Chemical Tools for Unravelling Sirtuin Function

Pubblicazioni

Metabolic control by sirtuins and other enzymes that sense NAD + , NADH, or their ratio.

Autori: Anderson, Kristin A.; Madsen, Andreas S.; Olsen, Christian A.; Hirschey, Matthew D.
Pubblicato in: Biochim. Biophys. Acta Bioenergetics, Numero 2, 2017, ISSN 0005-2728
Editore: Elsevier BV
DOI: 10.1016/j.bbabio.2017.09.005

Determination of Slow-Binding HDAC Inhibitor Potency and Subclass Selectivity

Autori: Carlos Moreno-Yruela; Christian A. Olsen
Pubblicato in: ACS Medicinal Chemistry Letters, Numero 12, 2022, ISSN 1948-5875
Editore: American Chemical Society
DOI: 10.1021/acsmedchemlett.1c00702

Hydroxamic acid-modified peptide microarrays for profiling isozyme-selective interactionsand inhibition of histone deacetylases

Autori: Carlos Moreno-Yruela, Michael Bæk, Adela-Eugenie Vrsanova, Clemens Schulte, Hans M. Maric & Christian A. Olsen
Pubblicato in: Nature Communications, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-20250-9

Class I histone deacetylases (HDAC1–3) are histone lysine delactylases

Autori: Carlos Moreno-Yruela, Di Zhang, Wei Wei, Michael Bæk, Jinjun Gao, Alexander L. Nielsen, Julie E. Bolding, Lu Yang, Samuel T. Jameson, Jiemin Wong, Christian A. Olsen, Yingming Zhao
Pubblicato in: Science Advances, Numero 52, 2022, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abi6696

Mitochondria-Targeted Inhibitors of the Human SIRT3 Lysine Deacetylase

Autori: Kathrin S. Troelsen; Michael Bæk; Alexander L. Nielsen; Andreas Stahl Madsen; Nima Rajabi; Christian A. Olsen
Pubblicato in: RSC Chemical Biology, Numero 6, 2021, ISSN 2633-0679
Editore: Royal Society of Chemistry
DOI: 10.1039/d0cb00216j

Histone Deacetylase 11 is an ε-N-Myristoyllysine Hydrolase

Autori: Madsen, Andreas; Olsen, Christian; Moreno-Yruela, Carlos; Galleano, Iacopo
Pubblicato in: Cell Chemical Biology, Numero 1, 2018, ISSN 2451-9448
Editore: Cell Press
DOI: 10.1101/211839

Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight

Autori: Nima Rajabi, Marina Auth, Kathrin R. Troelsen, Martin Pannek, Dhaval P. Bhatt, Martin Fontenas, Matthew D. Hirschey, Clemens Steegborn, Andreas S. Madsen, Christian A. Olsen
Pubblicato in: Angewandte Chemie International Edition, Numero 56/47, 2017, Pagina/e 14836-14841, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201709050

Arylfluorosulfate-Based Electrophiles for Covalent Protein Labeling: A New Addition to the Arsenal

Autori: Pablo Martín-Gago, Christian A. Olsen
Pubblicato in: Angewandte Chemie International Edition, Numero 58/4, 2019, Pagina/e 957-966, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201806037

Photo Cross‐Linking Probes Containing ϵ‐ N ‐Thioacyllysine and ϵ‐ N ‐Acyl‐(δ‐aza)lysine Residues

Autori: Michael Bæk, Pablo Martín‐Gago, Jonas S. Laursen, Julie L. H. Madsen, Saswati Chakladar, Christian A. Olsen
Pubblicato in: Chemistry – A European Journal, Numero 26/17, 2020, Pagina/e 3862-3869, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201905338

Dethioacylation by Sirtuins 1–3: Considerations for Drug Design Using Mechanism-Based Sirtuin Inhibition

Autori: Nima Rajabi, Alexander L. Nielsen, Christian A. Olsen
Pubblicato in: ACS Medicinal Chemistry Letters, 2020, ISSN 1948-5875
Editore: American Chemical Society
DOI: 10.1021/acsmedchemlett.9b00580

Aryl Fluorosulfate Based Inhibitors that Covalently Target the SIRT5 Lysine Deacylase

Autori: Julie Eilskov Bolding, Pablo Martin-Gago, Nima Rajabi, Luke Francis Gamon, Tobias Nørby Hansen, Christian R. O. Bartling, Kristian Strømgaard, Michael Jonathan Davies, Christian Adam Olsen
Pubblicato in: Angewandte Chemie, Numero 14337851, 2022, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202204565

Investigation of Carboxylic Acid Isosteres for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme

Autori: Nima Rajabi; Alexander L. Nielsen; Tobias Nikolaj Gress Hansen; Huy T. Nguyen; Michael Bæk; Julie E. Bolding; Oskar Ørts Bahlke; Sylvester E. G. Petersen; Christian R. O. Bartling; Kristian Strømgaard; Christian A. Olsen
Pubblicato in: Angewandte Chemie International Edition, Numero 52, 2022, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202115805

Chiral Posttranslational Modification to Lysine epsilon-Amino Groups

Autori: Carlos Moreno-Yruela, Michael Bæk, Fabrizio Monda, and Christian A. Olsen
Pubblicato in: Accounts of Chemical Research, Numero 12, 2022, ISSN 0001-4842
Editore: American Chemical Society
DOI: 10.1021/acs.accounts.2c00115

Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration

Autori: Alexander L. Nielsen; Nima Rajabi; Norio Kudo; Kathrine Lundø; Carlos Moreno-Yruela; Michael Bæk; Martin Fontenas; Alessia Lucidi; Andreas S. Madsen; Minoru Yoshida; Christian A. Olsen
Pubblicato in: RSC Chemical Biology, Numero 6, 2021, ISSN 2633-0679
Editore: Royal Society of Chemistry
DOI: 10.1039/d0cb00036a

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