Controlling Cartilage to Bone Transitions for Improved Treatment of Bone Defects and Osteoarthritis

Project Information

CarBon

Grant agreement ID: 721432

DOI

10.3030/721432

Project closed

EC signature date 25 August 2016

Start date 1 January 2017

End date 31 December 2020

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 3 607 596,36

EU contribution

€ 3 607 596,36

Coordinated by

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (7)

D6.3

14 multidisciplinary ESRs with excellent networks, at least half of them found a suitable position at end project;

D7.3

28 articles in peer-reviewed journals

D7.4

42 contributions of ESRs in international conferences

D6.2

14 ESRs trained in at least two disciplines

D7.5

3 articles in general lay press in three different countries

D7.6

3 possible products identified for further development

D6.1

14 ESRs recruited, appointed and PCDP drafted

Websites, patent fillings, videos etc. (2)

D7.2

Information for patients and general lay public on website

D7.1

Website on line

Publications

Peer reviewed articles (24)

Turning Nature’s own processes into design strategies for living bone implant biomanufacturing: a decade of Developmental Engineering

Author(s): Ioannis Papantoniou, Gabriella Nilsson Hall, Niki Loverdou, Raphaelle Lesage, Tim Herpelinck, Luis Mendes, Liesbet Geris
Published in: Advanced Drug Delivery Reviews, Issue 169, 2021, Page(s) 22-39, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2020.11.012

Ablation of the miRNA Cluster 24 Has Profound Effects on Extracellular Matrix Protein Abundance in Cartilage

Author(s): Veronika S. Georgieva, Julia Etich, Björn Bluhm, Mengjie Zhu, Christian Frie, Richard Wilson, Frank Zaucke, John Bateman, Bent Brachvogel
Published in: International Journal of Molecular Sciences, Issue 21/11, 2020, Page(s) 4112, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21114112

A new semi-orthotopic bone defect model for cell and biomaterial testing in regenerative medicine.

Author(s): Andrés Sastre E, Nossin Y, Jansen I, Kops N, Intini C, Witte-Bouma J, van Rietbergen B, Hofmann S, Ridwan Y, Gleeson JP, O'Brien FJ, Wolvius EB, van Osch GJVM, Farrell E.
Published in: Biomaterials, 2021, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2021.121187

COMP and TSP-4: Functional Roles in Articular Cartilage and Relevance in Osteoarthritis

Author(s): Kathrin Maly, Enrique Andres Sastre, Eric Farrell, Andrea Meurer, Frank Zaucke
Published in: International Journal of Molecular Sciences, Issue 22/5, 2021, Page(s) 2242, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22052242

The tyrosine kinase receptor EPHA2 is a drug target for osteoarthritis

Author(s): M.N. Ferrao Blanco; Y.M. Bastiaansen-Jenniskens; Roberto Narcisi; Mark Chambers; Andrew A. Pitsillides; G.J.V.M. van Osch
Published in: Osteoarthritis Cartilage, Issue 4, 2021, ISSN 2665-9131
Publisher: elsevier
DOI: 10.1016/j.joca.2020.02.060

Intra-articular injection of triamcinolone acetonide sustains macrophage levels and aggravates osteophytosis during degenerative joint disease in mice.

Author(s): Ferrao Blanco MN, Bastiaansen Jenniskens YM, Kops N, Chavli A, Narcisi R, Botter SM, Leenen PJM, van Osch GJVM, Fahy N
Published in: Br J Pharmacol, 2021, ISSN 1476-5381
Publisher: BJP
DOI: 10.1111/bph.15780

Restraint upon Embryonic Metatarsal Ex Vivo Growth by Hydrogel Reveals Interaction between Quasi-Static Load and the mTOR Pathway.

Author(s): Caetano-Silva S, Simbi BH, Marr N, Hibbert A, Allen SP, Pitsillides AA
Published in: Int J Mol Sci, 2021, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222413220

Ablation of the miRNA Cluster 24 Has Profound Effects on Extracellular Matrix Protein Abundance in Cartilage.

Author(s): Veronika S. Georgieva; Julia Etich; Björn Bluhm; Mengjie Zhu; Christian Frie; Richard Wilson; Frank Zaucke; John F. Bateman; Bent Brachvogel
Published in: International Journal of Molecular Sciences, Issue 3, 2020, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21114112

Effect of inflammation on hypertrophy to human articular chondrocytes

Author(s): M.N. Ferrao Blanco; Y.M. Bastiaansen-Jenniskens; Roberto Narcisi; G.J.V.M. van Osch
Published in: Cartilage, Issue 3, 2021, ISSN 1947-6035
Publisher: SAGE Publications Inc.
DOI: 10.1016/j.joca.2020.02.183

Fetal hematopoietic stem cell homing is controlled by VEGF regulating the integrity and oxidative status of the stromal-vascular bone marrow niches.

Author(s): Marion Mesnieres; Anna-Marei Böhm; Nicolas Peredo; Dana Trompet; Roger Valle-Tenney; Manmohan Bajaj; Nikky Corthout; Elena Nefyodova; Ruben Cardoen; Pieter Baatsen; Sebastian Munck; Andras Nagy; Andras Nagy; Jody J. Haigh; Satish Khurana; Satish Khurana; Catherine M. Verfaillie; Christa Maes
Published in: Cell Rep, Issue 5, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.109618

Editorial: Understanding and Modulating Bone and Cartilage Cell Fate for Regenerative Medicine.

Author(s): Roberto Narcisi; Eric Farrell
Published in: Frontiers in Bioeng Biotechnol, Issue 3, 2019, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2019.00008

The Chondro-Osseous Continuum: Is It Possible to Unlock the Potential Assigned Within?

Author(s): Behzad Javaheri, Soraia P. Caetano-Silva, Ioannis Kanakis, George Bou-Gharios, Andrew A. Pitsillides
Published in: Frontiers in Bioengineering and Biotechnology, Issue 6, 2018, ISSN 2296-4185
Publisher: Frontiers in in Bioengineering and Biotechnology
DOI: 10.3389/fbioe.2018.00028

Computational Modeling and Reverse Engineering to Reveal Dominant Regulatory Interactions Controlling Osteochondral Differentiation: Potential for Regenerative Medicine

Author(s): Raphaelle Lesage, Johan Kerkhofs, Liesbet Geris
Published in: Frontiers in Bioengineering and Biotechnology, Issue 6, 2018, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2018.00165

Angiogenic Potential of Tissue Engineered Cartilage From Human Mesenchymal Stem Cells Is Modulated by Indian Hedgehog and Serpin E1

Author(s): Yannick Nossin, Eric Farrell, Wendy J. L. M. Koevoet, Rodrigo A. Somoza, Arnold I. Caplan, Bent Brachvogel, Gerjo J. V. M. van Osch
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
Publisher: Frontiers in Bioengineering and Biotechnology
DOI: 10.3389/fbioe.2020.00327

Activation of Skeletal Stem and Progenitor Cells for Bone Regeneration Is Driven by PDGFRβ Signaling

Author(s): Anna-Marei Böhm, Naomi Dirckx, Robert J. Tower, Nicolas Peredo, Sebastiaan Vanuytven, Koen Theunis, Elena Nefyodova, Ruben Cardoen, Volkhard Lindner, Thierry Voet, Matthias Van Hul, Christa Maes
Published in: Developmental Cell, Issue 51/2, 2019, Page(s) 236-254.e12, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2019.08.013

Collagen type X is essential for successful mesenchymal stem cell-mediated cartilage formation and subsequent endochondral ossification

Author(s): CA Knuth, E Andres Sastre, NB Fahy, J Witte-Bouma, Y Ridwan, EM Strabbing, MJ Koudstaal, J van de Peppel, EB Wolvius, R Narcisi, E Farrell
Published in: European Cells and Materials, Issue 38, 2019, Page(s) 106-122, ISSN 1473-2262
Publisher: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v038a09

The Expression of Thrombospondin-4 Correlates with Disease Severity in Osteoarthritic Knee Cartilage

Author(s): Kathrin Maly, Inna Schaible, Jana Riegger, Rolf Brenner, Andrea Meurer, Frank Zaucke
Published in: International Journal of Molecular Sciences, Issue 20/2, 2019, Page(s) 447, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20020447

Spatiotemporal distribution of thrombospondin-4 and -5 in cartilage during endochondral bone formation and repair.

Author(s): Andrés Sastre E, Maly K, Zhu M, Witte-Bouma J, Trompet D, Böhm AM, Brachvogel B, van Nieuwenhoven CA, Maes C, van Osch GJVM, Zaucke F, Farrell E
Published in: Bone, 2021, ISSN 8756-3282
Publisher: Elsevier BV
DOI: 10.1016/j.bone.2021.115999

Cartilage Oligomeric Matrix Protein–Derived Peptides Secreted by Cartilage Do Not Induce Responses Commonly Observed during Osteoarthritis

Author(s): Enrique Andrés Sastre, Frank Zaucke, Janneke Witte-Bouma, Gerjo J.V.M van Osch, Eric Farrell
Published in: CARTILAGE, 2020, Page(s) 194760352096117, ISSN 1947-6035
Publisher: SAGE Publications Inc.
DOI: 10.1177/1947603520961170

Use of Computational Modeling to Study Joint Degeneration: A Review

Author(s): Satanik Mukherjee, Majid Nazemi, Ilse Jonkers, Liesbet Geris
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
Publisher: Frontiers Media S.A.
DOI: 10.3389/fbioe.2020.00093

The Releasate of Avascular Cartilage Demonstrates Inherent Pro-Angiogenic Properties In Vitro and In Vivo.

Author(s): Yannick Nossin; Eric Farrell; Wendy Koevoet; Frank R. Datema; Rodrigo A. Somoza; Arnold I. Caplan; Gerjo J.V.M. van Osch; Gerjo J.V.M. van Osch
Published in: Cartilage, Issue 4, 2021, ISSN 1947-6035
Publisher: SAGE Publications Inc.
DOI: 10.1177/19476035211047628

Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility

Author(s): Musuamba FT, Skottheim Rusten I, Lesage R, Russo G, Bursi R, Emili L, Wangorsch G, Manolis E, Karlsson KE, Kulesza A, Courcelles E, Boissel JP, Rousseau CF, Voisin EM, Alessandrello R, Curado N, Dall'ara E, Rodriguez B, Pappalardo F, Geris L.
Published in: CPT Pharmacometrics Syst Pharmacol, 2021, ISSN 2163-8306
Publisher: Nature Publishing Group
DOI: 10.1002/psp4.12669

Dissecting the effects of preconditioning with inflammatory cytokines and hypoxia on the angiogenic potential of Mesenchymal Stromal Cell (MSC)-derived soluble proteins and Extracellular Vesicles (EVs)

Author(s): Cansu Gorgun, Davide Ceresa, Raphaelle Lesage, Federico Villa, Daniele Reverberi, Carolina Balbi, Sara Santamaria, Katia Cortese, Paolo Malatesta, Liesbet Geris, Rodolfo Quarto, Roberta Tasso
Published in: Biomaterials, 2020, Page(s) 120633, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120633

Role of extracellular vesicles from adipose tissue- and bone marrow-mesenchymal stromal cells in endothelial proliferation and chondrogenesis.

Author(s): Gorgun C, Palamà MEF, Reverberi D, Gagliani MC, Cortese K, Tasso R, Gentili C.
Published in: Stem Cells Transl Med, 2021, ISSN 2157-6564
Publisher: AlphaMed Press
DOI: 10.1002/sctm.21-0107

Other (3)

Faculty Opinions recommendation of Misconceptions (1): epiphyseal fusion causes cessation of growth.

Author(s): Andrew Pitsillides, Dionysia Valkani
Published in: 2020
Publisher: Faculty Opinions
DOI: 10.3410/f.720251388.793572256

Arthrose – Die Rolle der Extrazellulären Matrix

Author(s): Maly K., Zaucke F. and Meurer A.
Published in: orthopädische Nachrichten |, Issue 09.2018, 2018, Page(s) p. 20-21
Publisher: Biermann Medizin

Faculty of 1000 evaluation for Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand.

Author(s): Andrew Pitsillides, Soraia P Caetano-Silva
Published in: 2019
Publisher: F1000 - Post-publication peer review of the biomedical literature
DOI: 10.3410/f.730362852.793539430

Conference proceedings (8)

Injury modulates mesenchymal stromal cell secretory activity: effects on angiogenesis

Author(s): Cansu Gorgun, Yannick M. Nossin, Eric Farrell, Gerjo J.V.M van Osch, Roberta Tasso
Published in: 5th TERMIS world congress-2018 conference proceedings, Issue 2018, 2018, Page(s) 350
Publisher: TERMIS-WC 2018

Mesenchymal stromal cell secretory activity: The role of secretome fractions in angiogenesis

Author(s): C. Gorgun, F. Villa, R. Quarto, R. Tasso
Published in: eCM Periodical, Issue 2019, Collection 3, 2019, Page(s) 374
Publisher: eCM Conferences

The incorporation of collagen type II into collagen hyaluronate scaffolds as potential off the shelf approach to long term stable cartilage tissue repair

Author(s): C. Intini, J.P. Gleeson, F.J. O’Brien
Published in: eCM Periodical, Issue 2019, Collection 3, 2019, Page(s) 400
Publisher: eCM Conferences

PAI1 and IHH reduce the pro-angiogenic potential of transient cartilage secretome

Author(s): Y. Nossin , J.L.M Koevoet , R. Somoza, A. Caplan, B Brachvogel , E. Farrell, G.J.V.M. van Osch
Published in: eCM Periodical, Issue 2019, Collection 3, 2019, Page(s) 1160
Publisher: eCM Conferences

Ηydrogel stiffness regulates the response of mesenchymal stem cells to dynamic loading

Author(s): F. Chariyev-Prinz, D.J. Kelly
Published in: eCM Periodical, Issue 2019, Collection 3, 2019, Page(s) 458
Publisher: eCM Conferences

Secretome of cartilage tissue engineered from chondrocytes or bone marrow-derived mesenchymal stem cells induce angiogenesis

Author(s): Y. Nossin , C. Gorgun, R. Tasso, J.L.M Koevoet , E. Farrell , G. J.V.M. van Osch
Published in: eCM Periodical, Issue 2019, Collection 3, 2019, Page(s) 855
Publisher: eCM Conferences

COMP’s derived potential matricryptins show no role on specific aspects of joint regeneration

Author(s): E. A. Sastre, G.J.V.M van Osch, J. W. Bouma , E. Farrell
Published in: eCM Periodical, Issue 2019, Collection 3, 2019, Page(s) 927
Publisher: eCM Conferences

Cartilage oligomeric matrix protein inhibits angiogenesis in vitro, depending upon its oligomerisation state

Author(s): E.A. Sastre , F. Zaucke , J.W. Bouma , K. Maly , G.J.V.M van Osch , E. Farrell
Published in: eCM Periodical, Issue 2019, Collection 3, 2019, Page(s) 449
Publisher: eCM Conferences

Book chapters (2)

The mechanics of Skeletal Development

Author(s): Astrid Novicky, Soraia P. Caetano-Silva, Behzad Javaheri and Andrew A. Pitsillides
Published in: 2018, ISBN 9780-128114674
Publisher: Developmental Biology and Muculoskeletal Tissue Engineering: Principles and applications, Elsevier

Using Cell and Organ Culture Models to Analyze Responses of Bone Cells to Mechanical Stimulation

Author(s): Soraia P. Caetano-Silva, Astrid Novicky, Behzad Javaheri, Simon C. F. Rawlinson, Andrew A. Pitsillides
Published in: Bone Research Protocols, Issue 1914, 2019, Page(s) 99-128, ISBN 978-1-4939-8996-6
Publisher: Springer New York
DOI: 10.1007/978-1-4939-8997-3_6