Single Molecule Nanoscale Sensors for Improved Therapies and Diagnostics

Project Information

NanoPD

Grant agreement ID: 724300

DOI

10.3030/724300

Project closed

EC signature date 27 March 2017

Start date 1 October 2017

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 997 680,00

EU contribution

€ 1 997 680,00

Coordinated by

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (27)

Selective Sensing of Proteins Using Aptamer Functionalized Nanopore Extended Field‐Effect Transistors

Author(s): Ren Ren, Xiaoyi Wang, Shenglin Cai, Yanjun Zhang, Yuri Korchev, Aleksandar P. Ivanov, Joshua B. Edel
Published in: Small Methods, 2020, Page(s) 2000356, ISSN 2366-9608
Publisher: Wiley
DOI: 10.1002/smtd.202000356

Understanding Electrical Conduction and Nanopore Formation During Controlled Breakdown

Author(s): Jasper P. Fried; Jacob L. Swett; Binoy Paulose Nadappuram; Aleksandra Fedosyuk; Pedro Sousa; Dayrl P. Briggs; Aleksandar P. Ivanov; Joshua B. Edel; Jan A. Mol; James Yates
Published in: Small, Issue 4, 2021, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202102543

Individually Addressable Multi-nanopores for Single-Molecule Targeted Operations

Author(s): Paolo Cadinu, Minkyung Kang, Binoy Paulose Nadappuram, Aleksandar P. Ivanov, Joshua B. Edel
Published in: Nano Letters, Issue 20/3, 2020, Page(s) 2012-2019, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.9b05307

Monitoring plasmon coupling and SERS enhancement through in situ nanoparticle spacing modulation

Author(s): L. Velleman, L. Scarabelli, D. Sikdar, A. A. Kornyshev, L. M. Liz-Marzán, J. B. Edel
Published in: Faraday Discussions, Issue 205, 2017, Page(s) 67-83, ISSN 1359-6640
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7fd00162b

Development of microfluidic platforms for the synthesis of metal complexes and evaluation of their DNA affinity using online FRET melting assays

Author(s): Viktoria Rakers, Paolo Cadinu, Joshua B. Edel, Ramon Vilar
Published in: Chemical Science, Issue 9/14, 2018, Page(s) 3459-3469, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8sc00528a

Double Barrel Nanopores as a New Tool for Controlling Single-Molecule Transport

Author(s): Paolo Cadinu, Giulia Campolo, Sergii Pud, Wayne Yang, Joshua B. Edel, Cees Dekker, Aleksandar P. Ivanov
Published in: Nano Letters, Issue 18/4, 2018, Page(s) 2738-2745, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.8b00860

Nanopore extended field-effect transistor for selective single-molecule biosensing

Author(s): Ren Ren, Yanjun Zhang, Binoy Paulose Nadappuram, Bernice Akpinar, David Klenerman, Aleksandar P. Ivanov, Joshua B. Edel, Yuri Korchev
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-00549-w

Graphene-edge dielectrophoretic tweezers for trapping of biomolecules

Author(s): Avijit Barik, Yao Zhang, Roberto Grassi, Binoy Paulose Nadappuram, Joshua B. Edel, Tony Low, Steven J. Koester, Sang-Hyun Oh
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-01635-9

Nanoscale tweezers for single-cell biopsies

Author(s): Binoy Paulose Nadappuram, Paolo Cadinu, Avijit Barik, Alexander J. Ainscough, Michael J. Devine, Minkyung Kang, Jorge Gonzalez-Garcia, Josef T. Kittler, Keith R. Willison, Ramon Vilar, Paolo Actis, Beata Wojciak-Stothard, Sang-Hyun Oh, Aleksandar P. Ivanov, Joshua B. Edel
Published in: Nature Nanotechnology, Issue 14/1, 2019, Page(s) 80-88, ISSN 1748-3387
Publisher: Nature Publishing Group
DOI: 10.1038/s41565-018-0315-8

Towards Electrotuneable Nanoplasmonic Fabry–Perot Interferometer

Author(s): Hayley Weir, Joshua B. Edel, Alexei A. Kornyshev, Debabrata Sikdar
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-017-19011-4

Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriers

Author(s): Jasmine Y. Y. Sze, Aleksandar P. Ivanov, Anthony E. G. Cass, Joshua B. Edel
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-01584-3

Single Molecule Trapping and Sensing Using Dual Nanopores Separated by a Zeptoliter Nanobridge

Author(s): Paolo Cadinu, Binoy Paulose Nadappuram, Dominic J. Lee, Jasmine Y. Y. Sze, Giulia Campolo, Yanjun Zhang, Andrew Shevchuk, Sylvain Ladame, Tim Albrecht, Yuri Korchev, Aleksandar P. Ivanov, Joshua B. Edel
Published in: Nano Letters, Issue 17/10, 2017, Page(s) 6376-6384, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.7b03196

Gated Single-Molecule Transport in Double-Barreled Nanopores

Author(s): Liang Xue, Paolo Cadinu, Binoy Paulose Nadappuram, Minkyung Kang, Ye Ma, Yuri Korchev, Aleksandar P. Ivanov, Joshua B. Edel
Published in: ACS Applied Materials & Interfaces, Issue 10/44, 2018, Page(s) 38621-38629, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.8b13721

A Tunable Nanoplasmonic Mirror at an Electrochemical Interface

Author(s): Ye Ma, Cristian Zagar, Daniel J. Klemme, Debabrata Sikdar, Leonora Velleman, Yunuen Montelongo, Sang-Hyun Oh, Anthony R. Kucernak, Joshua B. Edel, Alexei A. Kornyshev
Published in: ACS Photonics, Issue 5/11, 2018, Page(s) 4604-4616, ISSN 2330-4022
Publisher: American Chemical Society
DOI: 10.1021/acsphotonics.8b01105

Covalently Attached Antimicrobial Surfaces Using BODIPY: Improving Efficiency and Effectiveness

Author(s): William J. Peveler, Sacha Noimark, Hassan Al-Azawi, Gi Byoung Hwang, Colin R. Crick, Elaine Allan, Joshua B. Edel, Aleksandar P. Ivanov, Alexander J. MacRobert, Ivan P. Parkin
Published in: ACS Applied Materials & Interfaces, Issue 10/1, 2017, Page(s) 98-104, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.7b13273

Electrotunable nanoplasmonic liquid mirror

Author(s): Yunuen Montelongo, Debabrata Sikdar, Ye Ma, Alastair J. S. McIntosh, Leonora Velleman, Anthony R. Kucernak, Joshua B. Edel, Alexei A. Kornyshev
Published in: Nature Materials, Issue 16/11, 2017, Page(s) 1127-1135, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/nmat4969

Scissoring genes with light

Author(s): Aleksandar P. Ivanov, Joshua B. Edel
Published in: Nature Chemistry, Issue 10/8, 2018, Page(s) 800-801, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-018-0116-6

Chemically Modified Hydrogel-Filled Nanopores: A Tunable Platform for Single-Molecule Sensing

Author(s): Dana Al Sulaiman, Paolo Cadinu, Aleksandar P. Ivanov, Joshua B. Edel, Sylvain Ladame
Published in: Nano Letters, Issue 18/9, 2018, Page(s) 6084-6093, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.8b03111

Single-molecule nanopore sensing of actin dynamics and drug binding

Author(s): Xiaoyi Wang, Mark D. Wilkinson, Xiaoyan Lin, Ren Ren, Keith R. Willison, Aleksandar P. Ivanov, Jake Baum, Joshua B. Edel
Published in: Chemical Science, 2020, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9sc05710b

High-resolution label-free 3D mapping of extracellular pH of single living cells

Author(s): Yanjun Zhang, Yasufumi Takahashi, Sung Pil Hong, Fengjie Liu, Joanna Bednarska, Philip S. Goff, Pavel Novak, Andrew Shevchuk, Sahana Gopal, Iros Barozzi, Luca Magnani, Hideki Sakai, Yoshimoto Suguru, Takuto Fujii, Alexander Erofeev, Peter Gorelkin, Alexander Majouga, Dominik J. Weiss, Christopher Edwards, Aleksandar P. Ivanov, David Klenerman, Elena V. Sviderskaya, Joshua B. Edel, Yuri Korchev
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13535-1

Auxetic Thermoresponsive Nanoplasmonic Optical Switch

Author(s): Ye Ma, Debabrata Sikdar, Aleksandra Fedosyuk, Leonora Velleman, Minggang Zhao, Longhua Tang, Alexei A. Kornyshev, Joshua B. Edel
Published in: ACS Applied Materials & Interfaces, Issue 11/25, 2019, Page(s) 22754-22760, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.9b05530

Small molecule electro-optical binding assay using nanopores

Author(s): Shenglin Cai, Jasmine Y. Y. Sze, Aleksandar P. Ivanov, Joshua B. Edel
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09476-4

Rapid Fragmentation during Seeded Lysozyme Aggregation Revealed at the Single Molecule Level

Author(s): Markéta Kubánková, Xiaoyan Lin, Tim Albrecht, Joshua B. Edel, Marina K. Kuimova
Published in: Analytical Chemistry, 2019, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.9b01221

Electrotunable Nanoplasmonics for Amplified Surface Enhanced Raman Spectroscopy

Author(s): Ye Ma, Debabrata Sikdar, Aleksandra Fedosyuk, Leonora Velleman, Daniel J. Klemme, Sang-Hyun Oh, Anthony R. J. Kucernak, Alexei A. Kornyshev, Joshua B. Edel
Published in: ACS Nano, 2019, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.9b05257

In situ solid-state nanopore fabrication

Author(s): Jasper P. Fried; Jacob L. Swett; Binoy Paulose Nadappuram; Jan A. Mol; Joshua B. Edel; Aleksandar P. Ivanov; James Yates
Published in: Chemical Society Reviews, Issue 2, 2021, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cs00924e

Self-assembling two-dimensional nanophotonic arrays for reflectivity-based sensing

Author(s): Ye Ma, Debabrata Sikdar, Qian He, Daniel Kho, Anthony R. Kucernak, Alexei A. Kornyshev, Joshua B. Edel
Published in: Chemical Science, Issue 11/35, 2020, Page(s) 9563-9570, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sc02877k

Solid-state nanopore sensors

Author(s): Liang Xue, Hirohito Yamazaki, Ren Ren, Meni Wanunu, Aleksandar P. Ivanov, Joshua B. Edel
Published in: Nature Reviews Materials, 2020, ISSN 2058-8437
Publisher: NATURE RESEARCH
DOI: 10.1038/s41578-020-0229-6