Clearance Of Microbial Biofilms by Advancing diagnostics and Therapy

Project Information

COMBAT

Grant agreement ID: 724290

DOI

10.3030/724290

Project closed

EC signature date 24 April 2017

Start date 1 May 2017

End date 30 April 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 998 750,00

EU contribution

€ 1 998 750,00

Coordinated by

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (18)

Dual Effect: High NADH Levels Contribute to Efflux-Mediated Antibiotic Resistance but Drive Lethality Mediated by Reactive Oxygen Species

Author(s): Alejandro Arce-Rodríguez, Debbie Pankratz, Matthias Preusse, Pablo I Nikel 3, Susanne Häussler
Published in: mBIO, 2022, ISSN 2150-7511
Publisher: American Society for Microbiology
DOI: 10.1128/mbio.02434-21

Evolution of biofilm-adapted gene expression profiles in lasR-deficient clinical Pseudomonas aeruginosa isolates

Author(s): Alexander Jeske, Alejandro Arce-Rodriguez, Janne G Thöming, Jürgen Tomasch, Susanne Häussler
Published in: NPJ Biofilms Microbiomes, 2022, ISSN 2055-5008
Publisher: Nature Publishing Group
DOI: 10.1038/s41522-022-00268-1

Importance of flagella in acute and chronic Pseudomonas aeruginosa infections

Author(s): Anne Lorenz, Matthias Preuße, Sebastian Bruchmann, Vinay Pawar, Nora Grahl, Marina C Pils, Laura M Nolan, Alain Filloux, Siegfried Weiss, Susanne Häussler
Published in: Environmental Microbiology, 2018, ISSN 1462-2920
Publisher: Wiley-Blackwell
DOI: 10.1111/1462-2920.14468

Pseudomonas aeruginosa Is More Tolerant Under Biofilm Than Under Planktonic Growth Conditions: A Multi-Isolate Survey

Author(s): Janne G. Thöming; Susanne Häussler
Published in: Frontiers in Cellular and Infection Microbiology, Issue 1, 2022, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fcimb.2022.851784

<i>Pseudomonas aeruginosa</i> post‐translational responses to elevated <scp>c‐di‐GMP</scp> levels

Author(s): Sarina Bense; Julius Witte; Matthias Preuße; Michal Koska; Lorena Pezoldt; Astrid Dröge; Oliver Hartmann; Mathias Müsken; Julia Schulze; Timm Fiebig; Heike Bähre; Sebastian Felgner; Andreas Pich; Susanne Häussler
Published in: Molecular Microbiology, 2022, ISSN 1365-2958
Publisher: John Wiley & Sons Ltd.
DOI: 10.1111/mmi.14902

Host-induced spermidine production in motile Pseudomonas aeruginosa triggers phagocytic uptake

Author(s): Sebastian Felgner; Matthias Preusse; Ulrike Beutling; Stephanie Stahnke; Vinay Pawar; Manfred Rohde; Mark Brönstrup; Theresia E. B. Stradal; Susanne Häussler
Published in: eLife, Issue 1, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.55744

Predicting antimicrobial resistance in Pseudomonas aeruginosa with machine learning-enabled molecular diagnostics.

Author(s): Ariane Khaledi; Aaron Weimann; Monika Schniederjans; Ehsaneddin Asgari; Tzu-Hao Kuo; Antonio Oliver; Gabriel Cabot; Axel Kola; Petra Gastmeier; Michael Hogardt; Daniel Jonas; Mohammad R. K. Mofrad; Mohammad R. K. Mofrad; Andreas Bremges; Alice C. McHardy; Susanne Häussler
Published in: EMBO Molecular Medicine, Issue 1, 2020, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201910264

Parallel evolutionary paths to produce more than one Pseudomonas aeruginosa biofilm phenotype.

Author(s): Janne G. Thöming; Jürgen Tomasch; Matthias Preusse; Michal Koska; Nora Grahl; Sarah Pohl; Sven D. Willger; Volkhard Kaever; Mathias Müsken; Susanne Häussler
Published in: NPJ Biofilms and Microbiomes, Issue 1, 2020, ISSN 2055-5008
Publisher: Nature Publishing Group
DOI: 10.1038/s41522-019-0113-6

Targeting bioenergetics is key to counteracting the drug-tolerant state of biofilm-grown bacteria

Author(s): Monique Donnert; Sarah Elsheikh; Alejandro Arce-Rodríguez; Vinay Pawar; Peter Braubach; Danny Jonigk; Axel Haverich; Siegfried Weiss; Mathias Müsken; Susanne Häussler
Published in: PLOS Pathogens, Issue 1, 2020, ISSN 1553-7374
Publisher: Public Library of Science (PLOS)
DOI: 10.1371/journal.ppat.1009126

Organism-specific depletion of highly abundant RNA species from bacterial total RNA

Author(s): Florian Engelhardt, Jürgen Tomasch
Published in: Access Microbiology, 2020, ISSN 2516-8290
Publisher: Microbiology Society
DOI: 10.1099/acmi.0.000159

Genetic determinants of Pseudomonas aeruginosa fitness during biofilm growth.

Author(s): Silvia Schinner; Florian Engelhardt; Matthias Preusse; Janne G. Thöming; Jürgen Tomasch; Susanne Häussler
Published in: Biofilm, Issue 1, 2020, ISSN 2590-2075
Publisher: Elsevier
DOI: 10.1016/j.bioflm.2020.100023

Analysis of the organization and expression patterns of the convergent Pseudomonas aeruginosa lasR/rsaL gene pair uncovers mutual influence.

Author(s): Silvia Schinner; Matthias Preusse; Christopher Kesthely; Susanne Häussler
Published in: Molecular Microbiology, Issue 1, 2020, ISSN 1365-2958
Publisher: John Wiley & Sons Ltd.
DOI: 10.1111/mmi.14628

BACTOME—a reference database to explore the sequence- and gene expression-variation landscape of Pseudomonas aeruginosa clinical isolates

Author(s): Klaus Hornischer, Ariane Khaledi, Sarah Pohl, Monika Schniederjans, Lorena Pezoldt, Fiordiligie Casilag, Uthayakumar Muthukumarasamy, Sebastian Bruchmann, Janne Thöming, Adrian Kordes, Susanne Häussler
Published in: Nucleic Acids Research, 2018, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gky895

Establishment of an induced memory response in Pseudomonas aeruginosa during infection of a eukaryotic host

Author(s): Adrian Kordes, Nora Grahl, Michal Koska, Matthias Preusse, Alejandro Arce-Rodriguez, Wolf-Rainer Abraham, Volkhard Kaever, Susanne Häussler
Published in: The ISME Journal, Issue 13/8, 2019, Page(s) 2018-2030, ISSN 1751-7362
Publisher: Nature Publishing Group
DOI: 10.1038/s41396-019-0412-1

Genetically diverse Pseudomonas aeruginosa populations display similar transcriptomic profiles in a cystic fibrosis explanted lung

Author(s): Adrian Kordes, Matthias Preusse, Sven D. Willger, Peter Braubach, Danny Jonigk, Axel Haverich, Gregor Warnecke, Susanne Häussler
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-11414-3

Evolution of Pseudomonas aeruginosa toward higher fitness under standard laboratory conditions

Author(s): Igor Grekov, Janne Gesine Thöming, Adrian Kordes, Susanne Häussler
Published in: The ISME Journal, 2021, ISSN 1751-7362
Publisher: Nature Publishing Group
DOI: 10.1038/s41396-020-00841-6

Non-invasive, ratiometric determination of intracellular pH in Pseudomonas species using a novel genetically encoded indicator.

Author(s): Alejandro Arce-Rodríguez; Daniel C. Volke; Sarina Bense; Susanne Häussler; Pablo I. Nikel
Published in: Arce-Rodríguez , A , Volke , D C , Bense , S , Häussler , S & Nikel , P I 2019 , ' Non-invasive, ratiometric determination of intracellular pH in Pseudomonas species using a novel genetically encoded indicator ' , Microbial Biotechnology , vol. 12 , no. 4 , pp. 799-813 . https://doi.org/10.1111/1751-7915.13439, Issue 1, 2019, ISSN 1751-7907
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/1751-7915.13439

Single-Nucleotide Polymorphism-Based Genetic Diversity Analysis of Clinical Pseudomonas aeruginosa Isolates.

Author(s): Uthayakumar Muthukumarasamy; Matthias Preusse; Adrian Kordes; Michal Koska; Monika Schniederjans; Ariane Khaledi; Susanne Häussler
Published in: Genome Biology and Evolution, Issue 1, 2020, ISSN 1759-6653
Publisher: Oxford University Press
DOI: 10.1093/gbe/evaa059