A study of the roles of the immune and inflammatory systems in hypertension.

Project Information

InflammaTENSION

Grant agreement ID: 726318

DOI 10.3030/726318

Project closed

EC signature date 28 March 2017

Start date 1 May 2017

End date 30 April 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 957 573,75

EU contribution € 1 957 573,75

Coordinated by

THE UNIVERSITY OF EDINBURGH
United Kingdom

Publications

Peer reviewed articles (19)

Nox1/4 inhibition exacerbates age dependent perivascular inflammation and fibrosis in a model of spontaneous hypertension. Pharmacol Res. 2020 Nov;161:105235.

Author(s): Nosalski R, Mikolajczyk T, Siedlinski M, Saju B, Koziol J, Maffia P, Guzik TJ.
Published in: Pharmacological Research, Issue 10436618, 2020, Page(s) 161, 105235, ISSN 1043-6618
Publisher: Academic Press
DOI: 10.1016/j.phrs.2020.105235

White Blood Cells and Blood PressureA Mendelian Randomization Study

Author(s): Siedlinski M, Jozefczuk E, Xu X, Teumer A, Evangelou E, Schnabel RB, Welsh P, Maffia P, Erdmann J, Tomaszewski M, Caulfield MJ, Sattar N, Holmes MV, Guzik TJ.:
Published in: Circulation, Issue 00097322, 2020, Page(s) 141(16):1307-1317, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.119.045102

Therapeutic targeting of inflammation in hypertension: from novel mechanisms to translational perspective.

Author(s): Eleanor Murray; Ryszard Nosalski; Ryszard Nosalski; Neil MacRitchie; Maciej Tomaszewski; Maciej Tomaszewski; Pasquale Maffia; Pasquale Maffia; David G. Harrison; Tomasz J. Guzik; Tomasz J. Guzik
Published in: Cardiovascular Research, Issue 00086363, 2021, Page(s) 117(13):2589-2609, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvab330

Rivaroxaban plus aspirin in obese and overweight patients with vascular disease in the COMPASS trial.

Author(s): Guzik TJ., Ramasundarahettige C., Pogosova N., Lopez-Jaramillo P., Dyal L., Berkowitz SD, Muehlhofer E., Bhatt DL., Fox KAA, Yusuf S, Eikelboom JWE:
Published in: Journal of the American College of Cardiology,, Issue 07351097, 2021, Page(s) 77(5), pp. 511-525., ISSN 0735-1097
Publisher: Elsevier BV
DOI: 10.1016/j.jacc.2020.11.061

Nanoparticle theranostics in cardiovascular inflammation.

Author(s): Neil MacRitchie; Valentina Di Francesco; Miguel Ferreira; Tomasz J. Guzik; Tomasz J. Guzik; Paolo Decuzzi; Pasquale Maffia
Published in: Seminars in Immunology, Issue 10963618, 2021, Page(s) 56:101536, ISSN 1096-3618
Publisher: Academic Press
DOI: 10.1016/j.smim.2021.101536

Role of inflammatory chemokines in hypertension

Author(s): Tomasz Mikolajczyk; Piotr Szczepaniak; Francesca Vidler; Pasquale Maffia; Gerard J. Graham; Tomasz J. Guzik; Tomasz J. Guzik
Published in: Jaournal Of Pharmacology and Therapeutics, Issue 01637258, 2021, Page(s) 223, July 2021, 107799, ISSN 0163-7258
Publisher: Pergamon Press
DOI: 10.1016/j.pharmthera.2020.107799

COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options.

Author(s): Tomasz J. Guzik; Tomasz J. Guzik; Saidi A Mohiddin; Anthony Dimarco; Vimal Patel; K Savvatis; Federica M. Marelli-Berg; Meena S. Madhur; Maciej Tomaszewski; Pasquale Maffia; Pasquale Maffia; Fulvio D'Acquisto; Stuart A. Nicklin; Ali J. Marian; Ryszard Nosalski; Ryszard Nosalski; Eleanor Murray; Bartłomiej Guzik; Colin Berry; Rhian M. Touyz; Reinhold Kreutz; Dao Wen Wang; David Bhella; Orlando Sag
Published in: Cardiovascular Research, Issue 17553245, 2020, Page(s) 1755-3245, ISSN 1755-3245
Publisher: OXFORD UNIVERSITY PRESS
DOI: 10.1093/cvr/cvaa106

Molecular imaging of cardiovascular inflammation.

Author(s): MacRitchie, N., Noonan, J., Guzik, T. J. and Maffia, P.
Published in: British Journal of Pharmacology,, Issue 00071188, 2021, Page(s) 178(21), pp. 4216-4245, ISSN 0007-1188
Publisher: Wiley-Blackwell
DOI: 10.1111/bph.15654

Epigenetics and Immunometabolism in Diabetes and Aging

Author(s): Tomasz J. Guzik, Francesco Cosentino
Published in: Antioxidants & Redox Signaling, Issue 29/3, 2018, Page(s) 257-274, ISSN 1523-0864
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ars.2017.7299

Heterogenous treatment effects: secrets for a reliable treat-to-target trial?

Author(s): Tomasz J Guzik
Published in: Cardiovascular Research, Issue 113/7, 2017, Page(s) e18-e20, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvx081

When, where, and how to target vascular inflammation in the post-CANTOS era?

Author(s): Pasquale Maffia, Tomasz J Guzik
Published in: European Heart Journal, 2019, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehz133

Involvement of CD8+ T cell subsets in early response to vascular injury in patients with peripheral artery disease in vivo

Author(s): Pawel Maga, Tomasz P. Mikolajczyk, Lukasz Partyka, Mateusz Siedlinski, Mikolaj Maga, Marek Krzanowski, Krzysztof Malinowski, Kevin Luc, Rafal Nizankowski, Deepak L. Bhatt, Tomasz J. Guzik
Published in: Clinical Immunology, Issue 194, 2018, Page(s) 26-33, ISSN 1521-6616
Publisher: Academic Press
DOI: 10.1016/j.clim.2018.06.006

Th1-type immune responses to Porphyromonas gingivalis antigens exacerbate angiotensin II-dependent hypertension and vascular dysfunction

Author(s): Marta Czesnikiewicz-Guzik, Ryszard Nosalski, Tomasz P Mikolajczyk, Francesca Vidler, Tomasz Dohnal, Elzbieta Dembowska, Delyth Graham, David G Harrison, Tomasz J Guzik
Published in: British Journal of Pharmacology, 2018, ISSN 0007-1188
Publisher: Wiley-Blackwell
DOI: 10.1111/bph.14536

1,2,3,4,6‐Penta‐ O ‐galloyl‐β‐ d ‐glucose modulates perivascular inflammation and prevents vascular dysfunction in angiotensin II‐induced hypertension

Author(s): Tomasz P. Mikolajczyk, Ryszard Nosalski, Dominik S. Skiba, Joanna Koziol, Magdalena Mazur, Amauri S. Justo‐Junior, Paulina Kowalczyk, Zofia Kusmierczyk, Agata Schramm‐Luc, Kevin Luc, Pasquale Maffia, Delyth Graham, Anna K. Kiss, Marek Naruszewicz, Tomasz J. Guzik
Published in: British Journal of Pharmacology, Issue 2019 Jan 18, 2019, ISSN 0007-1188
Publisher: Wiley-Blackwell
DOI: 10.1111/bph.14583

Causal association between periodontitis and hypertension: evidence from Mendelian randomization and a randomized controlled trial of non-surgical periodontal therapy

Author(s): Marta Czesnikiewicz-Guzik, Grzegorz Osmenda, Mateusz Siedlinski, Richard Nosalski, Piotr Pelka, Daniel Nowakowski, Grzegorz Wilk, Tomasz P Mikolajczyk, Agata Schramm-Luc, Aneta Furtak, Pawel Matusik, Joanna Koziol, Miroslaw Drozdz, Eva Munoz-Aguilera, Maciej Tomaszewski, Evangelos Evangelou, Mark Caulfield, Tomasz Grodzicki, Francesco D'Aiuto, Tomasz J Guzik
Published in: European Heart Journal, Issue 40/42, 2019, Page(s) 3459-3470, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehz646

T-Cell–Derived miRNA-214 Mediates Perivascular Fibrosis in Hypertension

Author(s): Ryszard Nosalski, Mateusz Siedlinski, Laura Denby, Eilidh McGinnigle, Michal Nowak, Aurelie Nguyen Dinh Cat, Laura Medina-Ruiz, Marco Cantini, Dominik Skiba, Grzegorz Wilk, Grzegorz Osmenda, Julie Rodor, Manuel Salmeron-Sanchez, Gerard Graham, Pasquale Maffia, Delyth Graham, Andrew H. Baker, Tomasz J. Guzik
Published in: Circulation Research, Issue 126/8, 2020, Page(s) 988-1003, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.119.315428

Cardiovascular Effects of Pharmacological Targeting of Sphingosine Kinase 1

Author(s): Ewelina Józefczuk, Ryszard Nosalski, Blessy Saju, Eva Crespo, Piotr Szczepaniak, Tomasz Jan Guzik, Mateusz Siedlinski
Published in: Hypertension, Issue 75/2, 2020, Page(s) 383-392, ISSN 0194-911X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.119.13450

Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney.

Author(s): 3. Eales JM, Jiang X, Xu X, Saluja S, Akbarov A, Cano-Gamez E, McNulty MT, Finan C, Guo H, Wystrychowski W, Szulinska M, Thomas H, Pramanik S, Chopade S, Prestes P, Wise I, Evangelou E, Salehi M, Shakanti Y, Ekholm M, Denniff M, Nazgiewicz A, Eichinger F, Godfrey B, Antczak A, Glyda M, Król R, Eyre S, Brown J, Berzuini C, Bowes J, Caulfield M, Zukowska-Szczechowska E, Zywiec J, Bogdanski P, Kret
Published in: Nature Genetics, Issue 10614036, 2021, Page(s) 53(5), pp. 630-637., ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-021-00835-w

Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney.

Author(s): Jiang X, Eales JM, Scannali D, Nazgiewicz A, Prestes P, Maier M, Denniff M, Xu X, Saluja S, Cano-Gamez E, Wystrychowski W, Szulinska M, Antczak A, Byars S, Skrypnik D, Glyda M, Król R, Zywiec J, Zukowska-Szczechowska E, Burrell LM, Woolf AS, Greenstein A, Bogdanski P, Keavney B, Morris AP, Heagerty A, Williams B, Harrap SB, Trynka G, Samani NJ, Guzik TJ, Charchar FJ, Tomaszewski M.:
Published in: Eur Heart J, Issue 0195668X, 2020, Page(s) 4580-4588, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehaa794