Pancreatic islet dysfunction and type 2 diabetes – beyond the genome

Informazioni relative al progetto

PAINTBOX

ID dell’accordo di sovvenzione: 725840

DOI

10.3030/725840

Progetto chiuso

Data della firma CE 10 Agosto 2017

Data di avvio 1 Ottobre 2017

Data di completamento 30 Aprile 2023

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 969 445,00

Contributo UE

€ 1 969 445,00

Coordinato da

LUNDS UNIVERSITET
Sweden

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (15)

Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets

Autori: Karl Bacos, Alexander Perfilyev, Alexandros Karagiannopoulos, Elaine Cowan, Jones K Ofori, Ludivine Bertonnier-Brouty, Tina Rönn, Andreas Lindqvist, Cheng Luan, Sabrina Ruhrmann, Mtakai Ngara, Åsa Nilsson, Sevda Gheibi, Claire L Lyons, Jens O Lagerstedt, Mohammad Barghouth, Jonathan Ls Esguerra, Petr Volkov, Malin Fex, Hindrik Mulder, Nils Wierup, Ulrika Krus, Isabella Artner, Lena Eliasson, Ras
Pubblicato in: The Journal of Clinical Investigation, Numero 133(4), 2023, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci163612

Epigenetic regulation of insulin action and secretion - role in the pathogenesis of type 2 diabetes.

Autori: Charlotte Ling
Pubblicato in: Journal of Internal Medicine, 2020, ISSN 0954-6820
Editore: Blackwell Publishing Inc.
DOI: 10.1111/joim.13049

Epigenetic Changes in Islets of Langerhans Preceding the Onset of Diabetes

Autori: Meriem Ouni, Sophie Saussenthaler, Fabian Eichelmann, Markus Jähnert, Mandy Stadion, Clemens Wittenbecher, Tina Rönn, Lisa Zellner, Pascal Gottmann, Charlotte Ling, Matthias B. Schulze, Annette Schürmann
Pubblicato in: Diabetes, Numero 69/11, 2020, Pagina/e 2503-2517, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db20-0204

Novel Subgroups of Type 2 Diabetes Display Different Epigenetic Patterns That Associate With Future Diabetic Complications

Autori: Silja Schrader, Alexander Perfilyev, Emma Ahlqvist, Leif Groop, Allan Vaag, Mats Martinell, Sonia García-Calzón, Charlotte Ling
Pubblicato in: Diabetes Care, Numero 45(7), 2022, Pagina/e 1621–1630, ISSN 0149-5992
Editore: American Diabetes Association
DOI: 10.2337/dc21-2489

Gestational weight gain in pregnant women with obesity is associated with cord blood DNA methylation, which partially mediates offspring anthropometrics

Autori: Josefine Jönsson, Kristina M. Renault, Alexander Perfilyev, Allan Vaag, Emma Malchau Carlsen, Kirsten Nørgaard, Paul W. Franks, Charlotte Ling
Pubblicato in: Clinical and Translational Medicine, Numero 13(3), 2023, ISSN 2001-1326
Editore: John Wiley & Sons, Inc
DOI: 10.1002/ctm2.1215

Glucocorticoids and glucolipotoxicity alter the DNA methylome and function of human EndoC-βH1 cells

Autori: Cristiane Dos Santos, Alexandros Karagiannopoulos, Alex Rafacho, Alexander Perfilyev, Lena Eliasson, Charlotte Ling, Karl Bacos
Pubblicato in: Life Sciences, Numero 307, 2022, Pagina/e 120854, ISSN 0024-3205
Editore: Elsevier BV
DOI: 10.1016/j.lfs.2022.120854

MC1568 improves insulin secretion in islets from type 2 diabetes patients and rescues β-cell dysfunction caused by Hdac7 upregulation

Autori: Mahboubeh Daneshpajooh, Lena Eliasson, Karl Bacos, Charlotte Ling
Pubblicato in: Acta Diabetologica, Numero 55/12, 2018, Pagina/e 1231-1235, ISSN 0940-5429
Editore: Springer Verlag
DOI: 10.1007/s00592-018-1201-4

Epigenetics in Human Obesity and Type 2 Diabetes

Autori: Charlotte Ling, Tina Rönn
Pubblicato in: Cell Metabolism, Numero 29/5, 2019, Pagina/e 1028-1044, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2019.03.009

The effects of high glucose exposure on global gene expression and DNA methylation in human pancreatic islets

Autori: Elin Hall, Marloes Dekker Nitert, Petr Volkov, Siri Malmgren, Hindrik Mulder, Karl Bacos, Charlotte Ling
Pubblicato in: Molecular and Cellular Endocrinology, Numero 472, 2018, Pagina/e 57-67, ISSN 0303-7207
Editore: Elsevier BV
DOI: 10.1016/j.mce.2017.11.019

Glucolipotoxicity Alters Insulin Secretion via Epigenetic Changes in Human Islets

Autori: Elin Hall, Josefine Jönsson, Jones K. Ofori, Petr Volkov, Alexander Perfilyev, Marloes Dekker Nitert, Lena Eliasson, Charlotte Ling, Karl Bacos
Pubblicato in: Diabetes, Numero 68/10, 2019, Pagina/e 1965-1974, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db18-0900

ATAC-seq reveals alterations in open chromatin in pancreatic islets from subjects with type 2 diabetes

Autori: Madhusudhan Bysani, Rasmus Agren, Cajsa Davegårdh, Petr Volkov, Tina Rönn, Per Unneberg, Karl Bacos, Charlotte Ling
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-44076-8

The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis

Autori: Marie Balslev Backe, Chunyu Jin, Luz Andreone, Aditya Sankar, Karl Agger, Kristian Helin, Andreas Nygaard Madsen, Steen Seier Poulsen, Madhusudhan Bysani, Karl Bacos, Charlotte Ling, Marcelo Javier Perone, Birgitte Holst, Thomas Mandrup-Poulsen
Pubblicato in: Journal of Diabetes Research, Numero 2019, 2019, Pagina/e 1-15, ISSN 2314-6745
Editore: Hindawi Publishing Corporation
DOI: 10.1155/2019/5451038

Epigenetics of type 2 diabetes mellitus and weight change - a tool for precision medicine?

Autori: Charlotte Ling, Karl Bacos, Tina Rönn
Pubblicato in: Nature Reviews Endocrinology, Numero 18, 2022, Pagina/e 433–448, ISSN 1759-5029
Editore: Nature Publishing Group
DOI: 10.1038/s41574-022-00671-w

Lifestyle intervention in pregnant women with obesity impacts cord blood DNA methylation, which associates with body composition in the offspring

Autori: Josefine Jönsson; Kristina M Renault; Sonia García-Calzón; Alexander Perfilyev; Angela C. Estampador; Kirsten Nørgaard; Mads Vendelbo Lind; Allan Vaag; Line Hjort; Kim F. Michaelsen; Emma Malchau Carlsen; Emma Malchau Carlsen; Paul W. Franks; Charlotte Ling
Pubblicato in: Diabetes, Numero 70/4, 2021, Pagina/e 854-866, ISSN 1939-327X
Editore: American Diabetes Association
DOI: 10.2337/figshare.13501587

Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes

Autori: Sonia García-Calzón, Alexander Perfilyev, Mats Martinell, Monta Ustinova, Sebastian Kalamajski, Paul W. Franks, Karl Bacos, Ilze Elbere, Jussi Pihlajamäki, Petr Volkov, Allan Vaag, Leif Groop, Marlena Maziarz, Janis Klovins, Emma Ahlqvist, Charlotte Ling
Pubblicato in: Science Translational Medicine, Numero 12/561, 2020, Pagina/e eaaz1803, ISSN 1946-6234
Editore: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aaz1803