Molecular Tools for Nucleic Acid Manipulation for Biological Intervention

Deliverables

Other (2)

Summer School

A five day summer school, open to the public, will be organised by beneficiary KI entitled Nucleic Acids in Therapy

Science communication course

(month 8): a Science Communication course that develops their skills in conveying complex scientific ideas to a general audience, and provide the technical skills to prepare videos and podcasts will be provided.

Websites, patent fillings, videos etc. (1)

Website, ESR webpages and Moodle operational

Website, ESR webpages and Moodle operational

Publications

Peer reviewed articles (9)

Palladacyclic Conjugate Group Promotes Hybridization of Short Oligonucleotides

Author(s): Madhuri Hande, Sajal Maity, Tuomas Lönnberg
Published in: International Journal of Molecular Sciences, Issue 19/6, 2018, Page(s) 1588, ISSN 1422-0067
DOI: 10.3390/ijms19061588

A Versatile and Convenient Synthesis of 34 S-Labeled Phosphorothioate Oligonucleotides

Author(s): Rouven Stulz, Johan Meuller, Dženita Baždarević, Charlotte Wennberg Huldt, Roger Strömberg, Shalini Andersson, Anders Dahlén
Published in: ChemBioChem, Issue 19/19, 2018, Page(s) 2114-2119, ISSN 1439-4227
DOI: 10.1002/cbic.201800417

Novel peptide-dendrimer/lipid/oligonucleotide ternary complexes for efficient cellular uptake and improved splice-switching activity

Author(s): Osama Saher, Cristina S.J. Rocha, Eman M. Zaghloul, Oscar P.B. Wiklander, Susanna Zamolo, Marc Heitz, Kariem Ezzat, Dhanu Gupta, Jean-Louis Reymond, Rula Zain, Florian Hollfelder, Tamis Darbre, Karin E. Lundin, Samir EL Andaloussi, C.I. Edvard Smith
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 132, 2018, Page(s) 29-40, ISSN 0939-6411
DOI: 10.1016/j.ejpb.2018.09.002

Oligonucleotide–Palladacycle Conjugates as Splice-Correcting Agents

Author(s): Madhuri Hande, Osama Saher, Karin Lundin, C. Smith, Rula Zain, Tuomas Lönnberg
Published in: Molecules, Issue 24/6, 2019, Page(s) 1180, ISSN 1420-3049
DOI: 10.3390/molecules24061180

Exploiting Double Exchange Diels-Alder Cycloadditions for Immobilization of Peptide Nucleic Acids on Gold Nanoparticles

Author(s): Enrico Cadoni, Daniele Rosa-Gastaldo, Alex Manicardi, Fabrizio Mancin, Annemieke Madder
Published in: Frontiers in Chemistry, Issue 8, 2020, ISSN 2296-2646
DOI: 10.3389/fchem.2020.00004

Factors Influencing the Activity of Nanozymes in the Cleavage of an RNA Model Substrate

Author(s): Czescik, Zamolo, Darbre, Mancin, Scrimin
Published in: Molecules, Issue 24/15, 2019, Page(s) 2814, ISSN 1420-3049
DOI: 10.3390/molecules24152814

Multifunctional, CD44v6-Targeted ORMOSIL Nanoparticles Enhance Drugs Toxicity in Cancer Cells

Author(s): Morillas-Becerril, Peta, Gabrielli, Russo, Lubian, Nodari, Ferlin, Scrimin, Palù, Barzon, Castagliuolo, Mancin, Trevisan
Published in: Nanomaterials, Issue 10/2, 2020, Page(s) 298, ISSN 2079-4991
DOI: 10.3390/nano10020298

Oligonucleotide Binding to Non-B-DNA in MYC

Author(s): Tea Umek, Karin Sollander, Helen Bergquist, Jesper Wengel, Karin E. Lundin, C.I. Edvard Smith, Rula Zain
Published in: Molecules, Issue 24/5, 2019, Page(s) 1000, ISSN 1420-3049
DOI: 10.3390/molecules24051000

Sugar and Polymer Excipients Enhance Uptake and Splice-Switching Activity of Peptide-Dendrimer/Lipid/Oligonucleotide Formulations

Author(s): Osama Saher, Taavi Lehto, Olof Gissberg, Dhanu Gupta, Oskar Gustafsson, Samir EL Andaloussi, Tamis Darbre, Karin E. Lundin, C. I. Edvard Smith, Rula Zain
Published in: Pharmaceutics, Issue 11/12, 2019, Page(s) 666, ISSN 1999-4923
DOI: 10.3390/pharmaceutics11120666