Clearance Of Microbial Biofilms by Advancing diagnostics and Therapy

Informazioni relative al progetto

COMBAT

ID dell’accordo di sovvenzione: 724290

DOI

10.3030/724290

Progetto chiuso

Data della firma CE 24 Aprile 2017

Data di avvio 1 Maggio 2017

Data di completamento 30 Aprile 2022

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 998 750,00

Contributo UE

€ 1 998 750,00

Coordinato da

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (18)

Dual Effect: High NADH Levels Contribute to Efflux-Mediated Antibiotic Resistance but Drive Lethality Mediated by Reactive Oxygen Species

Autori: Alejandro Arce-Rodríguez, Debbie Pankratz, Matthias Preusse, Pablo I Nikel 3, Susanne Häussler
Pubblicato in: mBIO, 2022, ISSN 2150-7511
Editore: American Society for Microbiology
DOI: 10.1128/mbio.02434-21

Evolution of biofilm-adapted gene expression profiles in lasR-deficient clinical Pseudomonas aeruginosa isolates

Autori: Alexander Jeske, Alejandro Arce-Rodriguez, Janne G Thöming, Jürgen Tomasch, Susanne Häussler
Pubblicato in: NPJ Biofilms Microbiomes, 2022, ISSN 2055-5008
Editore: Nature Publishing Group
DOI: 10.1038/s41522-022-00268-1

Importance of flagella in acute and chronic Pseudomonas aeruginosa infections

Autori: Anne Lorenz, Matthias Preuße, Sebastian Bruchmann, Vinay Pawar, Nora Grahl, Marina C Pils, Laura M Nolan, Alain Filloux, Siegfried Weiss, Susanne Häussler
Pubblicato in: Environmental Microbiology, 2018, ISSN 1462-2920
Editore: Wiley-Blackwell
DOI: 10.1111/1462-2920.14468

Pseudomonas aeruginosa Is More Tolerant Under Biofilm Than Under Planktonic Growth Conditions: A Multi-Isolate Survey

Autori: Janne G. Thöming; Susanne Häussler
Pubblicato in: Frontiers in Cellular and Infection Microbiology, Numero 1, 2022, ISSN 1664-302X
Editore: Frontiers Media
DOI: 10.3389/fcimb.2022.851784

<i>Pseudomonas aeruginosa</i> post‐translational responses to elevated <scp>c‐di‐GMP</scp> levels

Autori: Sarina Bense; Julius Witte; Matthias Preuße; Michal Koska; Lorena Pezoldt; Astrid Dröge; Oliver Hartmann; Mathias Müsken; Julia Schulze; Timm Fiebig; Heike Bähre; Sebastian Felgner; Andreas Pich; Susanne Häussler
Pubblicato in: Molecular Microbiology, 2022, ISSN 1365-2958
Editore: John Wiley & Sons Ltd.
DOI: 10.1111/mmi.14902

Host-induced spermidine production in motile Pseudomonas aeruginosa triggers phagocytic uptake

Autori: Sebastian Felgner; Matthias Preusse; Ulrike Beutling; Stephanie Stahnke; Vinay Pawar; Manfred Rohde; Mark Brönstrup; Theresia E. B. Stradal; Susanne Häussler
Pubblicato in: eLife, Numero 1, 2020, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.55744

Predicting antimicrobial resistance in Pseudomonas aeruginosa with machine learning-enabled molecular diagnostics.

Autori: Ariane Khaledi; Aaron Weimann; Monika Schniederjans; Ehsaneddin Asgari; Tzu-Hao Kuo; Antonio Oliver; Gabriel Cabot; Axel Kola; Petra Gastmeier; Michael Hogardt; Daniel Jonas; Mohammad R. K. Mofrad; Mohammad R. K. Mofrad; Andreas Bremges; Alice C. McHardy; Susanne Häussler
Pubblicato in: EMBO Molecular Medicine, Numero 1, 2020, ISSN 1757-4676
Editore: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201910264

Parallel evolutionary paths to produce more than one Pseudomonas aeruginosa biofilm phenotype.

Autori: Janne G. Thöming; Jürgen Tomasch; Matthias Preusse; Michal Koska; Nora Grahl; Sarah Pohl; Sven D. Willger; Volkhard Kaever; Mathias Müsken; Susanne Häussler
Pubblicato in: NPJ Biofilms and Microbiomes, Numero 1, 2020, ISSN 2055-5008
Editore: Nature Publishing Group
DOI: 10.1038/s41522-019-0113-6

Targeting bioenergetics is key to counteracting the drug-tolerant state of biofilm-grown bacteria

Autori: Monique Donnert; Sarah Elsheikh; Alejandro Arce-Rodríguez; Vinay Pawar; Peter Braubach; Danny Jonigk; Axel Haverich; Siegfried Weiss; Mathias Müsken; Susanne Häussler
Pubblicato in: PLOS Pathogens, Numero 1, 2020, ISSN 1553-7374
Editore: Public Library of Science (PLOS)
DOI: 10.1371/journal.ppat.1009126

Organism-specific depletion of highly abundant RNA species from bacterial total RNA

Autori: Florian Engelhardt, Jürgen Tomasch
Pubblicato in: Access Microbiology, 2020, ISSN 2516-8290
Editore: Microbiology Society
DOI: 10.1099/acmi.0.000159

Genetic determinants of Pseudomonas aeruginosa fitness during biofilm growth.

Autori: Silvia Schinner; Florian Engelhardt; Matthias Preusse; Janne G. Thöming; Jürgen Tomasch; Susanne Häussler
Pubblicato in: Biofilm, Numero 1, 2020, ISSN 2590-2075
Editore: Elsevier
DOI: 10.1016/j.bioflm.2020.100023

Analysis of the organization and expression patterns of the convergent Pseudomonas aeruginosa lasR/rsaL gene pair uncovers mutual influence.

Autori: Silvia Schinner; Matthias Preusse; Christopher Kesthely; Susanne Häussler
Pubblicato in: Molecular Microbiology, Numero 1, 2020, ISSN 1365-2958
Editore: John Wiley & Sons Ltd.
DOI: 10.1111/mmi.14628

BACTOME—a reference database to explore the sequence- and gene expression-variation landscape of Pseudomonas aeruginosa clinical isolates

Autori: Klaus Hornischer, Ariane Khaledi, Sarah Pohl, Monika Schniederjans, Lorena Pezoldt, Fiordiligie Casilag, Uthayakumar Muthukumarasamy, Sebastian Bruchmann, Janne Thöming, Adrian Kordes, Susanne Häussler
Pubblicato in: Nucleic Acids Research, 2018, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gky895

Establishment of an induced memory response in Pseudomonas aeruginosa during infection of a eukaryotic host

Autori: Adrian Kordes, Nora Grahl, Michal Koska, Matthias Preusse, Alejandro Arce-Rodriguez, Wolf-Rainer Abraham, Volkhard Kaever, Susanne Häussler
Pubblicato in: The ISME Journal, Numero 13/8, 2019, Pagina/e 2018-2030, ISSN 1751-7362
Editore: Nature Publishing Group
DOI: 10.1038/s41396-019-0412-1

Genetically diverse Pseudomonas aeruginosa populations display similar transcriptomic profiles in a cystic fibrosis explanted lung

Autori: Adrian Kordes, Matthias Preusse, Sven D. Willger, Peter Braubach, Danny Jonigk, Axel Haverich, Gregor Warnecke, Susanne Häussler
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-11414-3

Evolution of Pseudomonas aeruginosa toward higher fitness under standard laboratory conditions

Autori: Igor Grekov, Janne Gesine Thöming, Adrian Kordes, Susanne Häussler
Pubblicato in: The ISME Journal, 2021, ISSN 1751-7362
Editore: Nature Publishing Group
DOI: 10.1038/s41396-020-00841-6

Non-invasive, ratiometric determination of intracellular pH in Pseudomonas species using a novel genetically encoded indicator.

Autori: Alejandro Arce-Rodríguez; Daniel C. Volke; Sarina Bense; Susanne Häussler; Pablo I. Nikel
Pubblicato in: Arce-Rodríguez , A , Volke , D C , Bense , S , Häussler , S & Nikel , P I 2019 , ' Non-invasive, ratiometric determination of intracellular pH in Pseudomonas species using a novel genetically encoded indicator ' , Microbial Biotechnology , vol. 12 , no. 4 , pp. 799-813 . https://doi.org/10.1111/1751-7915.13439, Numero 1, 2019, ISSN 1751-7907
Editore: Blackwell Publishing Inc.
DOI: 10.1111/1751-7915.13439

Single-Nucleotide Polymorphism-Based Genetic Diversity Analysis of Clinical Pseudomonas aeruginosa Isolates.

Autori: Uthayakumar Muthukumarasamy; Matthias Preusse; Adrian Kordes; Michal Koska; Monika Schniederjans; Ariane Khaledi; Susanne Häussler
Pubblicato in: Genome Biology and Evolution, Numero 1, 2020, ISSN 1759-6653
Editore: Oxford University Press
DOI: 10.1093/gbe/evaa059