Mechanics of cells: the role of intermediate filaments

Project Information

MECHANICS

Grant agreement ID: 724932

DOI 10.3030/724932

Project closed

EC signature date 27 January 2017

Start date 1 May 2017

End date 31 October 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 413 250,00

EU contribution € 2 413 250,00

Coordinated by

GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS
Germany

Publications

Peer reviewed articles (16)

Time-resolved MIET measurements of blood platelet spreading and adhesion

Author(s): Anna Zelena, Sebastian Isbaner, Daja Ruhlandt, Anna Chizhik, Chiara Cassini, Andrey S Klymchenko, Jörg Enderlein, Alexey Chizhik, Sarah Köster
Published in: Nanoscale, 2020, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0nr05611a

Focused ion beam-scanning electron microscopy links pathological myelin outfoldings to axonal changes in mice lacking Plp1 or Mag

Author(s): Anna M. Steyer, Tobias J. Buscham, Charlotta Lorenz, Sophie Hümmert, Maria A. Eichel-Vogel, Leonie C. Schadt, Julia M. Edgar, Sarah Köster, Wiebke Möbius, Klaus-Armin Nave, Hauke B. Werner
Published in: Glia, Issue 71(3), 2022, Page(s) 380-387, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.24290

Multiscale mechanics and temporal evolution of vimentin intermediate filament networks.

Author(s): Anna V. Schepers; Charlotta Lorenz; Peter Nietmann; Andreas Janshoff; Stefan Klumpp; Sarah Koester
Published in: Proc Natl Acad Sci U S A, Issue 118 (27), 2021, Page(s) e2102026118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2102026118

Structural model of the M7G46 Methyltransferase TrmB in complex with tRNA.

Author(s): Katharina F. Blersch; Jan-Philipp Burchert; Sophie-Charlotte August; Luisa Welp; Piotr Neumann; Sarah Köster; Henning Urlaub; Henning Urlaub; Ralf Ficner
Published in: RNA Biol, Issue 18 (12), 2021, Page(s) 2466-2479, ISSN 1547-6286
Publisher: Landes Bioscience
DOI: 10.1080/15476286.2021.1925477

Multiscale architecture: Mechanics of composite cytoskeletal networks

Author(s): Charlotta Lorenz, Sarah Köster
Published in: Biophysical Reviews, Issue 3 (3), 2022, Page(s) 031304, ISSN 1867-2450
Publisher: Springer Verlag
DOI: 10.1063/5.0099405

A minimalist model to measure interactions between proteins and synaptic vesicles

Author(s): Eleonora Perego, Sofiia Reshetniak, Charlotta Lorenz, Christian Hoffmann, Dragomir Milovanović, Silvio O. Rizzoli, Sarah Köster
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-77887-1

Keratin filament mechanics and energy dissipation are determined by metal-like plasticity

Author(s): Charlotta Lorenz, Johanna Forsting, Robert W. Style, Stefan Klumpp, and Sarah Köster
Published in: Matter, Issue 6, 2023, ISSN 2590-2385
Publisher: Cell Press
DOI: 10.1016/j.matt.2023.04.014

Force generation in human blood platelets by filamentous actomyosin structures

Author(s): Anna Zelená, Johannes Blumberg, Dimitri Probst, Rūta Gerasimaitė, Gražvydas Lukinavicius, Ulrich S. Schwarz, Sarah Köster
Published in: Biophysical Journal, 2023, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2023.07.010

Post-Translational Modifications Soften Vimentin Intermediate Filaments

Author(s): Julia Kraxner, Charlotta Lorenz, Julia Menzel, Iwan Parfentev, Ivan Silbern, Manuela Denz, Henning Urlaub, Blanche Schwappach, Sarah Köster
Published in: Nanoscale, 2020, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0nr07322a

Nonlinear Loading-Rate-Dependent Force Response of Individual Vimentin Intermediate Filaments to Applied Strain

Author(s): Johanna Block, Hannes Witt, Andrea Candelli, Erwin J. G. Peterman, Gijs J. L. Wuite, Andreas Janshoff, Sarah Köster
Published in: Physical Review Letters, Issue 118/4, 2017, ISSN 0031-9007
Publisher: American Physical Society
DOI: 10.1103/PhysRevLett.118.048101

Viscoelastic properties of vimentin originate from nonequilibrium conformational changes

Author(s): Johanna Block, Hannes Witt, Andrea Candelli, Jordi Cabanas Danes, Erwin J. G. Peterman, Gijs J. L. Wuite, Andreas Janshoff, Sarah Köster
Published in: Science Advances, Issue 4/6, 2018, Page(s) eaat1161, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.aat1161

Lateral Subunit Coupling Determines Intermediate Filament Mechanics

Author(s): Charlotta Lorenz, Johanna Forsting, Anna V. Schepers, Julia Kraxner, Susanne Bauch, Hannes Witt, Stefan Klumpp, Sarah Köster
Published in: Physical Review Letters, Issue 123/18, 2019, Page(s) 188102, ISSN 0031-9007
Publisher: American Physical Society
DOI: 10.1103/physrevlett.123.188102

Vimentin Intermediate Filaments Undergo Irreversible Conformational Changes during Cyclic Loading

Author(s): Johanna Forsting, Julia Kraxner, Hannes Witt, Andreas Janshoff, Sarah Köster
Published in: Nano Letters, Issue 19/10, 2019, Page(s) 7349-7356, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.9b02972

Influence of phosphorylation on intermediate filaments

Author(s): Julia Kraxner, Sarah Köster
Published in: Journal of Biological Chemistry, 2023, ISSN 1431-6730
Publisher: Walter de Gruyter GmbH & Co. KG
DOI: 10.1515/hsz-2023-0140

Tuning intermediate filament mechanics by variation of pH and ion charges

Author(s): Anna V. Schepers, Charlotta Lorenz, Sarah Köster
Published in: Nanoscale, Issue 12/28, 2020, Page(s) 15236-15245, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0nr02778b

Vimentin intermediate filaments stabilize dynamic microtubules by direct interactions

Author(s): Laura Schaedel, Charlotta Lorenz, Anna V. Schepers, Stefan Klumpp, Sarah Köster
Published in: Nature Communications, Issue 12 (1), 2021, Page(s) 3799, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23523-z

Book chapters (2)

Quantifying the Interaction Strength Between Biopolymers

Author(s): Charlotta Lorenz, Anna V. Schepers, Sarah Köster
Published in: Optical Tweezers : Methods and Protocols, 2022, Page(s) 701-723, ISBN 978-1-0716-2228-5
Publisher: Springer
DOI: 10.1007/978-1-0716-2229-2_25

Mechanics of Single Vimentin Intermediate Filaments Under Load

Author(s): Anna V. Schepers, Julia Kraxner, Charlotta Lorenz, Sarah Köster
Published in: Optical Tweezers : Methods and Protocols, 2022, ISBN 978-1-0716-2228-5
Publisher: Springer
DOI: 10.1007/978-1-0716-2229-2_24