European Network on Anti-Cancer Immuno-Therapy Improvement by modification of CAR and TCR Interactions and Nanoscale Geometry

Información del proyecto

EN_ACTI2NG

Identificador del acuerdo de subvención: 721358

DOI 10.3030/721358

Proyecto cerrado

Fecha de la firma de la CE 31 Agosto 2016

Fecha de inicio 1 Enero 2017

Fecha de finalización 30 Abril 2021

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total € 2 539 859,76

Aportación de la UE € 2 539 859,76

Coordinado por

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain

Resultado final

Documents, reports (9)

2nd annual meeting

2nd annual meeting report

workshop GMP and SOP design

Handbook GMP and SOP design, elaborated in conjunction with partner Cellular Therapeutics

International Immunology Meeting Freiburg 2018

Program 2018 International Immunology Meeting Freiburg

workshop from bench to bedside

handbook workshop 'Form bench to bedside'

3rd annual meeting

3rd annual meeting report

1st annual meeting

1st annual meeting report

workshop aptamer selection and therapeutic application

handbook HT-SELEX-mediated aptamer selection and therapeutic application

workshop T cell-based gene therapy

Handbook T cell-based gene therapy

workshop super-resolution fluorescence microscopy

handbook super-resolution fluorescence microscopy

Websites, patent fillings, videos etc. (3)

logo and website

website functional

vacancies advertisement

announcement of vacancies via consortium website/EURAXESS/etc and implementation of the application system for candidates

Integration workshop

meeting with all the recruited ESRs and all partners. This meeting will allow the students and partners to get to know each other and will include brief project presentations by all partners, explanation of the network structure and function, and rights and obligations of all participants.

Publicaciones

Peer reviewed articles (11)

ICOS Costimulation at the Tumor Site in Combination with CTLA-4 Blockade Therapy Elicits Strong Tumor Immunity

Autores: Mario Martínez Soldevilla, Helena Villanueva, Daniel Meraviglia-Crivelli, Ashwathi Puravankara Menon, Marta Ruiz, Javier Cebollero, María Villalba, Beatriz Moreno, Teresa Lozano, Diana Llopiz, Álvaro Pejenaute, Pablo Sarobe, Fernando Pastor
Publicado en: Molecular Therapy, Edición 27/11, 2019, Página(s) 1878-1891, ISSN 1525-0016
Editor: Nature Publishing Group
DOI: 10.1016/j.ymthe.2019.07.013

Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function

Autores: Benjamin Salzer, Christina M. Schueller, Charlotte U. Zajc, Timo Peters, Michael A. Schoeber, Boris Kovacic, Michelle C. Buri, Elisabeth Lobner, Omer Dushek, Johannes B. Huppa, Christian Obinger, Eva M. Putz, Wolfgang Holter, Michael W. Traxlmayr
Publicado en: Nature Communications, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-17970-3

Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function

Autores: Frederike A. Hartl, Esmeralda Beck-Garcìa, Nadine M. Woessner, Lea J. Flachsmann, Rubí M.-H. Velasco Cárdenas, Simon M. Brandl, Sanaz Taromi, Gina J. Fiala, Anna Morath, Pankaj Mishra, O. Sascha Yousefi, Julia Zimmermann, Nico Hoefflin, Maja Köhn, Birgitta M. Wöhrl, Robert Zeiser, Kristian Schweimer, Stefan Günther, Wolfgang W. Schamel, Susana Minguet
Publicado en: Nature Immunology, Edición 21/8, 2020, Página(s) 902-913, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-020-0732-3

Aptamers Against Live Targets: Is In Vivo SELEX Finally Coming to the Edge?

Autores: Mayte Sola, Ashwathi Puravankara Menon, Beatriz Moreno, Daniel Meraviglia-Crivelli, Mario Martínez Soldevilla, Fernando Cartón-García, Fernando Pastor
Publicado en: Molecular Therapy Nucleic Acids, 2020, ISSN 2162-2531
Editor: Nature Publishing Group
DOI: 10.1016/j.omtn.2020.05.025

Inefficient CAR-proximal signaling blunts antigen sensitivity

Autores: Venugopal Gudipati, Julian Rydzek, Iago Doel-Perez, Vasco Dos Reis Gonçalves, Lydia Scharf, Sebastian Königsberger, Elisabeth Lobner, Renate Kunert, Hermann Einsele, Hannes Stockinger, Michael Hudecek, Johannes B Huppa
Publicado en: Nature Immunology, 2020, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-020-0719-0

The TCR is an allosterically regulated macromolecular machinery changing its conformation while working

Autores: Wolfgang W. Schamel, Balbino Alarcon, Susana Minguet
Publicado en: Immunological Reviews, Edición 291/1, 2019, Página(s) 8-25, ISSN 0105-2896
Editor: Blackwell Publishing Inc.
DOI: 10.1111/imr.12788

Chimeric antigen receptors designed to overcome transforming growth factor‐β‐mediated repression in the adoptive T‐cell therapy of solid tumors

Autores: Jordan Hartley, Hinrich Abken
Publicado en: Clinical and Translational Immunology, 2019, ISSN 2050-0068
Editor: John Wiley and Sons Ltd
DOI: 10.1002/cti2.1064

Defocused imaging exploits supercritical-angle fluorescence emission for precise axial single molecule localization microscopy

Autores: Philipp Zelger, Lisa Bodner, Lukas Velas, Gerhard J. Schütz, Alexander Jesacher
Publicado en: Biomedical Optics Express, Edición 11/2, 2020, Página(s) 775, ISSN 2156-7085
Editor: The Optical Society
DOI: 10.1364/boe.375678

Flow cytometry multiplexed method for the detection of neutralizing human antibodies to the native SARS‐CoV‐2 spike protein

Autores: Lydia Horndler, Pilar Delgado, David Abia, Ivaylo Balabanov, Pedro Martínez‐Fleta, Georgina Cornish, Miguel A Llamas, Sergio Serrano‐Villar, Francisco Sánchez‐Madrid, Manuel Fresno, Hisse M van Santen, Balbino Alarcón
Publicado en: EMBO Molecular Medicine, Edición 13/3, 2021, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202013549

Three-dimensional localization microscopy using deep learning

Autores: P. Zelger, K. Kaser, B. Rossboth, L. Velas, G. J. Schütz, A. Jesacher
Publicado en: Optics Express, Edición 26/25, 2018, Página(s) 33166, ISSN 1094-4087
Editor: Optical Society of America
DOI: 10.1364/oe.26.033166

Three-dimensional single molecule localization close to the coverslip: a comparison of methods exploiting supercritical angle fluorescence

Autores: Philipp Zelger, Lisa Bodner, Martin Offterdinger, Lukas Velas, Gerhard J. Schütz, and Alexander Jesacher
Publicado en: Biomedical Optics Express, 2021, ISSN 2156-7085
Editor: The Optical Society
DOI: 10.1364/boe.413018