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Translational Research Network in Prostate Cancer

Deliverables

ESRs Recruitment

Recruitment of ESRs

Abstracts for international conferences; Publications submitted to high impact journals

Abstracts for international conferences; Publications submitted to high impact journals

Theses and awarding of doctoral degrees

These and awarding of doctoral degrees

PCDP and researcher declarations

PCDP and researcher declarations

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Publications

A meta-analytical approach to the molecular subtyping of prostate cancer

Author(s): McKinney C
Published in: European Urology Supplements, 18/08, 2019, Page(s) e3126, ISSN 1569-9056
Publisher: Elsevier B.V.

Proteomic analysis of formalin fixed tissues for the investigation of prostate cancer

Author(s): Mantsiou A, Makridakis M, Fasoulakis K, Fasoulakis C, Zoidakis J, Vlahou A
Published in: European Urology Supplements, 18/08, 2019, Page(s) e3081, ISSN 1569-9056
Publisher: Elsevier B.V.

In vitro prostate differentiation of induced pluripotent stem cells and organoid generation using seminal vesicle mesenchyme

Author(s): Singh P, Robson C.N, Heer R
Published in: European Urology Supplements, 17/10, 2018, Page(s) e2557, ISSN 1569-9056
Publisher: Elsevier B.V.

In vitro prostate tissue generation using induced pluripotent stem cells and rodent seminal vesicle mesenchyme

Author(s): Singh P, Robson C.N, Heer R
Published in: European Urology Supplements, 18/08, 2019, Page(s) e3092, ISSN 1569-9056
Publisher: Elsevier B.V.

Approaches to enrich for androgen receptor binding sites in low-cell number samples

Author(s): Umbreen S, Steele R.E., Poulose N, Mcdade S, Mccabe N, Mills I.G.
Published in: European Urology Supplements, 17/10, 2018, Page(s) e2499, ISSN 1569-9056
Publisher: Elsevier B.V.

SLFN5 regulates amino acid metabolism by altering LAT1 expression in CRPC

Author(s): Sánchez Martínez R, Salji M, Rushworth L, Galbraith L, Knight J, Samson O, Rodriguez Blanco G, Mackay G, Lilla S, Zanivan S, Blomme A, Leung H
Published in: European Urology Supplements, 18/08, 2019, Page(s) e3068, ISSN 1569-9056
Publisher: Elsevier B.V.

Establishment of prostate cancer organoids: tips, tricks and pitfalls

Author(s): Van Hemelryk A, Teubel W.J., De Ridder C.M.A., Erkens-Schulze S, Mout L, Van Royen M.E, Van Weerden W.M.
Published in: European Urology Supplements, 17/10, 2018, Page(s) e2530, ISSN 1569-9056
Publisher: Elsevier B.V.

Evaluating multicellular contributions to the maintenance of AR activity under conditions of androgen deprivation

Author(s): Umbreen S, Steele R.E., Poulose N, Congiano M, Afshan S, Beumer I, Nees M, Harkonen P, Mccabe N, Mcdade S, Mills I.G.
Published in: European Urology Supplements, 18/08, 2019, Page(s) e3137, ISSN 1569-9056
Publisher: Elsevier B.V.

Characterization of robust and prognostic molecular subtypes in prostate cancer

Author(s): McKinney C, McCabe N, Harkin D.P., Kennedy R, Blayney J
Published in: Cancer Research, 2020
Publisher: American Association for Cancer Research
DOI: 10.1158/1538-7445.am2020-2135

Assessment of prostate cancer aggressiveness using metabolomics evaluation of urine by NMR spectroscopy

Author(s): Kdadra M, Jagdhuber R, Kremer W, Eiglsperger J, Schiffer E
Published in: European Urology Supplements, 18/08, 2019, Page(s) e3111, ISSN 1569-9056
Publisher: Elsevier B.V.

A meta-analytical approach to the molecular subtyping of prostate cancer

Author(s): Mckinney C, Mccabe N, Harkin D.P, Kennedy R, Blayney J
Published in: European Urology Supplements, 17/10, 2018, Page(s) e2510, ISSN 1569-9056
Publisher: Elsevier B.V.

A novel panel of patient-derived preclinical models of prostate cancer: xenografts and PDX-derived organoids to recapitulate patients disease profiles

Author(s): Van Hemelryk A, De Ridder C.M.A., Erkens-Schulze S, Teubel W.J., Stuurman D, Mc Kinney C, Cangiano M, Beumer I.J., Van WeerdenW.M.
Published in: European Urology Supplements, 18/08, 2019, Page(s) e3116, ISSN 1569-9056
Publisher: Elsevier B.V.

Study on the possible interactions between FGFRL1- and AR-regulated mechanisms in prostate cancer

Author(s): Afshan S, Umbreen S, Yu L, Toriseva M, Nees M, Härkönen P, Mills I
Published in: European Urology Supplements, 18/08, 2019, Page(s) e3039, ISSN 1569-9056
Publisher: Elsevier B.V.

Identification of novel long non-coding RNA based biomarkers in prostate cancer

Author(s): Sattari M, Kohvakka A, Urhonen H, Moradi E, Rauhala H, Nykter M, Latonen L, Bova G.S., Kesseli J, Visakorpi T
Published in: European Urology Supplements, 18/08, 2019, Page(s) e3078, ISSN 1569-9056
Publisher: Elsevier B.V.

Regulation of SLFN5 by androgens in castration resistant prostate cancer

Author(s): Sánchez Martínez R, Salji M , Rushworth L, Lilla S, Zanivan S, Leung H
Published in: European Urology Supplements, 17/10, 2018, Page(s) e2555, ISSN 1569-9056
Publisher: Elsevier B.V.

Proteomic studies in clinical tissues for the investigation of prostate cancer

Author(s): Mantsiou A, Zoidakis J, Vlahou A
Published in: European Urology Supplements, 17/10, 2018, Page(s) e2498, ISSN 1569-9056
Publisher: Elsevier B.V.

Network analysis of prostate cancer-derived CWR22, LNCaP and VCAP xenografts for elucidation of the key regulators in castration resistance development

Author(s): Cangiano M, Granchi Z, Janssen B, Salji M, Leung H
Published in: European Urology Supplements, 17/10, 2018, Page(s) e2483, ISSN 1569-9056
Publisher: Elsevier B.V.

A transcription factor activity profile as a prognostic signature for recurrence predisposition in prostate cancer patients.

Author(s): Cangiano M, Leung H, Janssen B, Nykter M, Jenster G
Published in: European Urology Supplements, 18/08, 2019, Page(s) e3048-e3049, ISSN 1569-9056
Publisher: Elsevier B.V.

Gene Regulation Network Analysis on Human Prostate Orthografts Highlights a Potential Role for the JMJD6 Regulon in Clinical Prostate Cancer

Author(s): Mario Cangiano, Magda Grudniewska, Mark J. Salji, Matti Nykter, Guido Jenster, Alfonso Urbanucci, Zoraide Granchi, Bart Janssen, Graham Hamilton, Hing Y. Leung, Inès J. Beumer
Published in: Cancers, 13/9, 2021, Page(s) 2094, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13092094

Proteomics Analysis of Formalin Fixed Paraffin Embedded Tissues in the Investigation of Prostate Cancer

Author(s): Anna Mantsiou, Manousos Makridakis, Konstantinos Fasoulakis, Ioannis Katafigiotis, Constantinos A. Constantinides, Jerome Zoidakis, Maria G. Roubelakis, Antonia Vlahou, Vasiliki Lygirou
Published in: Journal of Proteome Research, 19/7, 2020, Page(s) 2631-2642, ISSN 1535-3893
Publisher: American Chemical Society
DOI: 10.1021/acs.jproteome.9b00587

The induction of core pluripotency master regulators in cancers defines poor clinical outcomes and treatment resistance

Author(s): A. C. Hepburn, R. E. Steele, R. Veeratterapillay, L. Wilson, E. E. Kounatidou, A. Barnard, P. Berry, J. R. Cassidy, M. Moad, A. El-Sherif, L. Gaughan, I. G. Mills, C. N. Robson, R. Heer
Published in: Oncogene, 38/22, 2019, Page(s) 4412-4424, ISSN 0950-9232
Publisher: Nature Publishing Group
DOI: 10.1038/s41388-019-0712-y

Novel patient-derived 3D culture models to guide clinical decision-making in prostate cancer

Author(s): Annelies Van Hemelryk, Wytske M. van Weerden
Published in: Current Opinion in Endocrine and Metabolic Research, 10, 2020, Page(s) 7-15, ISSN 2451-9650
Publisher: Elsevier Ltd.
DOI: 10.1016/j.coemr.2020.02.005

Propagation of human prostate tissue from induced pluripotent stem cells

Author(s): Anastasia C. Hepburn, Emma L. Curry, Mohammad Moad, Rebecca E. Steele, Omar E. Franco, Laura Wilson, Parmveer Singh, Adriana Buskin, Susan E. Crawford, Luke Gaughan, Ian G. Mills, Simon W. Hayward, Craig N. Robson, Rakesh Heer
Published in: STEM CELLS Translational Medicine, 9/7, 2020, Page(s) 734-745, ISSN 2157-6564
Publisher: AlphaMed Press
DOI: 10.1002/sctm.19-0286

In vitro prostate differentiation of induced pluripotent stem cells and organoid generation using seminal vesicle mesenchyme

Author(s): P. Singh, C.N. Robson, R. Heer
Published in: European Urology Supplements, 17/10, 2018, Page(s) e2557, ISSN 1569-9056
Publisher: Elsevier BV
DOI: 10.1016/s1569-9056(18)33034-3

Approaches to enrich for androgen receptor binding sites in low-cell number samples

Author(s): S. Umbreen, R.E. Steele, N. Poulose, S. Mcdade, N. Mccabe, I.G. Mills
Published in: European Urology Supplements, 17/10, 2018, Page(s) e2499, ISSN 1569-9056
Publisher: Elsevier BV
DOI: 10.1016/s1569-9056(18)32982-8

Metabolomics Biomarkers of Prostate Cancer: A Systematic Review

Author(s): Marouane Kdadra, Sebastian Höckner, Hing Leung, Werner Kremer, Eric Schiffer
Published in: Diagnostics, 9/1, 2019, Page(s) 21, ISSN 2075-4418
Publisher: Multidisciplinary Digital Publishing Institute
DOI: 10.3390/diagnostics9010021

Tissue proteomics studies in the investigation of prostate cancer

Author(s): Anna Mantsiou, Antonia Vlahou, Jerome Zoidakis
Published in: Expert Review of Proteomics, 15/7, 2018, Page(s) 593-611, ISSN 1478-9450
Publisher: Future Drugs Ltd.
DOI: 10.1080/14789450.2018.1491796