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Controlling Cartilage to Bone Transitions for Improved Treatment of Bone Defects and Osteoarthritis

Deliverables

D6.3

14 multidisciplinary ESRs with excellent networks, at least half of them found a suitable position at end project;

D7.3

28 articles in peer-reviewed journals

D7.4

42 contributions of ESRs in international conferences

D6.2

14 ESRs trained in at least two disciplines

D7.5

3 articles in general lay press in three different countries

D7.6

3 possible products identified for further development

D6.1

14 ESRs recruited, appointed and PCDP drafted

D7.2

Information for patients and general lay public on website

D7.1

Website on line

Publications

Turning Nature’s own processes into design strategies for living bone implant biomanufacturing: a decade of Developmental Engineering

Author(s): Ioannis Papantoniou, Gabriella Nilsson Hall, Niki Loverdou, Raphaelle Lesage, Tim Herpelinck, Luis Mendes, Liesbet Geris
Published in: Advanced Drug Delivery Reviews, Issue 169, 2021, Page(s) 22-39, ISSN 0169-409X
DOI: 10.1016/j.addr.2020.11.012

Ablation of the miRNA Cluster 24 Has Profound Effects on Extracellular Matrix Protein Abundance in Cartilage

Author(s): Veronika S. Georgieva, Julia Etich, Björn Bluhm, Mengjie Zhu, Christian Frie, Richard Wilson, Frank Zaucke, John Bateman, Bent Brachvogel
Published in: International Journal of Molecular Sciences, Issue 21/11, 2020, Page(s) 4112, ISSN 1422-0067
DOI: 10.3390/ijms21114112

COMP and TSP-4: Functional Roles in Articular Cartilage and Relevance in Osteoarthritis

Author(s): Kathrin Maly, Enrique Andres Sastre, Eric Farrell, Andrea Meurer, Frank Zaucke
Published in: International Journal of Molecular Sciences, Issue 22/5, 2021, Page(s) 2242, ISSN 1422-0067
DOI: 10.3390/ijms22052242

The Chondro-Osseous Continuum: Is It Possible to Unlock the Potential Assigned Within?

Author(s): Behzad Javaheri, Soraia P. Caetano-Silva, Ioannis Kanakis, George Bou-Gharios, Andrew A. Pitsillides
Published in: Frontiers in Bioengineering and Biotechnology, Issue 6, 2018, ISSN 2296-4185
DOI: 10.3389/fbioe.2018.00028

Computational Modeling and Reverse Engineering to Reveal Dominant Regulatory Interactions Controlling Osteochondral Differentiation: Potential for Regenerative Medicine

Author(s): Raphaelle Lesage, Johan Kerkhofs, Liesbet Geris
Published in: Frontiers in Bioengineering and Biotechnology, Issue 6, 2018, ISSN 2296-4185
DOI: 10.3389/fbioe.2018.00165

Isolation and Flow Cytometry Characterization of Extracellular-Vesicle Subpopulations Derived from Human Mesenchymal Stromal Cells

Author(s): Cansu Gorgun, Daniele Reverberi, Gianluca Rotta, Federico Villa, Rodolfo Quarto, Roberta Tasso
Published in: Current Protocols in Stem Cell Biology, Issue 48/1, 2019, Page(s) e76, ISSN 1941-7322
DOI: 10.1002/cpsc.76

Angiogenic Potential of Tissue Engineered Cartilage From Human Mesenchymal Stem Cells Is Modulated by Indian Hedgehog and Serpin E1

Author(s): Yannick Nossin, Eric Farrell, Wendy J. L. M. Koevoet, Rodrigo A. Somoza, Arnold I. Caplan, Bent Brachvogel, Gerjo J. V. M. van Osch
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
DOI: 10.3389/fbioe.2020.00327

Activation of Skeletal Stem and Progenitor Cells for Bone Regeneration Is Driven by PDGFRβ Signaling

Author(s): Anna-Marei Böhm, Naomi Dirckx, Robert J. Tower, Nicolas Peredo, Sebastiaan Vanuytven, Koen Theunis, Elena Nefyodova, Ruben Cardoen, Volkhard Lindner, Thierry Voet, Matthias Van Hul, Christa Maes
Published in: Developmental Cell, Issue 51/2, 2019, Page(s) 236-254.e12, ISSN 1534-5807
DOI: 10.1016/j.devcel.2019.08.013

Collagen type X is essential for successful mesenchymal stem cell-mediated cartilage formation and subsequent endochondral ossification

Author(s): CA Knuth, E Andres Sastre, NB Fahy, J Witte-Bouma, Y Ridwan, EM Strabbing, MJ Koudstaal, J van de Peppel, EB Wolvius, R Narcisi, E Farrell
Published in: European Cells and Materials, Issue 38, 2019, Page(s) 106-122, ISSN 1473-2262
DOI: 10.22203/ecm.v038a09

The tyrosine kinase receptor EPHA2 is a drug target for osteoarthritis

Author(s): M. N. Ferrao Blanco, Y.M. Bastiaansen-Jenniskens, R. Narcisi, M.G. Chambers, A.A. Pitsillides, G.J. van Osch
Published in: Osteoarthritis and Cartilage, Issue 28, 2020, Page(s) S36-S37, ISSN 1063-4584
DOI: 10.1016/j.joca.2020.02.060

The role of thrombospondin-4 and the cartilage oligomeric matrix protein in osteoarthritis

Author(s): K. Maly, I. Schaible, A. Meurer, F. Zaucke
Published in: Osteoarthritis and Cartilage, Issue 28, 2020, Page(s) S100-S101, ISSN 1063-4584
DOI: 10.1016/j.joca.2020.02.157

Effect of inflammation on hypertrophy to human articular chondrocytes

Author(s): M. N. Ferrao Blanco, Y.M. Bastiaansen-Jenniskens, R. Narcisi, G.J. van Osch
Published in: Osteoarthritis and Cartilage, Issue 28, 2020, Page(s) S113-S114, ISSN 1063-4584
DOI: 10.1016/j.joca.2020.02.183

The Expression of Thrombospondin-4 Correlates with Disease Severity in Osteoarthritic Knee Cartilage

Author(s): Kathrin Maly, Inna Schaible, Jana Riegger, Rolf Brenner, Andrea Meurer, Frank Zaucke
Published in: International Journal of Molecular Sciences, Issue 20/2, 2019, Page(s) 447, ISSN 1422-0067
DOI: 10.3390/ijms20020447

Cartilage Oligomeric Matrix Protein–Derived Peptides Secreted by Cartilage Do Not Induce Responses Commonly Observed during Osteoarthritis

Author(s): Enrique Andrés Sastre, Frank Zaucke, Janneke Witte-Bouma, Gerjo J.V.M van Osch, Eric Farrell
Published in: CARTILAGE, 2020, Page(s) 194760352096117, ISSN 1947-6035
DOI: 10.1177/1947603520961170

Use of Computational Modeling to Study Joint Degeneration: A Review

Author(s): Satanik Mukherjee, Majid Nazemi, Ilse Jonkers, Liesbet Geris
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
DOI: 10.3389/fbioe.2020.00093

Dissecting the effects of preconditioning with inflammatory cytokines and hypoxia on the angiogenic potential of Mesenchymal Stromal Cell (MSC)-derived soluble proteins and Extracellular Vesicles (EVs)

Author(s): Cansu Gorgun, Davide Ceresa, Raphaelle Lesage, Federico Villa, Daniele Reverberi, Carolina Balbi, Sara Santamaria, Katia Cortese, Paolo Malatesta, Liesbet Geris, Rodolfo Quarto, Roberta Tasso
Published in: Biomaterials, 2020, Page(s) 120633, ISSN 0142-9612
DOI: 10.1016/j.biomaterials.2020.120633

Faculty Opinions recommendation of Misconceptions (1): epiphyseal fusion causes cessation of growth.

Author(s): Andrew Pitsillides, Dionysia Valkani
Published in: 2020
DOI: 10.3410/f.720251388.793572256

Arthrose – Die Rolle der Extrazellulären Matrix

Author(s): Maly K., Zaucke F. and Meurer A.
Published in: orthopädische Nachrichten |, Issue 09.2018, 2018, Page(s) p. 20-21

Faculty of 1000 evaluation for Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand.

Author(s): Andrew Pitsillides, Soraia P Caetano-Silva
Published in: 2019
DOI: 10.3410/f.730362852.793539430

Injury modulates mesenchymal stromal cell secretory activity: effects on angiogenesis

Author(s): Cansu Gorgun, Yannick M. Nossin, Eric Farrell, Gerjo J.V.M van Osch, Roberta Tasso
Published in: 5th TERMIS world congress-2018 conference proceedings, Issue 2018, 2018, Page(s) 350

Mesenchymal stromal cell secretory activity: The role of secretome fractions in angiogenesis

Author(s): C. Gorgun, F. Villa, R. Quarto, R. Tasso
Published in: eCM Periodical, Issue 2019, Collection 3, 2019, Page(s) 374

The incorporation of collagen type II into collagen hyaluronate scaffolds as potential off the shelf approach to long term stable cartilage tissue repair

Author(s): C. Intini, J.P. Gleeson, F.J. O’Brien
Published in: eCM Periodical, Issue 2019, Collection 3, 2019, Page(s) 400

PAI1 and IHH reduce the pro-angiogenic potential of transient cartilage secretome

Author(s): Y. Nossin , J.L.M Koevoet , R. Somoza, A. Caplan, B Brachvogel , E. Farrell, G.J.V.M. van Osch
Published in: eCM Periodical, Issue 2019, Collection 3, 2019, Page(s) 1160

Ηydrogel stiffness regulates the response of mesenchymal stem cells to dynamic loading

Author(s): F. Chariyev-Prinz, D.J. Kelly
Published in: eCM Periodical, Issue 2019, Collection 3, 2019, Page(s) 458

Secretome of cartilage tissue engineered from chondrocytes or bone marrow-derived mesenchymal stem cells induce angiogenesis

Author(s): Y. Nossin , C. Gorgun, R. Tasso, J.L.M Koevoet , E. Farrell , G. J.V.M. van Osch
Published in: eCM Periodical, Issue 2019, Collection 3, 2019, Page(s) 855

COMP’s derived potential matricryptins show no role on specific aspects of joint regeneration

Author(s): E. A. Sastre, G.J.V.M van Osch, J. W. Bouma , E. Farrell
Published in: eCM Periodical, Issue 2019, Collection 3, 2019, Page(s) 927

Cartilage oligomeric matrix protein inhibits angiogenesis in vitro, depending upon its oligomerisation state

Author(s): E.A. Sastre , F. Zaucke , J.W. Bouma , K. Maly , G.J.V.M van Osch , E. Farrell
Published in: eCM Periodical, Issue 2019, Collection 3, 2019, Page(s) 449

The mechanics of Skeletal Development

Author(s): Astrid Novicky, Soraia P. Caetano-Silva, Behzad Javaheri and Andrew A. Pitsillides
Published in: 2018

Using Cell and Organ Culture Models to Analyze Responses of Bone Cells to Mechanical Stimulation

Author(s): Soraia P. Caetano-Silva, Astrid Novicky, Behzad Javaheri, Simon C. F. Rawlinson, Andrew A. Pitsillides
Published in: Bone Research Protocols, Issue 1914, 2019, Page(s) 99-128
DOI: 10.1007/978-1-4939-8997-3_6