Resultado final Other (4) Hands-on technical workshops A series of workshops will take place at beneficiaries or partner facilities to allow handson practical training in key areas ESRs will be expected to attend at least two of these training courses These will be organised in smaller groups with a maximum of 6 participants and will where possible be run in parallel on two occasions The workshops will last a minimum of 5 days 2 ECTS PhD awards ESRs will ultimately be awarded their PhD degrees Distribution of Recruitment advertisement and application form Add recruitment advertisement and application form to the in3 web-page and other job searching services such as Nature Jobs. Network-wide face to face training events We will organize 6 training courses allowing all ESR to participate in them The training courses will be in line with the project objectives and timescales and will be held as 2 day courses after the biyearly facetoface meetings Websites, patent fillings, videos etc. (2) On-line learning series An online lecture series will be setup to provide background information to the field of animal free safety assessment and also to create an interactive case study where practical skills will be fostered and trained The courses will takeplace from M13M20 at allocated time slots of no more than 2 hours per day to facilitate ESRs research activities The courses will be allowed overlap Course material will be provided before commencement Lectures will be recorded with documentation and outcomes and placed on the in3 webpage If the instructor allows the recorded courses will be added to the in3 YouTube channel The courses provided are listed below Total 122 hrs and 49 ECTS These courses will be supplemented by courses requested by ESRs or even courses given by ESRs We will keep in mind the possibility of creating a massive open online course MOOC for beyond lifetime of the project Establish in3 web page We will create the in3 website, which will facilitate both internal and external communication containing, description of the project, an ESR recruitment call, training programs, training material (slides from the courses, exercises), links to software, relevant training literature, FAQ on 3R-alternative methods or relevant websites e.g. Alttox.org, schedule of in3 events and information on the partners. P5 will be responsible for the technical organisation of webinars. The results of the project will be disseminated at local meetings and international conferences via poster presentations and oral communication. Results will be published in peer reviewed scientific journals. A yearly report summary will be generated and published online and disseminated to members of existing networks such as EUROTOX, ESTIV, SEURAT-1 and the EPAA (European partnership for alternatives approaches, a public-private partnership between European commission and the industry). A version of this will be translated and sent to local press agencies. Publicaciones Peer reviewed articles (17) CD34+ derived macrophage and dendritic cells display differential responses to paraquat Autores: Leonie F.H. Fransen, Martin O. Leonard Publicado en: Toxicology in Vitro, Issue 75, 2021, Page(s) 105198, ISSN 0887-2333 Editor: Elsevier BV DOI: 10.1016/j.tiv.2021.105198 Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound Autores: Sara Wellens, Lucie Dehouck, Vidya Chandrasekaran, Pranika Singh, Rodrigo Azevedo Loiola, Emmanuel Sevin, Thomas Exner, Paul Jennings, Fabien Gosselet, Maxime Culot Publicado en: Toxicology in Vitro, Issue 73, 2021, Page(s) 105112, ISSN 0887-2333 Editor: Elsevier BV DOI: 10.1016/j.tiv.2021.105112 Neuroinflammatory Response to TNFα and IL1β Cytokines Is Accompanied by an Increase in Glycolysis in Human Astrocytes In Vitro Autores: David Pamies, Chiara Sartori, Domitille Schvartz, Víctor González-Ruiz, Luc Pellerin, Carolina Nunes, Denise Tavel, Vanille Maillard, Julien Boccard, Serge Rudaz, Jean-Charles Sanchez, Marie-Gabrielle Zurich Publicado en: International Journal of Molecular Sciences, Issue 22/8, 2021, Page(s) 4065, ISSN 1422-0067 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms22084065 Differentiation of human iPSCs into functional podocytes Autores: Caroline Rauch, Elisabeth Feifel, Georg Kern, Cormac Murphy, Florian Meier, Walther Parson, Mario Beilmann, Paul Jennings, Gerhard Gstraunthaler, Anja Wilmes Publicado en: PLOS ONE, Issue 13/9, 2018, Page(s) e0203869, ISSN 1932-6203 Editor: Public Library of Science DOI: 10.1371/journal.pone.0203869 Development and analysis of an adverse outcome pathway network for human neurotoxicity Autores: Nicoleta Spinu, Anna Bal-Price, Mark T. D. Cronin, Steven J. Enoch, Judith C. Madden, Andrew P. Worth Publicado en: Archives of Toxicology, 2019, ISSN 0340-5761 Editor: Springer Verlag DOI: 10.1007/s00204-019-02551-1 Ensemble-Based Modeling of Chemical Compounds with Antimalarial Activity Autores: Ana Yisel Caballero-Alfonso, Maykel Cruz-Monteagudo, Eduardo Tejera, Emilio Benfenati, Fernanda Borges, M. Natália D.S. Cordeiro, Vinicio Armijos-Jaramillo, Yunierkis Perez-Castillo Publicado en: Current Topics in Medicinal Chemistry, Issue 19/11, 2019, Page(s) 957-969, ISSN 1568-0266 Editor: Bentham Science Publishers DOI: 10.2174/1568026619666190510100313 Multiclass Classifier for P-Glycoprotein Substrates, Inhibitors, and Non-Active Compounds Autores: Liadys Mora Lagares, Nikola Minovski, Marjana Novič Publicado en: Molecules, Issue 24/10, 2019, Page(s) 2006, ISSN 1420-3049 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/molecules24102006 Homology Modeling of the Human P-glycoprotein (ABCB1) and Insights into Ligand Binding through Molecular Docking Studies Autores: Liadys Mora Lagares, Nikola Minovski, Ana Yisel Caballero Alfonso, Emilio Benfenati, Sara Wellens, Maxime Culot, Fabien Gosselet, Marjana Novič Publicado en: International Journal of Molecular Sciences, Issue 21/11, 2020, Page(s) 4058, ISSN 1422-0067 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/ijms21114058 Methodology of aiQSAR: a group-specific approach to QSAR modelling Autores: Kristijan Vukovic, Domenico Gadaleta, Emilio Benfenati Publicado en: Journal of Cheminformatics, Issue 11/1, 2019, ISSN 1758-2946 Editor: Chemistry Central DOI: 10.1186/s13321-019-0350-y Quantitative adverse outcome pathway (qAOP) models for toxicity prediction Autores: Nicoleta Spinu, Mark T. D. Cronin, Steven J. Enoch, Judith C. Madden, Andrew P. Worth Publicado en: Archives of Toxicology, Issue 94/5, 2020, Page(s) 1497-1510, ISSN 0340-5761 Editor: Springer Verlag DOI: 10.1007/s00204-020-02774-7 Towards an Understanding of the Mode of Action of Human Aromatase Activity for Azoles through Quantum Chemical Descriptors-Based Regression and Structure Activity Relationship Modeling Analysis Autores: Chayawan Chayawan, Cosimo Toma, Emilio Benfenati, Ana Y. Caballero Alfonso Publicado en: Molecules, Issue 25/3, 2020, Page(s) 739, ISSN 1420-3049 Editor: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/molecules25030739 Generation and characterization of iPSC-derived renal proximal tubule-like cells with extended stability Autores: Vidya Chandrasekaran, Giada Carta, Daniel da Costa Pereira, Rajinder Gupta, Cormac Murphy, Elisabeth Feifel, Georg Kern, Judith Lechner, Anna Lina Cavallo, Shailesh Gupta, Florian Caiment, Jos C. S. Kleinjans, Gerhard Gstraunthaler, Paul Jennings, Anja Wilmes Publicado en: Scientific Reports, Issue 11/1, 2021, ISSN 2045-2322 Editor: Nature Publishing Group DOI: 10.1038/s41598-021-89550-4 Temporal transcriptomic alterations of cadmium exposed human iPSC-derived renal proximal tubule-like cells Autores: Pranika Singh, Vidya Chandrasekaran, Barry Hardy, Anja Wilmes, Paul Jennings, Thomas E. Exner Publicado en: Toxicology in Vitro, Issue 76, 2021, Page(s) 105229, ISSN 0887-2333 Editor: Elsevier BV DOI: 10.1016/j.tiv.2021.105229 Insights into PCDD/Fs and PAHs in Biomass Boilers Envisaging Risks of Ash Use as Fertilizers Autores: Helena Lopes, Susana Proença Publicado en: Applied Sciences, Issue 10/14, 2020, Page(s) 4951, ISSN 2076-3417 Editor: MDPI Open Access Journals DOI: 10.3390/app10144951 SAR and QSAR modeling of a large collection of LD50 rat acute oral toxicity data Autores: Domenico Gadaleta, Kristijan Vuković, Cosimo Toma, Giovanna J. Lavado, Agnes L. Karmaus, Kamel Mansouri, Nicole C. Kleinstreuer, Emilio Benfenati, Alessandra Roncaglioni Publicado en: Journal of Cheminformatics, Issue 11/1, 2019, ISSN 1758-2946 Editor: Chemistry Central DOI: 10.1186/s13321-019-0383-2 SARS-CoV-2 infects an upper airway model derived from induced pluripotent stem cells Autores: Ivo Djidrovski, Maria Georgiou, Grant L. Hughes, Edward I. Patterson, Aitor Casas-Sanchez, Shaun H. Pennington, Giancarlo A. Biagini, Marina Moya-Molina, Jelle van den Bor, Martine J. Smit, Git Chung, Majlinda Lako, Lyle Armstrong Publicado en: STEM CELLS, 2021, ISSN 1066-5099 Editor: AlphaMed Press Inc DOI: 10.1002/stem.3422 Small Airway Susceptibility to Chemical and Particle Injury Autores: Leonie Francina Hendrina Fransen, Martin Oliver Leonard Publicado en: Respiration, 2021, Page(s) 1-13, ISSN 0025-7931 Editor: Karger AG DOI: 10.1159/000519344 Buscando datos de OpenAIRE... Se ha producido un error en la búsqueda de datos de OpenAIRE No hay resultados disponibles
