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Controlling Cartilage to Bone Transitions for Improved Treatment of Bone Defects and Osteoarthritis

Deliverables

D7.2

Information for patients and general lay public on website

D7.1

Website on line

D6.1

14 ESRs recruited, appointed and PCDP drafted

Publications

The mechanics of Skeletal Development

Author(s): Astrid Novicky, Soraia P. Caetano-Silva, Behzad Javaheri and Andrew A. Pitsillides
Published in: 2018

Using Cell and Organ Culture Models to Analyze Responses of Bone Cells to Mechanical Stimulation

Author(s): Soraia P. Caetano-Silva, Astrid Novicky, Behzad Javaheri, Simon C. F. Rawlinson, Andrew A. Pitsillides
Published in: Bone Research Protocols, Issue 1914, 2019, Page(s) 99-128
DOI: 10.1007/978-1-4939-8997-3_6

The Chondro-Osseous Continuum: Is It Possible to Unlock the Potential Assigned Within?

Author(s): Behzad Javaheri, Soraia P. Caetano-Silva, Ioannis Kanakis, George Bou-Gharios, Andrew A. Pitsillides
Published in: Frontiers in Bioengineering and Biotechnology, Issue 6, 2018, ISSN 2296-4185
DOI: 10.3389/fbioe.2018.00028

Computational Modeling and Reverse Engineering to Reveal Dominant Regulatory Interactions Controlling Osteochondral Differentiation: Potential for Regenerative Medicine

Author(s): Raphaelle Lesage, Johan Kerkhofs, Liesbet Geris
Published in: Frontiers in Bioengineering and Biotechnology, Issue 6, 2018, ISSN 2296-4185
DOI: 10.3389/fbioe.2018.00165

Isolation and Flow Cytometry Characterization of Extracellular-Vesicle Subpopulations Derived from Human Mesenchymal Stromal Cells

Author(s): Cansu Gorgun, Daniele Reverberi, Gianluca Rotta, Federico Villa, Rodolfo Quarto, Roberta Tasso
Published in: Current Protocols in Stem Cell Biology, Issue 48/1, 2019, Page(s) e76, ISSN 1941-7322
DOI: 10.1002/cpsc.76

Angiogenic Potential of Tissue Engineered Cartilage From Human Mesenchymal Stem Cells Is Modulated by Indian Hedgehog and Serpin E1

Author(s): Yannick Nossin, Eric Farrell, Wendy J. L. M. Koevoet, Rodrigo A. Somoza, Arnold I. Caplan, Bent Brachvogel, Gerjo J. V. M. van Osch
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
DOI: 10.3389/fbioe.2020.00327

Activation of Skeletal Stem and Progenitor Cells for Bone Regeneration Is Driven by PDGFRβ Signaling

Author(s): Anna-Marei Böhm, Naomi Dirckx, Robert J. Tower, Nicolas Peredo, Sebastiaan Vanuytven, Koen Theunis, Elena Nefyodova, Ruben Cardoen, Volkhard Lindner, Thierry Voet, Matthias Van Hul, Christa Maes
Published in: Developmental Cell, Issue 51/2, 2019, Page(s) 236-254.e12, ISSN 1534-5807
DOI: 10.1016/j.devcel.2019.08.013

Collagen type X is essential for successful mesenchymal stem cell-mediated cartilage formation and subsequent endochondral ossification

Author(s): CA Knuth, E Andres Sastre, NB Fahy, J Witte-Bouma, Y Ridwan, EM Strabbing, MJ Koudstaal, J van de Peppel, EB Wolvius, R Narcisi, E Farrell
Published in: European Cells and Materials, Issue 38, 2019, Page(s) 106-122, ISSN 1473-2262
DOI: 10.22203/ecm.v038a09

The tyrosine kinase receptor EPHA2 is a drug target for osteoarthritis

Author(s): M. N. Ferrao Blanco, Y.M. Bastiaansen-Jenniskens, R. Narcisi, M.G. Chambers, A.A. Pitsillides, G.J. van Osch
Published in: Osteoarthritis and Cartilage, Issue 28, 2020, Page(s) S36-S37, ISSN 1063-4584
DOI: 10.1016/j.joca.2020.02.060

The role of thrombospondin-4 and the cartilage oligomeric matrix protein in osteoarthritis

Author(s): K. Maly, I. Schaible, A. Meurer, F. Zaucke
Published in: Osteoarthritis and Cartilage, Issue 28, 2020, Page(s) S100-S101, ISSN 1063-4584
DOI: 10.1016/j.joca.2020.02.157

Effect of inflammation on hypertrophy to human articular chondrocytes

Author(s): M. N. Ferrao Blanco, Y.M. Bastiaansen-Jenniskens, R. Narcisi, G.J. van Osch
Published in: Osteoarthritis and Cartilage, Issue 28, 2020, Page(s) S113-S114, ISSN 1063-4584
DOI: 10.1016/j.joca.2020.02.183

Faculty of 1000 evaluation for Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand.

Author(s): Andrew Pitsillides, Soraia P Caetano-Silva
Published in: 2019
DOI: 10.3410/f.730362852.793539430

Mesenchymal stromal cell secretory activity: The role of secretome fractions in angiogenesis

Author(s): C. Gorgun, F. Villa, R. Quarto, R. Tasso
Published in: eCM Periodical, Issue 2019, Collection 3, 2019, Page(s) 374

The incorporation of collagen type II into collagen hyaluronate scaffolds as potential off the shelf approach to long term stable cartilage tissue repair

Author(s): C. Intini, J.P. Gleeson, F.J. O’Brien
Published in: eCM Periodical, Issue 2019, Collection 3, 2019, Page(s) 400

PAI1 and IHH reduce the pro-angiogenic potential of transient cartilage secretome

Author(s): Y. Nossin , J.L.M Koevoet , R. Somoza, A. Caplan, B Brachvogel , E. Farrell, G.J.V.M. van Osch
Published in: eCM Periodical, Issue 2019, Collection 3, 2019, Page(s) 1160

Ηydrogel stiffness regulates the response of mesenchymal stem cells to dynamic loading

Author(s): F. Chariyev-Prinz, D.J. Kelly
Published in: eCM Periodical, Issue 2019, Collection 3, 2019, Page(s) 458

Secretome of cartilage tissue engineered from chondrocytes or bone marrow-derived mesenchymal stem cells induce angiogenesis

Author(s): Y. Nossin , C. Gorgun, R. Tasso, J.L.M Koevoet , E. Farrell , G. J.V.M. van Osch
Published in: eCM Periodical, Issue 2019, Collection 3, 2019, Page(s) 855

COMP’s derived potential matricryptins show no role on specific aspects of joint regeneration

Author(s): E. A. Sastre, G.J.V.M van Osch, J. W. Bouma , E. Farrell
Published in: eCM Periodical, Issue 2019, Collection 3, 2019, Page(s) 927

Cartilage oligomeric matrix protein inhibits angiogenesis in vitro, depending upon its oligomerisation state

Author(s): E.A. Sastre , F. Zaucke , J.W. Bouma , K. Maly , G.J.V.M van Osch , E. Farrell
Published in: eCM Periodical, Issue 2019, Collection 3, 2019, Page(s) 449