Molecular Tools for Nucleic Acid Manipulation for Biological Intervention

Risultati finali

Public engagement and dissemination of achievements

month 44: Participation in public open day to disseminate the project outcomes

A five day summer school, open to the public, will be organised by beneficiary KI entitled Nucleic Acids in Therapy

(month 8): a Science Communication course that develops their skills in conveying complex scientific ideas to a general audience, and provide the technical skills to prepare videos and podcasts will be provided.

Network Conference

month 44 A twoday conference to showcase the research area and the achievements of the network accessible to the general public This can be a free standing event or part of a relevant conference eg the Annual Meetings of the Oligonucleotide Therapeutics Society or the International Round Table on Nucleosides Nucleotides and Nucleic Acids in Stockholm JuneJuly 2018

Website, ESR webpages and Moodle operational

Pubblicazioni

Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides

Autori: Haneen Daralnakhla, Osama Saher, Susanna Zamolo, Safa Bazaz, Jeremy P. Bost, Marc Heitz, Karin E. Lundin, Samir EL Andaloussi, Tamis Darbre, Jean-Louis Reymond, Rula Zain, C. I. Edvard Smith
Pubblicato in: Pharmaceutics, Numero 13/1, 2021, Pagina/e 116, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13010116

Sequence dependence of Pd(II)-mediated base pairing by palladacyclic nucleobase surrogates

Autori: Madhuri Hande, Sajal Maity, Tuomas Lönnberg
Pubblicato in: Journal of Inorganic Biochemistry, Numero 222, 2021, Pagina/e 111506, ISSN 0162-0134
Editore: Elsevier BV
DOI: 10.1016/j.jinorgbio.2021.111506

Oligonucleotides Targeting DNA Repeats Downregulate Huntingtin Gene Expression in Huntington's Patient-Derived Neural Model System

Autori: Tea Umek, Thomas Olsson, Olof Gissberg, Osama Saher, Eman M. Zaghloul, Karin E. Lundin, Jesper Wengel, Eric Hanse, Henrik Zetterberg, Dzeneta Vizlin-Hodzic, C. I. Edvard Smith, Rula Zain
Pubblicato in: Nucleic Acid Therapeutics, 2021, ISSN 2159-3337
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/nat.2021.0021

PNA-Based MicroRNA Detection Methodologies

Autori: Enrico Cadoni, Alex Manicardi, Annemieke Madder
Pubblicato in: Molecules, Numero 25/6, 2020, Pagina/e 1296, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25061296

Beyond small molecules: targeting G-quadruplex structures with oligonucleotides and their analogues

Autori: Enrico Cadoni, Lessandro De Paepe, Alex Manicardi, Annemieke Madder
Pubblicato in: Nucleic Acids Research, Numero 49/12, 2021, Pagina/e 6638-6659, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkab334

Metal‐Mediated Base Pairing of Rigid and Flexible Benzaldoxime Metallacycles

Autori: Sajal Maity, Madhuri Hande, Tuomas Lönnberg
Pubblicato in: ChemBioChem, Numero 21/16, 2020, Pagina/e 2321-2328, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202000135

Transfecting tissue models with CRISPR/Cas9 plasmid DNA using peptide dendrimers

Autori: Susanna J. Zamolo, Tamis Darbre, Jean-Louis Reymond
Pubblicato in: Chemical Communications, Numero 56/80, 2020, Pagina/e 11981-11984, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d0cc04750c

Further Probing of Cu2+-Dependent PNAzymes Acting as Artificial RNA Restriction Enzymes.

Autori: Olivia Luige; Merita Murtola; Alice Ghidini; Roger Strömberg
Pubblicato in: Molecules, 24 (4), Numero 1, 2019, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3929/ethz-b-000327274

The Mechanism of Cleavage of RNA Phosphodiesters by a Gold Nanoparticle Nanozyme

Autori: Joanna Czescik, Fabrizio Mancin, Roger Strömberg, Paolo Scrimin
Pubblicato in: Chemistry – A European Journal, Numero 27/31, 2021, Pagina/e 8143-8148, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202100299

Teaching photosensitizers a new trick: red light-triggered G-quadruplex alkylation by ligand co-localization

Autori: Enrico Cadoni, Alex Manicardi, Mathieu Fossépré, Kaat Heirwegh, Mathieu Surin, Annemieke Madder
Pubblicato in: Chemical Communications, Numero 57/8, 2021, Pagina/e 1010-1013, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d0cc06030e

Synthesis and Hybridization Properties of Covalently Mercurated and Palladated Oligonucleotides

Autori: Dattatraya Ukale, Sajal Maity, Madhuri Hande, Tuomas Lönnberg
Pubblicato in: Synlett, Numero 30/15, 2019, Pagina/e 1733-1737, ISSN 0936-5214
Editore: Georg Thieme Verlag
DOI: 10.1055/s-0037-1611821

Palladacyclic Conjugate Group Promotes Hybridization of Short Oligonucleotides

Autori: Madhuri Hande, Sajal Maity, Tuomas Lönnberg
Pubblicato in: International Journal of Molecular Sciences, Numero 19/6, 2018, Pagina/e 1588, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19061588

A Versatile and Convenient Synthesis of 34 S-Labeled Phosphorothioate Oligonucleotides

Autori: Rouven Stulz, Johan Meuller, Dženita Baždarević, Charlotte Wennberg Huldt, Roger Strömberg, Shalini Andersson, Anders Dahlén
Pubblicato in: ChemBioChem, Numero 19/19, 2018, Pagina/e 2114-2119, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800417

Oligonucleotide–Palladacycle Conjugates as Splice-Correcting Agents

Autori: Madhuri Hande, Osama Saher, Karin Lundin, C. Smith, Rula Zain, Tuomas Lönnberg
Pubblicato in: Molecules, Numero 24/6, 2019, Pagina/e 1180, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24061180

Exploiting Double Exchange Diels-Alder Cycloadditions for Immobilization of Peptide Nucleic Acids on Gold Nanoparticles

Autori: Enrico Cadoni, Daniele Rosa-Gastaldo, Alex Manicardi, Fabrizio Mancin, Annemieke Madder
Pubblicato in: Frontiers in Chemistry, Numero 8, 2020, ISSN 2296-2646
Editore: Frontiers
DOI: 10.3389/fchem.2020.00004

Factors Influencing the Activity of Nanozymes in the Cleavage of an RNA Model Substrate

Autori: Czescik, Zamolo, Darbre, Mancin, Scrimin
Pubblicato in: Molecules, Numero 24/15, 2019, Pagina/e 2814, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24152814

Multifunctional, CD44v6-Targeted ORMOSIL Nanoparticles Enhance Drugs Toxicity in Cancer Cells

Autori: Morillas-Becerril, Peta, Gabrielli, Russo, Lubian, Nodari, Ferlin, Scrimin, Palù, Barzon, Castagliuolo, Mancin, Trevisan
Pubblicato in: Nanomaterials, Numero 10/2, 2020, Pagina/e 298, ISSN 2079-4991
Editore: MDPI
DOI: 10.3390/nano10020298

Oligonucleotide Binding to Non-B-DNA in MYC

Autori: Tea Umek, Karin Sollander, Helen Bergquist, Jesper Wengel, Karin E. Lundin, C.I. Edvard Smith, Rula Zain
Pubblicato in: Molecules, Numero 24/5, 2019, Pagina/e 1000, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24051000

Sugar and Polymer Excipients Enhance Uptake and Splice-Switching Activity of Peptide-Dendrimer/Lipid/Oligonucleotide Formulations

Autori: Osama Saher, Taavi Lehto, Olof Gissberg, Dhanu Gupta, Oskar Gustafsson, Samir EL Andaloussi, Tamis Darbre, Karin E. Lundin, C. I. Edvard Smith, Rula Zain
Pubblicato in: Pharmaceutics, Numero 11/12, 2019, Pagina/e 666, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics11120666

Poly(lipoic acid)-Based Nanoparticles as Self-Organized, Biocompatible, and Corona-Free Nanovectors

Autori: Jakub W. Trzciński, Lucía Morillas-Becerril, Sara Scarpa, Marco Tannorella, Francesco Muraca, Federico Rastrelli, Chiara Castellani, Marny Fedrigo, Annalisa Angelini, Regina Tavano, Emanuele Papini, Fabrizio Mancin
Pubblicato in: Biomacromolecules, Numero 22/2, 2021, Pagina/e 467-480, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.0c01321

Visible-light triggered templated ligation on surface using furan-modified PNAs

Autori: Alex Manicardi, Enrico Cadoni, Annemieke Madder
Pubblicato in: Chemical Science, Numero 11/43, 2020, Pagina/e 11729-11739, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d0sc04875e

New Alkyne and Amine Linkers for Versatile Multiple Conjugation of Oligonucleotides

Autori: Dmytro Honcharenko, Kristina Druceikaite, Malgorzata Honcharenko, Martin Bollmark, Ulf Tedebark, Roger Strömberg
Pubblicato in: ACS Omega, Numero 6/1, 2021, Pagina/e 579-593, ISSN 2470-1343
Editore: American Chemical Society
DOI: 10.1021/acsomega.0c05075

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