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An integrated interdisciplinary approach to animal-free chemical and nanomaterial safety assessment

Objective

All chemicals whether they are drugs, cosmetics, agrochemicals or others need to be tested for their safety to man and the environment. The use of whole animal studies for the prediction of adverse effects in man, is problematic due to species dependent effects, high costs and a large burden to animals in terms of numbers and suffering. While there have been major improvements in human in vitro and in silico techniques, there is still a lack of an integrated risk assessment platform. The in3 proposal aims to significantly further the development of animal-free chemical and nanomaterial (NM) safety evaluation by creating a scientific and training program aimed at integrating human in vitro testing with computational approaches. The project will focus on human induced pluripotent stem cells (hiPSC) derived tissues, including liver, kidney, brain, lung and vasculature and to utilise mechanistic toxicology, quantitative adverse outcome pathways, biokinetics, cheminformatics and modelling approaches to derive testable prediction models. hiPSC present the major advantages provide non-cancerous derived tissues with identical genetic backgrounds. All Early Stage Researchers (ESRs) will work towards the same goal, utilising the same chemicals, donor cells, assays and software packages. All data will be centrally housed in standardised formats, appropriately annotated and linked with protocols and material information. While ESRs will hone their skills in their own field of expertise, they will also collaborate to create an in depth safety evaluation testing platform for the chosen test compounds. By interaction, problem solving, training and secondments over the three years, they will acquire a unique set of interdisciplinary skills for chemical and NM safety assessment. The project aims to accelerate the realisation of animal-free safety assessment and to graduate 15 PhD students with the ideal skill sets to carry out the strategy designed in in3 in the near future.

Call for proposal

H2020-MSCA-ITN-2016
See other projects for this call

Coordinator

STICHTING VU
Address
De Boelelaan 1105
1081 HV Amsterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 510 748,56

Participants (13)

EVERCYTE GMBH
Austria
EU contribution
€ 255 934,08
Address
Leberstrasse 20/8
1110 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITE D'ARTOIS
France
EU contribution
€ 262 875,60
Address
Rue Du Temple 9
62000 Arras
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE LAUSANNE
Switzerland
EU contribution
€ 265 226,76
Address
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
BIOTALENTUM TUDASFEJLESZTO KFT
Hungary
EU contribution
€ 223 913,52
Address
Aulich Lajos Utca 26
2100 Goedoello
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 250 560
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Department of Health
United Kingdom
EU contribution
€ 273 287,88
Address
Quarry House, Quarry Hill
LS2 7UE Leeds
Activity type
Research Organisations
NEWCELLS BIOTECH LIMITED
United Kingdom
EU contribution
€ 273 287,88
Address
1 Times Square Scotswood Road
NE1 4EP Newcastle Upon Tyne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
EU contribution
€ 516 122,64
Address
Via Mario Negri 2
20156 Milano
Activity type
Research Organisations
LIVERPOOL JOHN MOORES UNIVERSITY
United Kingdom
EU contribution
€ 273 287,88
Address
Rodney Street 2 Egerton Court
L3 5UX Liverpool
Activity type
Higher or Secondary Education Establishments
KEMIJSKI INSTITUT
Slovenia
EU contribution
€ 234 997,56
Address
Hajdrihova 19
1000 Ljubljana
Activity type
Research Organisations
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 255 374,28
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
EDELWEISS CONNECT GMBH
Switzerland
EU contribution
€ 265 226,76
Address
Hochbergerstrasse 60C
4057 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MEDIZINISCHE UNIVERSITAT INNSBRUCK

Participation ended

Austria
EU contribution
€ 0
Address
Christoph Probst Platz 1
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments

Partners (5)

UNIVERSITAT KONSTANZ
Germany
Address
Universitatsstrasse 10
78464 Konstanz
Activity type
Higher or Secondary Education Establishments
European Union Reference Laboratory for Alternative Methods to Animal Testing
Italy
Address

Ispra
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
European Society of Toxicology in Vitro
Netherlands
Address

Houten
Activity type
Other
NANOTECH PARTNER SRO
Czechia
Address
Vaclavske Namesti 808 66 Nove Mesto
110 00 Praha
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
L'OREAL SA
France
Address
14 Rue Royale
75008 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)