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An integrated interdisciplinary approach to animal-free chemical and nanomaterial safety assessment

Deliverables

Hands-on technical workshops

A series of workshops will take place at beneficiaries or partner facilities to allow handson practical training in key areas ESRs will be expected to attend at least two of these training courses These will be organised in smaller groups with a maximum of 6 participants and will where possible be run in parallel on two occasions The workshops will last a minimum of 5 days 2 ECTS

PhD awards

ESRs will ultimately be awarded their PhD degrees

Distribution of Recruitment advertisement and application form

Add recruitment advertisement and application form to the in3 web-page and other job searching services such as Nature Jobs.

Network-wide face to face training events

We will organize 6 training courses allowing all ESR to participate in them The training courses will be in line with the project objectives and timescales and will be held as 2 day courses after the biyearly facetoface meetings

On-line learning series

An online lecture series will be setup to provide background information to the field of animal free safety assessment and also to create an interactive case study where practical skills will be fostered and trained The courses will takeplace from M13M20 at allocated time slots of no more than 2 hours per day to facilitate ESRs research activities The courses will be allowed overlap Course material will be provided before commencement Lectures will be recorded with documentation and outcomes and placed on the in3 webpage If the instructor allows the recorded courses will be added to the in3 YouTube channel The courses provided are listed below Total 122 hrs and 49 ECTS These courses will be supplemented by courses requested by ESRs or even courses given by ESRs We will keep in mind the possibility of creating a massive open online course MOOC for beyond lifetime of the project

Establish in3 web page

We will create the in3 website, which will facilitate both internal and external communication containing, description of the project, an ESR recruitment call, training programs, training material (slides from the courses, exercises), links to software, relevant training literature, FAQ on 3R-alternative methods or relevant websites e.g. Alttox.org, schedule of in3 events and information on the partners. P5 will be responsible for the technical organisation of webinars. The results of the project will be disseminated at local meetings and international conferences via poster presentations and oral communication. Results will be published in peer reviewed scientific journals. A yearly report summary will be generated and published online and disseminated to members of existing networks such as EUROTOX, ESTIV, SEURAT-1 and the EPAA (European partnership for alternatives approaches, a public-private partnership between European commission and the industry). A version of this will be translated and sent to local press agencies.

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Publications

CD34+ derived macrophage and dendritic cells display differential responses to paraquat

Author(s): Leonie F.H. Fransen, Martin O. Leonard
Published in: Toxicology in Vitro, 75, 2021, Page(s) 105198, ISSN 0887-2333
Publisher: Elsevier BV
DOI: 10.1016/j.tiv.2021.105198

Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound

Author(s): Sara Wellens, Lucie Dehouck, Vidya Chandrasekaran, Pranika Singh, Rodrigo Azevedo Loiola, Emmanuel Sevin, Thomas Exner, Paul Jennings, Fabien Gosselet, Maxime Culot
Published in: Toxicology in Vitro, 73, 2021, Page(s) 105112, ISSN 0887-2333
Publisher: Elsevier BV
DOI: 10.1016/j.tiv.2021.105112

Neuroinflammatory Response to TNFα and IL1β Cytokines Is Accompanied by an Increase in Glycolysis in Human Astrocytes In Vitro

Author(s): David Pamies, Chiara Sartori, Domitille Schvartz, Víctor González-Ruiz, Luc Pellerin, Carolina Nunes, Denise Tavel, Vanille Maillard, Julien Boccard, Serge Rudaz, Jean-Charles Sanchez, Marie-Gabrielle Zurich
Published in: International Journal of Molecular Sciences, 22/8, 2021, Page(s) 4065, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22084065

Differentiation of human iPSCs into functional podocytes

Author(s): Caroline Rauch, Elisabeth Feifel, Georg Kern, Cormac Murphy, Florian Meier, Walther Parson, Mario Beilmann, Paul Jennings, Gerhard Gstraunthaler, Anja Wilmes
Published in: PLOS ONE, 13/9, 2018, Page(s) e0203869, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0203869

Development and analysis of an adverse outcome pathway network for human neurotoxicity

Author(s): Nicoleta Spinu, Anna Bal-Price, Mark T. D. Cronin, Steven J. Enoch, Judith C. Madden, Andrew P. Worth
Published in: Archives of Toxicology, 2019, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-019-02551-1

Ensemble-Based Modeling of Chemical Compounds with Antimalarial Activity

Author(s): Ana Yisel Caballero-Alfonso, Maykel Cruz-Monteagudo, Eduardo Tejera, Emilio Benfenati, Fernanda Borges, M. Natália D.S. Cordeiro, Vinicio Armijos-Jaramillo, Yunierkis Perez-Castillo
Published in: Current Topics in Medicinal Chemistry, 19/11, 2019, Page(s) 957-969, ISSN 1568-0266
Publisher: Bentham Science Publishers
DOI: 10.2174/1568026619666190510100313

Multiclass Classifier for P-Glycoprotein Substrates, Inhibitors, and Non-Active Compounds

Author(s): Liadys Mora Lagares, Nikola Minovski, Marjana Novič
Published in: Molecules, 24/10, 2019, Page(s) 2006, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24102006

Homology Modeling of the Human P-glycoprotein (ABCB1) and Insights into Ligand Binding through Molecular Docking Studies

Author(s): Liadys Mora Lagares, Nikola Minovski, Ana Yisel Caballero Alfonso, Emilio Benfenati, Sara Wellens, Maxime Culot, Fabien Gosselet, Marjana Novič
Published in: International Journal of Molecular Sciences, 21/11, 2020, Page(s) 4058, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21114058

Methodology of aiQSAR: a group-specific approach to QSAR modelling

Author(s): Kristijan Vukovic, Domenico Gadaleta, Emilio Benfenati
Published in: Journal of Cheminformatics, 11/1, 2019, ISSN 1758-2946
Publisher: Chemistry Central
DOI: 10.1186/s13321-019-0350-y

Quantitative adverse outcome pathway (qAOP) models for toxicity prediction

Author(s): Nicoleta Spinu, Mark T. D. Cronin, Steven J. Enoch, Judith C. Madden, Andrew P. Worth
Published in: Archives of Toxicology, 94/5, 2020, Page(s) 1497-1510, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-020-02774-7

Towards an Understanding of the Mode of Action of Human Aromatase Activity for Azoles through Quantum Chemical Descriptors-Based Regression and Structure Activity Relationship Modeling Analysis

Author(s): Chayawan Chayawan, Cosimo Toma, Emilio Benfenati, Ana Y. Caballero Alfonso
Published in: Molecules, 25/3, 2020, Page(s) 739, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25030739

Generation and characterization of iPSC-derived renal proximal tubule-like cells with extended stability

Author(s): Vidya Chandrasekaran, Giada Carta, Daniel da Costa Pereira, Rajinder Gupta, Cormac Murphy, Elisabeth Feifel, Georg Kern, Judith Lechner, Anna Lina Cavallo, Shailesh Gupta, Florian Caiment, Jos C. S. Kleinjans, Gerhard Gstraunthaler, Paul Jennings, Anja Wilmes
Published in: Scientific Reports, 11/1, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-89550-4

Temporal transcriptomic alterations of cadmium exposed human iPSC-derived renal proximal tubule-like cells

Author(s): Pranika Singh, Vidya Chandrasekaran, Barry Hardy, Anja Wilmes, Paul Jennings, Thomas E. Exner
Published in: Toxicology in Vitro, 76, 2021, Page(s) 105229, ISSN 0887-2333
Publisher: Elsevier BV
DOI: 10.1016/j.tiv.2021.105229

Insights into PCDD/Fs and PAHs in Biomass Boilers Envisaging Risks of Ash Use as Fertilizers

Author(s): Helena Lopes, Susana Proença
Published in: Applied Sciences, 10/14, 2020, Page(s) 4951, ISSN 2076-3417
Publisher: MDPI Open Access Journals
DOI: 10.3390/app10144951

SAR and QSAR modeling of a large collection of LD50 rat acute oral toxicity data

Author(s): Domenico Gadaleta, Kristijan Vuković, Cosimo Toma, Giovanna J. Lavado, Agnes L. Karmaus, Kamel Mansouri, Nicole C. Kleinstreuer, Emilio Benfenati, Alessandra Roncaglioni
Published in: Journal of Cheminformatics, 11/1, 2019, ISSN 1758-2946
Publisher: Chemistry Central
DOI: 10.1186/s13321-019-0383-2

SARS-CoV-2 infects an upper airway model derived from induced pluripotent stem cells

Author(s): Ivo Djidrovski, Maria Georgiou, Grant L. Hughes, Edward I. Patterson, Aitor Casas-Sanchez, Shaun H. Pennington, Giancarlo A. Biagini, Marina Moya-Molina, Jelle van den Bor, Martine J. Smit, Git Chung, Majlinda Lako, Lyle Armstrong
Published in: STEM CELLS, 2021, ISSN 1066-5099
Publisher: AlphaMed Press Inc
DOI: 10.1002/stem.3422

Small Airway Susceptibility to Chemical and Particle Injury

Author(s): Leonie Francina Hendrina Fransen, Martin Oliver Leonard
Published in: Respiration, 2021, Page(s) 1-13, ISSN 0025-7931
Publisher: Karger AG
DOI: 10.1159/000519344