Functional characterisation of mitochondrial metabolic adaptations to innate sensing in dendritic cell subsets

Dendritic cells in cancer immunology and immunotherapy.

Auteurs: Wculek, Stefanie K.; Cueto, Francisco J.; Mujal, Adriana M.; Melero, Ignacio; Krummel, Matthew F.; Sancho, David
Publié dans: Nature Reviews Immunology, 20(1), 7-24., Numéro 1, 2020, Page(s) 7-24., ISSN 1474-1741
Éditeur: Nature Reviews
DOI: 10.1038/s41577-019-0210-z

The Flt3L/Flt3 Axis in Dendritic Cell Biology and Cancer Immunotherapy.

Auteurs: Francisco J. Cueto; David Sancho
Publié dans: Cancers, Vol 13, Iss 1525, Numéro 1, 2021, Page(s) 1525, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13071525

Metabolism of tissue macrophages in homeostasis and pathology- Review article

Auteurs: Wculek, S. K., Dunphy, G., Heras-Murillo, I., Mastrangelo, A., & Sancho, D
Publié dans: Cellular & Molecular Immunology, 19(3), 384-408, 2022, Page(s) 384-408, ISSN 2042-0226
Éditeur: Nature
DOI: 10.1038/s41423-021-00791-9

A Proposal for Nomenclature in Myeloid C-Type Lectin Receptors.

Auteurs: Carlos del Fresno; Francisco J. Cueto; David Sancho
Publié dans: Frontiers in Immunology, Vol 10 (2019), Numéro 5, 2019, ISSN 1664-3224
Éditeur: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.02098

Clec2d Joins the Cell Death Sensor Ranks.

Auteurs: del Fresno, Carlos; Sancho, David
Publié dans: IMMUNITY, Numéro 2020 Jan 14;52(1), 2020, ISSN 1074-7613
Éditeur: CELL PRESS
DOI: 10.1016/j.immuni.2019.12.015

Expression of HMGCS2 in intestinal epithelial cells is downregulated in inflammatory bowel disease associated with endoplasmic reticulum stress.

Auteurs: Martín-Adrados B, Wculek SK, Fernández-Bravo S, Torres-Ruiz R, Valle-Noguera A, Gomez-Sánchez MJ, Hernández-Walias JC, Ferreira FM, Corraliza AM, Sancho D, Esteban V, Rodriguez-Perales S, Cruz-Adalia A, Nakaya HI, Salas A, Bernardo D, Campos-Martín Y, Martínez-Zamorano E, Muñoz-López D, Gómez Del Moral M, Cubero FJ, Blumberg RS, Martínez-Naves E.
Publié dans: Frontiers in Immunology, Numéro 2023 Jun 30:14, 2023, Page(s) 1185517, ISSN 1664-3224
Éditeur: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2023.1185517

Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity

Auteurs: Rebeca Acín-Pérez; Rebeca Acín-Pérez; Salvador Iborra; Salvador Iborra; Yolanda Martí-Mateos; Emma C. L. Cook; Ruth Conde-Garrosa; Anton Petcherski; Mª Del Mar Muñoz; Raquel Martínez de Mena; Karthickeyan Chella Krishnan; Concepción Jiménez; Juan P. Bolaños; Juan P. Bolaños; Markku Laakso; Aldon J. Lusis; Orian S. Shirihai; David Sancho; José Antonio Enríquez; José Antonio Enríquez
Publié dans: Nature Metabolism, 2(9), 2020, Page(s) 974-988, ISSN 2522-5812
Éditeur: Nature
DOI: 10.1038/s42255-020-00273-8

DNGR-1, a Dendritic Cell-Specific Sensor of Tissue Damage That Dually Modulates Immunity and Inflammation.

Auteurs: Francisco J. Cueto; Carlos del Fresno; David Sancho
Publié dans: Frontiers in Immunology, 10, Numéro 6, 2020, Page(s) 3146, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2019.03146

Trained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infections

Auteurs: Paola Brandi, Laura Conejero, Francisco J.Cueto, Sarai Martínez-Cano, Gillian Dunphy, Manuel J.Gómez, Carlos Relaño, Paula Saz-Leal, MichelEnamorado, Ana Quintas, AnaDopazo, JoaquínAmores-Iniesta, Carlosdel Fresno, Estanislao Nistal-Villán, Carlos Ardavín, Antonio Nieto, Miguel Casanovas José Luis Subiza, David Sancho
Publié dans: Cell Reports, volume 39, issue 1, 2022, Page(s) 110184, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2021.110184

Cell death induced by cytotoxic CD8+ T cells is immunogenic and primes caspase-3–dependent spread immunity against endogenous tumor antigens

Auteurs: Paula Jaime-Sánchez; Iratxe Uranga-Murillo; Nacho Aguilo; Sofía C. Khouili; Maykel Arias; David Sancho; Julián Pardo
Publié dans: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1, Numéro 1, 2020, Page(s) e000528, ISSN 2051-1426
Éditeur: BMJ
DOI: 10.1136/jitc-2020-000528

Dendritic Cells and Microglia Have Non-redundant Functions in the Inflamed Brain with Protective Effects of Type 1 cDCs.

Auteurs: Mattia Gallizioli; Francesc Miró-Mur; Amaia Otxoa-de-Amezaga; Roger Cugota; Angélica Salas-Perdomo; Carles Justicia; Vanessa H Brait; Francisca Ruiz-Jaén; Maria Arbaizar; Jordi Pedragosa; Ester Bonfill-Teixidor; Mathias Gelderblom; Tim Magnus; Eva Cano; Carlos del Fresno; David Sancho; Anna M. Planas
Publié dans: Cell Reports, 33(3), 108291., Numéro 6, 2020, Page(s) 108291., ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2020.108291

The Bacterial Mucosal Immunotherapy MV130 Protects Against SARS-CoV-2 Infection and Improves COVID-19 Vaccines Immunogenicity

Auteurs: Carlos del Fresno; Carlos del Fresno; Juan García-Arriaza; Sarai Martínez-Cano; Sarai Martínez-Cano; Ignacio Heras-Murillo; Aitor Jarit-Cabanillas; Joaquín Amores-Iniesta; Paola Brandi; Gillian Dunphy; Carmen Suay-Corredera; Maria Rosaria Pricolo; Natalia Vicente; Andrés López-Perrote; Sofía Cabezudo; Ana González-Corpas; Oscar Llorca; Jorge Alegre-Cebollada; Urtzi Garaigorta; Pablo Gastam
Publié dans: Frontiers in Immunology, 12, Numéro 7, 2021, Page(s) 748103, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2021.748103

Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen

Auteurs: Stefanie K. Wculek, Joaquín Amores-Iniesta, Ruth Conde-Garrosa, Sofía C. Khouili, Ignacio Melero, David Sancho
Publié dans: Journal for ImmunoTherapy of Cancer, Numéro 7/1, 2019, Page(s) 100, ISSN 2051-1426
Éditeur: BioMed Central
DOI: 10.1186/s40425-019-0565-5

Flexible Signaling of Myeloid C-Type Lectin Receptors in Immunity and Inflammation

Auteurs: Carlos del Fresno, Salvador Iborra, Paula Saz-Leal, María Martínez-López, David Sancho
Publié dans: Frontiers in Immunology, Numéro 9, 2018, Page(s) 804, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2018.00804

Leishmania Hijacks Myeloid Cells for Immune Escape

Auteurs: María Martínez-López, Manuel Soto, Salvador Iborra, David Sancho
Publié dans: Frontiers in Microbiology, Numéro 9, 2018, Page(s) 883, ISSN 1664-302X
Éditeur: Frontiers Media
DOI: 10.3389/fmicb.2018.00883

Genealogy, Dendritic Cell Priming, and Differentiation of Tissue-Resident Memory CD8+ T Cells

Auteurs: Michel Enamorado, Sofía C. Khouili, Salvador Iborra, David Sancho
Publié dans: Frontiers in Immunology, Numéro 9, 2018, Page(s) 1751, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2018.01751

Dectin-1/2–induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses

Auteurs: Maria M. M. Kaisar, Manuel Ritter, Carlos del Fresno, Hulda S. Jónasdóttir, Alwin J. van der Ham, Leonard R. Pelgrom, Gabriele Schramm, Laura E. Layland, David Sancho, Clarissa Prazeres da Costa, Martin Giera, Maria Yazdanbakhsh, Bart Everts
Publié dans: PLOS Biology, Numéro 16/4, 2018, Page(s) e2005504, ISSN 1545-7885
Éditeur: Public Library of Science
DOI: 10.1371/journal.pbio.2005504

Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis

Auteurs: Tamara Girbl, Tchern Lenn, Lorena Perez, Loïc Rolas, Anna Barkaway, Aude Thiriot, Carlos del Fresno, Eleanor Lynam, Elin Hub, Marcus Thelen, Gerard Graham, Ronen Alon, David Sancho, Ulrich H. von Andrian, Mathieu-Benoit Voisin, Antal Rot, Sussan Nourshargh
Publié dans: Immunity, Numéro 49/6, 2018, Page(s) 1062-1076.e6, ISSN 1074-7613
Éditeur: Cell Press
DOI: 10.1016/j.immuni.2018.09.018

Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8+ T Cell Cross-Priming

Auteurs: Dieke van Dinther, Henrike Veninga, Salvador Iborra, Ellen G.F. Borg, Leoni Hoogterp, Katarzyna Olesek, Marieke R. Beijer, Sjoerd T.T. Schetters, Hakan Kalay, Juan J. Garcia-Vallejo, Kees L. Franken, Lamin B. Cham, Karl S. Lang, Yvette van Kooyk, David Sancho, Paul R. Crocker, Joke M.M. den Haan
Publié dans: Cell Reports, Numéro 22/6, 2018, Page(s) 1484-1495, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2018.01.021

Von Hippel-Lindau Protein Is Required for Optimal Alveolar Macrophage Terminal Differentiation, Self-Renewal, and Function

Auteurs: Helena M. Izquierdo, Paola Brandi, Manuel-José Gómez, Ruth Conde-Garrosa, Elena Priego, Michel Enamorado, Sarai Martínez-Cano, Iria Sánchez, Laura Conejero, Daniel Jimenez-Carretero, Silvia Martín-Puig, Martin Guilliams, David Sancho
Publié dans: Cell Reports, Numéro 24/7, 2018, Page(s) 1738-1746, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2018.07.034

DNGR-1 in dendritic cells limits tissue damage by dampening neutrophil recruitment

Auteurs: Carlos del Fresno, Paula Saz-Leal, Michel Enamorado, Stefanie K. Wculek, Sarai Martínez-Cano, Noelia Blanco-Menéndez, Oliver Schulz, Mattia Gallizioli, Francesc Miró-Mur, Eva Cano, Anna Planas, David Sancho
Publié dans: Science, Numéro 362/6412, 2018, Page(s) 351-356, ISSN 0036-8075
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/science.aan8423

Targeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to Infection

Auteurs: Paula Saz-Leal, Carlos del Fresno, Paola Brandi, Sarai Martínez-Cano, Otto M. Dungan, John D. Chisholm, William G. Kerr, David Sancho
Publié dans: Cell Reports, Numéro 25/5, 2018, Page(s) 1118-1126, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2018.09.092

Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity

Auteurs: María Martínez-López, Salvador Iborra, Ruth Conde-Garrosa, Annalaura Mastrangelo, Camille Danne, Elizabeth R. Mann, Delyth M. Reid, Valérie Gaboriau-Routhiau, Maria Chaparro, María P. Lorenzo, Lara Minnerup, Paula Saz-Leal, Emma Slack, Benjamin Kemp, Javier P. Gisbert, Andrzej Dzionek, Matthew J. Robinson, Francisco J. Rupérez, Nadine Cerf-Bensussan, Gordon D. Brown, David Bernardo, Salomé
Publié dans: Immunity, Numéro 50/2, 2019, Page(s) 446-461.e9, ISSN 1074-7613
Éditeur: Cell Press
DOI: 10.1016/j.immuni.2018.12.020

Metabolic Control of Dendritic Cell Functions: Digesting Information

Auteurs: Stefanie K. Wculek, Sofía C. Khouili, Elena Priego, Ignacio Heras-Murillo, David Sancho
Publié dans: Frontiers in Immunology, Numéro 10, 2019, Page(s) 775, ISSN 1664-3224
Éditeur: Frontiers Media
DOI: 10.3389/fimmu.2019.00775

cDC1s: New Orchestrators of Tissue Innate Immunity

Auteurs: Carlos del Fresno, David Sancho
Publié dans: Trends in Immunology, Numéro 40/7, 2019, Page(s) 559-561, ISSN 1471-4906
Éditeur: Elsevier BV
DOI: 10.1016/j.it.2019.05.002

A Neutrophil Timer Coordinates Immune Defense and Vascular Protection

Auteurs: José M. Adrover, Carlos del Fresno, Georgiana Crainiciuc, Maria Isabel Cuartero, María Casanova-Acebes, Linnea A. Weiss, Hector Huerga-Encabo, Carlos Silvestre-Roig, Jan Rossaint, Itziar Cossío, Ana V. Lechuga-Vieco, Jaime García-Prieto, Mónica Gómez-Parrizas, Juan A. Quintana, Ivan Ballesteros, Sandra Martin-Salamanca, Alejandra Aroca-Crevillen, Shu Zhen Chong, Maximilien Evrard, Karl Balab
Publié dans: Immunity, Numéro 50/2, 2019, Page(s) 390-402.e10, ISSN 1074-7613
Éditeur: Cell Press
DOI: 10.1016/j.immuni.2019.01.002

Poststroke Lung Infection by Opportunistic Commensal Bacteria Is Not Mediated by Their Expansion in the Gut Microbiota

Auteurs: Díaz-Marugan L, Gallizioli M, Márquez-Kisinousky L, Arboleya S, Mastrangelo A, Ruiz-Jaén F, Pedragosa J, Casals C, Morales FJ, Ramos-Romero S, Traserra S, Justicia C, Gueimonde M, Jiménez M, Torres JL, Urra X, Chamorro Á, Sancho D, de Los Reyes-Gavilán CG, Miró-Mur F, Planas AM.
Publié dans: Stroke, Numéro 2023 Jul;54(7), 2023, Page(s) 1875-1887, ISSN 0039-2499
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.123.042755

DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells

Auteurs: Francisco J. Cueto; Carlos del Fresno; Carlos del Fresno; Paola Brandi; Alexis J. Combes; Elena Hernández-García; Alfonso R. Sánchez-Paulete; Michel Enamorado; Michel Enamorado; Christian P. Bromley; Manuel Gómez; Ruth Conde-Garrosa; Santos Mañes; Santiago Zelenay; Ignacio Melero; Salvador Iborra; Matthew F. Krummel; David Sancho
Publié dans: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021), Numéro 3, 2021, Page(s) e002054, ISSN 2051-1426
Éditeur: BMJ Journals
DOI: 10.1136/jitc-2020-002054

Conventional type 1 dendritic cells protect against age-related adipose tissue dysfunction and obesity

Auteurs: Hernández-García E, Cueto FJ, Cook ECL, Redondo-Urzainqui A, Charro-Zanca S, Robles-Vera I, Conde-Garrosa R, Nikolić I, Sabio G, Sancho D, Iborra S.
Publié dans: Cell Mol Immunol. Feb;19(2):260-275, 2022, Page(s) 260-275, ISSN 2042-0226
Éditeur: Springer
DOI: 10.1038/s41423-021-00812-7

Sensing Tissue Damage by Myeloid C-Type Lectin Receptors

Auteurs: del Fresno, Carlos; Cueto, Francisco J.; Sancho, David
Publié dans: C-TYPE LECTINS IN IMMUNE HOMEOSTASIS, Numéro 2020:429, 2020, Page(s) 117-145, ISSN 0070-217X
Éditeur: Springer Verlag
DOI: 10.1007/82_2019_194

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