Chemical proteome mining for functional annotation of disease relevant proteins

Project Information

CHEMMINE

Grant agreement ID: 725085

DOI 10.3030/725085

Project closed

EC signature date 6 February 2017

Start date 1 March 2017

End date 31 August 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 936 250,00

EU contribution € 1 936 250,00

Coordinated by

TECHNISCHE UNIVERSITAET MUENCHEN
Germany

Publications

Peer reviewed articles (14)

Bidirectional sequestration between a bacterial hibernation factor and a glutamate metabolizing protein

Author(s): David Ranava, Christopher M. Scheidler, Martin Pfanzelt, Michaela Fiedler, Stephan A. Sieber, Sabine Schneider and Mee-Ngan F. Yap
Published in: PNAS, 2022, ISSN 1091-6490
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2207257119

ECE2 regulates neurogenesis and neuronal migration during human cortical development.

Author(s): Isabel Y. Buchsbaum; Isabel Y. Buchsbaum; Pavel Kielkowski; Grazia Giorgio; Grazia Giorgio; Adam C. O’Neill; Rossella Di Giaimo; Rossella Di Giaimo; Christina Kyrousi; Shahryar Khattak; Stephan A. Sieber; Stephen P. Robertson; Silvia Cappello
Published in: EMBO Reports, Issue 14693178, 2020, ISSN 1469-3178
Publisher: Wiley VCH
DOI: 10.15252/embr.201948204

Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping

Author(s): Jonas Drechsel, Christina Kyrousi, Silvia Cappello, Stephan A. Sieber
Published in: RSC Chemical Biology, Issue 1/4, 2020, Page(s) 209-213, ISSN 2633-0679
Publisher: RSC
DOI: 10.1039/d0cb00048e

Tailored Pyridoxal Probes Unravel Novel Cofactor‐Dependent Targets and Antibiotic Hits in Critical Bacterial Pathogens

Author(s): Martin Pfanzelt; Thomas E. Maher; Ramona M. Absmeier; Markus Schwarz; Stephan A. Sieber
Published in: Angewandte Chemie Int. Ed., Issue 15213773, 2022, ISSN 1521-3773
Publisher: Wiley VCH
DOI: 10.1002/anie.202117724

Eukaryotic catecholamine hormones influence the chemotactic control of Vibrio campbellii by binding to the coupling protein CheW

Author(s): Angela Weigert Muñoz, Elisabeth Hoyer, Kilian Schumacher, Marianne Grognot, Katja M. Taute, Stephan M. Hacker, Stephan A. Sieber and Kirsten Jung
Published in: PNAS, Issue 10916490, 2022, ISSN 1091-6490
Publisher: National Acadamie of Sciences
DOI: 10.1073/pnas.2118227119

Customizing Functionalized Cofactor Mimics to Study the Human Pyridoxal 5′-Phosphate-Binding Proteome

Author(s): Anja Fux, Martin Pfanzelt, Volker C. Kirsch, Annabelle Hoegl, Stephan A. Sieber
Published in: Cell Chemical Biology, Issue 26/10, 2019, Page(s) 1461-1468.e7, ISSN 2451-9456
Publisher: Elsivier
DOI: 10.1016/j.chembiol.2019.08.003

Mining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics

Author(s): Annabelle Hoegl, Matthew B. Nodwell, Volker C. Kirsch, Nina C. Bach, Martin Pfanzelt, Matthias Stahl, Sabine Schneider, Stephan A. Sieber
Published in: Nature Chemistry, Issue 10/12, 2018, Page(s) 1234-1245, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-018-0144-2

A Pronucleotide Probe for Live‐Cell Imaging of Protein AMPylation

Author(s): Pavel Kielkowski, Isabel Y. Buchsbaum, Tobias Becker, Kathrin Bach, Silvia Cappello, Stephan A. Sieber
Published in: ChemBioChem, 2020, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201900716

FICD activity and AMPylation remodelling modulate human neurogenesis

Author(s): Pavel Kielkowski, Isabel Y. Buchsbaum, Volker C. Kirsch, Nina C. Bach, Micha Drukker, Silvia Cappello, Stephan A. Sieber
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-14235-6

Biochemical and Proteomic Studies of Human Pyridoxal 5′-Phosphate-Binding Protein (PLPBP)

Author(s): Anja Fux, Stephan A. Sieber
Published in: ACS Chemical Biology, Issue 15/1, 2019, Page(s) 254-261, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.9b00857

A tailored phosphoaspartate probe unravels CprR as a response regulator in Pseudomonas aeruginosa interkingdom signaling

Author(s): Patrick W. A. Allihn, Mathias W. Hackl, Christina Ludwig, Stephan M. Hacker, Stephan A. Sieber
Published in: Chemical Science, Issue 12/13, 2021, Page(s) 4763-4770, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sc06226j

MS-Based in Situ Proteomics Reveals AMPylation of Host Proteins during Bacterial Infection

Author(s): Theresa Rauh, Sophie Brameyer, Pavel Kielkowski, Kirsten Jung, Stephan A. Sieber
Published in: ACS Infectious Diseases, Issue 6/12, 2020, Page(s) 3277-3289, ISSN 2373-8227
Publisher: ACS
DOI: 10.1021/acsinfecdis.0c00740

Indolin-2-one Nitroimidazole Antibiotics Exhibit an Unexpected Dual Mode of Action

Author(s): Till Reinhardt, Kyu M. Lee, Lukas Niederegger, Corinna R. Hess, and Stephan A. Sieber
Published in: ACS Chemical Biology, Issue 15548929, 2022, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.2c00462

Functionalised Cofactor Mimics for Interactome Discovery and Beyond

Author(s): Isabel V. L. Wilkinson, Martin Pfanzelt, Prof. Dr. Stephan A. Sieber
Published in: Angewandte Chemie Int. Ed., 2022, ISSN 1521-3757
Publisher: Wiley VCH
DOI: 10.1002/anie.202201136