Reverse Engineering Gene Regulatory Networks

Project Information

RetroNets

Grant agreement ID: 723106

DOI

10.3030/723106

Project closed

EC signature date 15 December 2016

Start date 1 April 2017

End date 30 September 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 993 858,00

EU contribution

€ 1 993 858,00

Coordinated by

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

Systematic analysis of low-affinity transcription factor binding site clusters in vitro and in vivo establishes their functional relevance

Author(s): Amir Shahein, Maria López-Malo, Ivan Istomin, Evan J. Olson, Shiyu Cheng, Sebastian J. Maerkl
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32971-0

A partially self-regenerating synthetic cell

Author(s): Barbora Lavickova, Nadanai Laohakunakorn, Sebastian J. Maerkl
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-20180-6

A high-throughput microfluidic nanoimmunoassay for detecting anti–SARS-CoV-2 antibodies in serum or ultralow-volume blood samples

Author(s): Zoe Swank, Grégoire Michielin, Hon Ming Yip, Patrick Cohen, Diego O. Andrey, Nicolas Vuilleumier, Laurent Kaiser, Isabella Eckerle, Benjamin Meyer, Sebastian J. Maerkl
Published in: Proceedings of the National Academy of Sciences, Issue 118/18, 2021, Page(s) e2025289118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2025289118

Biochemistry of Aminoacyl tRNA Synthetase and tRNAs and Their Engineering for Cell-Free and Synthetic Cell Applications

Author(s): Ragunathan Bava Ganesh, and Sebastian J. Maerkl
Published in: Frontiers in Bioengineering and Biotechnology, Issue 22964185, 2022, ISSN 2296-4185
Publisher: Frontiers Media S.A
DOI: 10.5281/zenodo.6452569

OnePot PURE Cell-Free System

Author(s): Laura Grasemann, Barbora Lavickova, M. Carolina Elizondo-Cantú and Sebastian J. Maerkl
Published in: Journal of Visualized Experiments, 2021, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/62625

Microfluidic Module for Real-Time Generation of Complex Multimolecule Temporal Concentration Profiles

Author(s): Kristina Woodruff, Sebastian J. Maerkl
Published in: Analytical Chemistry, Issue 90/1, 2017, Page(s) 696-701, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.7b04099

Microfluidic device for real-time formulation of reagents and their subsequent encapsulation into double emulsions

Author(s): Jui-Chia Chang, Zoe Swank, Oliver Keiser, Sebastian J. Maerkl, Esther Amstad
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-26542-x

Cell-free gene-regulatory network engineering with synthetic transcription factors

Author(s): Zoe Swank, Nadanai Laohakunakorn, Sebastian J. Maerkl
Published in: Proceedings of the National Academy of Sciences, Issue 116/13, 2019, Page(s) 5892-5901, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1816591116

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Author(s): Ardjan J. van der Linden, Maaruthy Yelleswarapu, Pascal A. Pieters, Zoe Swank, Wilhelm T. S. Huck, Sebastian J. Maerkl, Tom F. A. de Greef
Published in: Journal of Visualized Experiments, Issue 152, 2019, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/59655

Bottom-Up Construction of Complex Biomolecular Systems With Cell-Free Synthetic Biology

Author(s): Nadanai Laohakunakorn, Laura Grasemann, Barbora Lavickova, Grégoire Michielin, Amir Shahein, Zoe Swank, Sebastian J. Maerkl
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, ISSN 2296-4185
Publisher: Frontiers in Biotechnology and Bioengineering
DOI: 10.3389/fbioe.2020.00213

A Simple, Robust, and Low-Cost Method To Produce the PURE Cell-Free System

Author(s): Barbora Lavickova, Sebastian J. Maerkl
Published in: ACS Synthetic Biology, Issue 8/2, 2019, Page(s) 455-462, ISSN 2161-5063
Publisher: American Chemical Society
DOI: 10.1021/acssynbio.8b00427

Cascaded amplifying circuits enable ultrasensitive cellular sensors for toxic metals

Author(s): Xinyi Wan, Francesca Volpetti, Ekaterina Petrova, Chris French, Sebastian J. Maerkl and Baojun Wang
Published in: Nature Chemical Biology, Issue 15524450, 2019, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-019-0244-3

An automated do-it-yourself system for dynamic stem cell and organoid culture in standard multi-well plates

Author(s): Julia Tischler, Zoe Swank, Hao-An Hsiung, Stefano Vianello, Matthias P Lutolf and Sebastian J Maerkl
Published in: Cell Reports Methods, Issue 26672375, 2022, ISSN 2667-2375
Publisher: Elsevier
DOI: 10.1016/j.crmeth.2022.100244

CFPU: A Cell-Free Processing Unit for High-Throughput, Automated In Vitro Circuit Characterization in Steady-State Conditions

Author(s): Zoe Swank, Sebastian J. Maerkl
Published in: BioDesign Research, Issue 2021, 2021, Page(s) 1-11, ISSN 2693-1257
Publisher: AAAS
DOI: 10.34133/2021/2968181