Deliverables Documents, reports (1) Public engagement and dissemination of achievements month 44: Participation in public open day to disseminate the project outcomes Other (3) Summer School A five day summer school, open to the public, will be organised by beneficiary KI entitled Nucleic Acids in Therapy Science communication course (month 8): a Science Communication course that develops their skills in conveying complex scientific ideas to a general audience, and provide the technical skills to prepare videos and podcasts will be provided. Network Conference month 44 A twoday conference to showcase the research area and the achievements of the network accessible to the general public This can be a free standing event or part of a relevant conference eg the Annual Meetings of the Oligonucleotide Therapeutics Society or the International Round Table on Nucleosides Nucleotides and Nucleic Acids in Stockholm JuneJuly 2018 Websites, patent fillings, videos etc. (1) Website, ESR webpages and Moodle operational Website, ESR webpages and Moodle operational Publications Peer reviewed articles (24) Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides Author(s): Haneen Daralnakhla, Osama Saher, Susanna Zamolo, Safa Bazaz, Jeremy P. Bost, Marc Heitz, Karin E. Lundin, Samir EL Andaloussi, Tamis Darbre, Jean-Louis Reymond, Rula Zain, C. I. Edvard Smith Published in: Pharmaceutics, Issue 13/1, 2021, Page(s) 116, ISSN 1999-4923 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/pharmaceutics13010116 Sequence dependence of Pd(II)-mediated base pairing by palladacyclic nucleobase surrogates Author(s): Madhuri Hande, Sajal Maity, Tuomas Lönnberg Published in: Journal of Inorganic Biochemistry, Issue 222, 2021, Page(s) 111506, ISSN 0162-0134 Publisher: Elsevier BV DOI: 10.1016/j.jinorgbio.2021.111506 Further Probing of Cu2+-Dependent PNAzymes Acting as Artificial RNA Restriction Enzymes Author(s): Olivia Luige, Merita Murtola, Alice Ghidini, Roger Strömberg Published in: Molecules, Issue 24/4, 2019, Page(s) 672, ISSN 1420-3049 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/molecules24040672 Oligonucleotides Targeting DNA Repeats Downregulate Huntingtin Gene Expression in Huntington's Patient-Derived Neural Model System Author(s): Tea Umek, Thomas Olsson, Olof Gissberg, Osama Saher, Eman M. Zaghloul, Karin E. Lundin, Jesper Wengel, Eric Hanse, Henrik Zetterberg, Dzeneta Vizlin-Hodzic, C. I. Edvard Smith, Rula Zain Published in: Nucleic Acid Therapeutics, 2021, ISSN 2159-3337 Publisher: Mary Ann Liebert Inc. DOI: 10.1089/nat.2021.0021 PNA-Based MicroRNA Detection Methodologies Author(s): Enrico Cadoni, Alex Manicardi, Annemieke Madder Published in: Molecules, Issue 25/6, 2020, Page(s) 1296, ISSN 1420-3049 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/molecules25061296 Beyond small molecules: targeting G-quadruplex structures with oligonucleotides and their analogues Author(s): Enrico Cadoni, Lessandro De Paepe, Alex Manicardi, Annemieke Madder Published in: Nucleic Acids Research, Issue 49/12, 2021, Page(s) 6638-6659, ISSN 0305-1048 Publisher: Oxford University Press DOI: 10.1093/nar/gkab334 Metal‐Mediated Base Pairing of Rigid and Flexible Benzaldoxime Metallacycles Author(s): Sajal Maity, Madhuri Hande, Tuomas Lönnberg Published in: ChemBioChem, Issue 21/16, 2020, Page(s) 2321-2328, ISSN 1439-4227 Publisher: John Wiley & Sons Ltd. DOI: 10.1002/cbic.202000135 Transfecting tissue models with CRISPR/Cas9 plasmid DNA using peptide dendrimers Author(s): Susanna J. Zamolo, Tamis Darbre, Jean-Louis Reymond Published in: Chemical Communications, Issue 56/80, 2020, Page(s) 11981-11984, ISSN 1359-7345 Publisher: Royal Society of Chemistry DOI: 10.1039/d0cc04750c Further Probing of Cu2+-Dependent PNAzymes Acting as Artificial RNA Restriction Enzymes. Author(s): Olivia Luige; Merita Murtola; Alice Ghidini; Roger Strömberg Published in: Molecules, 24 (4), Issue 1, 2019, ISSN 1420-3049 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3929/ethz-b-000327274 The Mechanism of Cleavage of RNA Phosphodiesters by a Gold Nanoparticle Nanozyme Author(s): Joanna Czescik, Fabrizio Mancin, Roger Strömberg, Paolo Scrimin Published in: Chemistry – A European Journal, Issue 27/31, 2021, Page(s) 8143-8148, ISSN 0947-6539 Publisher: John Wiley & Sons Ltd. DOI: 10.1002/chem.202100299 Teaching photosensitizers a new trick: red light-triggered G-quadruplex alkylation by ligand co-localization Author(s): Enrico Cadoni, Alex Manicardi, Mathieu Fossépré, Kaat Heirwegh, Mathieu Surin, Annemieke Madder Published in: Chemical Communications, Issue 57/8, 2021, Page(s) 1010-1013, ISSN 1359-7345 Publisher: Royal Society of Chemistry DOI: 10.1039/d0cc06030e Synthesis and Hybridization Properties of Covalently Mercurated and Palladated Oligonucleotides Author(s): Dattatraya Ukale, Sajal Maity, Madhuri Hande, Tuomas Lönnberg Published in: Synlett, Issue 30/15, 2019, Page(s) 1733-1737, ISSN 0936-5214 Publisher: Georg Thieme Verlag DOI: 10.1055/s-0037-1611821 Palladacyclic Conjugate Group Promotes Hybridization of Short Oligonucleotides Author(s): Madhuri Hande, Sajal Maity, Tuomas Lönnberg Published in: International Journal of Molecular Sciences, Issue 19/6, 2018, Page(s) 1588, ISSN 1422-0067 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms19061588 A Versatile and Convenient Synthesis of 34 S-Labeled Phosphorothioate Oligonucleotides Author(s): Rouven Stulz, Johan Meuller, Dženita Baždarević, Charlotte Wennberg Huldt, Roger Strömberg, Shalini Andersson, Anders Dahlén Published in: ChemBioChem, Issue 19/19, 2018, Page(s) 2114-2119, ISSN 1439-4227 Publisher: John Wiley & Sons Ltd. DOI: 10.1002/cbic.201800417 Novel peptide-dendrimer/lipid/oligonucleotide ternary complexes for efficient cellular uptake and improved splice-switching activity Author(s): Osama Saher, Cristina S.J. Rocha, Eman M. Zaghloul, Oscar P.B. Wiklander, Susanna Zamolo, Marc Heitz, Kariem Ezzat, Dhanu Gupta, Jean-Louis Reymond, Rula Zain, Florian Hollfelder, Tamis Darbre, Karin E. Lundin, Samir EL Andaloussi, C.I. Edvard Smith Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 132, 2018, Page(s) 29-40, ISSN 0939-6411 Publisher: Elsevier BV DOI: 10.1016/j.ejpb.2018.09.002 Oligonucleotide–Palladacycle Conjugates as Splice-Correcting Agents Author(s): Madhuri Hande, Osama Saher, Karin Lundin, C. Smith, Rula Zain, Tuomas Lönnberg Published in: Molecules, Issue 24/6, 2019, Page(s) 1180, ISSN 1420-3049 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/molecules24061180 Exploiting Double Exchange Diels-Alder Cycloadditions for Immobilization of Peptide Nucleic Acids on Gold Nanoparticles Author(s): Enrico Cadoni, Daniele Rosa-Gastaldo, Alex Manicardi, Fabrizio Mancin, Annemieke Madder Published in: Frontiers in Chemistry, Issue 8, 2020, ISSN 2296-2646 Publisher: Frontiers DOI: 10.3389/fchem.2020.00004 Factors Influencing the Activity of Nanozymes in the Cleavage of an RNA Model Substrate Author(s): Czescik, Zamolo, Darbre, Mancin, Scrimin Published in: Molecules, Issue 24/15, 2019, Page(s) 2814, ISSN 1420-3049 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/molecules24152814 Multifunctional, CD44v6-Targeted ORMOSIL Nanoparticles Enhance Drugs Toxicity in Cancer Cells Author(s): Morillas-Becerril, Peta, Gabrielli, Russo, Lubian, Nodari, Ferlin, Scrimin, Palù, Barzon, Castagliuolo, Mancin, Trevisan Published in: Nanomaterials, Issue 10/2, 2020, Page(s) 298, ISSN 2079-4991 Publisher: MDPI DOI: 10.3390/nano10020298 Oligonucleotide Binding to Non-B-DNA in MYC Author(s): Tea Umek, Karin Sollander, Helen Bergquist, Jesper Wengel, Karin E. Lundin, C.I. Edvard Smith, Rula Zain Published in: Molecules, Issue 24/5, 2019, Page(s) 1000, ISSN 1420-3049 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/molecules24051000 Sugar and Polymer Excipients Enhance Uptake and Splice-Switching Activity of Peptide-Dendrimer/Lipid/Oligonucleotide Formulations Author(s): Osama Saher, Taavi Lehto, Olof Gissberg, Dhanu Gupta, Oskar Gustafsson, Samir EL Andaloussi, Tamis Darbre, Karin E. Lundin, C. I. Edvard Smith, Rula Zain Published in: Pharmaceutics, Issue 11/12, 2019, Page(s) 666, ISSN 1999-4923 Publisher: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/pharmaceutics11120666 Poly(lipoic acid)-Based Nanoparticles as Self-Organized, Biocompatible, and Corona-Free Nanovectors Author(s): Jakub W. Trzciński, Lucía Morillas-Becerril, Sara Scarpa, Marco Tannorella, Francesco Muraca, Federico Rastrelli, Chiara Castellani, Marny Fedrigo, Annalisa Angelini, Regina Tavano, Emanuele Papini, Fabrizio Mancin Published in: Biomacromolecules, Issue 22/2, 2021, Page(s) 467-480, ISSN 1525-7797 Publisher: American Chemical Society DOI: 10.1021/acs.biomac.0c01321 Visible-light triggered templated ligation on surface using furan-modified PNAs Author(s): Alex Manicardi, Enrico Cadoni, Annemieke Madder Published in: Chemical Science, Issue 11/43, 2020, Page(s) 11729-11739, ISSN 2041-6520 Publisher: Royal Society of Chemistry DOI: 10.1039/d0sc04875e New Alkyne and Amine Linkers for Versatile Multiple Conjugation of Oligonucleotides Author(s): Dmytro Honcharenko, Kristina Druceikaite, Malgorzata Honcharenko, Martin Bollmark, Ulf Tedebark, Roger Strömberg Published in: ACS Omega, Issue 6/1, 2021, Page(s) 579-593, ISSN 2470-1343 Publisher: American Chemical Society DOI: 10.1021/acsomega.0c05075 Searching for OpenAIRE data... 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