Functional Biology of Hepatic CD8+ T cells

Project Information

FATE

Grant agreement ID: 725038

DOI

10.3030/725038

Project closed

EC signature date 29 May 2017

Start date 1 July 2017

End date 30 June 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 390 000,00

EU contribution

€ 2 390 000,00

Coordinated by

OSPEDALE SAN RAFFAELE SRL
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (15)

A subset of Kupffer cells regulates metabolism through the expression of CD36.

Author(s): Blériot C, Barreby E, Dunsmore G, Ballaire R, Chakarov S, Ficht X, De Simone G, Andreata F, Fumagalli V, Guo W, Wan G, Gessain G, Khalilnezhad A, Zhang XM, Ang N, Chen P, Morgantini C, Azzimato V, Kong WT, Liu Z, Pai R, Lum J, Shihui F, Low I, Xu C, Malleret B, Kairi MFM, Balachander A, Cexus O, Larbi A, Lee B, Newell EW, Ng LG, Phoo WW, Sobota RM, Sharma A, Howland SW, Chen J, Bajenoff M, Yvan-C
Published in: Immunity, 2021, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2021.08.006

The interaction of CD4+ helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response

Author(s): Cohen M, Giladi A, Barboy O, Hamon P, Li B, Zada M, Gurevich-Shapiro A, Beccaria CG, David E, Maier BB, Buckup M, Kamer I, Deczkowska A, Le Berichel J, Bar J, Iannacone M, Tanay A, Merad M, Amit I.
Published in: Nature cancer, 2022, ISSN 2662-1347
Publisher: Nature Publishing Group
DOI: 10.1038/s43018-022-00338-5

Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming.

Author(s): De Simone G, Andreata F, Bleriot C, Fumagalli V, Laura C, Garcia-Manteiga JM, Di Lucia P, Gilotto S, Ficht X, De Ponti FF, Bono EB, Giustini L, Ambrosi G, Mainetti M, Zordan P, Bénéchet AP, Ravà M, Chakarov S, Moalli F, Bajenoff M, Guidotti LG, Ginhoux F, Iannacone M.
Published in: Immunity, 2021, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2021.05.005

CXCR3 Identifies Human Naive CD8+ T Cells with Enhanced Effector Differentiation Potential.

Author(s): "De Simone, G.; Mazza, E.M.C.; Cassotta, A.; Davydov, A.N.; Kuka, M.; Zanon, V.; De Paoli, F.; Scamardella, E.; Metsger, M.; Roberto, A.; Pilipow, K.; Colombo, F.S.; Tenedini, E.; Tagliafico, E.; Gattinoni, L.; Mavilio, D.; Peano, C.; Price, D.A.; Singh, S.P.; Farber, J.M.; Serra, V.; Cucca, F.; Ferrari, F.; Orrù , V.; Fiorillo, E.; Iannacone, M.; Chudakov, D.M.; Sallusto, F.; Lugli, E."
Published in: The Journal of Immunology, Issue 1, 2019, ISSN 1550-6606
Publisher: AAI
DOI: 10.4049/jimmunol.1901072

Group 1 ILCs regulate T cell-mediated liver immunopathology by controlling local IL-2 availability

Author(s): Fumagalli V, Venzin V, Di Lucia P, Moalli F, Ficht X, Ambrosi G, Giustini L, Andreata F, Grillo M, Magini D, Ravà M, Friedrich C, Fontenot JD, Bousso P, Gilmore SA, Khan S, Baca M, Vivier E, Gasteiger G, Kuka M, Guidotti LG, Iannacone M.
Published in: Science immunology, 2022, ISSN 2470-9468
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciimmunol.abi6112

Heterogeneity in antiviral B cell responses: Lessons from the movies.

Author(s): Mirela Kuka; Matteo Iannacone
Published in: Immunological Reviews, Issue 1, 2021, ISSN 1600-065X
Publisher: Wiley
DOI: 10.1111/imr.13041

Serum HBsAg clearance has minimal impact on CD8+ T cell responses in mouse models of HBV infection.

Author(s): Valeria Fumagalli; Pietro Di Lucia; Valentina Venzin; Elisa Bono; Robert Jordan; Christian R. Frey; William Delaney; Francis V. Chisari; Luca G. Guidotti; Matteo Iannacone
Published in: The Journal of Experimental Medicine, Issue 1, 2021, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20200298

The conduit system exports locally secreted IgM from lymph nodes

Author(s): Guilhem R. Thierry, Mirela Kuka, Marco De Giovanni, Isabelle Mondor, Nicolas Brouilly, Matteo Iannacone, Marc Bajénoff
Published in: The Journal of Experimental Medicine, Issue 215/12, 2018, Page(s) 2972-2983, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20180344

The role of type I interferons in CD4+ T cell differentiation

Author(s): Mirela Kuka, Marco De Giovanni, Matteo Iannacone
Published in: Immunology Letters, 2019, ISSN 0165-2478
Publisher: Elsevier BV
DOI: 10.1016/j.imlet.2019.01.013

Viral subversion of B cell responses within secondary lymphoid organs

Author(s): Mirela Kuka, Matteo Iannacone
Published in: Nature Reviews Immunology, Issue 18/4, 2018, Page(s) 255-265, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/nri.2017.133

Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming

Author(s): Alexandre P. Bénéchet, Giorgia De Simone, Pietro Di Lucia, Francesco Cilenti, Giulia Barbiera, Nina Le Bert, Valeria Fumagalli, Eleonora Lusito, Federica Moalli, Valentina Bianchessi, Francesco Andreata, Paola Zordan, Elisa Bono, Leonardo Giustini, Weldy V. Bonilla, Camille Bleriot, Kamini Kunasegaran, Gloria Gonzalez-Aseguinolaza, Daniel D. Pinschewer, Patrick T. F. Kennedy, Luigi Naldini, Mire
Published in: Nature, Issue 574/7777, 2019, Page(s) 200-205, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1620-6

Spatiotemporal regulation of type I interferon expression determines the antiviral polarization of CD4+ T cells

Author(s): Marco De Giovanni, Valeria Cutillo, Amir Giladi, Eleonora Sala, Carmela G. Maganuco, Chiara Medaglia, Pietro Di Lucia, Elisa Bono, Claudia Cristofani, Eleonora Consolo, Leonardo Giustini, Alessandra Fiore, Sarah Eickhoff, Wolfgang Kastenmüller, Ido Amit, Mirela Kuka, Matteo Iannacone
Published in: Nature Immunology, Issue 21/3, 2020, Page(s) 321-330, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-020-0596-6

Discovery and antiviral profile of new sulfamoylbenzamide derivatives as HBV capsid assembly modulators

Author(s): Ivanova Bencheva L, Donnici L, Ferrante L, Prandi A, Sinisi R, De Matteo M, Randazzo P, Conti M, Di Lucia P, Bono E, Giustini L, Vittoria Orsale M, Patsilinakos A, Monteagudo E, Iannacone M, Summa V, Guidotti LG, De Francesco R, Di Fabio R.
Published in: Bioorganic & medicinal chemistry letters, 2022, ISSN 0960-894X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bmcl.2022.128904

Immune surveillance of the liver by T cells.

Author(s): Xenia Ficht; Matteo Iannacone
Published in: Science Immunology, Issue 1, 2020, ISSN 2470-9468
Publisher: AAAS
DOI: 10.1126/sciimmunol.aba2351

In vivo imaging of adaptive immune responses to viruses.

Author(s): Marco De Giovanni; Matteo Iannacone
Published in: Current Opinion in Virology, Issue 1, 2018, ISSN 1879-6265
Publisher: Elsevier
DOI: 10.1016/j.coviro.2017.12.002

Non-peer reviewed articles (2)

Immunological insights in the treatment of chronic hepatitis B

Author(s): Matteo Iannacone, Francesco Andreata, Luca G Guidotti
Published in: Current opinion in immunology, 2022, ISSN 0952-7915
Publisher: Elsevier BV
DOI: 10.1016/j.coi.2022.102207

Immunobiology and pathogenesis of hepatitis B virus infection.

Author(s): Iannacone M, Guidotti LG.
Published in: Nature reviews. Immunology., 2022, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/s41577-021-00549-4