Controlling Cartilage to Bone Transitions for Improved Treatment of Bone Defects and Osteoarthritis

Informazioni relative al progetto

CarBon

ID dell’accordo di sovvenzione: 721432

DOI

10.3030/721432

Progetto chiuso

Data della firma CE 25 Agosto 2016

Data di avvio 1 Gennaio 2017

Data di completamento 31 Dicembre 2020

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 3 607 596,36

Contributo UE

€ 3 607 596,36

Coordinato da

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (7)

D6.3

14 multidisciplinary ESRs with excellent networks, at least half of them found a suitable position at end project;

D7.3

28 articles in peer-reviewed journals

D7.4

42 contributions of ESRs in international conferences

D6.2

14 ESRs trained in at least two disciplines

D7.5

3 articles in general lay press in three different countries

D7.6

3 possible products identified for further development

D6.1

14 ESRs recruited, appointed and PCDP drafted

Websites, patent fillings, videos etc. (2)

D7.2

Information for patients and general lay public on website

D7.1

Website on line

Pubblicazioni

Peer reviewed articles (24)

Turning Nature’s own processes into design strategies for living bone implant biomanufacturing: a decade of Developmental Engineering

Autori: Ioannis Papantoniou, Gabriella Nilsson Hall, Niki Loverdou, Raphaelle Lesage, Tim Herpelinck, Luis Mendes, Liesbet Geris
Pubblicato in: Advanced Drug Delivery Reviews, Numero 169, 2021, Pagina/e 22-39, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2020.11.012

Ablation of the miRNA Cluster 24 Has Profound Effects on Extracellular Matrix Protein Abundance in Cartilage

Autori: Veronika S. Georgieva, Julia Etich, Björn Bluhm, Mengjie Zhu, Christian Frie, Richard Wilson, Frank Zaucke, John Bateman, Bent Brachvogel
Pubblicato in: International Journal of Molecular Sciences, Numero 21/11, 2020, Pagina/e 4112, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21114112

A new semi-orthotopic bone defect model for cell and biomaterial testing in regenerative medicine.

Autori: Andrés Sastre E, Nossin Y, Jansen I, Kops N, Intini C, Witte-Bouma J, van Rietbergen B, Hofmann S, Ridwan Y, Gleeson JP, O'Brien FJ, Wolvius EB, van Osch GJVM, Farrell E.
Pubblicato in: Biomaterials, 2021, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2021.121187

COMP and TSP-4: Functional Roles in Articular Cartilage and Relevance in Osteoarthritis

Autori: Kathrin Maly, Enrique Andres Sastre, Eric Farrell, Andrea Meurer, Frank Zaucke
Pubblicato in: International Journal of Molecular Sciences, Numero 22/5, 2021, Pagina/e 2242, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22052242

The tyrosine kinase receptor EPHA2 is a drug target for osteoarthritis

Autori: M.N. Ferrao Blanco; Y.M. Bastiaansen-Jenniskens; Roberto Narcisi; Mark Chambers; Andrew A. Pitsillides; G.J.V.M. van Osch
Pubblicato in: Osteoarthritis Cartilage, Numero 4, 2021, ISSN 2665-9131
Editore: elsevier
DOI: 10.1016/j.joca.2020.02.060

Intra-articular injection of triamcinolone acetonide sustains macrophage levels and aggravates osteophytosis during degenerative joint disease in mice.

Autori: Ferrao Blanco MN, Bastiaansen Jenniskens YM, Kops N, Chavli A, Narcisi R, Botter SM, Leenen PJM, van Osch GJVM, Fahy N
Pubblicato in: Br J Pharmacol, 2021, ISSN 1476-5381
Editore: BJP
DOI: 10.1111/bph.15780

Restraint upon Embryonic Metatarsal Ex Vivo Growth by Hydrogel Reveals Interaction between Quasi-Static Load and the mTOR Pathway.

Autori: Caetano-Silva S, Simbi BH, Marr N, Hibbert A, Allen SP, Pitsillides AA
Pubblicato in: Int J Mol Sci, 2021, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms222413220

Ablation of the miRNA Cluster 24 Has Profound Effects on Extracellular Matrix Protein Abundance in Cartilage.

Autori: Veronika S. Georgieva; Julia Etich; Björn Bluhm; Mengjie Zhu; Christian Frie; Richard Wilson; Frank Zaucke; John F. Bateman; Bent Brachvogel
Pubblicato in: International Journal of Molecular Sciences, Numero 3, 2020, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21114112

Effect of inflammation on hypertrophy to human articular chondrocytes

Autori: M.N. Ferrao Blanco; Y.M. Bastiaansen-Jenniskens; Roberto Narcisi; G.J.V.M. van Osch
Pubblicato in: Cartilage, Numero 3, 2021, ISSN 1947-6035
Editore: SAGE Publications Inc.
DOI: 10.1016/j.joca.2020.02.183

Fetal hematopoietic stem cell homing is controlled by VEGF regulating the integrity and oxidative status of the stromal-vascular bone marrow niches.

Autori: Marion Mesnieres; Anna-Marei Böhm; Nicolas Peredo; Dana Trompet; Roger Valle-Tenney; Manmohan Bajaj; Nikky Corthout; Elena Nefyodova; Ruben Cardoen; Pieter Baatsen; Sebastian Munck; Andras Nagy; Andras Nagy; Jody J. Haigh; Satish Khurana; Satish Khurana; Catherine M. Verfaillie; Christa Maes
Pubblicato in: Cell Rep, Numero 5, 2021, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.109618

Editorial: Understanding and Modulating Bone and Cartilage Cell Fate for Regenerative Medicine.

Autori: Roberto Narcisi; Eric Farrell
Pubblicato in: Frontiers in Bioeng Biotechnol, Numero 3, 2019, ISSN 2296-4185
Editore: Frontiers
DOI: 10.3389/fbioe.2019.00008

The Chondro-Osseous Continuum: Is It Possible to Unlock the Potential Assigned Within?

Autori: Behzad Javaheri, Soraia P. Caetano-Silva, Ioannis Kanakis, George Bou-Gharios, Andrew A. Pitsillides
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 6, 2018, ISSN 2296-4185
Editore: Frontiers in in Bioengineering and Biotechnology
DOI: 10.3389/fbioe.2018.00028

Computational Modeling and Reverse Engineering to Reveal Dominant Regulatory Interactions Controlling Osteochondral Differentiation: Potential for Regenerative Medicine

Autori: Raphaelle Lesage, Johan Kerkhofs, Liesbet Geris
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 6, 2018, ISSN 2296-4185
Editore: Frontiers
DOI: 10.3389/fbioe.2018.00165

Angiogenic Potential of Tissue Engineered Cartilage From Human Mesenchymal Stem Cells Is Modulated by Indian Hedgehog and Serpin E1

Autori: Yannick Nossin, Eric Farrell, Wendy J. L. M. Koevoet, Rodrigo A. Somoza, Arnold I. Caplan, Bent Brachvogel, Gerjo J. V. M. van Osch
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 8, 2020, ISSN 2296-4185
Editore: Frontiers in Bioengineering and Biotechnology
DOI: 10.3389/fbioe.2020.00327

Activation of Skeletal Stem and Progenitor Cells for Bone Regeneration Is Driven by PDGFRβ Signaling

Autori: Anna-Marei Böhm, Naomi Dirckx, Robert J. Tower, Nicolas Peredo, Sebastiaan Vanuytven, Koen Theunis, Elena Nefyodova, Ruben Cardoen, Volkhard Lindner, Thierry Voet, Matthias Van Hul, Christa Maes
Pubblicato in: Developmental Cell, Numero 51/2, 2019, Pagina/e 236-254.e12, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2019.08.013

Collagen type X is essential for successful mesenchymal stem cell-mediated cartilage formation and subsequent endochondral ossification

Autori: CA Knuth, E Andres Sastre, NB Fahy, J Witte-Bouma, Y Ridwan, EM Strabbing, MJ Koudstaal, J van de Peppel, EB Wolvius, R Narcisi, E Farrell
Pubblicato in: European Cells and Materials, Numero 38, 2019, Pagina/e 106-122, ISSN 1473-2262
Editore: Swiss Society for Biomaterials
DOI: 10.22203/ecm.v038a09

The Expression of Thrombospondin-4 Correlates with Disease Severity in Osteoarthritic Knee Cartilage

Autori: Kathrin Maly, Inna Schaible, Jana Riegger, Rolf Brenner, Andrea Meurer, Frank Zaucke
Pubblicato in: International Journal of Molecular Sciences, Numero 20/2, 2019, Pagina/e 447, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20020447

Spatiotemporal distribution of thrombospondin-4 and -5 in cartilage during endochondral bone formation and repair.

Autori: Andrés Sastre E, Maly K, Zhu M, Witte-Bouma J, Trompet D, Böhm AM, Brachvogel B, van Nieuwenhoven CA, Maes C, van Osch GJVM, Zaucke F, Farrell E
Pubblicato in: Bone, 2021, ISSN 8756-3282
Editore: Elsevier BV
DOI: 10.1016/j.bone.2021.115999

Cartilage Oligomeric Matrix Protein–Derived Peptides Secreted by Cartilage Do Not Induce Responses Commonly Observed during Osteoarthritis

Autori: Enrique Andrés Sastre, Frank Zaucke, Janneke Witte-Bouma, Gerjo J.V.M van Osch, Eric Farrell
Pubblicato in: CARTILAGE, 2020, Pagina/e 194760352096117, ISSN 1947-6035
Editore: SAGE Publications Inc.
DOI: 10.1177/1947603520961170

Use of Computational Modeling to Study Joint Degeneration: A Review

Autori: Satanik Mukherjee, Majid Nazemi, Ilse Jonkers, Liesbet Geris
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 8, 2020, ISSN 2296-4185
Editore: Frontiers Media S.A.
DOI: 10.3389/fbioe.2020.00093

The Releasate of Avascular Cartilage Demonstrates Inherent Pro-Angiogenic Properties In Vitro and In Vivo.

Autori: Yannick Nossin; Eric Farrell; Wendy Koevoet; Frank R. Datema; Rodrigo A. Somoza; Arnold I. Caplan; Gerjo J.V.M. van Osch; Gerjo J.V.M. van Osch
Pubblicato in: Cartilage, Numero 4, 2021, ISSN 1947-6035
Editore: SAGE Publications Inc.
DOI: 10.1177/19476035211047628

Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility

Autori: Musuamba FT, Skottheim Rusten I, Lesage R, Russo G, Bursi R, Emili L, Wangorsch G, Manolis E, Karlsson KE, Kulesza A, Courcelles E, Boissel JP, Rousseau CF, Voisin EM, Alessandrello R, Curado N, Dall'ara E, Rodriguez B, Pappalardo F, Geris L.
Pubblicato in: CPT Pharmacometrics Syst Pharmacol, 2021, ISSN 2163-8306
Editore: Nature Publishing Group
DOI: 10.1002/psp4.12669

Dissecting the effects of preconditioning with inflammatory cytokines and hypoxia on the angiogenic potential of Mesenchymal Stromal Cell (MSC)-derived soluble proteins and Extracellular Vesicles (EVs)

Autori: Cansu Gorgun, Davide Ceresa, Raphaelle Lesage, Federico Villa, Daniele Reverberi, Carolina Balbi, Sara Santamaria, Katia Cortese, Paolo Malatesta, Liesbet Geris, Rodolfo Quarto, Roberta Tasso
Pubblicato in: Biomaterials, 2020, Pagina/e 120633, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120633

Role of extracellular vesicles from adipose tissue- and bone marrow-mesenchymal stromal cells in endothelial proliferation and chondrogenesis.

Autori: Gorgun C, Palamà MEF, Reverberi D, Gagliani MC, Cortese K, Tasso R, Gentili C.
Pubblicato in: Stem Cells Transl Med, 2021, ISSN 2157-6564
Editore: AlphaMed Press
DOI: 10.1002/sctm.21-0107

Other (3)

Faculty Opinions recommendation of Misconceptions (1): epiphyseal fusion causes cessation of growth.

Autori: Andrew Pitsillides, Dionysia Valkani
Pubblicato in: 2020
Editore: Faculty Opinions
DOI: 10.3410/f.720251388.793572256

Arthrose – Die Rolle der Extrazellulären Matrix

Autori: Maly K., Zaucke F. and Meurer A.
Pubblicato in: orthopädische Nachrichten |, Numero 09.2018, 2018, Pagina/e p. 20-21
Editore: Biermann Medizin

Faculty of 1000 evaluation for Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand.

Autori: Andrew Pitsillides, Soraia P Caetano-Silva
Pubblicato in: 2019
Editore: F1000 - Post-publication peer review of the biomedical literature
DOI: 10.3410/f.730362852.793539430

Conference proceedings (8)

Injury modulates mesenchymal stromal cell secretory activity: effects on angiogenesis

Autori: Cansu Gorgun, Yannick M. Nossin, Eric Farrell, Gerjo J.V.M van Osch, Roberta Tasso
Pubblicato in: 5th TERMIS world congress-2018 conference proceedings, Numero 2018, 2018, Pagina/e 350
Editore: TERMIS-WC 2018

Mesenchymal stromal cell secretory activity: The role of secretome fractions in angiogenesis

Autori: C. Gorgun, F. Villa, R. Quarto, R. Tasso
Pubblicato in: eCM Periodical, Numero 2019, Collection 3, 2019, Pagina/e 374
Editore: eCM Conferences

The incorporation of collagen type II into collagen hyaluronate scaffolds as potential off the shelf approach to long term stable cartilage tissue repair

Autori: C. Intini, J.P. Gleeson, F.J. O’Brien
Pubblicato in: eCM Periodical, Numero 2019, Collection 3, 2019, Pagina/e 400
Editore: eCM Conferences

PAI1 and IHH reduce the pro-angiogenic potential of transient cartilage secretome

Autori: Y. Nossin , J.L.M Koevoet , R. Somoza, A. Caplan, B Brachvogel , E. Farrell, G.J.V.M. van Osch
Pubblicato in: eCM Periodical, Numero 2019, Collection 3, 2019, Pagina/e 1160
Editore: eCM Conferences

Ηydrogel stiffness regulates the response of mesenchymal stem cells to dynamic loading

Autori: F. Chariyev-Prinz, D.J. Kelly
Pubblicato in: eCM Periodical, Numero 2019, Collection 3, 2019, Pagina/e 458
Editore: eCM Conferences

Secretome of cartilage tissue engineered from chondrocytes or bone marrow-derived mesenchymal stem cells induce angiogenesis

Autori: Y. Nossin , C. Gorgun, R. Tasso, J.L.M Koevoet , E. Farrell , G. J.V.M. van Osch
Pubblicato in: eCM Periodical, Numero 2019, Collection 3, 2019, Pagina/e 855
Editore: eCM Conferences

COMP’s derived potential matricryptins show no role on specific aspects of joint regeneration

Autori: E. A. Sastre, G.J.V.M van Osch, J. W. Bouma , E. Farrell
Pubblicato in: eCM Periodical, Numero 2019, Collection 3, 2019, Pagina/e 927
Editore: eCM Conferences

Cartilage oligomeric matrix protein inhibits angiogenesis in vitro, depending upon its oligomerisation state

Autori: E.A. Sastre , F. Zaucke , J.W. Bouma , K. Maly , G.J.V.M van Osch , E. Farrell
Pubblicato in: eCM Periodical, Numero 2019, Collection 3, 2019, Pagina/e 449
Editore: eCM Conferences

Book chapters (2)

The mechanics of Skeletal Development

Autori: Astrid Novicky, Soraia P. Caetano-Silva, Behzad Javaheri and Andrew A. Pitsillides
Pubblicato in: 2018, ISBN 9780-128114674
Editore: Developmental Biology and Muculoskeletal Tissue Engineering: Principles and applications, Elsevier

Using Cell and Organ Culture Models to Analyze Responses of Bone Cells to Mechanical Stimulation

Autori: Soraia P. Caetano-Silva, Astrid Novicky, Behzad Javaheri, Simon C. F. Rawlinson, Andrew A. Pitsillides
Pubblicato in: Bone Research Protocols, Numero 1914, 2019, Pagina/e 99-128, ISBN 978-1-4939-8996-6
Editore: Springer New York
DOI: 10.1007/978-1-4939-8997-3_6