1-7281-6936-1
Publisher: Computing in Cardiology
DOI: 10.22489/cinc.2019.291

Computational simulation of electromagnetic fields on human targets for magnetic targeting applications

Author(s): S. Fiocchi, E. Chiaramello, M. Bonato, G. Tognola, D. Catalucci, M. Parazzini, P. Ravazzani
Published in: 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2019, Page(s) 5674-5677, ISBN 978-1-5386-1311-5
Publisher: IEEE
DOI: 10.1109/embc.2019.8857364