Understanding the complexity and architecture in protein ubiquitination

Project Information

UbiArchitect

Grant agreement ID: 724804

DOI

10.3030/724804

Project terminated on 31 October 2018

EC signature date 22 March 2017

Start date 1 October 2017

End date 30 September 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 990 125,00

EU contribution

€ 1 990 125,00

Coordinated by

UNITED KINGDOM RESEARCH AND INNOVATION
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1’s Cytotoxic Potential

Author(s): Rebecca Feltham, Kunzah Jamal, Tencho Tenev, Gianmaria Liccardi, Isabel Jaco, Celia Monteiro Domingues, Otto Morris, Sidonie Wicky John, Alessandro Annibaldi, Marcella Widya, Conor J. Kearney, Danielle Clancy, Paul R. Elliott, Timo Glatter, Qi Qiao, Andrew J. Thompson, Alexey Nesvizhskii, Alexander Schmidt, David Komander, Hao Wu, Seamus Martin, Pascal Meier
Published in: Cell Reports, Issue 23/2, 2018, Page(s) 470-484, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2018.03.054

A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation

Author(s): Jonathan N. Pruneda, Robert J. Bastidas, Erithelgi Bertsoulaki, Kirby N. Swatek, Balaji Santhanam, Michael J. Clague, Raphael H. Valdivia, Sylvie Urbé, David Komander
Published in: Nature Microbiology, Issue 3/12, 2018, Page(s) 1377-1384, ISSN 2058-5276
Publisher: NPG
DOI: 10.1038/s41564-018-0271-y

Active site alanine mutations convert deubiquitinases into high‐affinity ubiquitin‐binding proteins

Author(s): Marie E Morrow, Michael T Morgan, Marcello Clerici, Katerina Growkova, Ming Yan, David Komander, Titia K Sixma, Michal Simicek, Cynthia Wolberger
Published in: EMBO reports, Issue 19/10, 2018, Page(s) e45680, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.201745680

Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies

Author(s): Kirby N. Swatek, Martina Aumayr, Jonathan N. Pruneda, Linda J. Visser, Stephen Berryman, Anja F. Kueck, Paul P. Geurink, Huib Ovaa, Frank J. M. van Kuppeveld, Tobias J. Tuthill, Tim Skern, David Komander
Published in: Proceedings of the National Academy of Sciences, Issue 115/10, 2018, Page(s) 2371-2376, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1710617115

An invisible ubiquitin conformation is required for efficient phosphorylation by PINK1

Author(s): Christina Gladkova, Alexander F Schubert, Jane L Wagstaff, Jonathan N Pruneda, Stefan MV Freund, David Komander
Published in: The EMBO Journal, Issue 36/24, 2017, Page(s) 3555-3572, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201797876

OTULIN deficiency in ORAS causes cell type‐specific LUBAC degradation, dysregulated TNF signalling and cell death

Author(s): Rune Busk Damgaard, Paul R Elliott, Kirby N Swatek, Eamonn R Maher, Polina Stepensky, Orly Elpeleg, David Komander, Yackov Berkun
Published in: EMBO Molecular Medicine, Issue 11/3, 2019, Page(s) e9324, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201809324

Mechanism of parkin activation by PINK1

Author(s): Christina Gladkova, Sarah L. Maslen, J. Mark Skehel, David Komander
Published in: Nature, Issue 559/7714, 2018, Page(s) 410-414, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0224-x

Structure of PINK1 in complex with its substrate ubiquitin

Author(s): Alexander F. Schubert, Christina Gladkova, Els Pardon, Jane L. Wagstaff, Stefan M. V. Freund, Jan Steyaert, Sarah L. Maslen, David Komander
Published in: Nature, 2017, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature24645

Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2

Author(s): Alessandro Annibaldi, Sidonie Wicky John, Tom Vanden Berghe, Kirby N. Swatek, Jianbin Ruan, Gianmaria Liccardi, Katiuscia Bianchi, Paul R. Elliott, Sze Men Choi, Samya Van Coillie, John Bertin, Hao Wu, David Komander, Peter Vandenabeele, John Silke, Pascal Meier
Published in: Molecular Cell, Issue 69/4, 2018, Page(s) 566-580.e5, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2018.01.027