Deliverables Documents, reports (39) E-newsletter (M48) Yearly update of the main project contacts and to external subscribers Press releases (M24) Outline what CUPIDO is, what it will do, who it is intended to, the innovation it will bring and its benefits. Visual identity kit (M36) Creation of a visual identity for the project, including the project logo and document templates, with the development of promotional and informational materials contributing to the overall perception of the project and its uniform impression. Extended model, describing relationship between FeCaPs and deposition site when exposed to an external magnetic field (M30) Definition of FeCaP deposition and flow at multiple scales taking into account various physico-chemical parameters such as particle size distribution, shape, magnetic susceptibility, etc Validation of therapeutic efficiency of drug-loaded dpCaP/FedpCaPs in HFrEF mouse model Definition of Proof of Concept that administration of dpCaP (and FedpCaP) therapeutic formulations exert beneficial cardiac effects in small animal model of cardiac disease. E-newsletter (M24) Yearly update of the main project contacts and to external subscribers Summary of annual workshops and networking events building communities (M36) Generation of period report regarding CUPIDO major results and activites Aptamer-mediated guidance of CaP (M12) CaP functionalized with aptamers for improved myocardial-specific targeting In vivo assessment of the studied nanopartilces using different imaging modalities (M30) In vivo assessment of loaded and unloaded dpCaPs and FedpCaPs for a full spectrum of biocompatibility, toxicity, blood-interaction, air/blood flow-interaction at pulmonary barrier, inflammatory responses, and pharmacokinetics. Summary of annual workshops and networking events building communities (M12) Generation of period report regarding CUPIDO major results and activites Demonstration of the therapeutic effect of formulation for the treatment of cardiovascular function in mini-pigs Definition of Proof of Concept that administration of dpCaP (and FedpCaP) therapeutic formulations exert beneficial cardiac effects in large animal model of cardiac disease. Project videos (M48) Interviews on key project figures produced and posted on YouTube and other networks to provide a basis for communication to a large audience Data on the efficiency of wearable device for continuous remote monitoring of cardiopulmonary activity of mini-pigs Validation of the efficacy of wearable device on continuous remote monitoring of cardiopulmonary activity of diseased mini-pigs upon inhalation treatment Extended model, describing relationship between FeCaPs and deposition site when exposed to an external magnetic field (M12) Definition of FeCaP deposition and flow at multiple scales taking into account various physico-chemical parameters such as particle size distribution, shape, magnetic susceptibility, etc Extension of open-source flow simulation framework to also include porous media flow. Establish relationship between different nanoparticles and deposition sites in both small and large animal models (M36) Definition of CaP deposition and flow at multiple scales taking into account various physico-chemical parameters such as particle size distribution, shape, magnetic susceptibility, etc Validation of nanoparticle biodistribution in large animals Demonstration of efficacy of nanoparticle biodistribution in large animals (mini-pigs). Extension of open-source flow simulation framework to also include porous media flow. Establish relationship between different nanoparticles and deposition sites in both small and large animal models (M18) Definition of CaP deposition and flow at multiple scales taking into account various physico-chemical parameters such as particle size distribution, shape, magnetic susceptibility, etc EMD-mediated guidance of FeCaP (M24) Optimized FeCaPs for electromagnetic-mediated guidance to the heart via an electromagnetic device. Distribution of electromagnetic fields in the target area due to the drug targeting systems Comparison of different system solutions able to generate the magnetic field gradient (or the magnetic field) needed to guide the FeCaPs at the level of the heart tissues Press releases (M12) Outline what CUPIDO is, what it will do, who it is intended to, the innovation it will bring and its benefits. In vitro assessment of nanoparticle behavior at/across the pulmonary barrier (M24) In vitro assessment of loaded and unloaded dpCaPs for a full spectrum of biocompatibility, toxicity, and air/blood flow-interaction at pulmonary barrier. Training satisfaction questionnaires Generation of training satisfaction questionnaires in regard of training topics and contents organized during the project EMD-mediated guidance of FeCaP (M12) Optimized FeCaPs for electromagnetic-mediated guidance to the heart via an electromagnetic device. E-newsletter (M12) Yearly update of the main project contacts and to external subscribers Aptamer-mediated guidance of CaP (M20) CaP functionalized with aptamers for improved myocardial-specific targeting Press releases (M48) Outline what CUPIDO is, what it will do, who it is intended to, the innovation it will bring and its benefits. Visual identity kit (M12) Creation of a visual identity for the project, including the project logo and document templates, with the development of promotional and informational materials contributing to the overall perception of the project and its uniform impression. In vitro assessment of nanoparticle behavior at/across the pulmonary barrier (M12) In vitro assessment of loaded and unloaded dpCaPs for a full spectrum of biocompatibility, toxicity, and air/blood flow-interaction at pulmonary barrier. Web portal, social media Facilitate the communication of information to the media and through the media to become the key multiplier to reach the wider public. Wearable devices for usage on mini-pigs (M24) Delivery of wearable garments designed and validated or a continuous and non-invasive monitoring of pig heart and respiratory activity In vivo assessment of the studied nanopartilces using different imaging modalities (M12) In vivo assessment of loaded and unloaded dpCaPs and FedpCaPs for a full spectrum of biocompatibility, toxicity, blood-interaction, air/blood flow-interaction at pulmonary barrier, inflammatory responses, and pharmacokinetics. Summary of annual workshops and networking events building communities (M18) Generation of period report regarding CUPIDO major results and activites Summary of annual workshops and networking events building communities (M48) Generation of period report regarding CUPIDO major results and activites Project videos (M24) Interviews on key project figures produced and posted on YouTube and other networks to provide a basis for communication to a large audience Press releases (M3) Outline what CUPIDO is, what it will do, who it is intended to, the innovation it will bring and its benefits. Functional assessment (compatibility, physic-chemical and biological stability) of CaP restoration and drug release The biological activity of the powders and the reconstitution of CaP population will be thoroughly evaluated in vitro in cardiomyocyte lines (HL-1), adult primary mouse cardiomyocytes and human induced pluripotent stem cells (hiPS)-derived cardiomyocytes. Functional assessment (compatibility, physic-chemical and biological stability) of FeCaP restoration and drug release The biological activity of the powders and the reconstitution of FeCaP population will be thoroughly evaluated in vitro in cardiomyocyte lines (HL-1), adult primary mouse cardiomyocytes and human induced pluripotent stem cells (hiPS)-derived cardiomyocytes. Visual identity kit (M48) Creation of a visual identity for the project, including the project logo and document templates, with the development of promotional and informational materials contributing to the overall perception of the project and its uniform impression. Wearable devices for usage on mini-pigs (M36) Delivery of wearable garments designed and validated or a continuous and non-invasive monitoring of pig heart and respiratory activity Publications Peer reviewed articles (13) Calcium Phosphate Nanoparticle Precipitation by a Continuous Flow Process: A Design of Experiment Approach Author(s): Lorenzo Degli Esposti, Alessandro Dotti, Alessio Adamiano, Claudia Fabbi, Eride Quarta, Paolo Colombo, Daniele Catalucci, Claudio De Luca, Michele Iafisco Published in: Crystals, Issue 10/10, 2020, Page(s) 953, ISSN 2073-4352 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cryst10100953 Cardiac power output accurately reflects external cardiac work over a wide range of inotropic states in pigs Author(s): Dawud Abawi, Alessandro Faragli, Michael Schwarzl, Martin Manninger, David Zweiker, Karl-Patrik Kresoja, Jochen Verderber, Birgit Zirngast, Heinrich Maechler, Paul Steendijk, Burkert Pieske, Heiner Post, Alessio Alogna Published in: BMC Cardiovascular Disorders, Issue 19/1, 2019, ISSN 1471-2261 Publisher: BioMed Central DOI: 10.1186/s12872-019-1212-2 Inhalation of peptide-loaded nanoparticles improves heart failure Author(s): Michele Miragoli, Paola Ceriotti, Michele Iafisco, Marco Vacchiano, Nicolò Salvarani, Alessio Alogna, Pierluigi Carullo, Gloria Belén Ramirez-Rodríguez, Tatiana Patrício, Lorenzo Degli Esposti, Francesca Rossi, Francesca Ravanetti, Silvana Pinelli, Rossella Alinovi, Marco Erreni, Stefano Rossi, Gianluigi Condorelli, Heiner Post, Anna Tampieri, Daniele Catalucci Published in: Science Translational Medicine, Issue 10/424, 2018, Page(s) eaan6205, ISSN 1946-6234 Publisher: American Association for the Advancement of Science DOI: 10.1126/scitranslmed.aan6205 The noncoding-RNA landscape in cardiovascular health and disease Author(s): Vittoria Di Mauro, Maria Barandalla-Sobrados, Daniele Catalucci Published in: Non-coding RNA Research, 2018, ISSN 2468-0540 Publisher: Elsevier DOI: 10.1016/j.ncrna.2018.02.001 Cardiac kinematic parameters computed from video of in situ beating heart Author(s): Lorenzo Fassina, Giacomo Rozzi, Stefano Rossi, Simone Scacchi, Maricla Galetti, Francesco Paolo Lo Muzio, Fabrizio Del Bianco, Piero Colli Franzone, Giuseppe Petrilli, Giuseppe Faggian, Michele Miragoli Published in: Scientific Reports, Issue 7, 2017, Page(s) 46143, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/srep46143 A combined low-frequency electromagnetic and fluidic stimulation for a controlled drug release from superparamagnetic calcium phosphate nanoparticles: potential application for cardiovascular diseases Author(s): Alessandra Marrella, Michele Iafisco, Alessio Adamiano, Stefano Rossi, Maurizio Aiello, Maria Barandalla-Sobrados, Pierluigi Carullo, Michele Miragoli, Anna Tampieri, Silvia Scaglione, Daniele Catalucci Published in: Journal of The Royal Society Interface, Issue 15/144, 2018, Page(s) 20180236, ISSN 1742-5689 Publisher: The Royal Society DOI: 10.1098/rsif.2018.0236 Calcium phosphate-based nanosystems for advanced targeted nanomedicine Author(s): Lorenzo Degli Esposti, Francesca Carella, Alessio Adamiano, Anna Tampieri, Michele Iafisco Published in: Drug Development and Industrial Pharmacy, Issue 44/8, 2018, Page(s) 1223-1238, ISSN 0363-9045 Publisher: Marcel Dekker Inc. DOI: 10.1080/03639045.2018.1451879 Time-Lapsing Perfusion: Proof of Concept of a Novel Method to Study Drug Delivery in Whole Organs Author(s): Alexandra K. Diem, Kristian Valen-Sendstad Published in: Biophysical Journal, Issue 117/12, 2019, Page(s) 2316-2323, ISSN 0006-3495 Publisher: Biophysical Society DOI: 10.1016/j.bpj.2019.09.029 Artery.FE: An implementation of the 1D blood flow equations in FEniCS Author(s): Syver Agdestein, Kristian Valen-Sendstad, Alexandra Diem Published in: Journal of Open Source Software, Issue 3/32, 2018, Page(s) 1107, ISSN 2475-9066 Publisher: Journal of Open Source Software DOI: 10.21105/joss.01107 On the use of superparamagnetic hydroxyapatite nanoparticles as an agent for magnetic and nuclear in vivo imaging Author(s): Alessio Adamiano, Michele Iafisco, Monica Sandri, Martina Basini, Paolo Arosio, Tamara Canu, Giovanni Sitia, Antonio Esposito, Vincenzo Iannotti, Giovanni Ausanio, Eirini Fragogeorgi, Maritina Rouchota, George Loudos, Alessandro Lascialfari, Anna Tampieri Published in: Acta Biomaterialia, Issue 73, 2018, Page(s) 458-469, ISSN 1742-7061 Publisher: Elsevier BV DOI: 10.1016/j.actbio.2018.04.040 Cardiovascular nanomedicine: the route ahead Author(s): Michele Iafisco, Alessio Alogna, Michele Miragoli, Daniele Catalucci Published in: Nanomedicine, Issue 14/18, 2019, Page(s) 2391-2394, ISSN 1743-5889 Publisher: Future Medicine Ltd. DOI: 10.2217/nnm-2019-0228 Magnetic calcium phosphates nanocomposites for the intracellular hyperthermia of cancers of bone and brain Author(s): Alessio Adamiano, Victoria M Wu, Francesca Carella, Gianrico Lamura, Fabio Canepa, Anna Tampieri, Michele Iafisco, Vuk Uskoković Published in: Nanomedicine, Issue 14/10, 2019, Page(s) 1267-1289, ISSN 1743-5889 Publisher: Future Medicine Ltd. DOI: 10.2217/nnm-2018-0372 Thermodilution vs estimated Fick cardiac output measurement in an elderly cohort of patients: A single-centre experience Author(s): Karl-Patrik Kresoja, Alessandro Faragli, Dawud Abawi, Oliver Paul, Burkert Pieske, Heiner Post, Alessio Alogna Published in: PLOS ONE, Issue 14/12, 2019, Page(s) e0226561, ISSN 1932-6203 Publisher: Public Library of Science DOI: 10.1371/journal.pone.0226561 Non-peer reviewed articles (1) Novel Basic Science Insights to Improve the Management of Heart Failure: Review of the Working Group on Cellular and Molecular Biology of the Heart of the Italian Society of Cardiology Author(s): Pietro Ameri, Gabriele Giacomo Schiattarella, Lia Crotti, Margherita Torchio, Edoardo Bertero, Daniele Rodolico, Maurizio Forte, Vittoria Di Mauro, Roberta Paolillo, Cristina Chimenti, Daniele Torella, Daniele Catalucci, Sebastiano Sciarretta, Cristina Basso, Ciro Indolfi, Cinzia Perrino Published in: International Journal of Molecular Sciences, Issue 21/4, 2020, Page(s) 1192, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms21041192 Conference proceedings (2) Porous Modelling of Cardiac Perfusion under Contraction to Demonstrate the Distribution of Therapeutic Nanoparticles Author(s): Alexandra Diem, Kristian Valen-Sendstad Published in: 2019 Computing in Cardiology Conference (CinC), 2019, ISBN 978-1-7281-6936-1 Publisher: Computing in Cardiology DOI: 10.22489/cinc.2019.291 Computational simulation of electromagnetic fields on human targets for magnetic targeting applications Author(s): S. Fiocchi, E. Chiaramello, M. Bonato, G. Tognola, D. Catalucci, M. Parazzini, P. Ravazzani Published in: 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2019, Page(s) 5674-5677, ISBN 978-1-5386-1311-5 Publisher: IEEE DOI: 10.1109/embc.2019.8857364 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
