Research:
All 11 ESRs worked on their individual research projects with a focus on methods for omics data generation (n=4), methods for data analysis (n=4) and data science (n=3). ESRs crossed boundaries and worked jointly to understand the nature of the omics measurements, the assumptions of statistical methods which were used for data analysis, to interpret the results and to discuss their possible impact.
The ESRs developed new techniques for high throughput and in depth glycomic and glycoproteomic data generation. They developed novel network methods for visualisation of the relationships between features of large omic datasets and robust and flexible statistical models for data integration and for assessing the effect of time varying biomarkers on traits. They integrated genetic markers, transcriptomic, epigenetic and glycomic datasets from the consortium cohorts: ORCADES, TwinsUK and Down Syndrome. Application of our novel methods for data generation and analysis resulted in new insights and potential new glycomic biomarkers. Genome wide analysis of genetic and epigenetic markers and their associations with glycans and chronic widespread pain (CWP) resulted in several novel loci. We derived a score based on glycans and clinical variables representing biological age.
Three of the 11 ESRs have already obtained their PhD, and four ESRs have obtained employment (two in industry, one in academia, and one in government).
Training:
Our network comprises ESRs in chemistry, statistics, biology and epidemiology. To train our ESRs we delivered a set of modules which covers the basics of relevant lab techniques, statistical and machine learning techniques, epidemiology and biology. The ESRs also followed a set of modules in commerce and entrepreneurship, complementary skills, and we developed a module for thinking interdisciplinary.
Secondments to partner institutions were key in the development of ESRs’ skills needed to perform high impact research in a multidisciplinary environment and to become scientists able to bridge disciplines.
Finally, organization of the two final workshops, including chairing of sessions, provided the ESRs a fruitful experience. Due to their active role, these activities were lively despite being online and well valued by participants.
Dissemination:
We have already published 35 papers in open access journals (as of September 2021) and there are several submitted papers, including six to a special issue containing contributions of one of the IMforFUTURE workshops. The ESRs have presented their work at international conferences and at our workshops.
Public Engagement:
All ESRs participated in public engagement activities in a primary school in Croatia and at the University of Split. We created a cartoon on the benefits of interdisciplinary collaborations.
