Dissecting to hit the therapeutic targets in nucleophosmin (NPM1)-mutated acute myeloid leukemia

Publicaciones

ARPIR: automatic RNA-Seq pipelines with interactive report

Autores: Giulio Spinozzi, Valentina Tini, Alessia Adorni, Brunangelo Falini, Maria Paola Martelli
Publicado en: BMC Bioinformatics, Edición 21/S19, 2020, ISSN 1471-2105
Editor: BioMed Central
DOI: 10.1186/s12859-020-03846-2

NPM1-mutated acute myeloid leukemia: from bench to bedside

Autores: Brunangelo Falini, Lorenzo Brunetti, Paolo Sportoletti, Maria Paola Martelli
Publicado en: Blood, Edición 136/15, 2020, Página(s) 1707-1721, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2019004226

Dactinomycin induces complete remission associated with nucleolar stress response in relapsed/refractory NPM1-mutated AML

Autores: Ilaria Gionfriddo, Lorenzo Brunetti, Federica Mezzasoma, Francesca Milano, Valeria Cardinali, Roberta Ranieri, Alessandra Venanzi, Sara Pierangeli, Calogero Vetro, Giulio Spinozzi, Erica Dorillo, Hsin Chieh Wu, Caroline Berthier, Raffaella Ciurnelli, Melanie J. Griffin, Claire E. Jennings, Enrico Tiacci, Paolo Sportoletti, Franca Falzetti, Hugues de Thé, Gareth J. Veal, Maria Paola Martelli, Brun
Publicado en: Leukemia, Edición 35/9, 2021, Página(s) 2552-2562, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/s41375-021-01192-7

Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy

Autores: Hsin-Chieh Wu, Domitille Rérolle, Caroline Berthier, Rita Hleihel, Takashi Sakamoto, Samuel Quentin, Shirine Benhenda, Claudia Morganti, Chengchen Wu, Lidio Conte, Sylvie Rimsky, Marie Sebert, Emmanuelle Clappier, Sylvie Souquere, Stéphanie Gachet, Jean Soulier, Sylvère Durand, Jennifer J. Trowbridge, Paule Bénit, Pierre Rustin, Hiba El Hajj, Emmanuel Raffoux, Lionel Ades, Raphael Itzykson, He
Publicado en: Cancer Discovery, 2021, ISSN 2159-8274
Editor: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-21-0177

Enasidenib and ivosidenib in AML

Autores: Maria Paola Martelli, Giovanni Martino, Valeria Cardinali, Brunangelo Falini, Giovanni Martinelli, Claudio Cerchione
Publicado en: Minerva Medica, Edición 111/5, 2020, ISSN 0026-4806
Editor: Edizioni Minerva Medica
DOI: 10.23736/s0026-4806.20.07024-x

A Curious Novel Combination of Nucleophosmin (NPM1) Gene Mutations Leading to Aberrant Cytoplasmic Dislocation of NPM1 in Acute Myeloid Leukemia (AML)

Autores: Alessandra Venanzi, Roberta Rossi, Giovanni Martino, Ombretta Annibali, Giuseppe Avvisati, Maria Grazia Mameli, Paolo Sportoletti, Enrico Tiacci, Brunangelo Falini, Maria Paola Martelli
Publicado en: Genes, Edición 12/9, 2021, Página(s) 1426, ISSN 2073-4425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes12091426

How I diagnose and treat NPM1 -mutated AML

Autores: Brunangelo Falini, Lorenzo Brunetti, Maria Paola Martelli
Publicado en: Blood, Edición 137/5, 2021, Página(s) 589-599, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2020008211

NOVEL NPM1 EXON 5 MUTATIONS AND GENE FUSIONS LEADING TO ABERRANT CYTOPLASMIC NUCLEOPHOSMIN IN AML

Autores: Maria Paola Martelli, Roberta Rossi, Alessandra Venanzi, Manja Meggendorfer, Vincenzo Maria Perriello, Giovanni Martino, Orietta Spinelli, Raffaella Ciurnelli, Emanuela Varasano, Lorenzo Brunetti, Stefano Ascani, Corinne Quadalti, Valeria Cardinali, Federica Mezzasoma, Ilaria Gionfriddo, Francesca Milano, Roberta Pacini, Alessia Tabarrini, Barbara Bigerna, Francesco Albano, Giorgina Specchia, Calo
Publicado en: Blood, 2021, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2021012732

GATA1 epigenetic deregulation contributes to the development of AML with NPM1 and FLT3-ITD cooperating mutations

Autores: Paolo Sportoletti, Letizia Celani, Emanuela Varasano, Roberta Rossi, Daniele Sorcini, Chiara Rompietti, Francesca Strozzini, Beatrice Del Papa, Valerio Guarente, Giulio Spinozzi, Debora Cecchini, Oxana Bereshchenko, Torsten Haferlach, Maria Paola Martelli, Franca Falzetti, Brunangelo Falini
Publicado en: Leukemia, Edición 33/7, 2019, Página(s) 1827-1832, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/s41375-019-0399-7

Mutant NPM1 Maintains the Leukemic State through HOX Expression

Autores: Lorenzo Brunetti, Michael C. Gundry, Daniele Sorcini, Anna G. Guzman, Yung-Hsin Huang, Raghav Ramabadran, Ilaria Gionfriddo, Federica Mezzasoma, Francesca Milano, Behnam Nabet, Dennis L. Buckley, Steven M. Kornblau, Charles Y. Lin, Paolo Sportoletti, Maria Paola Martelli, Brunangelo Falini, Margaret A. Goodell
Publicado en: Cancer Cell, Edición 34/3, 2018, Página(s) 499-512.e9, ISSN 1535-6108
Editor: Cell Press
DOI: 10.1016/j.ccell.2018.08.005

Diagnostic and therapeutic pitfalls in NPM1-mutated AML: notes from the field

Autores: Brunangelo Falini, Sofia Sciabolacci, Lorenza Falini, Lorenzo Brunetti, Maria Paola Martelli
Publicado en: Leukemia, Edición 35/11, 2021, Página(s) 3113-3126, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/s41375-021-01222-4

CD123 Is Consistently Expressed on NPM1-Mutated AML Cells

Autores: Vincenzo Maria Perriello, Ilaria Gionfriddo, Roberta Rossi, Francesca Milano, Federica Mezzasoma, Andrea Marra, Orietta Spinelli, Alessandro Rambaldi, Ombretta Annibali, Giuseppe Avvisati, Francesco Di Raimondo, Stefano Ascani, Brunangelo Falini, Maria Paola Martelli, Lorenzo Brunetti
Publicado en: Cancers, Edición 13/3, 2021, Página(s) 496, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13030496

SiCoDEA: a simple, fast and complete app for analyzing the effect of individual drugs and their combinations.

Autores: Giulio Spinozzi, Valentina Tini, Alessio Ferrari, Ilaria Gionfriddo, Roberta Ranieri, Francesca Milano, Sara Pierangeli, Serena Donnini, Serenella Silvestri, Brunangelo Falini, Maria Paola Martelli
Publicado en: bioRxiv, 2022, ISSN 2692-8205
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.04.19.488737

Prolonged XPO1 inhibition is essential for optimal anti-leukemic activity in NPM1-mutated AML

Autores: Giulia Pianigiani, Andrea Gagliardi, Federica Mezzasoma, Francesca Rocchio, Valentina Tini, Barbara Bigerna, Paolo Sportoletti, Simona Caruso, Andrea Marra, Giulio Spinozzi, Sharon Shacham, Yosef Landesman, Concetta Quintarelli, Franco Locatelli, Maria Paola Martelli, Brunangelo Falini, Lorenzo Brunetti
Publicado en: bioRxiv, 2022
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2021.12.11.472216

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