Chemical proteome mining for functional annotation of disease relevant proteins

Publicaciones

Bidirectional sequestration between a bacterial hibernation factor and a glutamate metabolizing protein

Autores: David Ranava, Christopher M. Scheidler, Martin Pfanzelt, Michaela Fiedler, Stephan A. Sieber, Sabine Schneider and Mee-Ngan F. Yap
Publicado en: PNAS, 2022, ISSN 1091-6490
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2207257119

ECE2 regulates neurogenesis and neuronal migration during human cortical development.

Autores: Isabel Y. Buchsbaum; Isabel Y. Buchsbaum; Pavel Kielkowski; Grazia Giorgio; Grazia Giorgio; Adam C. O’Neill; Rossella Di Giaimo; Rossella Di Giaimo; Christina Kyrousi; Shahryar Khattak; Stephan A. Sieber; Stephen P. Robertson; Silvia Cappello
Publicado en: EMBO Reports, Edición 14693178, 2020, ISSN 1469-3178
Editor: Wiley VCH
DOI: 10.15252/embr.201948204

Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping

Autores: Jonas Drechsel, Christina Kyrousi, Silvia Cappello, Stephan A. Sieber
Publicado en: RSC Chemical Biology, Edición 1/4, 2020, Página(s) 209-213, ISSN 2633-0679
Editor: RSC
DOI: 10.1039/d0cb00048e

Tailored Pyridoxal Probes Unravel Novel Cofactor‐Dependent Targets and Antibiotic Hits in Critical Bacterial Pathogens

Autores: Martin Pfanzelt; Thomas E. Maher; Ramona M. Absmeier; Markus Schwarz; Stephan A. Sieber
Publicado en: Angewandte Chemie Int. Ed., Edición 15213773, 2022, ISSN 1521-3773
Editor: Wiley VCH
DOI: 10.1002/anie.202117724

Eukaryotic catecholamine hormones influence the chemotactic control of Vibrio campbellii by binding to the coupling protein CheW

Autores: Angela Weigert Muñoz, Elisabeth Hoyer, Kilian Schumacher, Marianne Grognot, Katja M. Taute, Stephan M. Hacker, Stephan A. Sieber and Kirsten Jung
Publicado en: PNAS, Edición 10916490, 2022, ISSN 1091-6490
Editor: National Acadamie of Sciences
DOI: 10.1073/pnas.2118227119

Customizing Functionalized Cofactor Mimics to Study the Human Pyridoxal 5′-Phosphate-Binding Proteome

Autores: Anja Fux, Martin Pfanzelt, Volker C. Kirsch, Annabelle Hoegl, Stephan A. Sieber
Publicado en: Cell Chemical Biology, Edición 26/10, 2019, Página(s) 1461-1468.e7, ISSN 2451-9456
Editor: Elsivier
DOI: 10.1016/j.chembiol.2019.08.003

Mining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics

Autores: Annabelle Hoegl, Matthew B. Nodwell, Volker C. Kirsch, Nina C. Bach, Martin Pfanzelt, Matthias Stahl, Sabine Schneider, Stephan A. Sieber
Publicado en: Nature Chemistry, Edición 10/12, 2018, Página(s) 1234-1245, ISSN 1755-4330
Editor: Nature Publishing Group
DOI: 10.1038/s41557-018-0144-2

A Pronucleotide Probe for Live‐Cell Imaging of Protein AMPylation

Autores: Pavel Kielkowski, Isabel Y. Buchsbaum, Tobias Becker, Kathrin Bach, Silvia Cappello, Stephan A. Sieber
Publicado en: ChemBioChem, 2020, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201900716

FICD activity and AMPylation remodelling modulate human neurogenesis

Autores: Pavel Kielkowski, Isabel Y. Buchsbaum, Volker C. Kirsch, Nina C. Bach, Micha Drukker, Silvia Cappello, Stephan A. Sieber
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-14235-6

Biochemical and Proteomic Studies of Human Pyridoxal 5′-Phosphate-Binding Protein (PLPBP)

Autores: Anja Fux, Stephan A. Sieber
Publicado en: ACS Chemical Biology, Edición 15/1, 2019, Página(s) 254-261, ISSN 1554-8929
Editor: American Chemical Society
DOI: 10.1021/acschembio.9b00857

A tailored phosphoaspartate probe unravels CprR as a response regulator in Pseudomonas aeruginosa interkingdom signaling

Autores: Patrick W. A. Allihn, Mathias W. Hackl, Christina Ludwig, Stephan M. Hacker, Stephan A. Sieber
Publicado en: Chemical Science, Edición 12/13, 2021, Página(s) 4763-4770, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/d0sc06226j

MS-Based in Situ Proteomics Reveals AMPylation of Host Proteins during Bacterial Infection

Autores: Theresa Rauh, Sophie Brameyer, Pavel Kielkowski, Kirsten Jung, Stephan A. Sieber
Publicado en: ACS Infectious Diseases, Edición 6/12, 2020, Página(s) 3277-3289, ISSN 2373-8227
Editor: ACS
DOI: 10.1021/acsinfecdis.0c00740

Indolin-2-one Nitroimidazole Antibiotics Exhibit an Unexpected Dual Mode of Action

Autores: Till Reinhardt, Kyu M. Lee, Lukas Niederegger, Corinna R. Hess, and Stephan A. Sieber
Publicado en: ACS Chemical Biology, Edición 15548929, 2022, ISSN 1554-8929
Editor: American Chemical Society
DOI: 10.1021/acschembio.2c00462

Functionalised Cofactor Mimics for Interactome Discovery and Beyond

Autores: Isabel V. L. Wilkinson, Martin Pfanzelt, Prof. Dr. Stephan A. Sieber
Publicado en: Angewandte Chemie Int. Ed., 2022, ISSN 1521-3757
Editor: Wiley VCH
DOI: 10.1002/anie.202201136

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