Chemical proteome mining for functional annotation of disease relevant proteins

Project Information

CHEMMINE

Grant agreement ID: 725085

DOI

10.3030/725085

Project closed

EC signature date 6 February 2017

Start date 1 March 2017

End date 31 August 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 936 250,00

EU contribution

€ 1 936 250,00

Coordinated by

TECHNISCHE UNIVERSITAET MUENCHEN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

Bidirectional sequestration between a bacterial hibernation factor and a glutamate metabolizing protein

Author(s): David Ranava, Christopher M. Scheidler, Martin Pfanzelt, Michaela Fiedler, Stephan A. Sieber, Sabine Schneider and Mee-Ngan F. Yap
Published in: PNAS, 2022, ISSN 1091-6490
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2207257119

ECE2 regulates neurogenesis and neuronal migration during human cortical development.

Author(s): Isabel Y. Buchsbaum; Isabel Y. Buchsbaum; Pavel Kielkowski; Grazia Giorgio; Grazia Giorgio; Adam C. O’Neill; Rossella Di Giaimo; Rossella Di Giaimo; Christina Kyrousi; Shahryar Khattak; Stephan A. Sieber; Stephen P. Robertson; Silvia Cappello
Published in: EMBO Reports, Issue 2, 2020, ISSN 1469-3178
Publisher: Wiley VCH
DOI: 10.15252/embr.201948204

Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping

Author(s): Jonas Drechsel, Christina Kyrousi, Silvia Cappello, Stephan A. Sieber
Published in: RSC Chemical Biology, Issue 1/4, 2020, Page(s) 209-213, ISSN 2633-0679
Publisher: RSC
DOI: 10.1039/d0cb00048e

Tailored Pyridoxal Probes Unravel Novel Cofactor‐Dependent Targets and Antibiotic Hits in Critical Bacterial Pathogens

Author(s): Martin Pfanzelt; Thomas E. Maher; Ramona M. Absmeier; Markus Schwarz; Stephan A. Sieber
Published in: Angewandte Chemie Int. Ed., Issue 3, 2022, ISSN 1521-3773
Publisher: Wiley VCH
DOI: 10.1002/anie.202117724

Eukaryotic catecholamine hormones influence the chemotactic control of Vibrio campbellii by binding to the coupling protein CheW

Author(s): Angela Weigert Muñoz, Elisabeth Hoyer, Kilian Schumacher, Marianne Grognot, Katja M. Taute, Stephan M. Hacker, Stephan A. Sieber and Kirsten Jung
Published in: PNAS, 2022, ISSN 1091-6490
Publisher: National Acadamie of Sciences
DOI: 10.1073/pnas.2118227119

Customizing Functionalized Cofactor Mimics to Study the Human Pyridoxal 5′-Phosphate-Binding Proteome

Author(s): Anja Fux, Martin Pfanzelt, Volker C. Kirsch, Annabelle Hoegl, Stephan A. Sieber
Published in: Cell Chemical Biology, Issue 26/10, 2019, Page(s) 1461-1468.e7, ISSN 2451-9456
Publisher: Elsivier
DOI: 10.1016/j.chembiol.2019.08.003

Mining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics

Author(s): Annabelle Hoegl, Matthew B. Nodwell, Volker C. Kirsch, Nina C. Bach, Martin Pfanzelt, Matthias Stahl, Sabine Schneider, Stephan A. Sieber
Published in: Nature Chemistry, Issue 10/12, 2018, Page(s) 1234-1245, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-018-0144-2

A Pronucleotide Probe for Live‐Cell Imaging of Protein AMPylation

Author(s): Pavel Kielkowski, Isabel Y. Buchsbaum, Tobias Becker, Kathrin Bach, Silvia Cappello, Stephan A. Sieber
Published in: ChemBioChem, 2020, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201900716

FICD activity and AMPylation remodelling modulate human neurogenesis

Author(s): Pavel Kielkowski, Isabel Y. Buchsbaum, Volker C. Kirsch, Nina C. Bach, Micha Drukker, Silvia Cappello, Stephan A. Sieber
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-14235-6

Biochemical and Proteomic Studies of Human Pyridoxal 5′-Phosphate-Binding Protein (PLPBP)

Author(s): Anja Fux, Stephan A. Sieber
Published in: ACS Chemical Biology, Issue 15/1, 2019, Page(s) 254-261, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.9b00857

A tailored phosphoaspartate probe unravels CprR as a response regulator in Pseudomonas aeruginosa interkingdom signaling

Author(s): Patrick W. A. Allihn, Mathias W. Hackl, Christina Ludwig, Stephan M. Hacker, Stephan A. Sieber
Published in: Chemical Science, Issue 12/13, 2021, Page(s) 4763-4770, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sc06226j

MS-Based in Situ Proteomics Reveals AMPylation of Host Proteins during Bacterial Infection

Author(s): Theresa Rauh, Sophie Brameyer, Pavel Kielkowski, Kirsten Jung, Stephan A. Sieber
Published in: ACS Infectious Diseases, Issue 6/12, 2020, Page(s) 3277-3289, ISSN 2373-8227
Publisher: ACS
DOI: 10.1021/acsinfecdis.0c00740

Indolin-2-one Nitroimidazole Antibiotics Exhibit an Unexpected Dual Mode of Action

Author(s): Till Reinhardt, Kyu M. Lee, Lukas Niederegger, Corinna R. Hess, and Stephan A. Sieber
Published in: ACS Chemical Biology, Issue 15548929, 2022, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.2c00462

Functionalised Cofactor Mimics for Interactome Discovery and Beyond

Author(s): Isabel V. L. Wilkinson, Martin Pfanzelt, Prof. Dr. Stephan A. Sieber
Published in: Angewandte Chemie Int. Ed., 2022, ISSN 1521-3757
Publisher: Wiley VCH
DOI: 10.1002/anie.202201136