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Improving the flow in the pipeline of the next generation of marine biodiscovery scientists

Project description

DEENESFRITPL

Harnessing the power of the sea to unlock nature’s pharmacy

Marine life possesses the remarkable ability to produce biologically potent natural products, including antibiotics and anticancer compounds. Scientists are tapping into the potential of marine organisms for drug discovery. The EU-funded MarPipe project aims to develop antimicrobial and anticancer lead compounds. Additionally, it will explore the bioactivity of deep-sea samples collected during the Eurofleet-2 project in the sub-Antarctic region. By training 11 Early-Stage Researchers (ESRs), MarPipe will enable them to become leaders in marine drug discovery. The programme encompasses comprehensive training, encompassing research, technical and scientific skills, as well as participation in public scientific events and inter-sectoral networking exchanges. Ultimately, the project envisions the establishment of a marine biodiscovery start-up company.

Objective

MarPipe is a consortium of 11 partners (IBP-CNR, SZN, UiT, UNIABDN, GEOMAR, KULeuven, UCC, eCOAST, MEDINA, MicroDish, Italbiotec) based in 8 countries (I, N, UK, D, B, IRL, E, NL), including 3 from the non-academic sector. We will train 11 ESRs in marine drug-discovery, providing these researchers with unique skills toward becoming world leaders in this research field and to advance their careers in academia or industry. MarPipe PhDs will be trained in a programme including training-by-research, joint courses of technical, scientific and transferrable skills, active participation to public scientific events, and an intense inter-sectoral networking exchange plan.
Marine organisms have the capacity to produce a variety of biologically potent natural products, including antibiotic and anticancer compounds. MarPipe aims at further development of antimicrobial and anticancer lead compounds originating from a previous EU project (PharmaSea), and will also explore the bioactivity of deep-sea samples (5000m) collected during the recent Eurofleet-2 project in the sub-Antarctic. The PhD students will thus be involved in all phases of the drug discovery pipeline, from isolation of new microbial strains to pre-clinical development of lead compounds. Importantly, they will also be trained to overcome existing bottlenecks in the field, e.g. low yields and low chemodiversity, isolation of known compounds, toxicity of compounds.
The discovery rates of new bioactive antimicrobial and anticancer molecules will be enhanced through 11 PhD projects that cover all phases of the biodiscovery pipeline. As a final outcome of the project, we envisage the creation of a marine biodiscovery start-up company, which will include most of the MarPipe partners. The scientists of the future will be trained to become conscious about the socio-economic and policy context of their work, since several specific MarPipe PhD projects focus on legal, policy, innovation and entrepreneurship themes.

Fields of science

Programme(s)

Topic(s)

Call for proposal

H2020-MSCA-ITN-2016

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Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE
Net EU contribution
€ 258 061,32
Address
PIAZZALE ALDO MORO 7
00185 Roma
Italy

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Region
Centro (IT) Lazio Roma
Activity type
Research Organisations
Links
Total cost
€ 258 061,32

Participants (12)

Partners (1)

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Last update: 23 August 2022

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Permalink: https://cordis.europa.eu/project/id/721421

European Union, 2024