Functional characterisation of mitochondrial metabolic adaptations to innate sensing in dendritic cell subsets

Informazioni relative al progetto

MITOMAD

ID dell’accordo di sovvenzione: 725091

DOI

10.3030/725091

Progetto chiuso

Data della firma CE 6 Aprile 2017

Data di avvio 1 Dicembre 2017

Data di completamento 30 Novembre 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 995 000,00

Contributo UE

€ 1 995 000,00

Coordinato da

CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
Spain

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Other (5)

Dendritic cells in cancer immunology and immunotherapy.

Autori: Wculek, Stefanie K.; Cueto, Francisco J.; Mujal, Adriana M.; Melero, Ignacio; Krummel, Matthew F.; Sancho, David
Pubblicato in: Nature Reviews Immunology, 20(1), 7-24., Numero 1, 2020, Pagina/e 7-24., ISSN 1474-1741
Editore: Nature Reviews
DOI: 10.1038/s41577-019-0210-z

The Flt3L/Flt3 Axis in Dendritic Cell Biology and Cancer Immunotherapy.

Autori: Francisco J. Cueto; David Sancho
Pubblicato in: Cancers, Vol 13, Iss 1525, Numero 1, 2021, Pagina/e 1525, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13071525

Metabolism of tissue macrophages in homeostasis and pathology- Review article

Autori: Wculek, S. K., Dunphy, G., Heras-Murillo, I., Mastrangelo, A., & Sancho, D
Pubblicato in: Cellular & Molecular Immunology, 19(3), 384-408, 2022, Pagina/e 384-408, ISSN 2042-0226
Editore: Nature
DOI: 10.1038/s41423-021-00791-9

A Proposal for Nomenclature in Myeloid C-Type Lectin Receptors.

Autori: Carlos del Fresno; Francisco J. Cueto; David Sancho
Pubblicato in: Frontiers in Immunology, Vol 10 (2019), Numero 5, 2019, ISSN 1664-3224
Editore: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.02098

Clec2d Joins the Cell Death Sensor Ranks.

Autori: del Fresno, Carlos; Sancho, David
Pubblicato in: IMMUNITY, Numero 2020 Jan 14;52(1), 2020, ISSN 1074-7613
Editore: CELL PRESS
DOI: 10.1016/j.immuni.2019.12.015

Peer reviewed articles (27)

Expression of HMGCS2 in intestinal epithelial cells is downregulated in inflammatory bowel disease associated with endoplasmic reticulum stress.

Autori: Martín-Adrados B, Wculek SK, Fernández-Bravo S, Torres-Ruiz R, Valle-Noguera A, Gomez-Sánchez MJ, Hernández-Walias JC, Ferreira FM, Corraliza AM, Sancho D, Esteban V, Rodriguez-Perales S, Cruz-Adalia A, Nakaya HI, Salas A, Bernardo D, Campos-Martín Y, Martínez-Zamorano E, Muñoz-López D, Gómez Del Moral M, Cubero FJ, Blumberg RS, Martínez-Naves E.
Pubblicato in: Frontiers in Immunology, Numero 2023 Jun 30:14, 2023, Pagina/e 1185517, ISSN 1664-3224
Editore: FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2023.1185517

Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity

Autori: Rebeca Acín-Pérez; Rebeca Acín-Pérez; Salvador Iborra; Salvador Iborra; Yolanda Martí-Mateos; Emma C. L. Cook; Ruth Conde-Garrosa; Anton Petcherski; Mª Del Mar Muñoz; Raquel Martínez de Mena; Karthickeyan Chella Krishnan; Concepción Jiménez; Juan P. Bolaños; Juan P. Bolaños; Markku Laakso; Aldon J. Lusis; Orian S. Shirihai; David Sancho; José Antonio Enríquez; José Antonio Enríquez
Pubblicato in: Nature Metabolism, 2(9), 2020, Pagina/e 974-988, ISSN 2522-5812
Editore: Nature
DOI: 10.1038/s42255-020-00273-8

DNGR-1, a Dendritic Cell-Specific Sensor of Tissue Damage That Dually Modulates Immunity and Inflammation.

Autori: Francisco J. Cueto; Carlos del Fresno; David Sancho
Pubblicato in: Frontiers in Immunology, 10, Numero 6, 2020, Pagina/e 3146, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2019.03146

Trained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infections

Autori: Paola Brandi, Laura Conejero, Francisco J.Cueto, Sarai Martínez-Cano, Gillian Dunphy, Manuel J.Gómez, Carlos Relaño, Paula Saz-Leal, MichelEnamorado, Ana Quintas, AnaDopazo, JoaquínAmores-Iniesta, Carlosdel Fresno, Estanislao Nistal-Villán, Carlos Ardavín, Antonio Nieto, Miguel Casanovas José Luis Subiza, David Sancho
Pubblicato in: Cell Reports, volume 39, issue 1, 2022, Pagina/e 110184, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.110184

Cell death induced by cytotoxic CD8+ T cells is immunogenic and primes caspase-3–dependent spread immunity against endogenous tumor antigens

Autori: Paula Jaime-Sánchez; Iratxe Uranga-Murillo; Nacho Aguilo; Sofía C. Khouili; Maykel Arias; David Sancho; Julián Pardo
Pubblicato in: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1, Numero 1, 2020, Pagina/e e000528, ISSN 2051-1426
Editore: BMJ
DOI: 10.1136/jitc-2020-000528

Dendritic Cells and Microglia Have Non-redundant Functions in the Inflamed Brain with Protective Effects of Type 1 cDCs.

Autori: Mattia Gallizioli; Francesc Miró-Mur; Amaia Otxoa-de-Amezaga; Roger Cugota; Angélica Salas-Perdomo; Carles Justicia; Vanessa H Brait; Francisca Ruiz-Jaén; Maria Arbaizar; Jordi Pedragosa; Ester Bonfill-Teixidor; Mathias Gelderblom; Tim Magnus; Eva Cano; Carlos del Fresno; David Sancho; Anna M. Planas
Pubblicato in: Cell Reports, 33(3), 108291., Numero 6, 2020, Pagina/e 108291., ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.108291

Dendritic Cell-Mediated Cross-Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS-CoV-2.

Autori: Lázaro-Gorines R, Pérez P, Heras-Murillo I, Adán-Barrientos I, Albericio G, Astorgano D, Flores S, Luczkowiak J, Labiod N, Harwood SL, Segura-Tudela A, Rubio-Pérez L, Nugraha Y, Shang X, Li Y, Alfonso C, Adipietro KA, Abeyawardhane DL, Navarro R, Compte M, Yu W, MacKerell AD Jr, Sanz L, Weber DJ, Blanco FJ, Esteban M, Pozharski E, Godoy-Ruiz R, Muñoz IG, Delgado R, Sancho D, García-Arriaza J
Pubblicato in: Adv Sci (Weinh), 2023, Pagina/e 1-17, ISSN 2198-3844
Editore: WILEY
DOI: 10.1002/advs.202304818

The Bacterial Mucosal Immunotherapy MV130 Protects Against SARS-CoV-2 Infection and Improves COVID-19 Vaccines Immunogenicity

Autori: Carlos del Fresno; Carlos del Fresno; Juan García-Arriaza; Sarai Martínez-Cano; Sarai Martínez-Cano; Ignacio Heras-Murillo; Aitor Jarit-Cabanillas; Joaquín Amores-Iniesta; Paola Brandi; Gillian Dunphy; Carmen Suay-Corredera; Maria Rosaria Pricolo; Natalia Vicente; Andrés López-Perrote; Sofía Cabezudo; Ana González-Corpas; Oscar Llorca; Jorge Alegre-Cebollada; Urtzi Garaigorta; Pablo Gastam
Pubblicato in: Frontiers in Immunology, 12, Numero 7, 2021, Pagina/e 748103, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2021.748103

Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen

Autori: Stefanie K. Wculek, Joaquín Amores-Iniesta, Ruth Conde-Garrosa, Sofía C. Khouili, Ignacio Melero, David Sancho
Pubblicato in: Journal for ImmunoTherapy of Cancer, Numero 7/1, 2019, Pagina/e 100, ISSN 2051-1426
Editore: BioMed Central
DOI: 10.1186/s40425-019-0565-5

Flexible Signaling of Myeloid C-Type Lectin Receptors in Immunity and Inflammation

Autori: Carlos del Fresno, Salvador Iborra, Paula Saz-Leal, María Martínez-López, David Sancho
Pubblicato in: Frontiers in Immunology, Numero 9, 2018, Pagina/e 804, ISSN 1664-3224
Editore: Frontiers Media
DOI: 10.3389/fimmu.2018.00804

Leishmania Hijacks Myeloid Cells for Immune Escape

Autori: María Martínez-López, Manuel Soto, Salvador Iborra, David Sancho
Pubblicato in: Frontiers in Microbiology, Numero 9, 2018, Pagina/e 883, ISSN 1664-302X
Editore: Frontiers Media
DOI: 10.3389/fmicb.2018.00883

Genealogy, Dendritic Cell Priming, and Differentiation of Tissue-Resident Memory CD8+ T Cells

Autori: Michel Enamorado, Sofía C. Khouili, Salvador Iborra, David Sancho
Pubblicato in: Frontiers in Immunology, Numero 9, 2018, Pagina/e 1751, ISSN 1664-3224
Editore: Frontiers Media
DOI: 10.3389/fimmu.2018.01751

Dectin-1/2–induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses

Autori: Maria M. M. Kaisar, Manuel Ritter, Carlos del Fresno, Hulda S. Jónasdóttir, Alwin J. van der Ham, Leonard R. Pelgrom, Gabriele Schramm, Laura E. Layland, David Sancho, Clarissa Prazeres da Costa, Martin Giera, Maria Yazdanbakhsh, Bart Everts
Pubblicato in: PLOS Biology, Numero 16/4, 2018, Pagina/e e2005504, ISSN 1545-7885
Editore: Public Library of Science
DOI: 10.1371/journal.pbio.2005504

Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis

Autori: Tamara Girbl, Tchern Lenn, Lorena Perez, Loïc Rolas, Anna Barkaway, Aude Thiriot, Carlos del Fresno, Eleanor Lynam, Elin Hub, Marcus Thelen, Gerard Graham, Ronen Alon, David Sancho, Ulrich H. von Andrian, Mathieu-Benoit Voisin, Antal Rot, Sussan Nourshargh
Pubblicato in: Immunity, Numero 49/6, 2018, Pagina/e 1062-1076.e6, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2018.09.018

Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8+ T Cell Cross-Priming

Autori: Dieke van Dinther, Henrike Veninga, Salvador Iborra, Ellen G.F. Borg, Leoni Hoogterp, Katarzyna Olesek, Marieke R. Beijer, Sjoerd T.T. Schetters, Hakan Kalay, Juan J. Garcia-Vallejo, Kees L. Franken, Lamin B. Cham, Karl S. Lang, Yvette van Kooyk, David Sancho, Paul R. Crocker, Joke M.M. den Haan
Pubblicato in: Cell Reports, Numero 22/6, 2018, Pagina/e 1484-1495, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2018.01.021

Von Hippel-Lindau Protein Is Required for Optimal Alveolar Macrophage Terminal Differentiation, Self-Renewal, and Function

Autori: Helena M. Izquierdo, Paola Brandi, Manuel-José Gómez, Ruth Conde-Garrosa, Elena Priego, Michel Enamorado, Sarai Martínez-Cano, Iria Sánchez, Laura Conejero, Daniel Jimenez-Carretero, Silvia Martín-Puig, Martin Guilliams, David Sancho
Pubblicato in: Cell Reports, Numero 24/7, 2018, Pagina/e 1738-1746, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2018.07.034

DNGR-1 in dendritic cells limits tissue damage by dampening neutrophil recruitment

Autori: Carlos del Fresno, Paula Saz-Leal, Michel Enamorado, Stefanie K. Wculek, Sarai Martínez-Cano, Noelia Blanco-Menéndez, Oliver Schulz, Mattia Gallizioli, Francesc Miró-Mur, Eva Cano, Anna Planas, David Sancho
Pubblicato in: Science, Numero 362/6412, 2018, Pagina/e 351-356, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.aan8423

Targeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to Infection

Autori: Paula Saz-Leal, Carlos del Fresno, Paola Brandi, Sarai Martínez-Cano, Otto M. Dungan, John D. Chisholm, William G. Kerr, David Sancho
Pubblicato in: Cell Reports, Numero 25/5, 2018, Pagina/e 1118-1126, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2018.09.092

Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity

Autori: María Martínez-López, Salvador Iborra, Ruth Conde-Garrosa, Annalaura Mastrangelo, Camille Danne, Elizabeth R. Mann, Delyth M. Reid, Valérie Gaboriau-Routhiau, Maria Chaparro, María P. Lorenzo, Lara Minnerup, Paula Saz-Leal, Emma Slack, Benjamin Kemp, Javier P. Gisbert, Andrzej Dzionek, Matthew J. Robinson, Francisco J. Rupérez, Nadine Cerf-Bensussan, Gordon D. Brown, David Bernardo, Salomé
Pubblicato in: Immunity, Numero 50/2, 2019, Pagina/e 446-461.e9, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2018.12.020

Metabolic Control of Dendritic Cell Functions: Digesting Information

Autori: Stefanie K. Wculek, Sofía C. Khouili, Elena Priego, Ignacio Heras-Murillo, David Sancho
Pubblicato in: Frontiers in Immunology, Numero 10, 2019, Pagina/e 775, ISSN 1664-3224
Editore: Frontiers Media
DOI: 10.3389/fimmu.2019.00775

cDC1s: New Orchestrators of Tissue Innate Immunity

Autori: Carlos del Fresno, David Sancho
Pubblicato in: Trends in Immunology, Numero 40/7, 2019, Pagina/e 559-561, ISSN 1471-4906
Editore: Elsevier BV
DOI: 10.1016/j.it.2019.05.002

A Neutrophil Timer Coordinates Immune Defense and Vascular Protection

Autori: José M. Adrover, Carlos del Fresno, Georgiana Crainiciuc, Maria Isabel Cuartero, María Casanova-Acebes, Linnea A. Weiss, Hector Huerga-Encabo, Carlos Silvestre-Roig, Jan Rossaint, Itziar Cossío, Ana V. Lechuga-Vieco, Jaime García-Prieto, Mónica Gómez-Parrizas, Juan A. Quintana, Ivan Ballesteros, Sandra Martin-Salamanca, Alejandra Aroca-Crevillen, Shu Zhen Chong, Maximilien Evrard, Karl Balab
Pubblicato in: Immunity, Numero 50/2, 2019, Pagina/e 390-402.e10, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2019.01.002

Poststroke Lung Infection by Opportunistic Commensal Bacteria Is Not Mediated by Their Expansion in the Gut Microbiota

Autori: Díaz-Marugan L, Gallizioli M, Márquez-Kisinousky L, Arboleya S, Mastrangelo A, Ruiz-Jaén F, Pedragosa J, Casals C, Morales FJ, Ramos-Romero S, Traserra S, Justicia C, Gueimonde M, Jiménez M, Torres JL, Urra X, Chamorro Á, Sancho D, de Los Reyes-Gavilán CG, Miró-Mur F, Planas AM.
Pubblicato in: Stroke, Numero 2023 Jul;54(7), 2023, Pagina/e 1875-1887, ISSN 0039-2499
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.123.042755

Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis

Autori: Wculek SK, Heras-Murillo I, Mastrangelo A, Mañanes D, Galán M, Miguel V, Curtabbi A, Barbas C, Chandel NS, Enríquez JA, Lamas S, Sancho D
Pubblicato in: Immunity, 2023, Pagina/e 516-530, ISSN 1074-7613
Editore: Cell Press
DOI: 10.1016/j.immuni.2023.01.011

DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells

Autori: Francisco J. Cueto; Carlos del Fresno; Carlos del Fresno; Paola Brandi; Alexis J. Combes; Elena Hernández-García; Alfonso R. Sánchez-Paulete; Michel Enamorado; Michel Enamorado; Christian P. Bromley; Manuel Gómez; Ruth Conde-Garrosa; Santos Mañes; Santiago Zelenay; Ignacio Melero; Salvador Iborra; Matthew F. Krummel; David Sancho
Pubblicato in: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021), Numero 3, 2021, Pagina/e e002054, ISSN 2051-1426
Editore: BMJ Journals
DOI: 10.1136/jitc-2020-002054

Conventional type 1 dendritic cells protect against age-related adipose tissue dysfunction and obesity

Autori: Hernández-García E, Cueto FJ, Cook ECL, Redondo-Urzainqui A, Charro-Zanca S, Robles-Vera I, Conde-Garrosa R, Nikolić I, Sabio G, Sancho D, Iborra S.
Pubblicato in: Cell Mol Immunol. Feb;19(2):260-275, 2022, Pagina/e 260-275, ISSN 2042-0226
Editore: Springer
DOI: 10.1038/s41423-021-00812-7

Intravenous administration of BCG in mice promotes natural killer and T cell-mediated antitumor immunity in the lung

Autori: Moreo E, Jarit-Cabanillas A, Robles-Vera I, Uranga S, Guerrero C, Gómez AB, Mata-Martínez P, Minute L, Araujo-Voces M, Felgueres MJ, Esteso G, Uranga-Murillo I, Arias M, Pardo J, Martín C, Valés-Gómez M, Del Fresno C, Sancho D, Aguiló N.
Pubblicato in: Nature Communications, 2022, Pagina/e 1-17, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-41768-8

Thesis and dissertations (8)

Role of hypoxia inducible factors in alveolar macrophage physiology

Autori: Helena M. Izquierdo Fernández
Pubblicato in: 2018
Editore: n/a

DNGR-1 Acts as a cDC1-specific Checkpoint during Flt3L-based Cancer Immunotherapy

Autori: Francisco Javier Cueto Rodríguez
Pubblicato in: 2020
Editore: n/a

The myeloid C-type lectin receptor Mincle is a multifunctional sensor in immunity and homeostasis

Autori: María Martínez-López
Pubblicato in: 2019
Editore: n/a

Disturbed mitochondrial dynamics in CD8+ T cells impacts antiviral immunity

Autori: Sofía Chayeb Khouili
Pubblicato in: 2023
Editore: n/a

Una vacuna polibacteriana a través de mucosas protege contra infecciones virales respiratorias e índice inmunidad entrenada

Autori: Paola Brandi
Pubblicato in: 2020
Editore: n/a

Targeting dendritic cells for immunotherapy: cancer vaccines and metabolic modulation

Autori: Ignacio Heras Murillo
Pubblicato in: 2023
Editore: n/a

Role of SHIP-1 phosphatase in trained immunity modulation

Autori: Saz Leal, Paula
Pubblicato in: 2020
Editore: n/a
DOI: 10.4321/repisalud.7167

Mitochondrial complex I regulates antigen cross-presentation in dendritic cells

Autori: Elena Priego Saiz
Pubblicato in: 2023
Editore: n/a