Dissecting to hit the therapeutic targets in nucleophosmin (NPM1)-mutated acute myeloid leukemia

Project Information

ContraNPM1AML

Grant agreement ID: 725725

DOI 10.3030/725725

Project closed

EC signature date 29 March 2017

Start date 1 April 2017

End date 31 March 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 883 749,68

EU contribution € 1 883 749,68

Coordinated by

UNIVERSITA DEGLI STUDI DI PERUGIA
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (12)

ARPIR: automatic RNA-Seq pipelines with interactive report

Author(s): Giulio Spinozzi, Valentina Tini, Alessia Adorni, Brunangelo Falini, Maria Paola Martelli
Published in: BMC Bioinformatics, Issue 21/S19, 2020, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/s12859-020-03846-2

NPM1-mutated acute myeloid leukemia: from bench to bedside

Author(s): Brunangelo Falini, Lorenzo Brunetti, Paolo Sportoletti, Maria Paola Martelli
Published in: Blood, Issue 136/15, 2020, Page(s) 1707-1721, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2019004226

Dactinomycin induces complete remission associated with nucleolar stress response in relapsed/refractory NPM1-mutated AML

Author(s): Ilaria Gionfriddo, Lorenzo Brunetti, Federica Mezzasoma, Francesca Milano, Valeria Cardinali, Roberta Ranieri, Alessandra Venanzi, Sara Pierangeli, Calogero Vetro, Giulio Spinozzi, Erica Dorillo, Hsin Chieh Wu, Caroline Berthier, Raffaella Ciurnelli, Melanie J. Griffin, Claire E. Jennings, Enrico Tiacci, Paolo Sportoletti, Franca Falzetti, Hugues de Thé, Gareth J. Veal, Maria Paola Martelli, Brun
Published in: Leukemia, Issue 35/9, 2021, Page(s) 2552-2562, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-021-01192-7

Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy

Author(s): Hsin-Chieh Wu, Domitille Rérolle, Caroline Berthier, Rita Hleihel, Takashi Sakamoto, Samuel Quentin, Shirine Benhenda, Claudia Morganti, Chengchen Wu, Lidio Conte, Sylvie Rimsky, Marie Sebert, Emmanuelle Clappier, Sylvie Souquere, Stéphanie Gachet, Jean Soulier, Sylvère Durand, Jennifer J. Trowbridge, Paule Bénit, Pierre Rustin, Hiba El Hajj, Emmanuel Raffoux, Lionel Ades, Raphael Itzykson, He
Published in: Cancer Discovery, 2021, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-21-0177

Enasidenib and ivosidenib in AML

Author(s): Maria Paola Martelli, Giovanni Martino, Valeria Cardinali, Brunangelo Falini, Giovanni Martinelli, Claudio Cerchione
Published in: Minerva Medica, Issue 111/5, 2020, ISSN 0026-4806
Publisher: Edizioni Minerva Medica
DOI: 10.23736/s0026-4806.20.07024-x

A Curious Novel Combination of Nucleophosmin (NPM1) Gene Mutations Leading to Aberrant Cytoplasmic Dislocation of NPM1 in Acute Myeloid Leukemia (AML)

Author(s): Alessandra Venanzi, Roberta Rossi, Giovanni Martino, Ombretta Annibali, Giuseppe Avvisati, Maria Grazia Mameli, Paolo Sportoletti, Enrico Tiacci, Brunangelo Falini, Maria Paola Martelli
Published in: Genes, Issue 12/9, 2021, Page(s) 1426, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes12091426

How I diagnose and treat NPM1 -mutated AML

Author(s): Brunangelo Falini, Lorenzo Brunetti, Maria Paola Martelli
Published in: Blood, Issue 137/5, 2021, Page(s) 589-599, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2020008211

NOVEL NPM1 EXON 5 MUTATIONS AND GENE FUSIONS LEADING TO ABERRANT CYTOPLASMIC NUCLEOPHOSMIN IN AML

Author(s): Maria Paola Martelli, Roberta Rossi, Alessandra Venanzi, Manja Meggendorfer, Vincenzo Maria Perriello, Giovanni Martino, Orietta Spinelli, Raffaella Ciurnelli, Emanuela Varasano, Lorenzo Brunetti, Stefano Ascani, Corinne Quadalti, Valeria Cardinali, Federica Mezzasoma, Ilaria Gionfriddo, Francesca Milano, Roberta Pacini, Alessia Tabarrini, Barbara Bigerna, Francesco Albano, Giorgina Specchia, Calo
Published in: Blood, 2021, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2021012732

GATA1 epigenetic deregulation contributes to the development of AML with NPM1 and FLT3-ITD cooperating mutations

Author(s): Paolo Sportoletti, Letizia Celani, Emanuela Varasano, Roberta Rossi, Daniele Sorcini, Chiara Rompietti, Francesca Strozzini, Beatrice Del Papa, Valerio Guarente, Giulio Spinozzi, Debora Cecchini, Oxana Bereshchenko, Torsten Haferlach, Maria Paola Martelli, Franca Falzetti, Brunangelo Falini
Published in: Leukemia, Issue 33/7, 2019, Page(s) 1827-1832, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-019-0399-7

Mutant NPM1 Maintains the Leukemic State through HOX Expression

Author(s): Lorenzo Brunetti, Michael C. Gundry, Daniele Sorcini, Anna G. Guzman, Yung-Hsin Huang, Raghav Ramabadran, Ilaria Gionfriddo, Federica Mezzasoma, Francesca Milano, Behnam Nabet, Dennis L. Buckley, Steven M. Kornblau, Charles Y. Lin, Paolo Sportoletti, Maria Paola Martelli, Brunangelo Falini, Margaret A. Goodell
Published in: Cancer Cell, Issue 34/3, 2018, Page(s) 499-512.e9, ISSN 1535-6108
Publisher: Cell Press
DOI: 10.1016/j.ccell.2018.08.005

Diagnostic and therapeutic pitfalls in NPM1-mutated AML: notes from the field

Author(s): Brunangelo Falini, Sofia Sciabolacci, Lorenza Falini, Lorenzo Brunetti, Maria Paola Martelli
Published in: Leukemia, Issue 35/11, 2021, Page(s) 3113-3126, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-021-01222-4

CD123 Is Consistently Expressed on NPM1-Mutated AML Cells

Author(s): Vincenzo Maria Perriello, Ilaria Gionfriddo, Roberta Rossi, Francesca Milano, Federica Mezzasoma, Andrea Marra, Orietta Spinelli, Alessandro Rambaldi, Ombretta Annibali, Giuseppe Avvisati, Francesco Di Raimondo, Stefano Ascani, Brunangelo Falini, Maria Paola Martelli, Lorenzo Brunetti
Published in: Cancers, Issue 13/3, 2021, Page(s) 496, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13030496

Other (2)

SiCoDEA: a simple, fast and complete app for analyzing the effect of individual drugs and their combinations.

Author(s): Giulio Spinozzi, Valentina Tini, Alessio Ferrari, Ilaria Gionfriddo, Roberta Ranieri, Francesca Milano, Sara Pierangeli, Serena Donnini, Serenella Silvestri, Brunangelo Falini, Maria Paola Martelli
Published in: bioRxiv, 2022, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.04.19.488737

Prolonged XPO1 inhibition is essential for optimal anti-leukemic activity in NPM1-mutated AML

Author(s): Giulia Pianigiani, Andrea Gagliardi, Federica Mezzasoma, Francesca Rocchio, Valentina Tini, Barbara Bigerna, Paolo Sportoletti, Simona Caruso, Andrea Marra, Giulio Spinozzi, Sharon Shacham, Yosef Landesman, Concetta Quintarelli, Franco Locatelli, Maria Paola Martelli, Brunangelo Falini, Lorenzo Brunetti
Published in: bioRxiv, 2022
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.12.11.472216