Pancreatic islet dysfunction and type 2 diabetes – beyond the genome

Project Information

PAINTBOX

Grant agreement ID: 725840

DOI

10.3030/725840

Project closed

EC signature date 10 August 2017

Start date 1 October 2017

End date 30 April 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 969 445,00

EU contribution

€ 1 969 445,00

Coordinated by

LUNDS UNIVERSITET
Sweden

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (15)

Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets

Author(s): Karl Bacos, Alexander Perfilyev, Alexandros Karagiannopoulos, Elaine Cowan, Jones K Ofori, Ludivine Bertonnier-Brouty, Tina Rönn, Andreas Lindqvist, Cheng Luan, Sabrina Ruhrmann, Mtakai Ngara, Åsa Nilsson, Sevda Gheibi, Claire L Lyons, Jens O Lagerstedt, Mohammad Barghouth, Jonathan Ls Esguerra, Petr Volkov, Malin Fex, Hindrik Mulder, Nils Wierup, Ulrika Krus, Isabella Artner, Lena Eliasson, Ras
Published in: The Journal of Clinical Investigation, Issue 133(4), 2023, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci163612

Epigenetic regulation of insulin action and secretion - role in the pathogenesis of type 2 diabetes.

Author(s): Charlotte Ling
Published in: Journal of Internal Medicine, 2020, ISSN 0954-6820
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/joim.13049

Epigenetic Changes in Islets of Langerhans Preceding the Onset of Diabetes

Author(s): Meriem Ouni, Sophie Saussenthaler, Fabian Eichelmann, Markus Jähnert, Mandy Stadion, Clemens Wittenbecher, Tina Rönn, Lisa Zellner, Pascal Gottmann, Charlotte Ling, Matthias B. Schulze, Annette Schürmann
Published in: Diabetes, Issue 69/11, 2020, Page(s) 2503-2517, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db20-0204

Novel Subgroups of Type 2 Diabetes Display Different Epigenetic Patterns That Associate With Future Diabetic Complications

Author(s): Silja Schrader, Alexander Perfilyev, Emma Ahlqvist, Leif Groop, Allan Vaag, Mats Martinell, Sonia García-Calzón, Charlotte Ling
Published in: Diabetes Care, Issue 45(7), 2022, Page(s) 1621–1630, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/dc21-2489

Gestational weight gain in pregnant women with obesity is associated with cord blood DNA methylation, which partially mediates offspring anthropometrics

Author(s): Josefine Jönsson, Kristina M. Renault, Alexander Perfilyev, Allan Vaag, Emma Malchau Carlsen, Kirsten Nørgaard, Paul W. Franks, Charlotte Ling
Published in: Clinical and Translational Medicine, Issue 13(3), 2023, ISSN 2001-1326
Publisher: John Wiley & Sons, Inc
DOI: 10.1002/ctm2.1215

Glucocorticoids and glucolipotoxicity alter the DNA methylome and function of human EndoC-βH1 cells

Author(s): Cristiane Dos Santos, Alexandros Karagiannopoulos, Alex Rafacho, Alexander Perfilyev, Lena Eliasson, Charlotte Ling, Karl Bacos
Published in: Life Sciences, Issue 307, 2022, Page(s) 120854, ISSN 0024-3205
Publisher: Elsevier BV
DOI: 10.1016/j.lfs.2022.120854

MC1568 improves insulin secretion in islets from type 2 diabetes patients and rescues β-cell dysfunction caused by Hdac7 upregulation

Author(s): Mahboubeh Daneshpajooh, Lena Eliasson, Karl Bacos, Charlotte Ling
Published in: Acta Diabetologica, Issue 55/12, 2018, Page(s) 1231-1235, ISSN 0940-5429
Publisher: Springer Verlag
DOI: 10.1007/s00592-018-1201-4

Epigenetics in Human Obesity and Type 2 Diabetes

Author(s): Charlotte Ling, Tina Rönn
Published in: Cell Metabolism, Issue 29/5, 2019, Page(s) 1028-1044, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2019.03.009

The effects of high glucose exposure on global gene expression and DNA methylation in human pancreatic islets

Author(s): Elin Hall, Marloes Dekker Nitert, Petr Volkov, Siri Malmgren, Hindrik Mulder, Karl Bacos, Charlotte Ling
Published in: Molecular and Cellular Endocrinology, Issue 472, 2018, Page(s) 57-67, ISSN 0303-7207
Publisher: Elsevier BV
DOI: 10.1016/j.mce.2017.11.019

Glucolipotoxicity Alters Insulin Secretion via Epigenetic Changes in Human Islets

Author(s): Elin Hall, Josefine Jönsson, Jones K. Ofori, Petr Volkov, Alexander Perfilyev, Marloes Dekker Nitert, Lena Eliasson, Charlotte Ling, Karl Bacos
Published in: Diabetes, Issue 68/10, 2019, Page(s) 1965-1974, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db18-0900

ATAC-seq reveals alterations in open chromatin in pancreatic islets from subjects with type 2 diabetes

Author(s): Madhusudhan Bysani, Rasmus Agren, Cajsa Davegårdh, Petr Volkov, Tina Rönn, Per Unneberg, Karl Bacos, Charlotte Ling
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-44076-8

The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis

Author(s): Marie Balslev Backe, Chunyu Jin, Luz Andreone, Aditya Sankar, Karl Agger, Kristian Helin, Andreas Nygaard Madsen, Steen Seier Poulsen, Madhusudhan Bysani, Karl Bacos, Charlotte Ling, Marcelo Javier Perone, Birgitte Holst, Thomas Mandrup-Poulsen
Published in: Journal of Diabetes Research, Issue 2019, 2019, Page(s) 1-15, ISSN 2314-6745
Publisher: Hindawi Publishing Corporation
DOI: 10.1155/2019/5451038

Epigenetics of type 2 diabetes mellitus and weight change - a tool for precision medicine?

Author(s): Charlotte Ling, Karl Bacos, Tina Rönn
Published in: Nature Reviews Endocrinology, Issue 18, 2022, Page(s) 433–448, ISSN 1759-5029
Publisher: Nature Publishing Group
DOI: 10.1038/s41574-022-00671-w

Lifestyle intervention in pregnant women with obesity impacts cord blood DNA methylation, which associates with body composition in the offspring

Author(s): Josefine Jönsson; Kristina M Renault; Sonia García-Calzón; Alexander Perfilyev; Angela C. Estampador; Kirsten Nørgaard; Mads Vendelbo Lind; Allan Vaag; Line Hjort; Kim F. Michaelsen; Emma Malchau Carlsen; Emma Malchau Carlsen; Paul W. Franks; Charlotte Ling
Published in: Diabetes, Issue 70/4, 2021, Page(s) 854-866, ISSN 1939-327X
Publisher: American Diabetes Association
DOI: 10.2337/figshare.13501587

Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes

Author(s): Sonia García-Calzón, Alexander Perfilyev, Mats Martinell, Monta Ustinova, Sebastian Kalamajski, Paul W. Franks, Karl Bacos, Ilze Elbere, Jussi Pihlajamäki, Petr Volkov, Allan Vaag, Leif Groop, Marlena Maziarz, Janis Klovins, Emma Ahlqvist, Charlotte Ling
Published in: Science Translational Medicine, Issue 12/561, 2020, Page(s) eaaz1803, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aaz1803