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Molecular Tools for Nucleic Acid Manipulation for Biological Intervention

Deliverables

Public engagement and dissemination of achievements

month 44: Participation in public open day to disseminate the project outcomes

Summer School

A five day summer school, open to the public, will be organised by beneficiary KI entitled Nucleic Acids in Therapy

Science communication course

(month 8): a Science Communication course that develops their skills in conveying complex scientific ideas to a general audience, and provide the technical skills to prepare videos and podcasts will be provided.

Network Conference

month 44 A twoday conference to showcase the research area and the achievements of the network accessible to the general public This can be a free standing event or part of a relevant conference eg the Annual Meetings of the Oligonucleotide Therapeutics Society or the International Round Table on Nucleosides Nucleotides and Nucleic Acids in Stockholm JuneJuly 2018

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Publications

Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides

Author(s): Haneen Daralnakhla, Osama Saher, Susanna Zamolo, Safa Bazaz, Jeremy P. Bost, Marc Heitz, Karin E. Lundin, Samir EL Andaloussi, Tamis Darbre, Jean-Louis Reymond, Rula Zain, C. I. Edvard Smith
Published in: Pharmaceutics, 13/1, 2021, Page(s) 116, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13010116

Sequence dependence of Pd(II)-mediated base pairing by palladacyclic nucleobase surrogates

Author(s): Madhuri Hande, Sajal Maity, Tuomas Lönnberg
Published in: Journal of Inorganic Biochemistry, 222, 2021, Page(s) 111506, ISSN 0162-0134
Publisher: Elsevier BV
DOI: 10.1016/j.jinorgbio.2021.111506

Further Probing of Cu2+-Dependent PNAzymes Acting as Artificial RNA Restriction Enzymes

Author(s): Olivia Luige, Merita Murtola, Alice Ghidini, Roger Strömberg
Published in: Molecules, 24/4, 2019, Page(s) 672, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24040672

Oligonucleotides Targeting DNA Repeats Downregulate Huntingtin Gene Expression in Huntington's Patient-Derived Neural Model System

Author(s): Tea Umek, Thomas Olsson, Olof Gissberg, Osama Saher, Eman M. Zaghloul, Karin E. Lundin, Jesper Wengel, Eric Hanse, Henrik Zetterberg, Dzeneta Vizlin-Hodzic, C. I. Edvard Smith, Rula Zain
Published in: Nucleic Acid Therapeutics, 2021, ISSN 2159-3337
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/nat.2021.0021

PNA-Based MicroRNA Detection Methodologies

Author(s): Enrico Cadoni, Alex Manicardi, Annemieke Madder
Published in: Molecules, 25/6, 2020, Page(s) 1296, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25061296

Beyond small molecules: targeting G-quadruplex structures with oligonucleotides and their analogues

Author(s): Enrico Cadoni, Lessandro De Paepe, Alex Manicardi, Annemieke Madder
Published in: Nucleic Acids Research, 49/12, 2021, Page(s) 6638-6659, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkab334

Metal‐Mediated Base Pairing of Rigid and Flexible Benzaldoxime Metallacycles

Author(s): Sajal Maity, Madhuri Hande, Tuomas Lönnberg
Published in: ChemBioChem, 21/16, 2020, Page(s) 2321-2328, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202000135

Transfecting tissue models with CRISPR/Cas9 plasmid DNA using peptide dendrimers

Author(s): Susanna J. Zamolo, Tamis Darbre, Jean-Louis Reymond
Published in: Chemical Communications, 56/80, 2020, Page(s) 11981-11984, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cc04750c

Further Probing of Cu2+-Dependent PNAzymes Acting as Artificial RNA Restriction Enzymes.

Author(s): Olivia Luige; Merita Murtola; Alice Ghidini; Roger Strömberg
Published in: Molecules, 24 (4), 1, 2019, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3929/ethz-b-000327274

The Mechanism of Cleavage of RNA Phosphodiesters by a Gold Nanoparticle Nanozyme

Author(s): Joanna Czescik, Fabrizio Mancin, Roger Strömberg, Paolo Scrimin
Published in: Chemistry – A European Journal, 27/31, 2021, Page(s) 8143-8148, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202100299

Teaching photosensitizers a new trick: red light-triggered G-quadruplex alkylation by ligand co-localization

Author(s): Enrico Cadoni, Alex Manicardi, Mathieu Fossépré, Kaat Heirwegh, Mathieu Surin, Annemieke Madder
Published in: Chemical Communications, 57/8, 2021, Page(s) 1010-1013, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cc06030e

Synthesis and Hybridization Properties of Covalently Mercurated and Palladated Oligonucleotides

Author(s): Dattatraya Ukale, Sajal Maity, Madhuri Hande, Tuomas Lönnberg
Published in: Synlett, 30/15, 2019, Page(s) 1733-1737, ISSN 0936-5214
Publisher: Georg Thieme Verlag
DOI: 10.1055/s-0037-1611821

Palladacyclic Conjugate Group Promotes Hybridization of Short Oligonucleotides

Author(s): Madhuri Hande, Sajal Maity, Tuomas Lönnberg
Published in: International Journal of Molecular Sciences, 19/6, 2018, Page(s) 1588, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19061588

A Versatile and Convenient Synthesis of 34 S-Labeled Phosphorothioate Oligonucleotides

Author(s): Rouven Stulz, Johan Meuller, Dženita Baždarević, Charlotte Wennberg Huldt, Roger Strömberg, Shalini Andersson, Anders Dahlén
Published in: ChemBioChem, 19/19, 2018, Page(s) 2114-2119, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800417

Novel peptide-dendrimer/lipid/oligonucleotide ternary complexes for efficient cellular uptake and improved splice-switching activity

Author(s): Osama Saher, Cristina S.J. Rocha, Eman M. Zaghloul, Oscar P.B. Wiklander, Susanna Zamolo, Marc Heitz, Kariem Ezzat, Dhanu Gupta, Jean-Louis Reymond, Rula Zain, Florian Hollfelder, Tamis Darbre, Karin E. Lundin, Samir EL Andaloussi, C.I. Edvard Smith
Published in: European Journal of Pharmaceutics and Biopharmaceutics, 132, 2018, Page(s) 29-40, ISSN 0939-6411
Publisher: Elsevier BV
DOI: 10.1016/j.ejpb.2018.09.002

Oligonucleotide–Palladacycle Conjugates as Splice-Correcting Agents

Author(s): Madhuri Hande, Osama Saher, Karin Lundin, C. Smith, Rula Zain, Tuomas Lönnberg
Published in: Molecules, 24/6, 2019, Page(s) 1180, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24061180

Exploiting Double Exchange Diels-Alder Cycloadditions for Immobilization of Peptide Nucleic Acids on Gold Nanoparticles

Author(s): Enrico Cadoni, Daniele Rosa-Gastaldo, Alex Manicardi, Fabrizio Mancin, Annemieke Madder
Published in: Frontiers in Chemistry, 8, 2020, ISSN 2296-2646
Publisher: Frontiers
DOI: 10.3389/fchem.2020.00004

Factors Influencing the Activity of Nanozymes in the Cleavage of an RNA Model Substrate

Author(s): Czescik, Zamolo, Darbre, Mancin, Scrimin
Published in: Molecules, 24/15, 2019, Page(s) 2814, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24152814

Multifunctional, CD44v6-Targeted ORMOSIL Nanoparticles Enhance Drugs Toxicity in Cancer Cells

Author(s): Morillas-Becerril, Peta, Gabrielli, Russo, Lubian, Nodari, Ferlin, Scrimin, Palù, Barzon, Castagliuolo, Mancin, Trevisan
Published in: Nanomaterials, 10/2, 2020, Page(s) 298, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano10020298

Oligonucleotide Binding to Non-B-DNA in MYC

Author(s): Tea Umek, Karin Sollander, Helen Bergquist, Jesper Wengel, Karin E. Lundin, C.I. Edvard Smith, Rula Zain
Published in: Molecules, 24/5, 2019, Page(s) 1000, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24051000

Sugar and Polymer Excipients Enhance Uptake and Splice-Switching Activity of Peptide-Dendrimer/Lipid/Oligonucleotide Formulations

Author(s): Osama Saher, Taavi Lehto, Olof Gissberg, Dhanu Gupta, Oskar Gustafsson, Samir EL Andaloussi, Tamis Darbre, Karin E. Lundin, C. I. Edvard Smith, Rula Zain
Published in: Pharmaceutics, 11/12, 2019, Page(s) 666, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics11120666

Poly(lipoic acid)-Based Nanoparticles as Self-Organized, Biocompatible, and Corona-Free Nanovectors

Author(s): Jakub W. Trzciński, Lucía Morillas-Becerril, Sara Scarpa, Marco Tannorella, Francesco Muraca, Federico Rastrelli, Chiara Castellani, Marny Fedrigo, Annalisa Angelini, Regina Tavano, Emanuele Papini, Fabrizio Mancin
Published in: Biomacromolecules, 22/2, 2021, Page(s) 467-480, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.0c01321

Visible-light triggered templated ligation on surface using furan-modified PNAs

Author(s): Alex Manicardi, Enrico Cadoni, Annemieke Madder
Published in: Chemical Science, 11/43, 2020, Page(s) 11729-11739, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sc04875e

New Alkyne and Amine Linkers for Versatile Multiple Conjugation of Oligonucleotides

Author(s): Dmytro Honcharenko, Kristina Druceikaite, Malgorzata Honcharenko, Martin Bollmark, Ulf Tedebark, Roger Strömberg
Published in: ACS Omega, 6/1, 2021, Page(s) 579-593, ISSN 2470-1343
Publisher: American Chemical Society
DOI: 10.1021/acsomega.0c05075