European Network on Anti-Cancer Immuno-Therapy Improvement by modification of CAR and TCR Interactions and Nanoscale Geometry

Livrables

2nd annual meeting

2nd annual meeting report

workshop GMP and SOP design

Handbook GMP and SOP design, elaborated in conjunction with partner Cellular Therapeutics

International Immunology Meeting Freiburg 2018

Program 2018 International Immunology Meeting Freiburg

workshop from bench to bedside

handbook workshop 'Form bench to bedside'

3rd annual meeting

3rd annual meeting report

1st annual meeting

1st annual meeting report

workshop aptamer selection and therapeutic application

handbook HT-SELEX-mediated aptamer selection and therapeutic application

workshop T cell-based gene therapy

Handbook T cell-based gene therapy

workshop super-resolution fluorescence microscopy

handbook super-resolution fluorescence microscopy

logo and website

website functional

vacancies advertisement

announcement of vacancies via consortium website/EURAXESS/etc and implementation of the application system for candidates

Integration workshop

meeting with all the recruited ESRs and all partners. This meeting will allow the students and partners to get to know each other and will include brief project presentations by all partners, explanation of the network structure and function, and rights and obligations of all participants.

Publications

ICOS Costimulation at the Tumor Site in Combination with CTLA-4 Blockade Therapy Elicits Strong Tumor Immunity

Auteurs: Mario Martínez Soldevilla, Helena Villanueva, Daniel Meraviglia-Crivelli, Ashwathi Puravankara Menon, Marta Ruiz, Javier Cebollero, María Villalba, Beatriz Moreno, Teresa Lozano, Diana Llopiz, Álvaro Pejenaute, Pablo Sarobe, Fernando Pastor
Publié dans: Molecular Therapy, Numéro 27/11, 2019, Page(s) 1878-1891, ISSN 1525-0016
Éditeur: Nature Publishing Group
DOI: 10.1016/j.ymthe.2019.07.013

Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function

Auteurs: Benjamin Salzer, Christina M. Schueller, Charlotte U. Zajc, Timo Peters, Michael A. Schoeber, Boris Kovacic, Michelle C. Buri, Elisabeth Lobner, Omer Dushek, Johannes B. Huppa, Christian Obinger, Eva M. Putz, Wolfgang Holter, Michael W. Traxlmayr
Publié dans: Nature Communications, 2020, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-020-17970-3

Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function

Auteurs: Frederike A. Hartl, Esmeralda Beck-Garcìa, Nadine M. Woessner, Lea J. Flachsmann, Rubí M.-H. Velasco Cárdenas, Simon M. Brandl, Sanaz Taromi, Gina J. Fiala, Anna Morath, Pankaj Mishra, O. Sascha Yousefi, Julia Zimmermann, Nico Hoefflin, Maja Köhn, Birgitta M. Wöhrl, Robert Zeiser, Kristian Schweimer, Stefan Günther, Wolfgang W. Schamel, Susana Minguet
Publié dans: Nature Immunology, Numéro 21/8, 2020, Page(s) 902-913, ISSN 1529-2908
Éditeur: Nature Publishing Group
DOI: 10.1038/s41590-020-0732-3

Aptamers Against Live Targets: Is In Vivo SELEX Finally Coming to the Edge?

Auteurs: Mayte Sola, Ashwathi Puravankara Menon, Beatriz Moreno, Daniel Meraviglia-Crivelli, Mario Martínez Soldevilla, Fernando Cartón-García, Fernando Pastor
Publié dans: Molecular Therapy Nucleic Acids, 2020, ISSN 2162-2531
Éditeur: Nature Publishing Group
DOI: 10.1016/j.omtn.2020.05.025

Inefficient CAR-proximal signaling blunts antigen sensitivity

Auteurs: Venugopal Gudipati, Julian Rydzek, Iago Doel-Perez, Vasco Dos Reis Gonçalves, Lydia Scharf, Sebastian Königsberger, Elisabeth Lobner, Renate Kunert, Hermann Einsele, Hannes Stockinger, Michael Hudecek, Johannes B Huppa
Publié dans: Nature Immunology, 2020, ISSN 1529-2908
Éditeur: Nature Publishing Group
DOI: 10.1038/s41590-020-0719-0

The TCR is an allosterically regulated macromolecular machinery changing its conformation while working

Auteurs: Wolfgang W. Schamel, Balbino Alarcon, Susana Minguet
Publié dans: Immunological Reviews, Numéro 291/1, 2019, Page(s) 8-25, ISSN 0105-2896
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/imr.12788

Chimeric antigen receptors designed to overcome transforming growth factor‐β‐mediated repression in the adoptive T‐cell therapy of solid tumors

Auteurs: Jordan Hartley, Hinrich Abken
Publié dans: Clinical and Translational Immunology, 2019, ISSN 2050-0068
Éditeur: John Wiley and Sons Ltd
DOI: 10.1002/cti2.1064

Defocused imaging exploits supercritical-angle fluorescence emission for precise axial single molecule localization microscopy

Auteurs: Philipp Zelger, Lisa Bodner, Lukas Velas, Gerhard J. Schütz, Alexander Jesacher
Publié dans: Biomedical Optics Express, Numéro 11/2, 2020, Page(s) 775, ISSN 2156-7085
Éditeur: The Optical Society
DOI: 10.1364/boe.375678

Flow cytometry multiplexed method for the detection of neutralizing human antibodies to the native SARS‐CoV‐2 spike protein

Auteurs: Lydia Horndler, Pilar Delgado, David Abia, Ivaylo Balabanov, Pedro Martínez‐Fleta, Georgina Cornish, Miguel A Llamas, Sergio Serrano‐Villar, Francisco Sánchez‐Madrid, Manuel Fresno, Hisse M van Santen, Balbino Alarcón
Publié dans: EMBO Molecular Medicine, Numéro 13/3, 2021, ISSN 1757-4676
Éditeur: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202013549

Three-dimensional localization microscopy using deep learning

Auteurs: P. Zelger, K. Kaser, B. Rossboth, L. Velas, G. J. Schütz, A. Jesacher
Publié dans: Optics Express, Numéro 26/25, 2018, Page(s) 33166, ISSN 1094-4087
Éditeur: Optical Society of America
DOI: 10.1364/oe.26.033166

Three-dimensional single molecule localization close to the coverslip: a comparison of methods exploiting supercritical angle fluorescence

Auteurs: Philipp Zelger, Lisa Bodner, Martin Offterdinger, Lukas Velas, Gerhard J. Schütz, and Alexander Jesacher
Publié dans: Biomedical Optics Express, 2021, ISSN 2156-7085
Éditeur: The Optical Society
DOI: 10.1364/boe.413018

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