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Molecular Tools for Nucleic Acid Manipulation for Biological Intervention

Deliverables

Summer School

A five day summer school, open to the public, will be organised by beneficiary KI entitled Nucleic Acids in Therapy

Science communication course

(month 8): a Science Communication course that develops their skills in conveying complex scientific ideas to a general audience, and provide the technical skills to prepare videos and podcasts will be provided.

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Publications

Palladacyclic Conjugate Group Promotes Hybridization of Short Oligonucleotides

Author(s): Madhuri Hande, Sajal Maity, Tuomas Lönnberg
Published in: International Journal of Molecular Sciences, Issue 19/6, 2018, Page(s) 1588, ISSN 1422-0067
DOI: 10.3390/ijms19061588

A Versatile and Convenient Synthesis of 34 S-Labeled Phosphorothioate Oligonucleotides


Published in: ISSN 1439-4227
DOI: 10.1002/cbic.201800417

Novel peptide-dendrimer/lipid/oligonucleotide ternary complexes for efficient cellular uptake and improved splice-switching activity

Author(s): Osama Saher, Cristina S.J. Rocha, Eman M. Zaghloul, Oscar P.B. Wiklander, Susanna Zamolo, Marc Heitz, Kariem Ezzat, Dhanu Gupta, Jean-Louis Reymond, Rula Zain, Florian Hollfelder, Tamis Darbre, Karin E. Lundin, Samir EL Andaloussi, C.I. Edvard Smith
Published in: European Journal of Pharmaceutics and Biopharmaceutics, Issue 132, 2018, Page(s) 29-40, ISSN 0939-6411
DOI: 10.1016/j.ejpb.2018.09.002

Oligonucleotide–Palladacycle Conjugates as Splice-Correcting Agents

Author(s): Madhuri Hande, Osama Saher, Karin Lundin, C. Smith, Rula Zain, Tuomas Lönnberg
Published in: Molecules, Issue 24/6, 2019, Page(s) 1180, ISSN 1420-3049
DOI: 10.3390/molecules24061180

Exploiting Double Exchange Diels-Alder Cycloadditions for Immobilization of Peptide Nucleic Acids on Gold Nanoparticles

Author(s): Enrico Cadoni, Daniele Rosa-Gastaldo, Alex Manicardi, Fabrizio Mancin, Annemieke Madder
Published in: Frontiers in Chemistry, Issue 8, 2020, ISSN 2296-2646
DOI: 10.3389/fchem.2020.00004

Factors Influencing the Activity of Nanozymes in the Cleavage of an RNA Model Substrate

Author(s): Czescik, Zamolo, Darbre, Mancin, Scrimin
Published in: Molecules, Issue 24/15, 2019, Page(s) 2814, ISSN 1420-3049
DOI: 10.3390/molecules24152814

Multifunctional, CD44v6-Targeted ORMOSIL Nanoparticles Enhance Drugs Toxicity in Cancer Cells

Author(s): Morillas-Becerril, Peta, Gabrielli, Russo, Lubian, Nodari, Ferlin, Scrimin, Palù, Barzon, Castagliuolo, Mancin, Trevisan
Published in: Nanomaterials, Issue 10/2, 2020, Page(s) 298, ISSN 2079-4991
DOI: 10.3390/nano10020298

Oligonucleotide Binding to Non-B-DNA in MYC

Author(s): Tea Umek, Karin Sollander, Helen Bergquist, Jesper Wengel, Karin E. Lundin, C.I. Edvard Smith, Rula Zain
Published in: Molecules, Issue 24/5, 2019, Page(s) 1000, ISSN 1420-3049
DOI: 10.3390/molecules24051000

Sugar and Polymer Excipients Enhance Uptake and Splice-Switching Activity of Peptide-Dendrimer/Lipid/Oligonucleotide Formulations

Author(s): Osama Saher, Taavi Lehto, Olof Gissberg, Dhanu Gupta, Oskar Gustafsson, Samir EL Andaloussi, Tamis Darbre, Karin E. Lundin, C. I. Edvard Smith, Rula Zain
Published in: Pharmaceutics, Issue 11/12, 2019, Page(s) 666, ISSN 1999-4923
DOI: 10.3390/pharmaceutics11120666